CPP-ACP complex as a new adjunctive agent for remineralisation: A review

Oral Health and Preventive Dentistry

Volumn 9, Issue 2, 2011, Pages 151-165

  Gupta, Ruchi ^a   Prakash, Vijay ^a  

^a ITS Centre for Dental Studies and Research Muradnagar ^*  (India)

Author keywords

Amorphous calcium phosphate; Casein phosphopeptide; Remineralisation; Review

Indexed keywords

ANTICARIES AGENT; CALCIUM PHOSPHATE; CASEIN; CASEIN PHOSPHOPEPTIDE AMORPHOUS CALCIUM PHOSPHATE NANOCOMPLEX; CASEIN PHOSPHOPEPTIDE-AMORPHOUS CALCIUM PHOSPHATE NANOCOMPLEX; FLUORIDE; MOUTHWASH;

BACTERIUM ADHERENCE; CHEMISTRY; CHEWING GUM; DENTAL CARE; DOSE RESPONSE; DRUG EFFECT; DRUG INTERACTION; HUMAN; METHODOLOGY; REVIEW; TOOTH DISEASE; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; BACTERIAL ADHESION; CALCIUM PHOSPHATES; CARIOSTATIC AGENTS; CASEINS; CHEWING GUM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; FLUORIDES; HUMANS; MOUTHWASHES; TOOTH DEMINERALIZATION; TOOTH EROSION; TOOTH REMINERALIZATION;

EID: 80052165131     PISSN: 16021622     EISSN: 17579996     Source Type: Journal    
DOI: None     Document Type: Article

References (113)

1. Adebayo OA, Burrow MF, Tyas MJ. Effects of conditioners on microshear bond strength to enamel after carbamide peroxide bleaching and/or casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) treatment. J Dent 2007;35:862-870.
2. Adebayo OA, Burrow MF, Tyas MJ. Dentine bonding after CPP-ACP paste treatment with and without conditioning. J Dent 2008; 36:1013-24.
3. Adebayo OA, Burrow MF, Tyas MJ. A SEM evaluation of conditioned and bonded enamel following carbamide peroxide bleaching and casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) treatment. J Dent 2009;37:297-306.
4. Adebayo OA, Burrow MF, Tyas MJ. Resin-dentine interfacial morphology following CPP-ACP treatment. J Dent 2009;38:96-105.
5. Aimutis WR. Bioactive properties of milk proteins with particular focus on anticariogenesis. J Nutr 2004;134:989-995.
6. Anderson A, Skold-Larsson K, Hallgren A, Petersson LG, Twetman S. Effect of a dental cream containing amorphous cream phosphate complexes on white spot lesion regression assessed by laser fluorescence. Oral Health Prev Dent 2007;5:229-233.
7. Anderson EP, Smith JK, Elvehjem CA, Phillips PH. Dental caries in the cotton rat; the effect of fluidity of the ration. J Nutr 1948;35:371-377.
8. Ardu S, Castioni NV, Benbachir N, Krejci I. Minimally invasive treatment of white spot enamel lesions. Quint Int 2007;38:633-636.
9. Bailey DL, Adams GG, Tsao CE, Hyslop A, Escobar K, Manton DJ, Reynolds EC, Morgan MV. Regression of Post-orthodontic Lesions by a Remineralizing Cream. J Dent Res 2009;88:1148-1153.
10. Bibby BG, Averill HM. Caries control through phosphates. J Dent Res 1963;42:477-487.
11. Bibby BG, Huang CT, Zero D, Mundorff SA, Little MF. Dental caries in the cotton rat; the effect of fluidity of the ration. J Nutr 1980;35:371-377.
12. Bowen WH, Amsbaugh SM, Monell-Torrens S, Brunelle J, Kuzmiak-Jones H, Cole MF. A method to assess cariogenic potential of food-stuffs. J Am Dent Assoc 1980;100:677-681.
13. Bunting R. Bacteriological, chemical and nutritional studies of dental caries by the Michigan Research Group: A summary. J Dent Res 1934;17: 97-105.
14. Cai F, Shen P, Morgan MV, Reynolds EC. Remineralisation of enamel subsurface lesions in situ by sugar-free lozenges containing casein phosphopeptide-amorphous calcium phosphate. Aus Dent J 2003;48:240-243.
15. Caruana PC, Mulaify SA, Moazzez R, Bartlett D. The effect of casein and calcium containing paste on plaque pH following a subsequent carbohydrate challenge. J Dent 2009;37:522-526.
16. Cehreli SB, Gurpinar AO, Onur AM, Dagli FT. In vitro evaluation of casein phosphopeptide-amorphous calcium phosphate as a potential tooth transport medium: viability and apoptosis in L929 fibroblasts. Dent Traumatol 2008;24:314-319.
17. Cochrane NJ, Saranathan S, Cai F, Cross KJ, Reynolds EC. Enamel subsurface lesion remineralisation with casein phosphopeptide stabilised solutions of calcium, phosphate and fluoride. Caries Res 2008;42:88-97.
18. Crisp S, Lewis BG, Wilson AD. Glass ionomer cements: chemistry of erosion. J Dent Res 1976;55:1032-1041.
19. Cross KJ, Huq NL, Palamara JE, Perich JW, Reynolds EC. Physiochemical characterization of casein phosphopepide-amorphous calcium phosphate nanocomplexes. J Biol Chem 2005;280:15362-15369.
20. Cross KJ, Huq NL, Reynolds EC. Casein phosphopeptides in oral health-chemistry and clinical applications. Curr Pharm Des 2007;13:793-800.
21. de Rooij JF, Nancollas GH. The formation and remineralization of artificial white spot lesions: A constant composition approach. J Dent Res 1984;63:864-867.
22. Elsayad I, Sakr A, Badr Y. Combining casein phosphopeptide-amorphous calcium phosphate with fluoride: synergistic remineralisation potential of artificially demineralized enamel or not? J Biomed Opt 2009;14:044039.
23. Ferrazzano GF, Cantile T, Ingenito A, Chianese L, Quarto M. New strategies in dental caries prevention: experimental study on casein phosphopeptides. Eur J Paediatr Dent 2007;8:183-187.
24. Ferrazzano GF, Cantile T, Quarto M, Ingenito A, Chianese L, Addeo F. Protective effect of yogurt extract on dental enamel demineralization in vitro. Aust Dent J 2008;53:314-319.
25. GC Europe Recaldent Tooth Mousse Product Manual. GC Corporation, Tokyo, Japan.
26. Giulio AB, Matteo Z, Serena IP, Silvia M, Luigi C. In vitro evaluation of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) effect on stripped enamel surfaces. A SEM investigation. J Dent 2009;37:228-232.
27. Guggenheim B, Schmid R, Aeschlimann JM, Berrocal R, Neeser JR. Powdered milk micellar casein prevents oral colonization by Streptococcus sobrinus and dental caries in rats: a basis for the caries-protective effect of dairy products. Caries Res 1999;33:446-454.
28. Harper DS, Osborn JC, Clayton R, Hefferren JJ. Cariostatic evaluation of cheeses with diverse physical and compositional characteristics. Caries Res 1986; 20:123-130.
29. Hay KD, Morton RP. The efficacy of casein phosphoproteincalcium phosphate complex (DC-CP) [Dentacal] as a mouth moistener in patients with severe xerostomia. N Z Dent J 2003;99:46-48.
30. Hay KD, Thomson WM. A clinical trial of the anticaries efficacy of casein derivatives complexed with calcium phosphate in patients with salivary gland dysfunction Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002; 93:271-275.
31. Holler BE, Friedl K-H, Jung H, Hiller KA, Schmalz G. Fluoride uptake and distribution in enamel and dentin after application of different fluoride solutions. Clin Oral Invest 2002;6:137-144.
32. Holt C, van Kemenade MJJM. The interaction of phosphoproteins with calcium phosphate. In: Hukins DWL (ed). Calcified tissue. Boca Raton, FL: CRC Press, 1989:175-213.
33. Holt C, Wahlgren NM, Drakenberg T. Ability of a b-casein phosphopeptide to modulate the precipitation of calcium phosphate by forming amorphous dicalcium phosphate nanoclusters. Biochem J 1996;314:1035-1039.
34. Hubbell R, Bunting R. Calcium and phosphorous of saliva in relation to dental caries. J Nutr 1932;5:599-605.
35. Huq NL, Cross KJ, Reynolds EC. Molecular modelling of a multiphosphorylated sequence motif bound to hydroxyapatite surfaces. J Mol Mode 2000;6:35-47.
36. Huq NL, Cross KJ, Reynolds EC. Molecular modelling of the multiphosphorylated casein phosphopeptide alpha s1-casein (59-79). J Dairy Res 2004;71:1-5.
37. Iijima Y, Cai F, Shen P, Walker G, Reynolds C, Reynolds EC. Acid resistance of enamel subsurface lesions remineralized by a sugar-free chewing gum containing casein phosphopeptideamorphous calcium phosphate (CPP-ACP). Caries Res 2004;38:551-556.
38. Itthagarun A, King NM, Yiu C, Dawes C. The effect of chewing gums containing calcium phosphates on the remineralization of artificial caries like lesions in situ. Caries Res 2005;39:251-254.
39. Kecik D, Cehreli SB, Sar C, Unver B. Effect of acidulated phosphate fluoride and casein phosphopeptide-amorphous calcium phosphate application on shear bond strength of orthodontic brackets. Angle Orthod 2008;78:129-133.
40. Kolahi J, Fazilati M, Kadivar M. Towards tooth friendly soft drinks. Med Hypotheses 2009;73:524-525.
41. Krobicka A, Bowen WH, Pearson S, Youn DA. The effects of cheese snacks on caries in desalivated rats. J Dent Res 1987;66:1116-1119.
42. Kumar VL, Ittagarun A, King NM. The effect of casein phosphopeptide-amorphous calcium phosphate on remineralization of artificial caries-like lesions: an in vitro study. Aust Dent J 2008;53:34-40.
43. Lennon AM, Pfeffer M, Buchalla W, Becker K, Lennon S, Attin T. Effect of a casein/calcium phosphate-containing tooth cream and fluoride on enamel erosion in vitro. Caries Res 2006;40:154-157.
44. Luo LY, Wang Y, Li H, Zheng H, Gao SJ. Study on remineralization of human fluorosed teeth in vitro. Hua Xi Kou Qiang Yi Xue Za Zhi 2009;27:96-99.
45. Manton DJ, Bhide R, Hopcraft MS, Reynolds EC. Effect of ozone and Tooth Mousse on the efficacy of peroxide bleaching. Aust Dent J 2008;53: 128-132.
46. Matsuya S, Matsuya Y, Yamamoto Y, Yamane M. Erosion process of glass ionomer cement in organic acids. Dent Mat J 1984;3:210-219.
47. Mazzaoui SA, Burrow MF, Tyas MJ, Dashper SG, Eakins D, Reynolds EC. Incorporation of casein phosphopeptideamorphous calcium phosphate into a glass-ionomer cement. J Dent Res 2003;82:914-918.
48. Mellanby M. Diet and the teeth: an experimental study. Part II. A Diet and dental disease B Diet and dental structure in mammals other than the dog. Medical Research Council. London: His Majesty's Stationery Office Special report series No. 153 1930 162-278.
49. Mellanby M, Lee C, Pattison. The effect of diet on the environment and extension of caries in the teeth of children. Brit Med J 1924;2:354-355.
50. Meyers IA. Diagnosis and management of the worn dentition: risk management and pre-restorative strategies for the oral and dental environment. Ann R Australas Coll Dent Surg 2008;19:27-30.
51. Morgan MV, Adams GG, Bailey DL, Tsao CE, Fischman SL, Reynolds EC. The anticariogenic effect of sugar-free gum containing CPP-ACP nanocomplexes on approximal caries determined using digital bitewing radiography. Caries Res 2008;42:171-184.
52. Moule CA, Angelis F, Kim GH, Le S, Malipatil S, Foo MS, Burrow MF, Thomas D. Resin bonding using an all-etch or selfetch adhesive to enamel after carbamide peroxide and/or CPP-ACP treatment. Aus Dent J 2007;52: 133-137.
53. Navia JM, Lopez H. Rat caries assay of reference foods and sugar-containing snacks. J Dent Res 1983;62:893-898.
54. Neeser JR, Golliard M, Woltz A, Rouvet M, Dillmann ML, Guggenhiem B. In vitro modulation of oral bacterial adhesion to saliva-coated hydroxypatite beads by milk casein derivatives. Oral Microbiol Immunol 1994;9:193-201.
55. Neuhaus KW, Lussi A. Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and its effect on dental hard tissues. Schweiz Monatsschr Zahnmed 2009;119:110-116.
56. Ng F, Manton DJ. Aesthetic management of severely fluorosed incisors in an adolescent female. Aus Dent J 2007;52:243-248.
57. Nyvad B, Fejerskov O. Experimentally induced changes in ultrastructure of pellicle on enamel in vivo. In: Ten Cate JM, Leach SA/(eds)., Bacterial adhesion and preventive dentistry. Oxford: IRL Press Ltd, 1984:143-151.
58. Oshiro M, Yamaguchi K, Takamizawa T, Inage H, Watanabe T, Irokawa A, Ando S, Miyazaki M. Effect of CPP-ACP paste on tooth mineralization: an FE-SEM study. J Oral Sci 2007;49:115-120.
59. Panich M, Poolthong S. The effect of casein phosphopeptide-amorphous calcium phosphate and a cola soft drink on in vitro enamel hardness. J Am Dent Assoc 2009;140:455-460.
60. Pearce EIF, Bibby BG. Protein adsorption on bovine enamel. Arch Oral Biol 1966;11:329-336.
61. Perich JW, Reynolds EC. The use of synthetic phosphopeptides for epitope mapping of the αs1-casein phosphopeptide segment Bioorg Med Chem Lett 1992; 2:1153-1154.
62. Piekarz C, Ranjitkar S, Hunt D, McIntyre J. An in vitro assessment of the role of Tooth Mousse in preventing wine erosion. Aust Dent J 2008;53:22-25.
63. Pulido MT, Wefel JS, Hernandez MM, Denehy GE, Guzman-Armstrong S, Chalmers JM, Qian F. The inhibitory effect of MI paste, fluoride and a combination of both on the progression of artificial caries-like lesions in enamel. Oper Dent 2008;33:550-555.
64. Rahiotis C, Vougiouklakis G. Effect of a CPP-ACP agent on the demineralization and remineralization of dentine in vitro. J Dent 2007;35:695-698.
65. Rahiotis C, Vougiouklakis G, Eliades G. Characterization of oral films formed in the presence of a CPP-ACP agent: an in situ study. J Dent 2008;36:272-80.
66. Ramalingam L, Messer LB, Reynolds EC. Adding casein phosphopeptide-amorphous calcium phosphate to sports drinks to eliminate in vitro erosion. Pediatr Dent 2005; 27:61-67.
67. Ranjitkar S, Kaidonis JA, Richards LC, Townsend GC. The effect of CPP-ACP on enamel wear under severe erosive conditions. Arch Oral Biol 2009;54:527-532.
68. Ranjitkar S, Narayana T, Kaidonis JA, Hughes TE, Richards LC, Townsend GC. The effect of casein phosphopeptideamorphous calcium phosphate on erosive dentine wear. Aust Dent J 2009;54:101-107.
69. Ranjitkar S, Rodriguez JM, Kaidonis JA, Richards LC, Townsend GC, Bartlett DW. The effect of casein phosphopeptide-amorphous calcium phosphate on erosive enamel and dentine wear by toothbrush abrasion. J Dent 2009;37:250-254.
70. Rao SK, Bhat GS, Aradhya S, Devi A, Bhat M. Study of the efficacy of toothpaste containing casein phosphopeptide in the prevention of dental caries: a randomized controlled trial in 12-to 15-year-old high caries risk children in Bangalore, India. Caries Res 2009;43:430-435.
71. Rees J, Loyn T, Chadwick B. Pronamel and Tooth Mousse: an initial assessment of erosion prevention in vitro. J Dent 2007;35:355-357.
72. Rolla G, Rykke M. Evidence for presence of micelle-like protein globules in human saliva. Colloid Surface B Biointerfaces 1994;3:177-182.
73. Reynolds EC. The prevention of sub-surface demineralization of bovine enamel and change in plaque composition by casein in an intra-oral model. J Dent Res 1987;66:1120-1127.
74. Reynolds EC. Remineralization of enamel subsurface lesions by casein phosphopeptide-stabilized calcium phosphate solutions. J Dent Res 1997;76:1587-1595.
75. Reynolds EC. Anticariogenic complexes of amorphous calcium phosphate stabilized by casein phosphopeptides: a review. Spec Care Dentist 1998;18:8-16.
76. Reynolds EC. Anticariogenic casein phosphopeptides. Prot Peptide Lett 1999;6:295-303.
77. Reynolds EC. Dairy components in oral health. Aus J Dairy Tech 2003; 58:79-81.
78. Reynolds EC. Calcium phosphate-based remineralization systems: scientific evidence? Aust Dent J 2008;53:268-273.
79. Reynolds EC. Casein phosphopeptide-amorphous calcium phosphate: the scientific evidence. Adv Dent Res 2009; 21:25-29.
80. Reynolds EC, Black CL. Reduction of chocolate's cariogenicity by supplementation with sodium caseinate. Caries Res 1987; 21:445-451.
81. Reynolds EC, Black CL. Confectionery composition and rat caries. Caries Res 1987;21:538-545.
82. Reynolds EC, Black CL, Cross KJ, Eakins D, Huq NL, Morgan MV, Nowicki A, Perich JW, Riley PF, Shen P, Talbo G, Webber FW. Advances in enamel remineralization: anticariogenic casein phosphopeptide-amorphous calcium phosphate. J Clin Dent 1999;10:86-88.
83. Reynolds EC, Cai F, Cochrane NJ, Shen P, Walker GD, Morgan MV, Reynolds C. Fluoride and casein phosphopeptide-amorphous calcium phosphate. J Dent Res 2008;87:344-8.
84. Reynolds EC, Cai F, Shen P, Walker GD. Retention in plaque and remineralization of enamel lesions by various forms of calcium in a mouth rinse or sugar-free chewing gum. J Dent Res 2003;82:206-211.
85. Reynolds EC, Cain CJ, Webber FL, Black CL, Riley PF, Johnson IH, Perich JW. Anticariogenicity of calcium phosphate complexes of tryptic casein phosphopeptides in the rat. J Dent Res 1995;74:1272-1279.
86. Reynolds EC, del Rio A. Effect of casein and whey-protein solutions on caries experience and feeding patterns of the rat. Arch Oral Biol 1984;29:927-933.
87. Reynolds EC, Johnson IH. Effect of milk on caries incidence and bacterial composition of dental plaque in the rat. Arch Oral Biol 1981;26:445-451.
88. Reynolds EC, Riley PF, Adamson NJ. A selective pre cip i tation purification procedure for multiple phosphoseryl-containing peptides and methods for their identification. Anal Biochem 1994;217:277-284.
89. Rolla G, Rykke M. Evidence for presence of micelle-like protein globules in human saliva. Colloid Surface B Biointerfaces 1994;3:177-182.
90. Rose RK. Binding characteristics of streptococcus mutans for calcium and casein phosphopeptide. Caries Res 2000; 34:427-431.
91. Rose RK. Effects of an anticariogenic casein phosphopeptide on calcium diffusion in streptococcal model dental plaques. Arch Oral Biol 2000; 45:569-575.
92. Rosen S, Min DB, Herper DS, Herper WJ, Beck EX, Beck FM. Effect of cheese, with and without sucrose, on dental caries and recovery of Streptococcus mutans in rats. J Dent Res 1984;63:894-896.
93. Schirrmeister JF, Seger RK, Altenburger MJ, Lussi A, Hellwig E. Effects of various forms of calcium added to chewing gum on initial enamel carious lesions in situ. Caries Res 2007;41:108-114.
94. Schupbach P, Neeser JR, Golliard M, Rouvet M, Guggenheim B. Incorporation of caseinoglycomacropeptide and caseinophosphopeptide into the salivary pellicle inhibits adherence of mutans streptococci. J Dent Res 1996;75:1779-1788.
95. Shen P, Cai F, Nowicki A, Vincent J, Reynolds EC. Remineralization of enamel subsurface lesions by sugar-free chewing gum containing casein phosphopeptide-amorphous calcium phosphate. J Dent Res 2001;80:2066-2070.
96. Shen P, Cai F, Walker G, Reynolds C, Reynolds EC. Enamel remineralization by a mouthrinse containing casein phosphopeptide-amorphous calcium phosphate and fluoride in an in situ model. Aus Dent J Special Research Suppl 2004;49:4.
97. Silva MfdeA, Burgess RC, Sandham HJ, Jenkins GN. Effects of water-soluble components of cheese on experimental caries in humans. J Dent Res 1987; 66: 38-41.
98. Sudjalim TR, Woods MG, Manton DJ. Prevention of white spot lesions in orthodontic practice: a contemporary review. Aus Dent J 2006; 51:284-289.
99. Tantbirojn D, Huang A, Ericson MD. Change in surface hardness of enamel by a cola drink and a CPP-ACP paste. J Dent 2008;36:74-79.
100. Tantbirojn D, Huang A, Ericson MD, Poolthong S. Change in surface hardness of enamel by a cola drink and a CPPACP paste. J Dent 2008;36:74-79.
101. Ung M, Huq NL, Cross KJ, Reynolds EC. Investigation of the binding of casein phosphopeptides to the major enamel pellicle proteins Aus Dent J Special Research Suppl 2004;49:4.
102. Vanthana S, Michael B, Yasushi S, Junji T. Resin bonding to dentine after casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) treatments. J Adhes Sci Tech 2009;23:1149-1161.
103. Vitorino R, Lobo MJ, Duarte JR, Ferrer-Correia AJ, Domingues PM, Amado FM. The role of salivary peptides in dental caries. Biomed Chromatogr 2005;19:214-222.
104. Vlacic J, Meyers IA, Walsh LJ. Combined CPP-ACP and photoactivated disinfection (PAD) therapy in arresting root surface caries: a case report. Br Dent J 2007;203:457-459.
105. Walker G, Cai F, Shen P, Reynolds, Ward B, Christopher Fone C, Honda S, Koganei M, Oda M, Reynolds E. Increased remineralization of tooth enamel by milk containing added casein phosphopeptide-amorphous calcium phosphate. J Dairy Res 2006;73:74-78.
106. Walker GD, Cai F, Shen P, Bailey DL, Yuan Y, Cochrane NJ, Reynolds C, Reynolds EC. Consumption of milk with added casein phosphopeptide-amorphous calcium phosphate remineralizes enamel subsurface lesions in situ. Aust Dent J 2009;54:245-249.
107. Willershausen B, Schulz-Dobrick B, Gleissner C. In vitro evaluation of enamel remineralisation by a casein phosphopeptide-amorphous calcium phosphate paste. Oral Health Prev Dent 2009;7:13-21.
108. Wilson AD, McLean JW. Glass-ionomer cement Chicago, IL: Quintessence Publishing, 1988.
109. Yamaguchi K, Miyazaki M, Takamizawa T, Inage H, Kurokawa H. Ultrasonic determination of the effect of casein phosphopeptide-amorphous calcium phosphate paste on the demineralization of bovine dentin. Caries Res 2007;41: 204-207.
110. Yamaguchi K, Miyazaki M, Takamizawa T, Inage H, Moore BK. Effect of CPP-ACP paste on mechanical properties of bovine enamel as determined by an ultrasonic device. J Dent 2006;34:230-236.
111. Young DA, Kutsch VK, Whitehouse J. A clinician's guide to CAMBRA: a simple approach. Compend Contin Educ Dent 2009;30:92-98.
112. Zhou CH, Sun XH, Zhu XC. Quantification of remineralized effect of casein phosphopeptiode-amorphous calcium phosphate on post-orthodontic white spot lesion. Shanghai Kou Qiang Yi Xue 2009;18:449-454.
113. Zita AC, McDonald, Andrews AL. Dietary habits and the dental caries experience in 200 children. J Dent Res 1956;38:860-865.