Amygdalofrontal functional disconnectivity and aggression in schizophrenia

Schizophrenia Bulletin

Volumn 36, Issue 5, 2010, Pages 1020-1028

  Hoptman, Matthew J ^a,b   D'Angelo, Debra ^a   Catalano, Dean ^a   Mauro, Cristina J ^a   Shehzad, Zarrar E ^c   Kelly, A M Clare ^b,c   Castellanos, Francisco X ^a,b,c   Javitt, Daniel C ^a,b   Milham, Michael P ^c  

^a NATHAN S KLINE INSTITUTE FOR PSYCHIATRIC RESEARCH   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NEW YORK UNIVERSITY CHILD STUDY CENTER   (United States)

Author keywords

aggression; amygdala; functional connectivity; schizophrenia

Indexed keywords

CHLORPROMAZINE;

ADULT; AGGRESSION; AMYGDALOID NUCLEUS; ARTICLE; BRAIN DYSFUNCTION; BRAIN REGION; CEREBROSPINAL FLUID; CLINICAL ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE ASSOCIATION; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; LIFE HISTORY; MALE; MULTIPLE REGRESSION; PARAMETER; PREFRONTAL CORTEX; PRIORITY JOURNAL; QUESTIONNAIRE; SCHIZOAFFECTIVE PSYCHOSIS; SCHIZOPHRENIA; SCORING SYSTEM; SELF CONCEPT; SOCIAL DISABILITY; STATISTICAL MODEL; TIME SERIES ANALYSIS; WHITE MATTER;

AGGRESSION; AMYGDALA; BRAIN MAPPING; HUMANS; MAGNETIC RESONANCE IMAGING; NERVE NET; PREFRONTAL CORTEX; PSYCHOTIC DISORDERS; RISK FACTORS; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY;

EID: 77955979612     PISSN: 05867614     EISSN: 17451701     Source Type: Journal    
DOI: 10.1093/schbul/sbp012     Document Type: Article

References (57)

1. Friston KJ, Frith CD. Schizophrenia: a disconnection syndrome? Clin Neurosci. 1995;3:89-97.
2. Lim KO, Hedehus M, Moseley M, de Crespigny A, Sullivan EV, Pfefferbaum A. Compromised white matter tract integrity in schizophrenia inferred from diffusion tensor imaging. Arch Gen Psychiatry. 1999;56:367-374.
3. Buchsbaum MS, Tang CY, Peled S, et al. MRI white matter diffusion anisotropy and PET metabolic rate in schizophrenia. Neuroreport. 1998;9:425-430.
4. Ardekani BA, Nierenberg J, Hoptman MJ, Javitt DC, Lim KO. MRI study of white matter diffusion anisotropy in schizophrenia. Neuroreport. 2003;14:2025-2029.
5. Kubicki M, McCarley R, Westin CF, et al. A review of diffusion tensor imaging studies in schizophrenia. J Psychiatr Res. 2007;41:15-30.
6. Butler PD, Zemon V, Schechter I, et al. Early-stage visual processing and cortical amplification deficits in schizophrenia. Arch Gen Psychiatry. 2005;62:495-504.
7. Hubl D, Koenig T, Strik W, et al. Pathways that make voices: white matter changes in auditory hallucinations. Arch Gen Psychiatry. 2004;61:658-668.
8. Szeszko PR, Robinson DG, Ashtari M, et al. Clinical and neuropsychological correlates of white matter abnormalities in recent onset schizophrenia. Neuropsychopharmacology. 2008;33:976-984.
9. Wolkin A, Choi SJ, Szilagyi S, Sanfilipo M, Rotrosen JP, Lim KO. Inferior frontal white matter anisotropy and negative symptoms of schizophrenia: a diffusion tensor imaging study. Am J Psychiatry. 2003;160:572-574.
10. Hoptman MJ, Volavka J, Johnson G, Weiss E, Bilder RM, Lim KO. Frontal white matter, aggression and impulsivity in men with schizophrenia. Biol Psychiatry. 2002;52:9-14.
11. Hoptman MJ, Ardekani BA, Butler PD, Nierenberg J, Javitt DC, Lim KO. DTI and impulsivity in schizophrenia: a first voxelwise correlational study. Neuroreport. 2004;15:2467-2470.
12. Lim KO, Ardekani BA, Nierenberg J, Butler PD, Javitt DC, Hoptman MJ. Voxelwise correlational analyses of white matter integrity in multiple cognitive domains in schizophrenia. Am J Psychiatry. 2006;163:2008-2010.
13. Szeszko PR, Ardekani BA, Ashtari M, et al. White matter abnormalities in first-episode schizophrenia or schizoaffective disorder: a diffusion tensor imaging study. Am J Psychiatry. 2005;162:602-605.
14. Kumra S, Ashtari M, Cervellione KL, et al. White matter abnormalities in early-onset schizophrenia: a voxel-based diffusion tensor imaging study. J Am Acad Child Adolesc Psychiatry. 2005;44:934-941.
15. Biswal B, Yetkin FZ, Haughton VM, Hyde JS. Functional connectivity in the motor cortex of resting human brain using echo-planar MRI. Magn Reson Med. 1995;34:537-541.
16. Damoiseaux JS, Rombouts SA, Barkhof F, et al. Consistent resting-state networks across healthy subjects. Proc Natl Acad Sci\USA. 2006;103:13848-13853.
17. Fransson P, Skiold B, Horsch S, Nordell A, Blennow M, Lagercrantz H. Resting-state networks in the infant brain. Proc Natl Acad Sci\USA. 2007;104:15531-15536.
18. Greicius MD, Menon V. Default-mode activity during a passive sensory task: uncoupled from deactivation but impacting activation. J Cogn Neurosci. 2004;16:1484-1492.
19. Margulies DS, Kelly AM, Uddin LQ, Biswal BB, Castellanos FX, Milham MP. Mapping the functional connectivity of anterior cingulate cortex. NeuroImage. 2007;37:579-588.
20. Greicius MD, Kiviniemi V, Tervonen O, et al. Persistent default-mode network connectivity during light sedation. Hum Brain Mapp. 2008;29:839-847.
21. Seeley WW, Menon V, Schatzberg AF, et al. Dissociable intrinsic connectivity networks for salience processing and executive control. J Neurosci. 2007;27:2349-2356.
22. Fox MD, Snyder AZ, Zacks JM, Raichle ME. Coherent spontaneous activity accounts for trial-to-trial variability in human evoked brain responses. Nat Neurosci. 2006;9:23-25.
23. Liang M, Zhou Y, Jiang T, et al. Widespread functional dis-connectivity in schizophrenia with resting-state functional magnetic resonance imaging. Neuroreport. 2006;17:209-213.
24. Liu H, Liu Z, Liang M, et al. Decreased regional homogeneity in schizophrenia: a resting state functional magnetic resonance imaging study. Neuroreport. 2006;17:19-22.
25. Bluhm RL, Miller J, Lanius RA, et al. Spontaneous low-frequency fluctuations in the BOLD signal in schizophrenic patients: anomalies in the default network. Schizophr Bull. 2007;33:1004-1012.
26. Garrity AG, Pearlson GD, McKiernan K, Lloyd D, Kiehl KA, Calhoun VD. Aberrant "default mode" functional connectivity in schizophrenia. Am J Psychiatry. 2007;164:450-457.
27. Zhou Y, Liang M, Jiang T, et al. Functional dysconnectivity of the dorsolateral prefrontal cortex in first-episode schizophrenia using resting-state fMRI. Neurosci Lett. 2007;417:297-302.
28. Meyer-Lindenberg A, Poline JB, Kohn PD, et al. Evidence for abnormal cortical functional connectivity during working memory in schizophrenia. Am J Psychiatry. 2001;158:1809-1817.
29. Meyer-Lindenberg AS, Olsen RK, Kohn PD, et al. Regionally specific disturbance of dorsolateral prefrontal-hippocampal functional connectivity in schizophrenia. Arch Gen Psychiatry. 2005;62:379-386.
30. Waltz JA, Gold JM. Probabilistic reversal learning impairments in schizophrenia: further evidence of orbitofrontal dysfunction. Schizophr Res. 2007;93:296-303.
31. Hoptman MJ, Nolan KA. The role of prefrontal abnormalities in schizophrenia. In: Javitt DC, Kantrowitz JT, eds. Schizophrenia. 3rd edn. New York, NY: Springer; 2008.
32. Penn DL, Corrigan PW, Bentall RP, Racenstein JM, Newman L. Social cognition in schizophrenia. Psychol Bull. 1997;121:114-132.
33. Kubicki M, Westin C-F, Maier SE, et al. Uncinate fasciculus findings in schizophrenia: a magnetic resonance diffusion tensor imaging study. Am J Psychiatry. 2002;159:813-820.
34. Volavka J. Neurobiology of Violence. 2nd edn. Washington, DC: APA Publishing; 2002.
35. Grafman J, Schwab K, Warden D, Pridgen A, Brown HR, Salazar AM. Frontal lobe injuries, violence, and aggression: a report of the Vietnam Head Injury Study. Neurology. 1996;46:1231-1238.
36. Steadman HJ, Mulvey EP, Monahan J, et al. Violence by people discharged from acute psychiatric inpatient facilities and by others in the same neighborhoods. Arch Gen Psychiatry. 1998;55:393-401.
37. Hoptman MJ, Volavka J, Weiss EM, et al. Quantitative MRI measures of orbitofrontal cortex in patients with chronic schizophrenia or schizoaffective disorder. Psychiatry Res. 2005;140:133-145.
38. Antonucci AS, Gansler DA, Tan S, BhadeliaR,PatzS,Fulwiler C. Orbitofrontal correlates of aggression and impulsivity in psychiatric patients. Psychiatry Res. 2006;147:213-220.
39. Rusch N, Spoletini I, Wilke M, et al. Inferior frontal white matter volume and suicidality in schizophrenia. Psychiatry Res. 2008;164:206-214.
40. Stein JL, Wiedholz LM, Bassett DS, et al. A validated network of effective amygdala connectivity. NeuroImage. 2007;36:736-745.
41. Buss AH, Perry M. The Aggression Questionnaire. J Pers Soc Psychol. 1992;63:452-459.
42. First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV-TR Axis I Disorders-Patient Edition (SCID-I/P, 11/2002 Revision). New York, NY: Biometrics Research Department, New York State Psychiatric Institute; 2002.
43. American Psychiatric Association.Practice guideline for the treatment of patients with schizophrenia. Am J Psychiatry. 1997;154:(suppl):1-63.
44. Psychological Corporation.Wechsler Abbreviated Scale of Intelligence (WASI) Manual. San Antonio, TX: Psychological Corporation, 2006.
45. Kay SR, Opler LA, Fiszbein A. Positive and Negative Syndrome Scale (PANSS) Manual. Toronto: Multi-Health Systems; 1992.
46. Coccaro EF, Berman ME, Kavoussi RJ. Assessment of life history of aggression: development and psychometric characteristics. Psychiatry Res. 1997;73:147-157.
47. Buss A, Durkee A. An inventory for assessing different kinds of hostility. J Consult Psychol. 1957;21:343-349.
48. Castellanos FX, Margulies DS, Kelly C, et al. Cingulate-precuneus interactions: a new locus of dysfunction in adult attention-deficit/ hyperactivity disorder. Biol Psychiatry. 2008;63:332-337.
49. Kelly AMC, Uddin LQ, Biswal BB, Castellanos FX, Mil-ham MP. Competition between functional brain networks mediates behavioral variability. NeuroImage. 2008;39:527-537.
50. Cox RW. AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. Comput Biomed Res. 1996;29:162-173.
51. Brunet-Gouet E, Decety J. Social brain dysfunctions in schizophrenia: a review of neuroimaging studies. Psychiatry Res. 2006;148:75-92.
52. Pezawas L, Meyer-Lindenberg A, Drabant EM, et al. 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nat Neurosci. 2005;8:828-834.
53. Radulescu AR, Mujica-Parodi LR. A systems approach to prefrontal-limbic dysregulation in schizophrenia. Neuropsy-chobiology. 2008;57:206-216.
54. Lewis DA, Levitt P. Schizophrenia as a disorder of neurode-velopment. Annu Rev Neurosci. 2002;25:409-432.
55. Fransson P. How default is the default mode of brain function? Further evidence from intrinsic BOLD signal fluctuations. Neuropsychologia. 2006.
56. Fox MD, Snyder AZ, Vincent JL, Corbetta M, Van E, Raichle ME. The human brain is intrinsically organized into dynamic, anticorrelated functional networks. Proc Natl Acad Sci\USA. 2005;102:9673-9678.
57. Shehzad Z, Kelly AMC, Reiss PT, et al. The resting brain: unconstrained yet reliable. Cereb Cortex. In press.