Etiology and prognostic significance of severe uremic pruritus in chronic hemodialysis patients

Kidney International

Volumn 69, Issue 9, 2006, Pages 1626-1632

  Narita, I ^a   Alchi, B ^a   Omori, K ^a   Sato, F ^a   Ajiro, J ^a   Saga, D ^a   Kondo, D ^a   Skatsume, M ^a   Maruyama, S ^b   Kazama, J J ^a   Akazawa, K ^a   Gejyo, F ^a  

^a NIIGATA UNIVERSITY GRADUATE SCHOOL OF MEDICAL AND DENTAL SCIENCES   (Japan)

^b Joetsu General Hospital   (Japan)

Author keywords

2 microglobulin; Gender; Hemodialysis; Prognosis; Quality of life; Uremic pruritus; Visual analogue scale

Indexed keywords

ALBUMIN; ANTIHISTAMINIC AGENT; ANTIPRURITIC AGENT; BETA 2 MICROGLOBULIN; CALCIUM; PARATHYROID HORMONE; PHOSPHATE; SEDATIVE AGENT;

ADULT; AGE; AGED; ALBUMIN BLOOD LEVEL; ARTICLE; CLINICAL FEATURE; DIABETES MELLITUS; DISEASE SEVERITY; FEMALE; GENDER; HEMODIALYSIS; HUMAN; HYPERCALCEMIA; HYPERPHOSPHATEMIA; LABORATORY TEST; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; PARATHYROID HORMONE BLOOD LEVEL; PATHOGENESIS; PHOTOTHERAPY; PRIORITY JOURNAL; PROGNOSIS; PROSPECTIVE STUDY; PRURITUS; QUALITY OF LIFE; QUESTIONNAIRE; RISK FACTOR; SLEEP DISORDER; UREA NITROGEN BLOOD LEVEL; UREMIA; UREMIC PRURITUS; VISUAL ANALOG SCALE;

AGED; BETA 2-MICROGLOBULIN; BIOLOGICAL MARKERS; BLOOD UREA NITROGEN; FEMALE; HUMANS; HYPERCALCEMIA; MALE; MIDDLE AGED; PHOSPHATES; PROGNOSIS; PRURITUS; RENAL DIALYSIS; RISK FACTORS; SLEEP DISORDERS; TREATMENT OUTCOME; UREMIA;

EID: 33646501504     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/sj.ki.5000251     Document Type: Article

References (23)

1. Bencini PL, Montagnino G, Citterio A et al. Cutaneous abnormalities in uremic patients. Nephron 1985; 40: 316-321.
2. Ponticelli C, Bencini PL. Pruritus in dialysis patients: a neglected problem. Nephrol Dial Transplant 1995; 10: 2174-2176.
3. Schwartz IF, Iaina A. Uraemic pruritus. Nephrol Dial Transplant 1999; 14: 834-839.
4. Ponticelli C, Bencini PL. Uremic pruritus: a review [editorial]. Nephron 1992; 60: 1-5.
5. Goicoechea M, de Sequera P, Ochando A et al. Uremic pruritus: an unresolved problem in hemodialysis patients [letter]. Nephron 1999; 82: 73-74.
6. Massry SG, Popovtzer MM, Coburn JW et al. Intractable pruritus as a manifestation of secondary hyperparathyroidism in uremia. Disappearance of itching after subtotal parathyroidectomy. N Engl J Med 1968; 279: 697-700.
7. Graf H, Kovarik J, Stummvoll HK et al. Disappearance of uraemic pruritus after lowering dialysate magnesium concentration. Br Med J 1979; 2: 1478-1479.
8. Hiroshige K, Kabashima N, Takasugi M et al. Optimal dialysis improves uremic pruritus. Am J Kidney Dis 1995; 25: 413-419.
9. Carmichael AJ, McHugh MI, Martin AM. Renal itch as an indicator of poor outcome [letter]. Lancet 1991; 337: 1225-1226.
10. Duo LJ. Electrical needle therapy of uremic pruritus. Nephron 1987; 47: 179-183.
11. Mettang T, Fritz P, Weber J et al. Uremic pruritus in patients on hemodialysis or continuous ambulatory peritoneal dialysis (CAPD). The role of plasma histamine and skin mast cells. Clin Nephrol 1990; 34: 136-141.
12. Pederson JA, Matter BJ, Czerwinski AW et al. Relief of idiopathic generalized pruritus in dialysis patients treated with activated oral charcoal. Ann Int Med 1980; 93: 446-448.
13. Blachley JD, Blankenship DM, Menter A et al. Uremic pruritus: skin divalent ion content and response to ultraviolet phototherapy. Am J Kidney Dis 1985; 5: 237-241.
14. Dimkovic N, Djukanovic L, Radmilovic A et al. Uremic pruritus and skin mast cells. Nephron 1992; 61: 5-9.
15. Qureshi AR, Alvestrand A, Divino-Filho JC et al. Inflammation, malnutrition, and cardiac disease as predictors of mortality in hemodialysis patients. J Am Soc Nephrol 2002; 13: S28-S36.
16. Spiegel DM, Costante N, Janiga AM et al. Deposition and removal of cutaneous beta 2-microglobulin. Am J Nephrol 1992; 12: 330-335.
17. Gejyo F, Homma N, Suzuki Y et al. Serum levels of beta 2-microglobulin as a new form of amyloid protein in patients undergoing long-term hemodialysis. N Engl J Med 1986; 314: 585-586.
18. Noel LH, Zingraff J, Bardin T et al. Tissue distribution of dialysis amyloidosis. Clin Nephrol 1987; 27: 175-178.
19. Mettang T, Pauli-Magnus C, Alscher DM. Uraemic pruritus - new perspectives and insights from recent trials. Nephrol Dial Transplant 2002; 17: 1558-1563.
20. Bergstrom J, Lindholm B. Malnutrition, cardiac disease, and mortality: an integrated point of view. Am J Kidney Dis 1998; 32: 834-841.
21. Zimmermann J, Herrlinger S, Pruy A et al. Inflammation enhances cardiovascular risk and mortality in hemodialysis patients. Kidney Int 1999; 55: 648-658.
22. Jedras M, Zakrzewska-Pniewska B, Wardyn K, Switalski M. Uremic neuropathy -II. Is pruritus in dialyzed patients related to neuropathy? Pol Arch Med Wewn 1998; 99: 462-469.
23. t/V: an analysis of error. J Am Soc Nephrol 1993; 4: 1205-1213.