The TGF-β route to renal fibrosis is not linear: The miR-21 viaduct

Journal of the American Society of Nephrology

Volumn 22, Issue 9, 2011, Pages 1573-1575

  Eddy, Allison A ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN 2 RECEPTOR; COLLAGEN TYPE 1; DICER; FIBRONECTIN; MESSENGER RNA; MICRORNA 21; RIBONUCLEASE III; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

3' UNTRANSLATED REGION; BINDING SITE; CHRONIC KIDNEY DISEASE; COMPLEX FORMATION; CYTOPLASM; EDITORIAL; GENE EXPRESSION; GENE OVEREXPRESSION; GENE SILENCING; GENETIC TRANSCRIPTION; HUMAN; KIDNEY FIBROSIS; KIDNEY FUNCTION; KIDNEY TUBULE EPITHELIUM; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; RNA PROCESSING; RNA TRANSLATION; SIGNAL TRANSDUCTION; UPREGULATION;

EID: 80052309282     PISSN: 10466673     EISSN: 15333450     Source Type: Journal    
DOI: 10.1681/ASN.2011070698     Document Type: Editorial

References (29)

1. Zeisberg M., Neilson E.G.: Mechanisms of tubulointerstitial fibrosis. J Am Soc Nephrol 21: 1819-1834, 2010
2. Kopp J.B.: TGF-beta signaling and the renal tubular epithelial cell: Too much, too little, and just right. J Am Soc Nephrol 21: 1241-1243, 2010
3. Kulkarni A.B., Huh C.G., Becker D., Geiser A., Lyght M., Flanders K.C., Roberts A.B., Sporn M.B., Ward J.M., Karlsson S.: Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci U S A 90: 770-774, 1993 (Pubitemid 23028947)
4. Xavier S., Niranjan T., Krick S., Zhang T., Ju W., Shaw A.S., Schiffer M., Bottinger E.P.: TbetaRI independently activates Smad- and CD2AP-dependent pathways in podocytes. J Am Soc Nephrol 20: 2127-2137, 2009
5. Sato M., Muragaki Y., Saika S., Roberts A.B., Ooshima A.: Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction. J Clin Invest 112: 1486-1494, 2003 (Pubitemid 38056275)
6. Zhong X., Chung A.C.K., Chen H-Y, Meng X-M, Lan H.Y.: Smad3-mediated upregulation of miR-21 promotes renal fibrosis. J Am Soc Nephrol 22: 1668-1681, 2011
7. Lee R.C., Feinbaum R.L., Ambros V.: The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75: 843-854, 1993 (Pubitemid 24014542)
8. Wightman B., Ha I., Ruvkun G.: Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell 75: 855-862, 1993 (Pubitemid 24014543)
9. Chan J.A., Krichevsky A.M., Kosik K.S.: MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res 65: 6029-6033, 2005 (Pubitemid 40994386)
10. Denby L., Ramdas V., McBride M.W., Wang J., Robinson H., McClure J., Crawford W., Hillyard D.Z., Khanin R., Agami R., Dominiczak A.F., Sharpe C.C., Baker A.H.: miR-21 and miR-214 are consistently modulated during renal injury in rodent models. Am J Pathol 179: 661-672, 2011
11. Dey N., Das F., Mariappan M.M., Mandal C.C., Ghosh-Choudhury N., Kasinath B.S., Ghosh Choudhury G: microRNA-21 orchestrates high glucose-induced signals to TORC1 for renal cell pathology in diabetes. J Biol Chem http://www.jbc.org/ content/early/2011/05/25/jbc.M110.208066
12. Davis B.N., Hilyard A.C., Lagna G., Hata A.: SMAD proteins control DROSHA-mediated microRNA maturation. Nature 454: 56-61, 2008 (Pubitemid 351931982)
13. Krichevsky A.M., Gabriely G.: miR-21: A small multi-faceted RNA. J Cell Mol Med 13: 39-53, 2009
14. Thum T., Gross C., Fiedler J., Fischer T., Kissler S., Bussen M., Galuppo P., Just S., Rottbauer W., Frantz S., Castoldi M., Soutschek J., Koteliansky V., Rosenwald A., Basson M.A., Licht J.D., Pena J.T., Rouhanifard S.H., Muckenthaler M.U., Tuschl T., Martin G.R., Bauersachs J., Engelhardt S.: MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature 456: 980-984, 2008
15. Patrick D.M., Montgomery R.L., Qi X., Obad S., Kauppinen S., Hill J.A., Van Rooij E., Olson E.N.: Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice. J Clin Invest 120: 3912-3916, 2010
16. Godwin J.G., Ge X., Stephan K., Jurisch A., Tullius S.G., Iacomini J.: Identification of a microRNA signature of renal ischemia reperfusion injury. Proc Natl Acad Sci U S A 107: 14339-14344, 2010
17. Wei Q., Bhatt K., He H.Z., Mi Q.S., Haase V.H., Dong Z.: Targeted deletion of Dicer from proximal tubules protects against renal ischemia-reperfusion injury. J Am Soc Nephrol 21: 756-761, 2010
18. Cekaite L., Clancy T., Sioud M: Increased miR-21 expression during human monocyte differentiation into DCs. Front Biosci (Elite Ed) 2: 818-828, 2010
19. Zhou J., Wang K.C., Wu W., Subramaniam S., Shyy J.Y., Chiu J.J., Li J.Y., Chien S.: MicroRNA-21 targets peroxisome proliferators-activated receptor-{alpha} in an autoregulatory loop to modulate flow-induced endothelial inflammation. Proc Natl Acad Sci U S A 108: 10355-10360, 2011
20. Sabatel C., Malvaux L., Bovy N., Deroanne C., Lambert V., Gonzalez M.L., Colige A., Rakic J.M., Noel A., Martial J.A., Struman I.: MicroRNA-21 exhibits antiangiogenic function by targeting RhoB expression in endothelial cells. PLoS One 6: e16979, 2011
21. Liu G., Friggeri A., Yang Y., Milosevic J., Ding Q., Thannickal V.J., Kaminski N., Abraham E.: miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis. J Exp Med 207: 1589-1597, 2010
22. Iliopoulos D., Jaeger S.A., Hirsch H.A., Bulyk M.L., Struhl K.: STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer. Mol Cell 39: 493-506, 2010
23. Krupa A., Jenkins R., Luo D.D., Lewis A., Phillips A., Fraser D.: Loss of MicroRNA-192 promotes fibrogenesis in diabetic nephropathy. J Am Soc Nephrol 21: 438-447, 2010
24. Kato M., Zhang J., Wang M., Lanting L., Yuan H., Rossi J.J., Natarajan R.: MicroRNA-192 in diabetic kidney glomeruli and its function in TGFbeta- induced collagen expression via inhibition of E-box repressors. Proc Natl Acad Sci U S A 104: 3432-3437, 2007 (Pubitemid 46364176)
25. Chung A.C., Huang X.R., Meng X., Lan H.Y.: miR-192 mediates TGF-beta/ Smad3-driven renal fibrosis. J Am Soc Nephrol 21: 1317-1325, 2010
26. Wang B., Koh P., Winbanks C., Coughlan M.T., McClelland A., Watson A., Jandeleit-Dahm K., Burns W.C., Thomas M.C., Cooper M.E., Kantharidis P.: miR-200a prevents renal fibrogenesis through repression of TGFbeta2 expression. Diabetes 60: 280-287, 2011
27. Du B., Ma L.M., Huang M.B., Zhou H., Huang H.L., Shao P., Chen Y.Q., Qu L.H.: High glucose down-regulates miR-29a to increase collagen IV production in HK-2 cells. FEBS Lett 584: 811-816, 2010
28. Lorenzen J.M., Kielstein J.T., Hafer C., Gupta S.K., Kumpers P., Faulhaber- Walter R, Haller H, Fliser D, Thum T: Circulating miR-210 predicts survival in critically ill patients with acute kidney injury. Clin J Am Soc Nephrol 6: 1540-1546, 2011
29. Martin M.M., Buckenberger J.A., Jiang J., Malana G.E., Nuovo G.J., Chotani M., Feldman D.S., Schmittgen T.D., Elton T.S.: The human angiotensin II type 1 receptor +1166 A/C polymorphism attenuates microrna-155 binding. J Biol Chem 282: 24262-24269, 2007 (Pubitemid 47328062)