Proliferation and apoptotic rates and increased frequency of p63-positive cells in the prostate acinar epithelium of alloxan-induced diabetic rats

International Journal of Experimental Pathology

Volumn 91, Issue 2, 2010, Pages 144-154

  Arcolino, Fanny Oliveira ^a   Ribeiro, Daniele Lisboa ^a   Gobbo, Marina Guimarães ^a   Taboga, Sebastião Roberto ^a   Goes, Rejane Maira ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Androgen receptor; Apoptosis; Cell proliferation; Diabetes; P63; Prostate

Indexed keywords

ANDROGEN RECEPTOR; CYCLINE; ESTRADIOL; GLUCOSE; HUMAN INSULIN; INSULIN; PROTEIN P63; TESTOSTERONE;

ALLOXAN DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BODY WEIGHT; CELL DEATH; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; ESTRADIOL BLOOD LEVEL; GLUCOSE BLOOD LEVEL; IMMUNOCYTOCHEMISTRY; MALE; MORPHOMETRICS; NICK END LABELING; NONHUMAN; ORGAN WEIGHT; PRIORITY JOURNAL; PROSTATE EPITHELIUM; PROTEIN LOCALIZATION; RAT; TESTOSTERONE BLOOD LEVEL; TREATMENT DURATION;

ANIMALS; APOPTOSIS; BLOOD GLUCOSE; BODY WEIGHT; CELL PROLIFERATION; DIABETES MELLITUS, EXPERIMENTAL; EPITHELIUM; GONADAL STEROID HORMONES; INSULIN; MALE; ORGAN SIZE; PROLIFERATING CELL NUCLEAR ANTIGEN; PROSTATE; RATS; RATS, WISTAR; RECEPTORS, ANDROGEN; TUMOR SUPPRESSOR PROTEIN P53;

EID: 77749324195     PISSN: 09599673     EISSN: 13652613     Source Type: Journal    
DOI: 10.1111/j.1365-2613.2009.00696.x     Document Type: Article

References (62)

1. Andreoni G.I., Veneziano D.B., Giannotti-Filho O., Marigo C., Mirra A.P., Fonseca L.A.M. (2001) Cancer incidence in eighteen cities of the State of São Paulo, Brazil Incidência de câncer em dezoito cidades do Estado de São Paulo. Rev. Saúde Pública. 35, 362 367.
2. Antonioli E. (2003) 77f Modulação hormonal do comportamento das células musculares lisas prostáticas in vitro e in vivoDissertação (Mestrado) Campinas : Instituto de Biologia- Universidade Estadual de Campinas.
3. Blanchere M., Mestayer C., Saunier E., Broshuis M. (2001) Transforming growth factor B in the human prostate: its role in stromal-epithelial interactions in non-cancerous cell culture. Prostate 46, 311 318.
4. Bonkhoff H. (1996) Role of the basal cells in premalignant changes of the human prostate: a stem cell concept for the development of prostate cancer. Eur. Urol. 30, 201 205.
5. Bonkhoff H. Remberger K. (1996) Differentiation pathways and histogenetic aspects of normal and abnormal prostatic growth: a stem cell model. Prostate 28, 98 106.
6. Bonkhoff H., Stein U., Remberger K. (1994) The proliferative function of basal cells in the normal and hyperplastic human prostate. Prostate 24, 114 118.
7. Bravo R. Macdonald-Bravo H. (1987) Existence of two populations of cyclin/proliferating cell nuclear antigen during the cell cycle: association with DNA replication sites. J. Cell Biol. 105, 1549 1554.
8. Cagnon V.H.A., Camargo A.M., Rosa R.M., Fabiani C.R., Padovani C.R., Martinez F.E. (2000) Ultrastructure study of the ventral lobe of the prostate of mice with streptozotocin induced diabetes (C57bl/6j). Tissue Cell 32, 275 283.
9. Carvalho C.A., Camargo A.M., Cagnon V.H.A., Padovani C.R. (2003) Effects of experimental diabetes on the structure and ultrastructure of the coagulating gland of C57BL/6J and NOD mice. Anat. Rec. A Discov. Mol. Cell. Evol. Biol. 270, 129 136.
10. Cheatham B. Kahn C.R. (1995) Insulin action and the insulin signaling network. Endocrinol. Rev. 16, 117 142.
11. Chen B., Jiang D., Tang L. (2006) Advanced glycation end-products induce apoptosis involving the signaling pathways of oxidative stress in bovine retinal pericytes. Life Sci. 79, 1040 1048.
12. Cunha G.R., Alarid E.T., Turner T., Donjacour A.A., Boutin E.L., Foster B.A. (1992) Normal and abnormal development of the male urogenital tract. Role of androgens, mesenchymal-epithelial interactions, and growth factors. J. Androl. 13, 465 475.
13. Cunha G.R., Donjacour A.A., Hayward S.W. (1998) Reciprocal mesenchymal-epithelial interaction in development of the male urogenital tract. In : Reproductive and Developmental Toxicology, pp. 509 530 (eds K.S. Korach New York : Marcel Dekker.
14. Cunha R.G., Cooke P.S., Kurita T. (2004) Role of estromal-epithelial interactions in hormonal responses. Arch. Histol. Cytol. 67, 417 434.
15. De Marzo A.M., Nelson W.G., Meeker A.K., Coffey D.S. (1998) Stem cell features of benign and malignant prostate epithelial cells. J. Urol. 160, 2381 2392.
16. De Marzo A.M., Nakai Y., Nelson W.G. (2007) Inflammation, atrophy, and prostate carcinogenesis. Urol. Oncol. 25, 398 400.
17. Ellison L.F. Wilkins K. (2009) Cancer prevalence in the Canadian population. Health Rep. 20, 7 19.
18. Favaro W.J., Padovani C.R., Cagnon V.H.A. (2008) Ultrastructural and proliferative features of the ventral lobe of the prostate in non-obese diabetic mice (NOD) following androgen and estrogen replacement associated to insulin therapy. Tissue Cell 41, 119 132.
19. Galkowska H., Olszewsk W.L., Wojewodzka U., Mijal J., Filipiuk E. (2003) Expression of apoptosis- and cell cycle-related proteins in epidermis of venous leg and diabetic foot ulcers. Surgery 134, 213 220.
20. Gao J. Isaacs J.T. (1998) Development of an androgen receptor-null model for identifying the initiation site for androgen stimulation of proliferation and suppression of programmed (apoptotic) death of PC-82 human prostate cancer cells. Cancer Res. 58, 3299 3306.
21. Grisanzio C. Signoretti S. (2008) p63 in Prostate Biology and Pathology. J. Cell. Biochem. 103, 1354 1368.
22. Gulbahar M.Y., Yuksel H., Guvenc T., Okut H. (2005) Assessment of proliferative activity by AgNOR and PCNA in prostatic tissues of lambs implanted with zeranol. Reprod. Domest. Anim. 40, 468 474.
23. Ikeda K., Wada Y., Foster H.E. Jr., Wang Z., Weiss R.M., Latifpour J. (2000) Experimental diabetes-induced regression of the rat prostate is associated with an increased expression of transforming growth factor-β. J. Urol. 164, 180 185.
24. Isaacs J.T. (1984) Antagonistic effect of androgen on prostatic cell death. Prostate 5, 545 557.
25. Isaacs J.T. (1987) Development and characteristics of the available animal model systems for the study of prostatic cancer. Prog. Clin. Biol. Res. 239, 513 576.
26. Isaacs J.T. Coffey D.S. (1989) Etiology and disease process of benign prostatic hyperplasia. Prostate Suppl. 2, 33 50.
27. Jansson L. Sandler S. (1992) Alloxan, but not streptozotocin, increases blood perfusion of pancreativ islet in rats. Am. J. Physiol. 263, E57 E63.
28. Jemal A., Siegel R., Ward E., Murray T., Xu J., Thun M.J. (2008) Cancer Statistics. CA Cancer J. Clin. 58, 71 96.
29. Kaghad M., Bonnet H., Yang A. et al. (1997) Monoallelically expressed gene related to p53 at1p36, a region frequently deleted in neuroblastoma and other human cancers. Cell 90, 809 819.
30. Kelly K. Yin J.J. (2008) Prostate cancer and metastasis initiating stem cells. Cell Res. 18, 528 537.
31. Kelman Zvi. (1997) PCNA: structure, functions and interactions. Oncogene 14, 629 640.
32. Kerr J.F.R. Searle J. (1973) Deletion of cells by apoptosis during castration-induced involution of the rat prostate. Virchows Arch. 13, 87 102.
33. Kobayashi T. Puro D.G. (2007) Loss of insulin-mediated vasoprotection: early effect of diabetes on pericyte-containing microvessels of the retina. Invest. Ophthalmol. Vis. Sci. 48, 2350 2355.
34. Kurita T., Medina R.T., Mills A.A., Cunha G.R. (2004) Role of p63 and basal cells in the prostate. Development 131, 4955 4064.
35. Kyprianou N. Isaacs J.T. (1988) Activation of programmed cell death in the rate ventral prostate after castration. Endocrinology 122, 552 562.
36. Lam J.S. Reiter R.E. (2006) Stem cells in prostate an prostate cancer development. Urol. Oncol. 24, 131 140.
37. Lamers M.L., Gimenes F.A., Nogueira F.N., Nicolau J., Gama P., Santos M.F. (2007) Chronic hyperglycaemia increases TGFbeta2 signaling and the expression of extracellular matrix proteins in the rat parotid gland. Matrix Biol. 26, 572 582.
38. Lenzen S. (2008) The mechanisms of alloxan and streptozotocin-induced diabetes. Diabetologia 51, 216 226.
39. Marker P.C., Donjacour A.A., Dahiya R., Cunha G.R. (2003) Hormonal cellular and molecular control of prostatic development. Dev. Biol. 253, 165 174.
40. Prins G.S. Birch L. (1993) Immunocytochemical analysis of androgen receptor along the ducts of the separate rat prostate lobes after androgen withdrawal and replacement. Endocrinology 132, 169 178.
41. Prins G.S., Jung M.H., Vellanoweth R.L., Chatterjee B., Roy A.K. (1996) Age-dependent expression of the androgen receptor gene in the prostate and its implication in glandular differentiation and hyperplasia. Dev. Genet. 18, 99 106.
42. Ribeiro D.L., Candido E.M., Caldeira E., Manzaro A.J., Taboga S.R., Cagnon V.H.A. (2006) Prostatic stromal microenvironment and experimental diabetes. Eur. J. Histochem. 5, 51 60.
43. Ribeiro D.L., Marques S.F., Alberti S. et al. (2008) Malignant lesions in the ventral prostate of alloxan-induced diabetic rats. Int. J. Exp. Pathol. 89, 276 283.
44. Ribeiro D.L., Taboga S.R., Góes R.M. (2009) Diabetes induces stromal remodelling and increase in chondroitin sulfate proteoglycans of the rat ventral prostate. Int. J. Exp. Pathol. In press. doi
45. Richarson G. (2004) The banking of embryonic stem cells: the legal and ethical framework in the UK. Law Hum. Genome Rev. 20, 147 160.
46. Schalken J.A. van Leenders G. (2003) Cellular and molecular biology of the prostate: stem cell biology. Urology 62, 11 20.
47. Senoo M., Pinto F., Crum C.P., McKeon F. (2007) p63 is essential for the proliferative potential of stem cells in stratified epithelia. Cell 129, 523 536.
48. Signoretti S., Waltregny D., Dilks J. et al. (2001) p63 is a prostate basal cell marker and is required for prostate development. Am. J. Pathol. 157, 1769 1775.
49. Singh P., Uzgare A., Litvinov I., Denmeade S.R., Isaacs J.T. (2006) Combinatorial androgen receptor targeted therapy for prostate cancer. Endocr. Relat. Cancer 13, 653 666.
50. Soto C., Mena R., Luna J. et al. (2004) Silymarin induces recovery of pancreatic function after alloxan damage in rats. Life Sci. 75, 2167 2180.
51. Staak A., Kassis A.P., Olshen A. et al. (2003) Quantitation of apoptotic activity following castration in human prostatic tissue invivo. Prostate 54, 212 219.
52. Straus D.S. (1981) Effets of insulin on cellular growth and proliferation. Life Sci. 29, 2131 2139.
53. Sugimura Y., Cunha G.R., Donjacour A.A. (1986) Morphogenesis of ductal networks in the mouse prostate. Biol. Reprod. 34, 961 971.
54. Tesone M., de Souza Valle L.B., Foglia V.G., Charreau E.H. (1976) Endocrine function of the testis in streptozotocin diabetic rats. Acta Physiol. Lat. Am. 26, 387 394.
55. Tesone M., Oliveira-Filho R.M., Valle L.B. et al. (1980) Androgen receptors in the diabetic rat. Diabetologia 18, 385 390.
56. Uzgare A.R., Xu Y., Isaacs J.T. (2004) In vitro culturing and characteristics of transit amplifying epithelial cells from human prostate tissue. J. Cell. Biochem. 91, 196 205.
57. Weeks I. Woodhead J.S. (1984) Chemiluminescence immunoassays. J. Clin. Immunoassays 7, 82 89.
58. Weibel E.R. (1963) Principles and methods for the morphometric study of the lung and other organs. Lab. Invest. 12, 131 155.
59. Yan J. Brown T.R. (2008) Cell proliferation and expression of cell cycle regulatory proteins that control the g1/s transition are age dependent and lobe specific in the brown Norway rat model of prostatic hyperplasia. Endocrinology 149, 193 207.
60. Yang A., Kaghad M., Wang Y., Gillett E., Fleming M.D., Dotsch V. (1998) p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol. Cell 2, 305 316.
61. Yang A., Schweitzer R., Sun D. et al. (1999) p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature 398, 714 718.
62. Yuan X. Balk S.P. (2009) Mechanisms mediating androgen receptor reactivation after castration. Urol. Oncol. 27, 36 41.