메뉴 건너뛰기




Volumn 6, Issue 5, 2011, Pages 712-729

Modeling circadian clocks: Roles, advantages, and limitations

Author keywords

Circadian rhythms; Interlocked feedback loops; Mathematical modeling; Molecular noise; Synchronisation; Temperature compensation

Indexed keywords


EID: 80052274696     PISSN: 1895104X     EISSN: 16443632     Source Type: Journal    
DOI: 10.2478/s11535-011-0062-4     Document Type: Review
Times cited : (15)

References (129)
  • 5
    • 0037194790 scopus 로고    scopus 로고
    • Coordination of circadian timing in mammals
    • Reppert S. M., Weaver D. R., Coordination of circadian timing in mammals, Nature, 2002, 418, 935-941.
    • (2002) Nature , vol.418 , pp. 935-941
    • Reppert, S.M.1    Weaver, D.R.2
  • 6
    • 28844502722 scopus 로고    scopus 로고
    • Circadian clocks - the fall and rise of physiology
    • Roenneberg T., Merrow M., Circadian clocks - the fall and rise of physiology. Nat. Rev. Mol. Cell. Biol., 2005, 6, 965-971.
    • (2005) Nat. Rev. Mol. Cell. Biol. , vol.6 , pp. 965-971
    • Roenneberg, T.1    Merrow, M.2
  • 7
    • 0002410465 scopus 로고    scopus 로고
    • Circadian and circannual programmes in avian migration
    • Gwinner E., Circadian and circannual programmes in avian migration, J. Exp. Biol., 1996, 199, 39-48.
    • (1996) J. Exp. Biol. , vol.199 , pp. 39-48
    • Gwinner, E.1
  • 8
    • 0038813643 scopus 로고    scopus 로고
    • Illuminating the circadian clock in monarch butterfly migration
    • Froy O., Gotter A. L., Casselman A. L., Reppert S. M., Illuminating the circadian clock in monarch butterfly migration. Science, 2003, 300, 1303-1305.
    • (2003) Science , vol.300 , pp. 1303-1305
    • Froy, O.1    Gotter, A.L.2    Casselman, A.L.3    Reppert, S.M.4
  • 10
    • 22744451756 scopus 로고    scopus 로고
    • Plant circadian clocks increase photosynthesis, growth, survival, and competitive advantage
    • Dodd A. N., Salathia N., Hall A., Kévei E., Tóth R., Nagy F., et al., Plant circadian clocks increase photosynthesis, growth, survival, and competitive advantage. Science, 2005, 309, 630-633.
    • (2005) Science , vol.309 , pp. 630-633
    • Dodd, A.N.1    Salathia, N.2    Hall, A.3    Kévei, E.4    Tóth, R.5    Nagy, F.6
  • 11
    • 0033955796 scopus 로고    scopus 로고
    • Time measurement and the control of flowering in plants
    • Samach A., Coupland G., Time measurement and the control of flowering in plants. Bioessays, 2000, 22, 38-47.
    • (2000) Bioessays , vol.22 , pp. 38-47
    • Samach, A.1    Coupland, G.2
  • 12
    • 0001567288 scopus 로고
    • Circadian rhythms and the time measurement in photoperiodism
    • Bunning E., Circadian rhythms and the time measurement in photoperiodism, Cold Spring Harb. Symp. Quant. Bio. l, 1960, 25, 249-256.
    • (1960) Cold Spring Harb. Symp. Quant. Bio.L , vol.25 , pp. 249-256
    • Bunning, E.1
  • 13
    • 33845611615 scopus 로고    scopus 로고
    • Interplay of circadian clocks and metabolic rhythms
    • Wijnen H., Young M. W., Interplay of circadian clocks and metabolic rhythms, Annu. Rev. Genet., 2006, 40, 409-448.
    • (2006) Annu. Rev. Genet. , vol.40 , pp. 409-448
    • Wijnen, H.1    Young, M.W.2
  • 15
    • 0042490526 scopus 로고    scopus 로고
    • A clockwork web: circadian timing in brain and periphery, in health and disease
    • Hastings M. H., Reddy A. B., Maywood E. S. A clockwork web: circadian timing in brain and periphery, in health and disease. Nat. Rev. Neurosci., 2003, 4, 649-661.
    • (2003) Nat. Rev. Neurosci. , vol.4 , pp. 649-661
    • Hastings, M.H.1    Reddy, A.B.2    Maywood, E.S.3
  • 16
    • 0035047945 scopus 로고    scopus 로고
    • Molecular analysis of mammalian circadian rhythms
    • Reppert S. M., Weaver D. R., Molecular analysis of mammalian circadian rhythms, Annu. Rev. Physiol., 2001, 63, 647-676.
    • (2001) Annu. Rev. Physiol. , vol.63 , pp. 647-676
    • Reppert, S.M.1    Weaver, D.R.2
  • 17
    • 0035458732 scopus 로고    scopus 로고
    • Time zones: a comparative genetics of circadian clocks
    • Young M. W., Kay S. A., Time zones: a comparative genetics of circadian clocks. Nat. Rev. Genet., 2001, 2, 702-715.
    • (2001) Nat. Rev. Genet. , vol.2 , pp. 702-715
    • Young, M.W.1    Kay, S.A.2
  • 18
    • 0015119210 scopus 로고
    • Clock mutants of Drosophila melanogaster
    • Konopka R. J., Benzer S., Clock mutants of Drosophila melanogaster, Proc. Natl. Acad. Sci. USA, 1971, 68, 2112-2116.
    • (1971) Proc. Natl. Acad. Sci. USA , vol.68 , pp. 2112-2116
    • Konopka, R.J.1    Benzer, S.2
  • 19
    • 4544329329 scopus 로고    scopus 로고
    • Clock genes, oscillators, and cellular networks in the suprachiasmatic nuclei
    • Hastings M. H., Herzog E. D., Clock genes, oscillators, and cellular networks in the suprachiasmatic nuclei. J. Biol. Rhythms, 2004, 19, 400-413.
    • (2004) J. Biol. Rhythms , vol.19 , pp. 400-413
    • Hastings, M.H.1    Herzog, E.D.2
  • 20
    • 77951927020 scopus 로고    scopus 로고
    • Suprachiasmatic nucleus: cell autonomy and network properties
    • Welsh D. K., Takahashi J. S., Kay S. A., Suprachiasmatic nucleus: cell autonomy and network properties. Annu. Rev. Physiol, 2010, 72, 551-577.
    • (2010) Annu. Rev. Physiol , vol.72 , pp. 551-577
    • Welsh, D.K.1    Takahashi, J.S.2    Kay, S.A.3
  • 22
    • 22544449867 scopus 로고    scopus 로고
    • Why and how do we model circadian rhythms?
    • Beersma D. G., Why and how do we model circadian rhythms?, J. Biol. Rhythms, 2005, 20, 304-313.
    • (2005) J. Biol. Rhythms , vol.20 , pp. 304-313
    • Beersma, D.G.1
  • 24
    • 0018116973 scopus 로고
    • What do mathematical models tell us about circadian clocks?
    • Pavlidis T., What do mathematical models tell us about circadian clocks?, Bull. Math. Biol., 1978, 40, 625-635.
    • (1978) Bull. Math. Biol. , vol.40 , pp. 625-635
    • Pavlidis, T.1
  • 25
    • 80052281434 scopus 로고    scopus 로고
    • Modeling circadian clocks: From equations to oscillations
    • DOI: 10. 2478/s11535-011-0061-5
    • Gonze D., Modeling circadian clocks: From equations to oscillations, Cent. Eur. J. Biol., 2011, DOI: 10. 2478/s11535-011-0061-5.
    • (2011) Cent. Eur. J. Biol
    • Gonze, D.1
  • 27
    • 0029846766 scopus 로고    scopus 로고
    • Circadian rhythms and protein turnover: the effect of temperature on the period lengths of clock mutants simulated by the Goodwin oscillator
    • Ruoff P., Mohsenzadeh S., Rensing L., Circadian rhythms and protein turnover: the effect of temperature on the period lengths of clock mutants simulated by the Goodwin oscillator. Naturwissenschaften, 1996, 83, 514-517.
    • (1996) Naturwissenschaften , vol.83 , pp. 514-517
    • Ruoff, P.1    Mohsenzadeh, S.2    Rensing, L.3
  • 28
    • 0029991824 scopus 로고    scopus 로고
    • The temperature-compensated Goodwin model simulates many circadian clock propoerties
    • Ruoff P., Rensing L., The temperature-compensated Goodwin model simulates many circadian clock propoerties. J. Theor. Biol., 1996, 179, 275-285.
    • (1996) J. Theor. Biol. , vol.179 , pp. 275-285
    • Ruoff, P.1    Rensing, L.2
  • 29
    • 70449321820 scopus 로고
    • Biophysical and mathematical models of circadian rhythms
    • Schmitt O. H., Biophysical and mathematical models of circadian rhythms. Cold Spring Harb. Symp. Quant. Biol., 1960, 25, 207-210.
    • (1960) Cold Spring Harb. Symp. Quant. Biol. , vol.25 , pp. 207-210
    • Schmitt, O.H.1
  • 30
    • 0031148769 scopus 로고    scopus 로고
    • Hierarchically coupled ultradian oscillators generating robust circadian rhythms
    • Barrio R. A., Zhang L., Maini P. K., Hierarchically coupled ultradian oscillators generating robust circadian rhythms. Bull. Math. Biol., 1997, 59, 517-532.
    • (1997) Bull. Math. Biol. , vol.59 , pp. 517-532
    • Barrio, R.A.1    Zhang, L.2    Maini, P.K.3
  • 31
    • 33646231986 scopus 로고    scopus 로고
    • A model for generating circadian rhythm by coupling ultradian oscillators
    • Paetkau V., Edwards R., Illner R., A model for generating circadian rhythm by coupling ultradian oscillators. Theor. Biol. Med. Model., 2006, 3, 12.
    • (2006) Theor. Biol. Med. Model. , vol.3 , pp. 12
    • Paetkau, V.1    Edwards, R.2    Illner, R.3
  • 32
    • 0014486609 scopus 로고
    • Populations of interacting oscillators and circadian rhythms
    • Pavlidis T., Populations of interacting oscillators and circadian rhythms. J. Theor. Biol., 1969, 22, 418-436.
    • (1969) J. Theor. Biol. , vol.22 , pp. 418-436
    • Pavlidis, T.1
  • 34
    • 0037795575 scopus 로고    scopus 로고
    • Towards a detailed computational model for the mammalian circadian clock
    • Leloup J. C., Goldbeter A. Towards a detailed computational model for the mammalian circadian clock. Proc. Natl. Acad. Sci. USA., 2003, 100, 7051-7056.
    • (2003) Proc. Natl. Acad. Sci. USA. , vol.100 , pp. 7051-7056
    • Leloup, J.C.1    Goldbeter, A.2
  • 35
    • 4444301677 scopus 로고    scopus 로고
    • Modeling the mammalian circadian clock: sensitivity analysis and multiplicity of oscillatory mechanisms
    • Leloup J. C., Goldbeter A., Modeling the mammalian circadian clock: sensitivity analysis and multiplicity of oscillatory mechanisms. J. Theor. Biol., 2004, 230, 541-562.
    • (2004) J. Theor. Biol. , vol.230 , pp. 541-562
    • Leloup, J.C.1    Goldbeter, A.2
  • 36
    • 0012211698 scopus 로고    scopus 로고
    • Life before the clock: modeling circadian evolution
    • Roenneberg T., Merrow M., Life before the clock: modeling circadian evolution. J. Biol. Rhythms., 2002, 17, 495-505.
    • (2002) J. Biol. Rhythms. , vol.17 , pp. 495-505
    • Roenneberg, T.1    Merrow, M.2
  • 37
    • 0000096719 scopus 로고
    • On the mechanism of temperature compensation in a biological clock
    • Hastings J. W., Sweeney B. M., On the mechanism of temperature compensation in a biological clock, Proc. Natl. Acad. Sci. USA, 1957, 43, 804-811.
    • (1957) Proc. Natl. Acad. Sci. USA , vol.43 , pp. 804-811
    • Hastings, J.W.1    Sweeney, B.M.2
  • 38
    • 0026279113 scopus 로고
    • Amplitude model for the effects of mutations and temperature on period and phase resetting of the Neurospora circadian oscillator
    • Lakin-Thomas P. L., Brody S., Cote G. G., Amplitude model for the effects of mutations and temperature on period and phase resetting of the Neurospora circadian oscillator. J. Biol. Rhythms, 1991, 6, 281-297.
    • (1991) J. Biol. Rhythms , vol.6 , pp. 281-297
    • Lakin-Thomas, P.L.1    Brody, S.2    Cote, G.G.3
  • 39
    • 0003044595 scopus 로고
    • Introducing Temperature-Compensation in any Reaction Kinetic Oscillator Model
    • Ruoff P., Introducing Temperature-Compensation in any Reaction Kinetic Oscillator Model., J. Interdiscipl. Cycle Research 1992, 23, 92-99.
    • (1992) J. Interdiscipl. Cycle Research , vol.23 , pp. 92-99
    • Ruoff, P.1
  • 40
    • 0030758944 scopus 로고    scopus 로고
    • Modeling temperature compensation in chemical and biological oscillators
    • Ruoff P., Rensing L., Kommedal R., Mohsenzadeh S., Modeling temperature compensation in chemical and biological oscillators. Chronobiol. Int., 1997, 14, 499-510.
    • (1997) Chronobiol. Int. , vol.14 , pp. 499-510
    • Ruoff, P.1    Rensing, L.2    Kommedal, R.3    Mohsenzadeh, S.4
  • 41
    • 0030804324 scopus 로고    scopus 로고
    • Temperature compensation of circadian rhythms: control of the period in a model for circadian oscillations of the per protein in Drosophila
    • Leloup J. C., Goldbeter A., Temperature compensation of circadian rhythms: control of the period in a model for circadian oscillations of the per protein in Drosophila. Chronobiol. Int., 1997, 14, 511-520.
    • (1997) Chronobiol. Int. , vol.14 , pp. 511-520
    • Leloup, J.C.1    Goldbeter, A.2
  • 42
    • 14644414782 scopus 로고    scopus 로고
    • Temperature compensation in circadian clock models
    • Kurosawa G., Iwasa Y., Temperature compensation in circadian clock models., J. Theor. Biol., 2005, 233, 453-468.
    • (2005) J. Theor. Biol. , vol.233 , pp. 453-468
    • Kurosawa, G.1    Iwasa, Y.2
  • 43
    • 33846839325 scopus 로고    scopus 로고
    • Temperature compensation through systems biology
    • Ruoff P., Zakhartsev M., Westerhoff HV., Temperature compensation through systems biology. FEBS J., 274, 2007, 940-950.
    • (2007) FEBS J. , vol.274 , pp. 940-950
    • Ruoff, P.1    Zakhartsev, M.2    Westerhoff, H.V.3
  • 44
    • 70349598539 scopus 로고    scopus 로고
    • The control of the controller: molecular mechanisms for robust perfect adaptation and temperature compensation
    • Ni X. Y., Drengstig T., Ruoff P., The control of the controller: molecular mechanisms for robust perfect adaptation and temperature compensation. Biophys. J., 2009, 97, 1244-1253.
    • (2009) Biophys. J. , vol.97 , pp. 1244-1253
    • Ni, X.Y.1    Drengstig, T.2    Ruoff, P.3
  • 45
    • 33846568101 scopus 로고    scopus 로고
    • A proposal for robust temperature compensation of circadian rhythms
    • Hong C. I., Conrad E. D., Tyson J. J., A proposal for robust temperature compensation of circadian rhythms. Proc. Natl. Acad. Sci. USA, 2007, 104, 1195-1200.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 1195-1200
    • Hong, C.I.1    Conrad, E.D.2    Tyson, J.J.3
  • 46
    • 0027994487 scopus 로고
    • Circadian clock locus frequency: protein encoded by a single open reading frame defines period length and temperature compensation
    • Aronson B. D., Johnson K. A., Dunlap J. C., Circadian clock locus frequency: protein encoded by a single open reading frame defines period length and temperature compensation. Proc. Natl. Acad. Sci. USA, 1994, 91, 7683-7687.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 7683-7687
    • Aronson, B.D.1    Johnson, K.A.2    Dunlap, J.C.3
  • 47
    • 39149126958 scopus 로고    scopus 로고
    • Isoform switching facilitates period control in the Neurospora crassa circadian clock
    • Akman O. E., Locke J. C., Tang S., Carré I., Millar A. J., Rand D. A., Isoform switching facilitates period control in the Neurospora crassa circadian clock. Mol. Syst. Biol., 2008, 4, 164.
    • (2008) Mol. Syst. Biol. , vol.4 , pp. 164
    • Akman, O.E.1    Locke, J.C.2    Tang, S.3    Carré, I.4    Millar, A.J.5    Rand, D.A.6
  • 48
    • 0033595790 scopus 로고    scopus 로고
    • Interlocked feedback loops within the Drosophila circadian oscillator
    • Glossop N. R., Lyons L. C., Hardin P. E., Interlocked feedback loops within the Drosophila circadian oscillator. Science, 1999, 286, 766-768.
    • (1999) Science , vol.286 , pp. 766-768
    • Glossop, N.R.1    Lyons, L.C.2    Hardin, P.E.3
  • 49
    • 0034617102 scopus 로고    scopus 로고
    • Interconnected feedback loops in the Neurospora circadian system
    • Lee K., Loros J. J., Dunlap J. C., Interconnected feedback loops in the Neurospora circadian system. Science, 2000, 289, 107-110.
    • (2000) Science , vol.289 , pp. 107-110
    • Lee, K.1    Loros, J.J.2    Dunlap, J.C.3
  • 51
    • 0034331929 scopus 로고    scopus 로고
    • Circadian clockwork: two loops are better than one
    • Hastings M. H., Circadian clockwork: two loops are better than one, Nat. Rev. Neurosci., 2000, 1, 143-146.
    • (2000) Nat. Rev. Neurosci. , vol.1 , pp. 143-146
    • Hastings, M.H.1
  • 52
    • 0029094843 scopus 로고
    • A model for circadian oscillations in the Drosophila period protein (PER)
    • Goldbeter A., A model for circadian oscillations in the Drosophila period protein (PER), Proc. R. Soc. Lond. B, 1995, 261, 319-324.
    • (1995) Proc. R. Soc. Lond. B , vol.261 , pp. 319-324
    • Goldbeter, A.1
  • 53
    • 0033375755 scopus 로고    scopus 로고
    • Limit cycle models for circadian rhythms based on transcriptional regulation in Drosophila and Neurospora
    • Leloup J.-C., Gonze D., Goldbeter A., Limit cycle models for circadian rhythms based on transcriptional regulation in Drosophila and Neurospora, J. Biol. Rhythms, 1999, 14, 433-448.
    • (1999) J. Biol. Rhythms , vol.14 , pp. 433-448
    • Leloup, J.-C.1    Gonze, D.2    Goldbeter, A.3
  • 54
    • 0035449932 scopus 로고    scopus 로고
    • Modeling circadian oscillations with interlocking positive and negative feedback loops
    • Smolen P., Baxter D. A., Byrne J. H., Modeling circadian oscillations with interlocking positive and negative feedback loops. J. Neurosci., 2001, 21, 6644-6656.
    • (2001) J. Neurosci. , vol.21 , pp. 6644-6656
    • Smolen, P.1    Baxter, D.A.2    Byrne, J.H.3
  • 55
    • 0037154231 scopus 로고    scopus 로고
    • Robustness of circadian rhythms with respect to molecular noise
    • Gonze D., Halloy J., Goldbeter A., Robustness of circadian rhythms with respect to molecular noise, Proc. Natl. Acad. Sci. USA, 2002, 99, 673-678.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 673-678
    • Gonze, D.1    Halloy, J.2    Goldbeter, A.3
  • 56
    • 56749160113 scopus 로고    scopus 로고
    • Design principles of biochemical oscillators
    • Novak B., Tyson J. J., Design principles of biochemical oscillators, Nat. Rev. Mol. Cell. Biol., 2008, 9, 981-991.
    • (2008) Nat. Rev. Mol. Cell. Biol. , vol.9 , pp. 981-991
    • Novak, B.1    Tyson, J.J.2
  • 57
    • 0006092502 scopus 로고    scopus 로고
    • Designer gene networks: Towards fundamental cellular control
    • Hasty J., Isaacs F., Dolnik M., McMillen D., Collins J. J., Designer gene networks: Towards fundamental cellular control. Chaos, 2001, 11, 207-220.
    • (2001) Chaos , vol.11 , pp. 207-220
    • Hasty, J.1    Isaacs, F.2    Dolnik, M.3    Mc Millen, D.4    Collins, J.J.5
  • 58
    • 0037079015 scopus 로고    scopus 로고
    • Computational approaches to cellular rhythms
    • Goldbeter A., Computational approaches to cellular rhythms, Nature, 2002, 420, 238-245.
    • (2002) Nature , vol.420 , pp. 238-245
    • Goldbeter, A.1
  • 61
    • 46849090495 scopus 로고    scopus 로고
    • Robust, tunable biological oscillations from interlinked positive and negative feedback loops
    • Tsai T. Y., Choi Y. S., Ma W., Pomerening J. R., Tang C., Ferrell J. E., Robust, tunable biological oscillations from interlinked positive and negative feedback loops. Science, 2008, 321, 126-129.
    • (2008) Science , vol.321 , pp. 126-129
    • Tsai, T.Y.1    Choi, Y.S.2    Ma, W.3    Pomerening, J.R.4    Tang, C.5    Ferrell, J.E.6
  • 62
    • 23944453894 scopus 로고    scopus 로고
    • PER/TIM-mediated amplification, gene dosage effects and temperature compensation in an interlockingfeedback loop model of the Drosophila circadian clock
    • Ruoff P., Christensen M. K., Sharma V. K., PER/TIM-mediated amplification, gene dosage effects and temperature compensation in an interlockingfeedback loop model of the Drosophila circadian clock. J Theor Biol, 2005, 237, 41-57.
    • (2005) J Theor Biol , vol.237 , pp. 41-57
    • Ruoff, P.1    Christensen, M.K.2    Sharma, V.K.3
  • 63
    • 12244277104 scopus 로고    scopus 로고
    • Modeling feedback loops of the mammalian circadian oscillator
    • Becker-Weimann S., Wolf J., Herzel H., Kramer A., Modeling feedback loops of the mammalian circadian oscillator. Biophys. J., 2004, 87, 3023-3034.
    • (2004) Biophys. J. , vol.87 , pp. 3023-3034
    • Becker-Weimann, S.1    Wolf, J.2    Herzel, H.3    Kramer, A.4
  • 65
    • 70450173299 scopus 로고    scopus 로고
    • Weather and seasons together demand complex biological clocks
    • Troein C., Locke J. C., Turner M. S., Millar A. J., Weather and seasons together demand complex biological clocks. Curr. Biol., 2009, 19, 1961-1964.
    • (2009) Curr. Biol. , vol.19 , pp. 1961-1964
    • Troein, C.1    Locke, J.C.2    Turner, M.S.3    Millar, A.J.4
  • 66
    • 78649798276 scopus 로고    scopus 로고
    • The contributions of interlocking loops and extensive nonlinearity to the properties of circadian clock models
    • Saithong T., Painter K. J., Millar A. J. The contributions of interlocking loops and extensive nonlinearity to the properties of circadian clock models. PLoS One., 2010, 5, e13867.
    • (2010) PLoS One. , vol.5
    • Saithong, T.1    Painter, K.J.2    Millar, A.J.3
  • 67
    • 84981690399 scopus 로고
    • Attenuation of the petal movement rhythm of Kalanchoe with light pulses
    • Engelmann W., Johnsson A., Kobler H. G., Schimmel M., Attenuation of the petal movement rhythm of Kalanchoe with light pulses. Physiol. Plant, 1978, 43, 68-76.
    • (1978) Physiol. Plant , vol.43 , pp. 68-76
    • Engelmann, W.1    Johnsson, A.2    Kobler, H.G.3    Schimmel, M.4
  • 68
    • 37049244617 scopus 로고
    • Suppressing Drosophila circadian rhythm with dim light
    • Winfree A. T., Suppressing Drosophila circadian rhythm with dim light. Science, 1974, 183, 970-972.
    • (1974) Science , vol.183 , pp. 970-972
    • Winfree, A.T.1
  • 69
    • 0035016219 scopus 로고    scopus 로고
    • A molecular explanation for the long-term suppression of circadian rhythms by a single light pulse
    • Leloup J. C., Goldbeter A., A molecular explanation for the long-term suppression of circadian rhythms by a single light pulse. Am. J. Physiol., 2001, 280, R1206-1212.
    • (2001) Am. J. Physiol. , vol.280 , pp. 1206-1212
    • Leloup, J.C.1    Goldbeter, A.2
  • 70
    • 0005846864 scopus 로고
    • Critical pulses of anisomycin drive the circadian oscillator in Gonyaulax towards its singularity
    • Taylor W., Krasnow R., Dunlap J. C., Broda H., Hastings J. W., Critical pulses of anisomycin drive the circadian oscillator in Gonyaulax towards its singularity. J. Comp. Physiol, 1982, 148, 11-26.
    • (1982) J. Comp. Physiol , vol.148 , pp. 11-26
    • Taylor, W.1    Krasnow, R.2    Dunlap, J.C.3    Broda, H.4    Hastings, J.W.5
  • 71
    • 33751080351 scopus 로고    scopus 로고
    • Molecular mechanism of suppression of circadian rhythms by a critical stimulus
    • Huang G., Wang L., Liu Y., Molecular mechanism of suppression of circadian rhythms by a critical stimulus. EMBO J., 2006, 25, 5349-5357.
    • (2006) EMBO J. , vol.25 , pp. 5349-5357
    • Huang, G.1    Wang, L.2    Liu, Y.3
  • 72
    • 35748968484 scopus 로고    scopus 로고
    • Melanopsin-dependent photo-perturbation reveals desynchronization underlying the singularity of mammalian circadian clocks
    • Ukai H., Kobayashi T. J., Nagano M., Masumoto K. H., Sujino M., Kondo T., et al., Melanopsin-dependent photo-perturbation reveals desynchronization underlying the singularity of mammalian circadian clocks. Nat. Cell. Biol., 2007, 9, 1327-1334.
    • (2007) Nat. Cell. Biol. , vol.9 , pp. 1327-1334
    • Ukai, H.1    Kobayashi, T.J.2    Nagano, M.3    Masumoto, K.H.4    Sujino, M.5    Kondo, T.6
  • 73
    • 34250384394 scopus 로고
    • A functional analysis of circadian pacemakers in nocturnal rodents. V. Pacemaker structure: A clock for all seasons
    • Pittendrigh C. S., Daan S., A functional analysis of circadian pacemakers in nocturnal rodents. V. Pacemaker structure: A clock for all seasons. J. Comp. Physiol., 1976, 106, 333-355.
    • (1976) J. Comp. Physiol. , vol.106 , pp. 333-355
    • Pittendrigh, C.S.1    Daan, S.2
  • 74
    • 0027217544 scopus 로고
    • Light intensity and splitting in the golden hamster
    • Pickard G. E., Turek F. W., Sollars P. J., Light intensity and splitting in the golden hamster. Physiol. Behav., 1993, 54, 1-5.
    • (1993) Physiol. Behav. , vol.54 , pp. 1-5
    • Pickard, G.E.1    Turek, F.W.2    Sollars, P.J.3
  • 75
    • 0034721687 scopus 로고    scopus 로고
    • Antiphase oscillation of the left and right suprachiasmatic nuclei
    • de la Iglesia H. O., Meyer J., Carpino A. Jr., Schwartz W. J., Antiphase oscillation of the left and right suprachiasmatic nuclei., Science, 2000, 290, 799-801.
    • (2000) Science , vol.290 , pp. 799-801
    • De la Iglesia, H.O.1    Meyer, J.2    Carpino Jr., A.3    Schwartz, W.J.4
  • 76
    • 0002560906 scopus 로고
    • Splitting of circadian rhythms in the rat
    • Boulos Z., Terman M., Splitting of circadian rhythms in the rat, J. Comp. Physiol., 1979, 134, 75-83.
    • (1979) J. Comp. Physiol. , vol.134 , pp. 75-83
    • Boulos, Z.1    Terman, M.2
  • 77
    • 0026752442 scopus 로고
    • Forced splitting of human sleep in free-running rhythms
    • Zulley J., Carr D., Forced splitting of human sleep in free-running rhythms., J. Sleep Res., 1992, 1, 108-111.
    • (1992) J. Sleep Res. , vol.1 , pp. 108-111
    • Zulley, J.1    Carr, D.2
  • 78
    • 0036479605 scopus 로고    scopus 로고
    • A model for "splitting" of running-wheel activity in hamsters
    • Oda G. A., Friesen W. O., A model for "splitting" of running-wheel activity in hamsters., J. Biol. Rhythms., 2002, 17, 76-88.
    • (2002) J. Biol. Rhythms. , vol.17 , pp. 76-88
    • Oda, G.A.1    Friesen, W.O.2
  • 79
    • 0042668694 scopus 로고    scopus 로고
    • Simulation of circadian rhythm generation in the suprachiasmatic nucleus with locally coupled self-sustained oscillators
    • Kunz H., Achermann P., Simulation of circadian rhythm generation in the suprachiasmatic nucleus with locally coupled self-sustained oscillators, J. Theor. Biol., 2003, 224, 63-78.
    • (2003) J. Theor. Biol. , vol.224 , pp. 63-78
    • Kunz, H.1    Achermann, P.2
  • 80
    • 45849146078 scopus 로고    scopus 로고
    • Design principles for phase-splitting behaviour of coupled cellular oscillators: clues from hamsters with 'split' circadian rhythms
    • Indic P., Schwartz W. J., Paydarfar D., Design principles for phase-splitting behaviour of coupled cellular oscillators: clues from hamsters with 'split' circadian rhythms. J. R. Soc. Interface, 2008, 5, 873-883.
    • (2008) J. R. Soc. Interface , vol.5 , pp. 873-883
    • Indic, P.1    Schwartz, W.J.2    Paydarfar, D.3
  • 81
    • 0035905782 scopus 로고    scopus 로고
    • Modelling cellular behaviour.
    • Endy D., Brent R., Modelling cellular behaviour., Nature, 2001, 409, 391-395.
    • (2001) Nature , vol.409 , pp. 391-395
    • Endy, D.1    Brent, R.2
  • 82
    • 15244359622 scopus 로고    scopus 로고
    • Modelling genetic networks with noisy and varied experimental data: the circadian clock in Arabidopsis thaliana.
    • Locke J. C., Millar A. J., Turner M. S., Modelling genetic networks with noisy and varied experimental data: the circadian clock in Arabidopsis thaliana., J. Theor. Biol., 2005, 234, 383-393.
    • (2005) J. Theor. Biol. , vol.234 , pp. 383-393
    • Locke, J.C.1    Millar, A.J.2    Turner, M.S.3
  • 84
  • 85
    • 0033532569 scopus 로고    scopus 로고
    • Chaos and birhythmicity in a model for circadian oscillations of the PER and TIM proteins in Drosophila
    • Leloup J. C., Goldbeter A., Chaos and birhythmicity in a model for circadian oscillations of the PER and TIM proteins in Drosophila, J. Theor. Biol., 1999, 198, 445-459.
    • (1999) J. Theor. Biol. , vol.198 , pp. 445-459
    • Leloup, J.C.1    Goldbeter, A.2
  • 86
    • 32144448876 scopus 로고    scopus 로고
    • Bifurcations in a mathematical model for circadian oscillations of clock genes.
    • Tsumoto K., Yoshinaga T., Iida H., Kawakami H., Aihara K., Bifurcations in a mathematical model for circadian oscillations of clock genes., J. Theor. Biol., 2006, 239, 101-122.
    • (2006) J. Theor. Biol. , vol.239 , pp. 101-122
    • Tsumoto, K.1    Yoshinaga, T.2    Iida, H.3    Kawakami, H.4    Aihara, K.5
  • 87
    • 0027302961 scopus 로고
    • Hypothesis: the central oscillator of the circadian clock is a controlled chaotic attractor.
    • Lloyd A. L., Lloyd D., Hypothesis: the central oscillator of the circadian clock is a controlled chaotic attractor., Biosystems, 1993, 29, 77-85.
    • (1993) Biosystems , vol.29 , pp. 77-85
    • Lloyd, A.L.1    Lloyd, D.2
  • 88
    • 0034288615 scopus 로고    scopus 로고
    • Entrainment versus chaos in a model for a circadian oscillator driven by lightdark cycles.
    • Gonze D., Goldbeter A., Entrainment versus chaos in a model for a circadian oscillator driven by lightdark cycles., J. Stat. Phys., 2000, 101, 649-663.
    • (2000) J. Stat. Phys. , vol.101 , pp. 649-663
    • Gonze, D.1    Goldbeter, A.2
  • 89
    • 45549092930 scopus 로고    scopus 로고
    • Modeling the circadian clock: from molecular mechanism to physiological disorders
    • Leloup J. C., Goldbeter A., Modeling the circadian clock: from molecular mechanism to physiological disorders, BioEssays, 2008, 30, 590-600.
    • (2008) BioEssays , vol.30 , pp. 590-600
    • Leloup, J.C.1    Goldbeter, A.2
  • 90
    • 33645429016 scopus 로고
    • Exact Stochastic Simulation of Coupled Chemical Reactions
    • Gillespie D. T., Exact Stochastic Simulation of Coupled Chemical Reactions, J. Phys. Chem., 1977, 81, 2340-2361.
    • (1977) J. Phys. Chem. , vol.81 , pp. 2340-2361
    • Gillespie, D.T.1
  • 91
    • 0034688220 scopus 로고    scopus 로고
    • Circadian clocks limited by noise
    • Barkai N., Leibler S., Circadian clocks limited by noise, Nature, 2000, 403, 267-268.
    • (2000) Nature , vol.403 , pp. 267-268
    • Barkai, N.1    Leibler, S.2
  • 92
    • 12244269952 scopus 로고    scopus 로고
    • Stochastic simulation of the mammalian circadian clock
    • Forger D. B., Peskin C. S., Stochastic simulation of the mammalian circadian clock, Proc. Natl. Acad. Sci. USA, 2005, 102, 321-324.
    • (2005) Proc. Natl. Acad. Sci. USA , vol.102 , pp. 321-324
    • Forger, D.B.1    Peskin, C.S.2
  • 93
    • 33746064032 scopus 로고    scopus 로고
    • Propensity of a circadian clock to adjust to the 24h day-night light cycle and its sensitivity to molecular noise
    • Calander N., Propensity of a circadian clock to adjust to the 24h day-night light cycle and its sensitivity to molecular noise, J. Theor. Biol., 2006, 241, 716-724.
    • (2006) J. Theor. Biol. , vol.241 , pp. 716-724
    • Calander, N.1
  • 94
    • 0036037385 scopus 로고    scopus 로고
    • Intercellular coupling mechanism for synchronized and noise-resistant circadian oscillators
    • Ueda H. R., Hirose K., Iino M., Intercellular coupling mechanism for synchronized and noise-resistant circadian oscillators, J. Theor. Biol., 2002, 216, 501-512.
    • (2002) J. Theor. Biol. , vol.216 , pp. 501-512
    • Ueda, H.R.1    Hirose, K.2    Iino, M.3
  • 95
    • 33745725676 scopus 로고    scopus 로고
    • Circadian rhythms and molecular noise
    • Gonze D., Goldbeter A., Circadian rhythms and molecular noise, Chaos, 2006, 16, 026110.
    • (2006) Chaos , vol.16 , pp. 026110
    • Gonze, D.1    Goldbeter, A.2
  • 96
    • 55949092941 scopus 로고    scopus 로고
    • Stochastic phase oscillator models for circadian clocks
    • Rougemont J., Naef F., Stochastic phase oscillator models for circadian clocks, Adv. Exp. Med. Biol., 2008, 641, 141-149.
    • (2008) Adv. Exp. Med. Biol. , vol.641 , pp. 141-149
    • Rougemont, J.1    Naef, F.2
  • 97
  • 98
    • 37549016445 scopus 로고    scopus 로고
    • Stochastic gene expression outof-steady-state in the cyanobacterial circadian clock
    • Chabot J. R., Pedraza J. M., Luitel P., van Oudenaarden A., Stochastic gene expression outof-steady-state in the cyanobacterial circadian clock, Nature, 2007, 450, 1249-1252.
    • (2007) Nature , vol.450 , pp. 1249-1252
    • Chabot, J.R.1    Pedraza, J.M.2    Luitel, P.3    van Oudenaarden, A.4
  • 99
    • 0003109905 scopus 로고
    • Circadian Oscillations in Cells and the Circadian Organization of Multi-cellular Systems
    • F. O. Schmitt and F. G. Worden (Eds.), Cambridge: MIT Press
    • Pittendrigh C. S., Circadian Oscillations in Cells and the Circadian Organization of Multi-cellular Systems, In: Schmitt FO, Worden FG (Eds.), The Neurosciences, MIT Press, Cambridge, 1974, 437-458.
    • (1974) The Neurosciences , pp. 437-458
    • Pittendrigh, C.S.1
  • 100
    • 0015145767 scopus 로고
    • Populations of biochemical oscillators as circadian clocks
    • Pavlidis T., Populations of biochemical oscillators as circadian clocks, J. Theor. Biol., 1971, 33, 319-338.
    • (1971) J. Theor. Biol. , vol.33 , pp. 319-338
    • Pavlidis, T.1
  • 101
    • 0018166953 scopus 로고
    • Qualitative similarities between the behaviour of coupled oscillators and circadian rhythms
    • Pavlidis T., Qualitative similarities between the behaviour of coupled oscillators and circadian rhythms, Bull. Math. Biol., 1978, 40, 675-692.
    • (1978) Bull. Math. Biol. , vol.40 , pp. 675-692
    • Pavlidis, T.1
  • 102
    • 0014108715 scopus 로고
    • Biological rhythms and the behavior of populations of coupled oscillators
    • Winfree A. T., Biological rhythms and the behavior of populations of coupled oscillators, J. Theor. Biol., 1967, 16, 15-42.
    • (1967) J. Theor. Biol. , vol.16 , pp. 15-42
    • Winfree, A.T.1
  • 104
    • 0037147192 scopus 로고    scopus 로고
    • Oscillating systems. On emerging coherence
    • Winfree A. T., Oscillating systems. On emerging coherence, Science, 2003, 298, 2336-2337.
    • (2003) Science , vol.298 , pp. 2336-2337
    • Winfree, A.T.1
  • 105
    • 0033389820 scopus 로고    scopus 로고
    • Modeling circadian rhythm generation in the suprachiasmatic nucleus with locally coupled self-sustained oscillators: phase shifts and phase response curves
    • Achermann P., Kunz H., Modeling circadian rhythm generation in the suprachiasmatic nucleus with locally coupled self-sustained oscillators: phase shifts and phase response curves, J. Biol. Rhythms., 1999, 14, 460-468.
    • (1999) J. Biol. Rhythms. , vol.14 , pp. 460-468
    • Achermann, P.1    Kunz, H.2
  • 106
    • 23244452215 scopus 로고    scopus 로고
    • Spontaneous synchronization of coupled circadian oscillators
    • Gonze D., Bernard S., Waltermann C., Kramer A., Herzel H., Spontaneous synchronization of coupled circadian oscillators, Biophys J. 2005, 89, 120-129.
    • (2005) Biophys J. , vol.89 , pp. 120-129
    • Gonze, D.1    Bernard, S.2    Waltermann, C.3    Kramer, A.4    Herzel, H.5
  • 107
    • 41749123435 scopus 로고    scopus 로고
    • Global parameter search reveals design principles of the mammalian circadian clock
    • Locke J. C., Westermark P. O., Kramer A., Herzel H., Global parameter search reveals design principles of the mammalian circadian clock, BMC Syst. Biol., 2008, 2, 22.
    • (2008) BMC Syst. Biol. , vol.2 , pp. 22
    • Locke, J.C.1    Westermark, P.O.2    Kramer, A.3    Herzel, H.4
  • 108
    • 66149190669 scopus 로고    scopus 로고
    • Small-world network models of intercellular coupling predict enhanced synchronization in the suprachiasmatic nucleus
    • Vasalou C., Herzog E. D., Henson M. A., Small-world network models of intercellular coupling predict enhanced synchronization in the suprachiasmatic nucleus, J. Biol. Rhythms, 2009, 24, 243-254.
    • (2009) J. Biol. Rhythms , vol.24 , pp. 243-254
    • Vasalou, C.1    Herzog, E.D.2    Henson, M.A.3
  • 109
    • 34247622366 scopus 로고    scopus 로고
    • Synchronization-induced rhythmicity of circadian oscillators in the suprachiasmatic nucleus
    • Bernard S., Gonze D., Cajavec B., Herzel H., Kramer A., Synchronization-induced rhythmicity of circadian oscillators in the suprachiasmatic nucleus, PLoS Comput. Biol., 2007, 3, e68.
    • (2007) PLoS Comput. Biol. , vol.3
    • Bernard, S.1    Gonze, D.2    Cajavec, B.3    Herzel, H.4    Kramer, A.5
  • 110
    • 34250367538 scopus 로고    scopus 로고
    • A molecular model for intercellular synchronization in the mammalian circadian clock
    • To T. L., Henson M. A., Herzog E. D., Doyle F. J., A molecular model for intercellular synchronization in the mammalian circadian clock, Biophys. J., 2007, 92, 3792-3803.
    • (2007) Biophys. J. , vol.92 , pp. 3792-3803
    • To, T.L.1    Henson, M.A.2    Herzog, E.D.3    Doyle, F.J.4
  • 111
    • 70349939410 scopus 로고    scopus 로고
    • Light-dark cycle memory in the mammalian suprachiasmatic nucleus
    • Ospeck M. C., Coffey B., Freeman D., Light-dark cycle memory in the mammalian suprachiasmatic nucleus, Biophys. J., 2009, 97, 1513-1524.
    • (2009) Biophys. J. , vol.97 , pp. 1513-1524
    • Ospeck, M.C.1    Coffey, B.2    Freeman, D.3
  • 112
    • 34249066145 scopus 로고    scopus 로고
    • Beyond intuitive modeling: combining biophysical models with innovative experiments to move the circadian clock field forward
    • Forger D., Gonze D., Virshup D., Welsh D. K., Beyond intuitive modeling: combining biophysical models with innovative experiments to move the circadian clock field forward, J. Biol. Rhythms., 2007, 22, 200-210.
    • (2007) J. Biol. Rhythms. , vol.22 , pp. 200-210
    • Forger, D.1    Gonze, D.2    Virshup, D.3    Welsh, D.K.4
  • 113
    • 70350055193 scopus 로고    scopus 로고
    • Circadian clocks and phosphorylation: Insights from computational modeling
    • Leloup J.-C., Circadian clocks and phosphorylation: Insights from computational modeling, Cent. Eur. J. Biol., 2009, 4, 290-303.
    • (2009) Cent. Eur. J. Biol. , vol.4 , pp. 290-303
    • Leloup, J.-C.1
  • 114
    • 34249056535 scopus 로고    scopus 로고
    • Uncovering physiologic mechanisms of circadian rhythms and sleep/wake regulation through mathematical modeling
    • Kronauer R. E., Gunzelmann G., van Dongen H. P., Doyle F. J., Klerman E. B., Uncovering physiologic mechanisms of circadian rhythms and sleep/wake regulation through mathematical modeling, J. Biol. Rhythms, 2007, 22, 233-245.
    • (2007) J. Biol. Rhythms , vol.22 , pp. 233-245
    • Kronauer, R.E.1    Gunzelmann, G.2    van Dongen, H.P.3    Doyle, F.J.4    Klerman, E.B.5
  • 115
    • 77950793989 scopus 로고    scopus 로고
    • A multiscale model to investigate circadian rhythmicity of pacemaker neurons in the suprachiasmatic nucleus
    • Vasalou C., Henson M. A., A multiscale model to investigate circadian rhythmicity of pacemaker neurons in the suprachiasmatic nucleus, PLoS Comput. Biol., 2010, 6, e1000706.
    • (2010) PLoS Comput. Biol. , vol.6
    • Vasalou, C.1    Henson, M.A.2
  • 116
    • 12244296161 scopus 로고    scopus 로고
    • No transcription-translation feedback in circadian rhythm of KaiC phosphorylation
    • Tomita J., Nakajima, M., Kondo, T., Iwasaki, H. No transcription-translation feedback in circadian rhythm of KaiC phosphorylation, Science, 2005, 307, 251-254.
    • (2005) Science , vol.307 , pp. 251-254
    • Tomita, J.1    Nakajima, M.2    Kondo, T.3    Iwasaki, H.4
  • 117
    • 33748441404 scopus 로고    scopus 로고
    • A model for the circadian rhythm of cyanobacteria that maintains oscillation without gene expression
    • Kurosawa G., Aihara K., Iwasa, Y. A model for the circadian rhythm of cyanobacteria that maintains oscillation without gene expression, Biophys J., 2006, 91, 2015-2023.
    • (2006) Biophys J. , vol.91 , pp. 2015-2023
    • Kurosawa, G.1    Aihara, K.2    Iwasa, Y.3
  • 119
    • 33845979486 scopus 로고    scopus 로고
    • A mathematical model for the Kaiprotein-based chemical oscillator and clock gene expression rhythms in cyanobacteria
    • Miyoshi F., Nakayama Y., Kaizu K., Iwasaki H., Tomita M. A mathematical model for the Kaiprotein-based chemical oscillator and clock gene expression rhythms in cyanobacteria, J Biol Rhythms, 2007, 22, 69-80.
    • (2007) J Biol Rhythms , vol.22 , pp. 69-80
    • Miyoshi, F.1    Nakayama, Y.2    Kaizu, K.3    Iwasaki, H.4    Tomita, M.5
  • 121
    • 77958163101 scopus 로고    scopus 로고
    • A sequestration feedback determines dynamics and temperature entrainment of the KaiABC circadian clock
    • Brettschneider C., Rose R. J., Hertel S., Axmann I. M., Heck A. J., Kollmann M. A sequestration feedback determines dynamics and temperature entrainment of the KaiABC circadian clock. Mol Syst Biol., 2010, 6, 389.
    • (2010) Mol Syst Biol. , vol.6 , pp. 389
    • Brettschneider, C.1    Rose, R.J.2    Hertel, S.3    Axmann, I.M.4    Heck, A.J.5    Kollmann, M.6
  • 123
    • 79251566511 scopus 로고    scopus 로고
    • Circadian clocks in human red blood cells
    • O'Neill J. S., Reddy A. B., Circadian clocks in human red blood cells, Nature, 2011, 469, 498-503.
    • (2011) Nature , vol.469 , pp. 498-503
    • O'Neill, J.S.1    Reddy, A.B.2
  • 125
    • 77950854528 scopus 로고    scopus 로고
    • Tumor growth rate determines the timing of optimal chronomodulated treatment schedules
    • Bernard S., Cajavec Bernard B., Lévi F., Herzel H., Tumor growth rate determines the timing of optimal chronomodulated treatment schedules, PLoS Comput. Biol., 2010, 6, e1000712.
    • (2010) PLoS Comput. Biol. , vol.6
    • Bernard, S.1    Cajavec Bernard, B.2    Lévi, F.3    Herzel, H.4
  • 126
    • 0034688173 scopus 로고    scopus 로고
    • A synthetic oscillatory network of transcriptional regulators
    • Elowitz M. B., Leibler S., A synthetic oscillatory network of transcriptional regulators, Nature, 2000, 403, 335-338.
    • (2000) Nature , vol.403 , pp. 335-338
    • Elowitz, M.B.1    Leibler, S.2
  • 128
    • 58249117722 scopus 로고    scopus 로고
    • Fussenegger M., A tunable synthetic mammalian oscillator
    • Tigges M., Marquez-Lago T. T., Stelling J., Fussenegger M., A tunable synthetic mammalian oscillator, Nature, 2009, 457, 309-312.
    • (2009) Nature , vol.457 , pp. 309-312
    • Tigges, M.1    Marquez-Lago, T.T.2    Stelling, J.3
  • 129
    • 0033984612 scopus 로고    scopus 로고
    • Modeling the molecular regulatory mechanism of circadian rhythms in Drosophila
    • Leloup J. C., Goldbeter A., Modeling the molecular regulatory mechanism of circadian rhythms in Drosophila, BioEssays, 2000, 22, 84-93.
    • (2000) BioEssays , vol.22 , pp. 84-93
    • Leloup, J.C.1    Goldbeter, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.