Narrowband ultraviolet B phototherapy for patients with refractory uraemic pruritus: A randomized controlled trial

British Journal of Dermatology

Volumn 165, Issue 3, 2011, Pages 633-639

  Ko, M J ^a,b   Yang, J Y ^b,c   Wu, H Y ^b,c   Hu, F C ^b,d   Chen, S I ^b   Tsai, P J ^e   Jee, S H ^b   Chiu, H C ^a,b  

^a TAIPEI CITY HOSPITAL   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^c FAR EASTERN MEMORIAL HOSPITAL   (Taiwan)

^d International Harvard Statistical Consulting Company   (Taiwan)

^e Ming der Clinics   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; BODY MASS; BODY SURFACE; CHRONIC KIDNEY DISEASE; CLINICAL ARTICLE; CLINICAL FEATURE; COMORBIDITY; CONTROLLED STUDY; FEMALE; FOLLOW UP; HEMODIALYSIS; HEMODIALYSIS PATIENT; HUMAN; MALE; NARROWBAND ULTRAVIOLET B PHOTOTHERAPY; PERITONEAL DIALYSIS; PHOTOTHERAPY; PRIORITY JOURNAL; PRURITUS; QUESTIONNAIRE; RADIATION DOSE; RADIATION EXPOSURE; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE; SCORING SYSTEM; SINGLE BLIND PROCEDURE; SLEEP QUALITY; THERAPY EFFECT; TREATMENT DURATION; ULTRAVIOLET A RADIATION; ULTRAVIOLET B RADIATION; UREMIC PRURITUS; VISUAL ANALOG SCALE;

AGED; CHRONIC DISEASE; FEMALE; HUMANS; MALE; MIDDLE AGED; PRURITUS; SINGLE-BLIND METHOD; TREATMENT OUTCOME; ULTRAVIOLET THERAPY; UREMIA;

EID: 80052189567     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2011.10448.x     Document Type: Article

References (33)

1. Mathur VS, Lindberg J, Germain M, et al. A longitudinal study of uremic pruritus in hemodialysis patients. Clin J Am Soc Nephrol 2010; 5: 1410-19.
2. Pisoni RL, Wikstrom B, Elder SJ, et al. Pruritus in haemodialysis patients: international results from the Dialysis Outcomes and Practice Patterns Study (DOPPS). Nephrol Dial Transplant 2006; 21: 3495-505. (Pubitemid 44817100)
3. Dyachenko P, Shustak A, Rozenman D,. Hemodialysis-related pruritus and associated cutaneous manifestations. Int J Dermatol 2006; 45: 664-7. (Pubitemid 44056664)
4. Yosipovitch G, Zucker I, Boner G, et al. A questionnaire for the assessment of pruritus: validation in uremic patients. Acta Derm Venereol 2001; 81: 108-11. (Pubitemid 32662150)
5. Morton CA, Lafferty M, Hau C, et al. Pruritus and skin hydration during dialysis. Nephrol Dial Transplant 1996; 11: 2031-6. (Pubitemid 26345469)
6. Massry SG, Popovtzer MM, Coburn JW, et al. Intractable pruritus as a manifestation of secondary hyperparathyroidism in uremia. Disappearance of itching after subtotal parathyroidectomy. N Engl J Med 1968; 279: 697-700.
7. Graf H, Kovarik J, Stummvoll HK, et al. Disappearance of uraemic pruritus after lowering dialysate magnesium concentration. Br Med J 1979; 2: 1478-9. (Pubitemid 10162318)
8. Narita I, Alchi B, Omori K, et al. Etiology and prognostic significance of severe uremic pruritus in chronic hemodialysis patients. Kidney Int 2006; 69: 1626-32.
9. Kuypers DR,. Skin problems in chronic kidney disease. Nat Clin Pract Nephrol 2009; 5: 157-70.
10. Kaysen GA,. The microinflammatory state in uremia: causes and potential consequences. J Am Soc Nephrol 2001; 12: 1549-57. (Pubitemid 32666340)
11. Garssen J, Vandebriel RJ, De Gruijl FR, et al. UVB exposure-induced systemic modulation of Th1- and Th2-mediated immune responses. Immunology 1999; 97: 506-14. (Pubitemid 29314649)
12. Gilchrest BA, Rowe JW, Brown RS, et al. Ultraviolet phototherapy of uremic pruritus. Long-term results and possible mechanism of action. Ann Intern Med 1979; 91: 17-21. (Pubitemid 9244627)
13. De Marchi S, Cecchin E, Villalta D, et al. Relief of pruritus and decreases in plasma histamine concentrations during erythropoietin therapy in patients with uremia. N Engl J Med 1992; 326: 969-74.
14. Coven TR, Burack LH, Gilleaudeau R, et al. Narrowband UV-B produces superior clinical and histopathological resolution of moderate-to-severe psoriasis in patients compared with broadband UV-B. Arch Dermatol 1997; 133: 1514-22.
15. Zanolli M,. Phototherapy treatment of psoriasis today. J Am Acad Dermatol 2003; 49 (Suppl.): S78-86. (Pubitemid 36951251)
16. Hearn RM, Kerr AC, Rahim KF, et al. Incidence of skin cancers in 3867 patients treated with narrow-band ultraviolet B phototherapy. Br J Dermatol 2008; 159: 931-5.
17. Walters IB, Ozawa M, Cardinale I, et al. Narrowband (312-nm) UV-B suppresses interferon gamma and interleukin (IL)-12 and increases IL-4 transcripts: differential regulation of cytokines at the single-cell level. Arch Dermatol 2003; 139: 155-61. (Pubitemid 36216253)
18. Szepietowski JC, Morita A, Tsuji T,. Ultraviolet B induces mast cell apoptosis: a hypothetical mechanism of ultraviolet B treatment for uraemic pruritus. Med Hypotheses 2002; 58: 167-70. (Pubitemid 34174430)
19. Wallengren J, Sundler F,. Phototherapy reduces the number of epidermal and CGRP-positive dermal nerve fibres. Acta Derm Venereol 2004; 84: 111-15. (Pubitemid 38523744)
20. Ada S, Seckin D, Budakoglu I, et al. Treatment of uremic pruritus with narrowband ultraviolet B phototherapy: an open pilot study. J Am Acad Dermatol 2005; 53: 149-51. (Pubitemid 40826713)
21. Seckin D, Demircay Z, Akin O,. Generalized pruritus treated with narrowband UVB. Int J Dermatol 2007; 46: 367-70. (Pubitemid 46585385)
22. Hsu MM, Yang CC,. Uraemic pruritus responsive to broadband ultraviolet (UV) B therapy does not readily respond to narrowband UVB therapy. Br J Dermatol 2003; 149: 888-9. (Pubitemid 37412018)
23. Hemodialysis Adequacy 2006 Work Group. Clinical practice guidelines for hemodialysis adequacy, update 2006. Am J Kidney Dis 2006; 48 (Suppl. 1): S2-90.
24. Peritoneal Dialysis Adequacy Work Group. Clinical practice guidelines for peritoneal dialysis adequacy. Am J Kidney Dis 2006; 48 (Suppl. 1): S98-129.
25. Chen Y-Y, Tsai T-F,. The minimal erythema dose of 311 nm narrow-band UVB in Taiwanese. Dermatol Sinica 2002; 20: 286-93.
26. Gilchrest BA, Rowe JW, Brown RS, et al. Relief of uremic pruritus with ultraviolet phototherapy. N Engl J Med 1977; 297: 136-8.
27. Zeger SL, Liang KY,. Longitudinal data analysis for discrete and continuous outcomes. Biometrics 1986; 42: 121-30.
28. Liang K-Y, Zeger SL,. Longitudinal data analysis using generalized linear models. Biometrika 1986; 73: 13-22.
29. McCarney R, Warner J, Iliffe S, et al. The Hawthorne effect: a randomised, controlled trial. BMC Med Res Methodol 2007; 7: 30.
30. Hindson C, Taylor A, Martin A, et al. UVA light for relief of uraemic pruritus. Lancet 1981; 1: 215.
31. Taylor R, Taylor AE, Diffey BL, et al. A placebo-controlled trial of UV-A phototherapy for the treatment of uraemic pruritus. Nephron 1983; 33: 14-16. (Pubitemid 13173055)
32. Spiro JG, Scott S, MacMillan J, et al. Treatment of uremic pruritus with blue light. Photodermatology 1985; 2: 319-21. (Pubitemid 15235994)
33. Patel TS, Freedman BI, Yosipovitch G,. An update on pruritus associated with CKD. Am J Kidney Dis 2007; 50: 11-20. (Pubitemid 46964882)