Diabetes causes multiple genetic alterations and downregulates expression of DNA repair genes in the prostate

Laboratory Investigation

Volumn 91, Issue 9, 2011, Pages 1363-1374

  Ye, Chunwei ^a   Li, Xiaojuan ^a   Wang, Yu ^a   Zhang, Yuying ^a   Cai, Mengyin ^a   Zhu, Baoyi ^a   Mu, Panwei ^a   Xia, Xuan ^a   Zhao, Yi ^a   Weng, Jianping ^a   Gao, Xin ^a   Wen, Xingqiao ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

diabetes mellitus; DNA damage; microarray; oxidative stress; prostate

Indexed keywords

DNA; GLUCOSE; MRE11 PROTEIN; XRCC3 PROTEIN;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CYCLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DNA DAMAGE; DNA MICROARRAY; DNA REPAIR; DOWN REGULATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROSTATE; RAT; REAL TIME POLYMERASE CHAIN REACTION; UNINDEXED SEQUENCE; UPREGULATION; WESTERN BLOTTING;

EID: 80052285649     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2011.87     Document Type: Article

References (33)

1. Yang WM, Lu JM, Weng JM, et al. Prevalence of diabetes among men and women in China. N Engl J Med 2010;362:1090-1101.
2. Weng J, Li Y, Xu W, et al. Effect of intensive insulin therapy on beta-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: a multicentre randomised parallel-group trial. Lancet 2008;371:1753-1760. (Pubitemid 351697950)
3. Arcolino FO, Ribeiro DL, Gobbo MG, et al. Proliferation and apoptotic rates and increased frequency of p63-positive cells in the prostate acinar epithelium of alloxan-induced diabetic rats. Int J Exp Pathol 2010;91:144-154.
4. Soudamani S, Yuvaraj S, Malini T, et al. Experimental diabetes has adverse effects on the differentiation of ventral prostate during sexual maturation of rats. Anat Rec A Discov Mol Cell Evol Biol 2005;287:1281-1289. (Pubitemid 43010439)
5. Suthagar E, Soudamani S, Yuvaraj S, et al. Effects of streptozotocin (STZ)-induced diabetes and insulin replacement on rat ventral prostate. Biomed Pharmacother 2009;63:43-50.
6. Mitsuma T, Nogimori T. Effects of streptozotocin-induced diabetes mellitus on hypothalamic-pituitary-thyroid axis in rats. Endocrinol Jpn 1982;29:695-700. (Pubitemid 13079821)
7. Favaro WJ, Padovani CR, Cagnon VH. Ultrastructural and proliferative features of the ventral lobe of the prostate in non-obese diabetic mice (NOD) following androgen and estrogen replacement associated to insulin therapy. Tissue Cell 2009;41:119-132.
8. Dennis GJ, Sherman BT, Hosack DA, et al. DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol 2003;4:P3.
9. Wen X, Li X, Liao B, et al. Knockdown of p21-activated kinase 6 inhibits prostate cancer growth and enhances chemosensitivity to docetaxel. Urology 2009;73:1407-1411.
10. Wen XQ, Li XJ, Su ZL, et al. Reduced expression of alpha- tocopherolassociated protein is associated with tumor cell proliferation and the increased risk of prostate cancer recurrence. Asian J Androl 2007;9:206-212.
11. Sharifi AM, Eslami H, Larijani B, et al. Involvement of caspase-8,-9, and-3 in high glucose-induced apoptosis in PC12 cells. Neurosci Lett 2009;459:47-51.
12. Samikkannu T, Thomas JJ, Bhat GJ, et al. Acute effect of high glucose on long-term cell growth: a role for transient glucose increase in proximal tubule cell injury. Am J Physiol Renal Physiol 2006;291:162-175.
13. Shimoi K, Kasai H, Yokota N, et al. Comparison between highperformance liquid chromatography and enzyme-linked immunosorbent assay for the determination of 8-hydroxy-20-deoxyguanosine in human urine. Cancer Epidemiol Biomarkers Prev 2002;11:767-770. (Pubitemid 34851912)
14. Wu LL, Chiou CC, Chang PY, et al. Urinary 8-OHdG: a marker of oxidative stress to DNA and a risk factor for cancer, atherosclerosis and diabetics. Clin Chim Acta 2004;339:1-9. (Pubitemid 37542453)
15. Leitzmann MF, Ahn J, Albanes D, et al. Diabetes mellitus and prostate cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Cancer Causes Control 2008;19:1267-1276.
16. Gong Z, Neuhouser ML, Goodman PJ, et al. Obesity, diabetes, and risk of prostate cancer: results from the prostate cancer prevention trial. Cancer Epidemiol Biomarkers Prev 2006;15:1977-1983. (Pubitemid 44664277)
17. Abdollah F, Briganti A, Suardi N, et al. Does diabetes mellitus increase the risk of high-grade prostate cancer in patients undergoing radical prostatectomy? Prostate Cancer Prostatic Dis 2011;14:74-78.
18. Tseng CH. Diabetes and risk of prostate cancer: a study using the National Health Insurance. Diabetes Care 2011;34:616-621.
19. Tseng CH. Prostate cancer mortality in Taiwanese men: increasing age-standardized trend in general population and increased risk in diabetic men. Ann Med 2011;43:142-150.
20. Brownlee M. Biochemistry and molecular cell biology of diabetic complications. Nature 2001;414:813-820. (Pubitemid 34000785)
21. Robertson RP, Harmon J, Tran PO, et al. Glucose toxicity in beta-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection. Diabetes 2003;52:581-587. (Pubitemid 36323562)
22. Lau AT, Wang Y, Chiu JF. Reactive oxygen species: current knowledge and applications in cancer research and therapeutic. J Cell Biochem 2008;104:657-667. (Pubitemid 351671652)
23. Cooke MS, Evans MD, Dizdaroglu M, et al. Oxidative DNA damage: mechanisms, mutation, and disease. FASEB J 2003;17:1195-1214. (Pubitemid 36775767)
24. Czornak K, Chughtai S, Chrzanowska KH. Mystery of DNA repair: the role of the MRN complex and ATM kinase in DNA damage repair. J Appl Genet 2008;49:383-396.
25. Zha S, Boboila C, Alt FW. Mre11: roles in DNA repair beyond homologous recombination. Nat Struct Mol Biol 2009;16:798-800.
26. Liu N, Lamerdin JE, Tebbs RS, et al. XRCC2 and XRCC3, new human Rad51-family members, promote chromosome stability and protect against DNA cross-links and other damages. Mol Cell 1998;1: 783-793. (Pubitemid 128379063)
27. Cui X, Brenneman M, Meyne J, et al. The XRCC2 and XRCC3 repair genes are required for chromosome stability in mammalian cells. Mutat Res 1999;434:75-88. (Pubitemid 29287113)
28. Petermann E, Orta ML, Issaeva N, et al. Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair. Mol Cell 2010; 37:492-502.
29. Vigneri P, Frasca F, Sciacca L, et al. Diabetes and cancer. Endocr Relat Cancer 2009;16:1103-1123.
30. Snyder CF, Stein KB, Barone BB, et al. Does pre-existing diabetes affect prostate cancer prognosis? A systematic review. Prostate Cancer Prostatic Dis 2010;13:58-64.
31. Kasper JS, Giovannucci E. A meta-analysis of diabetes mellitus and the risk of prostate cancer. Cancer Epidemiol Biomarkers Prev 2006;15:2056-2062. (Pubitemid 44877026)
32. Tavani A, Gallus S, Bertuzzi M, et al. Diabetes mellitus and the risk of prostate cancer in Italy. Eur Urol 2005;47:313-317. (Pubitemid 40248849)
33. Kumar B, Koul S, Khandrika L, et al. Oxidative stress is inherent in prostate cancer cells and is required for aggressive phenotype. Cancer Res 2008;68:1777-1785. (Pubitemid 351416563)