A novel inhibitor of apoptosis protein (IAP)-interacting protein, Vestigial-like (Vgl)-4, counteracts apoptosis-inhibitory function of IAPs by nuclear sequestration

Biochemical and Biophysical Research Communications

Volumn 412, Issue 3, 2011, Pages 454-459

  Jin, Hyung Seung ^a   Park, Hyung Sun ^a   Shin, Jun Ha ^a   Kim, Dong Hwan ^a   Jun, Sung Hun ^a   Lee, Chang Jun ^a   Lee, Tae H ^a  

^a Yonsei University   (South Korea)

Author keywords

CIAP1; CIAP2; IAP regulator; TRAF2; Vgl 4; XIAP

Indexed keywords

INHIBITOR OF APOPTOSIS PROTEIN; INHIBITOR OF APOPTOSIS PROTEIN 1; INHIBITOR OF APOPTOSIS PROTEIN 2; PROTEIN BAX; PROTEIN INHIBITOR; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; UNCLASSIFIED DRUG; VESTIGIAL LIKE 4 PROTEIN; X LINKED INHIBITOR OF APOPTOSIS;

APOPTOSIS; ARTICLE; CELL NUCLEUS; CYTOPLASM; HEART MUSCLE CELL; HUMAN; HUMAN CELL; NUCLEAR SEQUESTRATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION;

ACTIVE TRANSPORT, CELL NUCLEUS; APOPTOSIS; CELL NUCLEUS; HEK293 CELLS; HELA CELLS; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; TNF RECEPTOR-ASSOCIATED FACTOR 2; TRANSCRIPTION FACTORS; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

INTRACISTERNAL A-PARTICLES;

EID: 80052261187     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.07.117     Document Type: Article

References (19)

1. Vaux D.L., Silke J. IAPs, RINGs and ubiquitylation. Nat. Rev. Mol. Cell Biol. 2005, 6:287-297.
2. Salvesen G.S., Duckett C.S. IAP proteins: blocking the road to death's door. Nat. Rev. Mol. Cell Biol. 2002, 3:401-410.
3. Rothe M., Pan M.G., Henzel W.J., Ayres T.M., Goeddel D.V. The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell 1995, 83:1243-1252.
4. Samuel T., Welsh K., Lober T., Togo S.H., Zapata J.M., Reed J.C. Distinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspases. J. Biol. Chem. 2006, 281:1080-1090.
5. Verhagen A.M., Ekert P.G., Pakusch M., Silke J., Connolly L.M., Reid G.E., Moritz R.L., Simpson R.J., Vaux D.L. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell 2000, 102:43-53.
6. Verhagen A.M., Silke J., Ekert P.G., Pakusch M., Kaufmann H., Connolly L.M., Day C.L., Tikoo A., Burke R., Wrobel C., Moritz R.L., Simpson R.J., Vaux D.L. HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins. J. Biol. Chem. 2002, 277:445-454.
7. Hegde R., Srinivasula S.M., Zhang Z., Wassell R., Mukattash R., Cilenti L., DuBois G., Lazebnik Y., Zervos A.S., Fernandes-Alnemri T., Alnemri E.S. Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction. J. Biol. Chem. 2002, 277:432-438.
8. Liston P., Fong W.G., Kelly N.L., Toji S., Miyazaki T., Conte D., Tamai K., Craig C.G., McBurney M.W., Korneluk R.G. Identification of XAF1 as an antagonist of XIAP anti-caspase activity. Nat. Cell Biol. 2001, 3:128-133.
9. Chen H.H., Mullett S.J., Stewart A.F. Vgl-4, a novel member of the vestigial-like family of transcription cofactors, regulates alpha1-adrenergic activation of gene expression in cardiac myocytes. J. Biol. Chem. 2004, 279:30800-30806.
10. Park S.M., Yoon J.B., Lee T.H. Receptor interacting protein is ubiquitinated by cellular inhibitor of apoptosis proteins (c-IAP1 and c-IAP2) in vitro. FEBS Lett. 2004, 566:151-156.
11. Jin H.S., Lee D.H., Kim D.H., Chung J.H., Lee S.J., Lee T.H. CIAP1, cIAP2, And XIAP act cooperatively via nonredundant pathways to regulate genotoxic stress-induced nuclear factor-kappaB activation. Cancer Res. 2009, 69:1782-1791.
12. Lee J.S., Hong U.S., Lee T.H., Yoon S.K., Yoon J.B. Mass spectrometric analysis of tumor necrosis factor receptor-associated factor 1 ubiquitination mediated by cellular inhibitor of apoptosis 2. Proteomics 2004, 4:3376-3382.
13. Jeon H.K., Jin H.S., Lee D.H., Choi W.S., Moon C.K., Oh Y.J., Lee T.H. Proteome analysis associated with cadmium adaptation in U937 cells: identification of calbindin-D28k as a secondary cadmium-responsive protein that confers resistance to cadmium-induced apoptosis. J. Biol. Chem. 2004, 279:31575-31583.
14. Janssens S., Tinel A., Lippens S., Tschopp J. PIDD mediates NF-kappaB activation in response to DNA damage. Cell 2005, 123:1079-1092.
15. Vischioni B., Giaccone G., Span S.W., Kruyt F.A., Rodriguez J.A. Nuclear shuttling and TRAF2-mediated retention in the cytoplasm regulate the subcellular localization of cIAP1 and cIAP2. Exp. Cell Res. 2004, 298:535-548.
16. Reed J.C., Zha H., Aime-Sempe C., Takayama S., Wang H.G. Structure-function analysis of Bcl-2 family proteins. Regulators of programmed cell death. Adv. Exp. Med. Biol. 1996, 406:99-112.
17. Samuel T., Okada K., Hyer M., Welsh K., Zapata J.M., Reed J.C. cIAP1 localizes to the nuclear compartment and modulates the cell cycle. Cancer Res. 2005, 65:210-218.
18. Plenchette S., Cathelin S., Rebe C., Launay S., Ladoire S., Sordet O., Ponnelle T., Debili N., Phan T.H., Padua R.A., Dubrez-Daloz L., Solary E. Translocation of the inhibitor of apoptosis protein c-IAP1 from the nucleus to the Golgi in hematopoietic cells undergoing differentiation: a nuclear export signal-mediated event. Blood 2004, 104:2035-2043.
19. Jin H.S., Lee T.H. Cell cycle-dependent expression of cIAP2 at G2/M phase contributes to survival during mitotic cell cycle arrest. Biochem. J. 2006, 399:335-342.