EBV-encoded LMP1 increases nuclear β-catenin accumulation and its transcriptional activity in nasopharyngeal carcinoma

Tumor Biology

Volumn 32, Issue 4, 2011, Pages 623-630

  You, Shuyuan ^a,b   Zhang, Fenfen ^a   Meng, Fengjiao ^a   Li, Hui ^a   Liu, Qiuyu ^c   Liang, Yingjie ^a   Dong, Yu ^a   Yang, Wancai ^d   Han, Anjia ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b Shenzhen Yantian District People's Hospital   (China)

^c HENAN PROVINCIAL PEOPLE'S HOSPITAL   (China)

^d UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

LMP1; Nasopharyngeal carcinoma; catenin

Indexed keywords

BETA CATENIN; LATENT MEMBRANE PROTEIN 1;

ADULT; AGED; ARTICLE; BIOACCUMULATION; CANCER CELL CULTURE; CELL DIFFERENTIATION; CELL NUCLEUS; CONTROLLED STUDY; EMBRYO; EPSTEIN BARR VIRUS; FEMALE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; NASOPHARYNX CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STRAIN DIFFERENCE; UPREGULATION; VIRUS CARCINOGENESIS;

EID: 80052310658     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-011-0161-x     Document Type: Article

References (25)

1. Wang D, Liebowitz D, Kieff E. An ebv membrane protein expressed in immortalized lymphocytes transforms established rodent cells. Cell. 1985;43:831-40.
2. Moorthy RK, Thorley-Lawson DA. All three domains of the Epstein- Barr virus-encoded latent membrane protein lmp-1 are required for transformation of rat-1 fibroblasts. J Virol. 1993;67:1638-46. (Pubitemid 23067672)
3. Kaye KM, Izumi KM, Kieff E. Epstein-Barr virus latent membrane protein 1 is essential for b-lymphocyte growth transformation. Proc Natl Acad Sci U S A. 1993;90:9150-4. (Pubitemid 23306469)
4. Hu LF, Chen F, Zheng X, Ernberg I, Cao SL, Christensson B, et al. Clonability and tumorigenicity of human epithelial cells expressing the ebv encoded membrane protein lmp1. Oncogene. 1993;8:1575-83. (Pubitemid 23189054)
5. Henderson S, Rowe M, Gregory C, Croom-Carter D, Wang F, Longnecker R, et al. Induction of bcl-2 expression by Epstein- Barr virus latent membrane protein 1 protects infected b cells from programmed cell death. Cell. 1991;65:1107-15. (Pubitemid 121001325)
6. Horikawa T, Yoshizaki T, Sheen TS, Lee SY, Furukawa M. Association of latent membrane protein 1 and matrix metalloproteinase 9 with metastasis in nasopharyngeal carcinoma. Cancer. 2000;89:715-23. (Pubitemid 30658568)
7. Yoshizaki T, Sato H, Furukawa M, Pagano JS. The expression of matrix metalloproteinase 9 is enhanced by Epstein-Barr virus latent membrane protein 1. Proc Natl Acad Sci U S A. 1998;95:3621-6.
8. Wang C, Ai M, Ren W, Xiao H, Li X, Tang F, et al. Epstein-Barr virus encoded latent membrane protein 1 induces traf1 expression to promote anti-apoptosis activity via nf-kappab signaling pathway in nasopharyngeal carcinoma. Chin Med J Engl. 2003;116:1022-8. (Pubitemid 36975152)
9. Rothenberger S, Bachmann E, Berger C, McQuain C, Odermatt BF, Knecht H. Natural 30 base pair and 69 base pair deletion variants of the lmp1 oncogene do stimulate nf-kappab-mediated transcription. Oncogene. 1997;14:2123-6. (Pubitemid 27237015)
10. Izumi KM, Kaye KM, Kieff ED. The Epstein-Barr virus lmp1 amino acid sequence that engages tumor necrosis factor receptor associated factors is critical for primary b lymphocyte growth transformation. Proc Natl Acad Sci U S A. 1997;94:1447-52. (Pubitemid 27087871)
11. Reya T, Clevers H. Wnt signalling in stem cells and cancer. Nature. 2005;434:843-50. (Pubitemid 40558990)
12. Wong NA, Pignatelli M. Beta-catenin - a linchpin in colorectal carcinogenesis? Am J Pathol. 2002;160:389-401.
13. Shi W, Bastianutto C, Li A, Perez-Ordonez B, Ng R, Chow KY, et al. Multiple dysregulated pathways in nasopharyngeal carcinoma revealed by gene expression profiling. Int J Cancer. 2006;119:2467-75. (Pubitemid 44546973)
14. Zeng ZY, Zhou YH, Zhang WL, Xiong W, Fan SQ, Li XL, et al. Gene expression profiling of nasopharyngeal carcinoma reveals the abnormally regulated wnt signaling pathway. Hum Pathol. 2007;38:120-33. (Pubitemid 44880208)
15. Morrison JA, Gulley ML, Pathmanathan R, Raab-Traub N. Differential signaling pathways are activated in the Epstein-Barr virus-associated malignancies nasopharyngeal carcinoma and hodgkin lymphoma. Cancer Res. 2004;64:5251-60. (Pubitemid 39006545)
16. Morrison JA, Klingelhutz AJ, Raab-Traub N. Epstein-Barr virus latent membrane protein 2a activates beta-catenin signaling in epithelial cells. J Virol. 2003;77:12276-84. (Pubitemid 37339880)
17. Everly DJ, Kusano S, Raab-Traub N. Accumulation of cytoplasmic beta-catenin and nuclear glycogen synthase kinase 3beta in Epstein-Barr virus-infected cells. J Virol. 2004;78:11648-55. (Pubitemid 39390751)
18. Jang KL, Shackelford J, Seo SY, Pagano JS. Up-regulation of beta-catenin by a viral oncogene correlates with inhibition of the seven in absentia homolog 1 in b lymphoma cells. Proc Natl Acad Sci U S A. 2005;102:18431-6. (Pubitemid 43011243)
19. Shair KH, Schnegg CI, Raab-Traub N. Epstein-Barr virus latent membrane protein-1 effects on junctional plakoglobin and induction of a cadherin switch. Cancer Res. 2009;69:5734-42.
20. Cheung ST, Huang DP, Hui AB, Lo KW, Ko CW, Tsang YS, et al. Nasopharyngeal carcinoma cell line (c666-1) consistently harbouring Epstein-Barr virus. Int J Cancer. 1999;83:121-6. (Pubitemid 29409487)
21. Maruyama K, Ochiai A, Akimoto S, Nakamura S, Baba S, Moriya Y, et al. Cytoplasmic beta-catenin accumulation as a predictor of hematogenous metastasis in human colorectal cancer. Oncology- Basel. 2000;59:302-9.
22. Kinzler KW, Vogelstein B. Lessons from hereditary colorectal cancer. Cell. 1996;87:159-70. (Pubitemid 26358996)
23. Samowitz WS, Powers MD, Spirio LN, Nollet F, van Roy F, Slattery ML. Beta-catenin mutations are more frequent in small colorectal adenomas than in larger adenomas and invasive carcinomas. Cancer Res. 1999;59:1442-4. (Pubitemid 29160107)
24. Jamora C, Fuchs E. Intercellular adhesion, signalling and the cytoskeleton. Nat Cell Biol. 2002;4:E101-8. (Pubitemid 34308851)
25. Webb N, Connolly G, Tellam J, Yap AS, Khanna R. Epstein-Barr virus associated modulation of wnt pathway is not dependent on latent membrane protein-1. PLoS ONE. 2008;3:e3254.