메뉴 건너뛰기




Volumn 79, Issue 9, 2011, Pages 3733-3743

Beta interferon-mediated activation of signal transducer and activator of transcription protein 1 interferes with Rickettsia conorii replication in human endothelial cells

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; INTERFERON REGULATORY FACTOR 7; INTERFERON REGULATORY FACTOR 9; JANUS KINASE; NEUTRALIZING ANTIBODY; SERINE; SMALL INTERFERING RNA; STAT1 PROTEIN; TETRACYCLINE; TYROSINE;

EID: 80052309762     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.05008-11     Document Type: Article
Times cited : (24)

References (49)
  • 1
    • 77951934412 scopus 로고    scopus 로고
    • Essential role of mitochondrial antiviral signaling, IFN regulatory factor (IRF3), and IRF7 in Chlamydophila pneumoniae-mediated IFN-beta response and control of bacterial replication in human endothelial cells
    • Buss, C., et al. 2010. Essential role of mitochondrial antiviral signaling, IFN regulatory factor (IRF3), and IRF7 in Chlamydophila pneumoniae-mediated IFN-beta response and control of bacterial replication in human endothelial cells. J. Immunol. 184:3072-3078.
    • (2010) J. Immunol. , vol.184 , pp. 3072-3078
    • Buss, C.1
  • 2
    • 67249144899 scopus 로고    scopus 로고
    • Unphosphorylated STAT1 prolongs the expression of interferon-induced immune regulatory genes
    • Cheon, H., and G. R. Stark. 2009. Unphosphorylated STAT1 prolongs the expression of interferon-induced immune regulatory genes. Proc. Natl. Acad. Sci. U. S. A. 106:9373-9378.
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 9373-9378
    • Cheon, H.1    Stark, G.R.2
  • 3
    • 0028234529 scopus 로고
    • Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
    • Darnell, J. E., Jr., I. M. Kerr, and G. R. Stark. 1994. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264:1415-1421.
    • (1994) Science , vol.264 , pp. 1415-1421
    • Darnell Jr., J.E.1    Kerr, I.M.2    Stark, G.R.3
  • 4
    • 0030024563 scopus 로고    scopus 로고
    • Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease
    • Durbin, J. E., R. Hackenmiller, M. C. Simon, and D. E. Levy. 1996. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 84:443-450.
    • (1996) Cell , vol.84 , pp. 443-450
    • Durbin, J.E.1    Hackenmiller, R.2    Simon, M.C.3    Levy, D.E.4
  • 5
    • 0346849592 scopus 로고    scopus 로고
    • Evaluation of a PCR assay for quantitation of Rickettsia rickettsii and closely related spotted fever group rickettsiae
    • Eremeeva, M. E., G. A. Dasch, and D. J. Silverman. 2003. Evaluation of a PCR assay for quantitation of Rickettsia rickettsii and closely related spotted fever group rickettsiae. J. Clin. Microbiol. 41:5466-5472.
    • (2003) J. Clin. Microbiol. , vol.41 , pp. 5466-5472
    • Eremeeva, M.E.1    Dasch, G.A.2    Silverman, D.J.3
  • 6
    • 0027816928 scopus 로고
    • Interferon-gamma and tumor necrosis factor-alpha exert their antirickettsial effect via induction of synthesis of nitric oxide
    • Feng, H. M., and D. H. Walker. 1993. Interferon-gamma and tumor necrosis factor-alpha exert their antirickettsial effect via induction of synthesis of nitric oxide. Am. J. Pathol. 143:1016-1023.
    • (1993) Am. J. Pathol. , vol.143 , pp. 1016-1023
    • Feng, H.M.1    Walker, D.H.2
  • 7
    • 0021821539 scopus 로고
    • Alpha-interferon-induced transcription of HLA and metallothionein genes containing homologous upstream sequences
    • Friedman, R. L., and G. R. Stark. 1985. Alpha-interferon-induced transcription of HLA and metallothionein genes containing homologous upstream sequences. Nature 314:637-639.
    • (1985) Nature , vol.314 , pp. 637-639
    • Friedman, R.L.1    Stark, G.R.2
  • 8
    • 0025172081 scopus 로고
    • ISGF3, the transcriptional activator induced by interferon alpha, consists of multiple interacting polypeptide chains
    • Fu, X. Y., D. S. Kessler, S. A. Veals, D. E. Levy, and J. E. Darnell, Jr. 1990. ISGF3, the transcriptional activator induced by interferon alpha, consists of multiple interacting polypeptide chains. Proc. Natl. Acad. Sci. U. S. A. 87:8555-8559.
    • (1990) Proc. Natl. Acad. Sci. U. S. A. , vol.87 , pp. 8555-8559
    • Fu, X.Y.1    Kessler, D.S.2    Veals, S.A.3    Levy, D.E.4    Darnell Jr., J.E.5
  • 9
    • 0026686488 scopus 로고
    • The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction
    • Fu, X. Y., C. Schindler, T. Improta, R. Aebersold, and J. E. Darnell, Jr. 1992. The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction. Proc. Natl. Acad. Sci. U. S. A. 89:7840-7843.
    • (1992) Proc. Natl. Acad. Sci. U. S. A. , vol.89 , pp. 7840-7843
    • Fu, X.Y.1    Schindler, C.2    Improta, T.3    Aebersold, R.4    Darnell Jr., J.E.5
  • 10
    • 0035811006 scopus 로고    scopus 로고
    • Biologic consequences of Stat1-independent IFN signaling
    • Gil, M. P., et al. 2001. Biologic consequences of Stat1-independent IFN signaling. Proc. Natl. Acad. Sci. U. S. A. 98:6680-6685.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 6680-6685
    • Gil, M.P.1
  • 11
    • 17844380477 scopus 로고    scopus 로고
    • Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction
    • Honda, K., et al. 2005. Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction. Nature 434:1035-1040.
    • (2005) Nature , vol.434 , pp. 1035-1040
    • Honda, K.1
  • 12
    • 17144404177 scopus 로고    scopus 로고
    • IRF-7 is the master regulator of type-I interferondependent immune responses
    • Honda, K., et al. 2005. IRF-7 is the master regulator of type-I interferondependent immune responses. Nature 434:772-777.
    • (2005) Nature , vol.434 , pp. 772-777
    • Honda, K.1
  • 13
    • 33748475531 scopus 로고    scopus 로고
    • Type I interferon gene induction by the interferon regulatory factor family of transcription factors
    • Honda, K., A. Takaoka, and T. Taniguchi. 2006. Type I interferon gene induction by the interferon regulatory factor family of transcription factors. Immunity 25:349-360.
    • (2006) Immunity , vol.25 , pp. 349-360
    • Honda, K.1    Takaoka, A.2    Taniguchi, T.3
  • 14
    • 33745092438 scopus 로고    scopus 로고
    • Toll-like receptor signaling and IRF transcription factors
    • Honda, K., and T. Taniguchi. 2006. Toll-like receptor signaling and IRF transcription factors. IUBMB Life 58:290-295.
    • (2006) IUBMB Life , vol.58 , pp. 290-295
    • Honda, K.1    Taniguchi, T.2
  • 15
    • 33748051738 scopus 로고    scopus 로고
    • IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors
    • Honda, K., and T. Taniguchi. 2006. IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors. Nat. Rev. Immunol. 6:644-658.
    • (2006) Nat. Rev. Immunol. , vol.6 , pp. 644-658
    • Honda, K.1    Taniguchi, T.2
  • 16
    • 2342489869 scopus 로고    scopus 로고
    • NFkappaB activation suppresses host cell apoptosis during Rickettsia rickettsii infection via regulatory effects on intracellular localization or levels of apoptogenic and anti-apoptotic proteins
    • Joshi, S. G., C. W. Francis, D. J. Silverman, and S. K. Sahni. 2004. NFkappaB activation suppresses host cell apoptosis during Rickettsia rickettsii infection via regulatory effects on intracellular localization or levels of apoptogenic and anti-apoptotic proteins. FEMS Microbiol. Lett. 234:333-341.
    • (2004) FEMS Microbiol. Lett. , vol.234 , pp. 333-341
    • Joshi, S.G.1    Francis, C.W.2    Silverman, D.J.3    Sahni, S.K.4
  • 17
    • 0028865139 scopus 로고
    • IL-6 and IL-8 production from cultured human endothelial cells stimulated by infection with Rickettsia conorii via a cellassociated IL-1 alpha-dependent pathway
    • Kaplanski, G., et al. 1995. IL-6 and IL-8 production from cultured human endothelial cells stimulated by infection with Rickettsia conorii via a cellassociated IL-1 alpha-dependent pathway. J. Clin. Invest. 96:2839-2844.
    • (1995) J. Clin. Invest. , vol.96 , pp. 2839-2844
    • Kaplanski, G.1
  • 18
    • 0035862950 scopus 로고    scopus 로고
    • Specificity of signaling by STAT1 depends on SH2 and C-terminal domains that regulate Ser727 phosphorylation, differentially affecting specific target gene expression
    • Kovarik, P., et al. 2001. Specificity of signaling by STAT1 depends on SH2 and C-terminal domains that regulate Ser727 phosphorylation, differentially affecting specific target gene expression. EMBO J. 20:91-100.
    • (2001) EMBO J. , vol.20 , pp. 91-100
    • Kovarik, P.1
  • 19
    • 18944380369 scopus 로고    scopus 로고
    • Upregulation of the JAK/STAT1 signal pathway during Chlamydia trachomatis infection
    • Lad, S. P., E. Y. Fukuda, J. Li, L. M. de la Maza, and E. Li. 2005. Upregulation of the JAK/STAT1 signal pathway during Chlamydia trachomatis infection. J. Immunol. 174:7186-7193.
    • (2005) J. Immunol. , vol.174 , pp. 7186-7193
    • Lad, S.P.1    Fukuda, E.Y.2    Li, J.3    de la Maza, L.M.4    Li, E.5
  • 20
    • 0024147529 scopus 로고
    • Transcriptional regulation of interferon-stimulated genes: a DNA response element and induced proteins that recognize it
    • Levy, D., N. Reich, D. Kessler, R. Pine, and J. E. Darnell, Jr. 1988. Transcriptional regulation of interferon-stimulated genes: a DNA response element and induced proteins that recognize it. Cold Spring Harbor Symp. Quant. Biol. 53:799-802.
    • (1988) Cold Spring Harbor Symp. Quant. Biol. , vol.53 , pp. 799-802
    • Levy, D.1    Reich, N.2    Kessler, D.3    Pine, R.4    Darnell Jr., J.E.5
  • 21
    • 0023987751 scopus 로고
    • Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional control
    • Levy, D. E., D. S. Kessler, R. Pine, N. Reich, and J. E. Darnell, Jr. 1988. Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional control. Genes Dev. 2:383-393.
    • (1988) Genes Dev , vol.2 , pp. 383-393
    • Levy, D.E.1    Kessler, D.S.2    Pine, R.3    Reich, N.4    Darnell Jr., J.E.5
  • 22
    • 0024721567 scopus 로고
    • Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha-stimulated transcription, reconstituted in vitro
    • Levy, D. E., D. S. Kessler, R. Pine, and J. E. Darnell, Jr. 1989. Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha-stimulated transcription, reconstituted in vitro. Genes Dev. 3:1362-1371.
    • (1989) Genes Dev , vol.3 , pp. 1362-1371
    • Levy, D.E.1    Kessler, D.S.2    Pine, R.3    Darnell Jr., J.E.4
  • 23
    • 0032538891 scopus 로고    scopus 로고
    • Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7
    • Marie, I., J. E. Durbin, and D. E. Levy. 1998. Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7. EMBO J. 17:6660-6669.
    • (1998) EMBO J , vol.17 , pp. 6660-6669
    • Marie, I.1    Durbin, J.E.2    Levy, D.E.3
  • 24
    • 13344282731 scopus 로고    scopus 로고
    • Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway
    • Meraz, M. A., et al. 1996. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 84:431-442.
    • (1996) Cell , vol.84 , pp. 431-442
    • Meraz, M.A.1
  • 25
    • 33845704539 scopus 로고    scopus 로고
    • Reemergence of rickettsiosis in Oran
    • Mouffok, N., et al. 2006. Reemergence of rickettsiosis in Oran, Algeria. Ann. N. Y. Acad. Sci. 1078:180-184.
    • (2006) Algeria. Ann. N. Y. Acad. Sci. , vol.1078 , pp. 180-184
    • Mouffok, N.1
  • 27
    • 4344627833 scopus 로고    scopus 로고
    • Type I interferon production enhances susceptibility to Listeria monocytogenes infection
    • O'Connell, R. M., et al. 2004. Type I interferon production enhances susceptibility to Listeria monocytogenes infection. J. Exp. Med. 200:437-445.
    • (2004) J. Exp. Med. , vol.200 , pp. 437-445
    • O'Connell, R.M.1
  • 28
    • 0032246967 scopus 로고    scopus 로고
    • Guillain-Barre polyneuropathy associated with Mediterranean spotted fever: case report
    • Popivanova, N., D. Hristova, and E. Hadjipetrova. 1998. Guillain-Barre polyneuropathy associated with Mediterranean spotted fever: case report. Clin. Infect. Dis. 27:1549.
    • (1998) Clin. Infect. Dis. , vol.27 , pp. 1549
    • Popivanova, N.1    Hristova, D.2    Hadjipetrova, E.3
  • 29
    • 33646865107 scopus 로고    scopus 로고
    • STAT1 regulates IFN-alpha beta- and IFN-gamma-dependent control of infection with Chlamydia pneumoniae by nonhemopoietic cells
    • Rothfuchs, A. G., et al. 2006. STAT1 regulates IFN-alpha beta- and IFNgamma-dependent control of infection with Chlamydia pneumoniae by nonhemopoietic cells. J. Immunol. 176:6982-6990.
    • (2006) J. Immunol. , vol.176 , pp. 6982-6990
    • Rothfuchs, A.G.1
  • 30
    • 0036073379 scopus 로고    scopus 로고
    • Rickettsia rickettsii infection of cultured human endothelial cells induces heme oxygenase 1 expression
    • Rydkina, E., A. Sahni, D. J. Silverman, and S. K. Sahni. 2002. Rickettsia rickettsii infection of cultured human endothelial cells induces heme oxygenase 1 expression. Infect. Immun. 70:4045-4052.
    • (2002) Infect. Immun. , vol.70 , pp. 4045-4052
    • Rydkina, E.1    Sahni, A.2    Silverman, D.J.3    Sahni, S.K.4
  • 31
    • 34447284713 scopus 로고    scopus 로고
    • Comparative analysis of host-cell signalling mechanisms activated in response to infection with Rickettsia conorii and Rickettsia typhi
    • Rydkina, E., A. Sahni, D. J. Silverman, and S. K. Sahni. 2007. Comparative analysis of host-cell signalling mechanisms activated in response to infection with Rickettsia conorii and Rickettsia typhi. J. Med. Microbiol. 56:896-906.
    • (2007) J. Med. Microbiol. , vol.56 , pp. 896-906
    • Rydkina, E.1    Sahni, A.2    Silverman, D.J.3    Sahni, S.K.4
  • 32
    • 0031924778 scopus 로고    scopus 로고
    • Proteasome-independent activation of nuclear factor kappaB in cytoplasmic extracts from human endothelial cells by Rickettsia rickettsii
    • Sahni, S. K., et al. 1998. Proteasome-independent activation of nuclear factor kappaB in cytoplasmic extracts from human endothelial cells by Rickettsia rickettsii. Infect. Immun. 66:1827-1833.
    • (1998) Infect. Immun. , vol.66 , pp. 1827-1833
    • Sahni, S.K.1
  • 33
    • 0032434924 scopus 로고    scopus 로고
    • Positive feedback regulation of type I IFN genes by the IFN-inducible transcription factor IRF-7
    • Sato, M., et al. 1998. Positive feedback regulation of type I IFN genes by the IFN-inducible transcription factor IRF-7. FEBS Lett. 441:106-110.
    • (1998) FEBS Lett , vol.441 , pp. 106-110
    • Sato, M.1
  • 34
    • 0024661528 scopus 로고
    • Complications in Mediterranean boutonneuse fever: prospective study of 78 patients
    • (In Spanish.)
    • Soriano, V., M. Sabria, J. Davins, and J. M. Manterola. 1989. Complications in Mediterranean boutonneuse fever: prospective study of 78 patients. Rev. Clin. Esp. 184:459-463. (In Spanish.)
    • (1989) Rev. Clin. Esp. , vol.184 , pp. 459-463
    • Soriano, V.1    Sabria, M.2    Davins, J.3    Manterola, J.M.4
  • 35
    • 9644301041 scopus 로고    scopus 로고
    • Epidemiologic features of Mediterranean spotted fever in Portugal
    • (In Portuguese.)
    • Sousa, R., S. D. Nobrega, F. Bacellar, and J. Torgal. 2003. Epidemiologic features of Mediterranean spotted fever in Portugal. Acta Med. Port. 16: 429-436. (In Portuguese.)
    • (2003) Acta Med. Port. , vol.16 , pp. 429-436
    • Sousa, R.1    Nobrega, S.D.2    Bacellar, F.3    Torgal, J.4
  • 36
    • 0025719793 scopus 로고
    • Rickettsia rickettsii infection of cultured endothelial cells induces release of large von Willebrand factor multimers from Weibel-Palade bodies
    • Sporn, L. A., R. J. Shi, S. O. Lawrence, D. J. Silverman, and V. J. Marder. 1991. Rickettsia rickettsii infection of cultured endothelial cells induces release of large von Willebrand factor multimers from Weibel-Palade bodies. Blood 78:2595-2602.
    • (1991) Blood , vol.78 , pp. 2595-2602
    • Sporn, L.A.1    Shi, R.J.2    Lawrence, S.O.3    Silverman, D.J.4    Marder, V.J.5
  • 37
    • 0027215044 scopus 로고
    • E-selectin-dependent neutrophil adhesion to Rickettsia rickettsii-infected endothelial cells
    • Sporn, L. A., S. O. Lawrence, D. J. Silverman, and V. J. Marder. 1993. E-selectin-dependent neutrophil adhesion to Rickettsia rickettsii-infected endothelial cells. Blood 81:2406-2412.
    • (1993) Blood , vol.81 , pp. 2406-2412
    • Sporn, L.A.1    Lawrence, S.O.2    Silverman, D.J.3    Marder, V.J.4
  • 38
    • 0030979518 scopus 로고    scopus 로고
    • Rickettsia rickettsii infection of cultured human endothelial cells induces NF-kappaB activation
    • Sporn, L. A., et al. 1997. Rickettsia rickettsii infection of cultured human endothelial cells induces NF-kappaB activation. Infect. Immun. 65:2786-2791.
    • (1997) Infect. Immun. , vol.65 , pp. 2786-2791
    • Sporn, L.A.1
  • 39
    • 1642463012 scopus 로고    scopus 로고
    • STAT1 knockout mice are highly susceptible to pulmonary mycobacterial infection
    • Sugawara, I., H. Yamada, and S. Mizuno. 2004. STAT1 knockout mice are highly susceptible to pulmonary mycobacterial infection. Tohoku J. Exp. Med. 202:41-50.
    • (2004) Tohoku J. Exp. Med. , vol.202 , pp. 41-50
    • Sugawara, I.1    Yamada, H.2    Mizuno, S.3
  • 40
    • 0344355688 scopus 로고    scopus 로고
    • High-efficiency and low-toxicity adenovirus-assisted endothelial transfection
    • Takahashi, T. 1999. High-efficiency and low-toxicity adenovirus-assisted endothelial transfection. Methods Mol. Med. 30:307-314.
    • (1999) Methods Mol. Med. , vol.30 , pp. 307-314
    • Takahashi, T.1
  • 41
    • 0034733672 scopus 로고    scopus 로고
    • Cross talk between interferon-gamma and -alpha/beta signaling components in caveolar membrane domains
    • Takaoka, A., et al. 2000. Cross talk between interferon-gamma and -alpha/beta signaling components in caveolar membrane domains. Science 288: 2357-2360.
    • (2000) Science , vol.288 , pp. 2357-2360
    • Takaoka, A.1
  • 42
    • 0026733617 scopus 로고
    • von Willebrand factor release and thrombomodulin and tissue factor expression in Rickettsia conorii-infected endothelial cells
    • Teysseire, N., D. Arnoux, F. George, J. Sampol, and D. Raoult. 1992. von Willebrand factor release and thrombomodulin and tissue factor expression in Rickettsia conorii-infected endothelial cells. Infect. Immun. 60:4388-4393.
    • (1992) Infect. Immun. , vol.60 , pp. 4388-4393
    • Teysseire, N.1    Arnoux, D.2    George, F.3    Sampol, J.4    Raoult, D.5
  • 43
    • 0028819298 scopus 로고
    • Rickettsia conorii entry into Vero cells
    • Teysseire, N., J. A. Boudier, and D. Raoult. 1995. Rickettsia conorii entry into Vero cells. Infect. Immun. 63:366-374.
    • (1995) Infect. Immun. , vol.63 , pp. 366-374
    • Teysseire, N.1    Boudier, J.A.2    Raoult, D.3
  • 44
    • 0025113830 scopus 로고
    • Selection of alpha/beta interferon- and gamma interferon-resistant rickettsiae by passage of Rickettsia prowazekii in L929 cells
    • Turco, J., and H. H. Winkler. 1990. Selection of alpha/beta interferon- and gamma interferon-resistant rickettsiae by passage of Rickettsia prowazekii in L929 cells. Infect. Immun. 58:3279-3285.
    • (1990) Infect. Immun. , vol.58 , pp. 3279-3285
    • Turco, J.1    Winkler, H.H.2
  • 45
    • 0031931443 scopus 로고    scopus 로고
    • Nitric oxidemediated inhibition of the ability of Rickettsia prowazekii to infect mouse fibroblasts and mouse macrophagelike cells
    • Turco, J., H. Liu, S. F. Gottlieb, and H. H. Winkler. 1998. Nitric oxidemediated inhibition of the ability of Rickettsia prowazekii to infect mouse fibroblasts and mouse macrophagelike cells. Infect. Immun. 66:558-566.
    • (1998) Infect. Immun. , vol.66 , pp. 558-566
    • Turco, J.1    Liu, H.2    Gottlieb, S.F.3    Winkler, H.H.4
  • 47
    • 0033828692 scopus 로고    scopus 로고
    • Establishment of a novel endothelial target mouse model of a typhus group rickettsiosis: evidence for critical roles for gamma interferon and CD8 T lymphocytes
    • Walker, D. H., V. L. Popov, and H. M. Feng. 2000. Establishment of a novel endothelial target mouse model of a typhus group rickettsiosis: evidence for critical roles for gamma interferon and CD8 T lymphocytes. Lab. Invest. 80:1361-1372.
    • (2000) Lab. Invest. , vol.80 , pp. 1361-1372
    • Walker, D.H.1    Popov, V.L.2    Feng, H.M.3
  • 48
    • 42349101098 scopus 로고    scopus 로고
    • Emerging and re-emerging rickettsioses: endothelial cell infection and early disease events
    • Walker, D. H., and N. Ismail. 2008. Emerging and re-emerging rickettsioses: endothelial cell infection and early disease events. Nat. Rev. Microbiol. 6:375-386.
    • (2008) Nat. Rev. Microbiol. , vol.6 , pp. 375-386
    • Walker, D.H.1    Ismail, N.2
  • 49
    • 3242813113 scopus 로고    scopus 로고
    • The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses
    • Yoneyama, M., et al. 2004. The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat. Immunol. 5:730-737.
    • (2004) Nat. Immunol. , vol.5 , pp. 730-737
    • Yoneyama, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.