Development of a taste-masked generic ibuprofen suspension: Top-down approach guided by electronic tongue measurements

Journal of Pharmaceutical Sciences

Volumn 100, Issue 10, 2011, Pages 4460-4470

  Woertz, Katharina ^a   Tissen, Corinna ^a   Kleinebudde, Peter ^a   Breitkreutz, Joerg ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Analysis; Excipients; Formulation; In vitro models; Multivariate analysis; Pediatric

Indexed keywords

FLAVORING AGENT; IBUPROFEN; PRESERVATIVE; SODIUM; STABILIZING AGENT; SWEETENING AGENT; GENERIC DRUG; NONSTEROID ANTIINFLAMMATORY AGENT; SOLUTION AND SOLUBILITY;

ARTICLE; ASTRINGENCY; BITTER TASTE; DIFFRACTION; DRUG FORMULATION; ELECTRONIC SENSOR; ELECTRONIC TONGUE; PH; SENSOR; SUSPENSION; TASTE; TASTE ACUITY; VISCOSITY; CHEMISTRY; COMPARATIVE STUDY; DEVICES; DRUG EFFECTS; EQUIPMENT DESIGN; EVALUATION STUDY; GENETIC PROCEDURES; HUMAN; MEDICINAL CHEMISTRY; PARTICLE SIZE; PERCEPTION; PHARMACEUTICS; PHYSIOLOGY; PROCEDURES; SOLUTION AND SOLUBILITY; TONGUE; TRANSDUCER;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BIOSENSING TECHNIQUES; CHEMISTRY, PHARMACEUTICAL; DRUGS, GENERIC; EQUIPMENT DESIGN; FLAVORING AGENTS; HUMANS; HYDROGEN-ION CONCENTRATION; IBUPROFEN; PARTICLE SIZE; PERCEPTUAL MASKING; PHARMACEUTICAL SOLUTIONS; TASTE; TECHNOLOGY, PHARMACEUTICAL; TONGUE; TRANSDUCERS; VISCOSITY;

EID: 80052271337     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22629     Document Type: Article

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