Epstein-Barr virus associated modulation of Wnt pathway is not dependent on latent membrane protein-1

PLoS ONE

Volumn 3, Issue 9, 2008, Pages

  Webb, Natasha ^a   Connolly, Geoff ^a   Tellam, Judy ^a   Yap, Alpha S ^b   Khanna, Rajiv ^a  

^a QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CATENIN; AXIN; BETA CATENIN; GLYCOGEN SYNTHASE KINASE 3ALPHA; LATENT MEMBRANE PROTEIN 1; WNT PROTEIN; CADHERIN; EBV ASSOCIATED MEMBRANE ANTIGEN, EPSTEIN BARR VIRUS; EBV-ASSOCIATED MEMBRANE ANTIGEN, EPSTEIN-BARR VIRUS; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; MATRIX PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CARCINOMA CELL; CONTROLLED STUDY; EPSTEIN BARR VIRUS; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE SEQUENCE; HUMAN; HUMAN CELL; NASOPHARYNX CARCINOMA; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; TRANSCRIPTION INITIATION; ANIMAL; BIOLOGICAL MODEL; CELL MEMBRANE; DOG; METABOLISM;

HUMAN HERPESVIRUS 4;

ALPHA CATENIN; ANIMALS; BETA CATENIN; CADHERINS; CELL MEMBRANE; DOGS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE EXPRESSION REGULATION, VIRAL; GLYCOGEN SYNTHASE KINASE 3; HERPESVIRUS 4, HUMAN; HUMANS; MODELS, BIOLOGICAL; TRANSCRIPTIONAL ACTIVATION; VIRAL MATRIX PROTEINS; WNT PROTEINS;

EID: 52449124737     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0003254     Document Type: Article

References (23)

1. Kieff E, Fields BN, Knipe DM, Howley PM (1996) Epstein-Barr virus and its replication. Virology. Philadelphia: Raven Press. pp 2343-2396.
2. Khanna R, Burrows SR (2000) Role of cytotoxic T lymphocytes in Epstein-Barr virus-associated diseases. Annu Rev Microbiol 54: 19-48.
3. Khanna R, Moss DJ, Gandhi M (2005) Applications of emerging immunotherapeutic strategies for Epstein-Barr virus-associated malignancies. Nature Clinical Practice Oncolcogy 2: 138-149.
4. Kulwichit W, Edwards RH, Davenport EM, Baskar JF, Godfrey V, et al. (1998) Expression of the Epstein-Barr virus latent membrane protein 1 induces B cell lymphoma in transgenic mice. ProcNatlAcadSciUSA 95: 11963-11968.
5. Henderson S, Rowe M, Gregory C, Croom-Carter D, Wang F, et al. (1991) Induction of bcl-2 expression by Epstein-Barr virus latent membrane protein 1 protects infected B cells from programmed cell death. Cell 65: 1107-1115.
6. Miller WE, Cheshire JL, Baldwin AS Jr, Raab-Traub N (1998) The NPC derived C15 LMP1 protein confers enhanced activation of NF-kappa B and induction of the EGFR in epithelial cells. Oncogene 16: 1869-1877.
7. Miller WE, Mosialos G, Kieff E, Raab-Traub N (1997) Epstein-Barr virus LMP1 induction of the epidermal growth factor receptor is mediated through a TRAF signaling pathway distinct from NF-kappaB activation. Journal of Virology 71: 586-594.
8. Lam N, Sugden B (2003 Jun 16) LMP1, a viral relative of the TNF receptor family, signals principally from intracellular compartments. EMBO J 22(12): 3027-3038.
9. Izumi KM, Kaye KM, Kieff ED (1997) The Epstein-Barr virus LMP1 amino acid sequence that engages tumor necrosis factor receptor associated factors is critical for primary B lymphocyte growth transformation. Proc Natl Acad Sci U S A 94: 1447-1452.
10. Shackelford J, Maier C, Pagano JS (2003) Epstein-Barr virus activates beta-catenin in type III latently infected B lymphocyte lines: association with deubiquitinating enzymes. Proc Natl Acad Sci U S A 100: 15572-15576.
11. Morrison JA, Klingelhutz AJ, Raab-Traub N (2003) Epstein-Barr virus latent membrane protein 2A activates beta-catenin signaling in epithelial cells. Journal of Virology 77: 12276-12284.
12. Morrison JA, Raab-Traub N (2005) Roles of the ITAM and PY motifs of Epstein-Barr virus latent membrane protein 2A in the inhibition of epithelial cell differentiation and activation of {beta}-catenin signaling. Journal of Virology 79: 2375-2382.
13. Everly DN Jr, Kusano S, Raab-Traub N (2004) Accumulation of cytoplasmic beta-catenin and nuclear glycogen synthase kinase 3beta in Epstein-Barr virus-infected cells. Journal of Virology 78: 11648-11655.
14. Tsai CN, Tsai CL, Tse KP, Chang HY, Chang YS (2002) The Epstein-Barr virus oncogene product, latent membrane protein 1, induces the downregulation of E-cadherin gene expression via activation of DNA methyltransferases. Proc Natl Acad Sci U S A 99: 10084-10089.
15. Lo AK, Huang DP, Lo KW, Chui YL, Li HM, et al. (2004) Phenotypic alterations induced by the Hong Kong-prevalent Epstein-Barr virus-encoded LMP1 variant (2117-LMP1) in nasopharyngeal epithelial cells. International Journal of Cancer 109: 919-925.
16. Tan EL, Sam CK (2007) Biological properties of TW01 cells expressing latent membrane protein-1 gene of EBV-derived from nasopharyngeal carcinoma cells at different stages of malignancy. Exp Oncol 29: 166-174.
17. Dawson CW, Tramountanis G, Eliopoulos AG, Young LS (2003) Epstein-Barr virus latent membrane protein 1 (LMP1) activates the phosphatidylinositol 3-kinase/Akt pathway to promote cell survival and induce actin filament remodeling. J Biol Chem 278: 3694-3704.
18. Tellam J, Connolly G, Webb N, Duraiswamy J, Khanna R (2003) Proteasomal targeting of a viral oncogene abrogates oncogenic phenotype and enhances immunogenicity. Blood 102: 4535-4540.
19. He TC, Sparks AB, Rago C, Hermeking H, Zawel L, et al. (1998) Identification of c-MYC as a target of the APC pathway. Science 281: 1509-1512.
20. Tetsu O, McCormick F (1999) Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 398: 422-426.
21. Morrison JA, Gulley ML, Pathmanathan R, Raab-Traub N (2004) Differential signaling pathways are activated in the Epstein-Barr virus-associated malignancies nasopharyngeal carcinoma and Hodgkin lymphoma. Cancer Research 64: 5251-5260.
22. Kao RH, Huang LC, Hsu YH (2002) Mapping the methylation pattern by bisulfite genomic sequencing of the E-cadherin promoter CpG island in nasopharyngeal carcinoma. Anticancer Research 22: 4109-4113.
23. Tsao SW, Liu Y, Wang X, Yuen PW, Leung SY, et al. (2003) The association of E-cadherin expression and the methylation status of the E-cadherin gene in nasopharyngeal carcinoma cells. European Journal of Cancer 39: 524-531.