Enamel subsurface lesion remineralisation with casein phosphopeptide stabilised solutions of calcium, phosphate and fluoride

Caries Research

Volumn 42, Issue 2, 2008, Pages 88-97

  Cochrane, N J ^a   Saranathan, S ^a   Cai, F ^a   Cross, K J ^a   Reynolds, E C ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Casein phosphopeptide amorphous calcium fluoride phosphate; Casein phosphopeptide amorphous calcium phosphate; Enamel subsurface lesion remineralisation

Indexed keywords

ANTICARIES AGENT; CALCIUM; CASEIN; CASEIN PHOSPHOPEPTIDE AMORPHOUS CALCIUM PHOSPHATE NANOCOMPLEX; CASEIN PHOSPHOPEPTIDE-AMORPHOUS CALCIUM PHOSPHATE NANOCOMPLEX; FLUORIDE; PHOSPHATE;

ARTICLE; CHEMISTRY; DENTAL CARE; ELECTRON PROBE MICROANALYSIS; ENAMEL; HUMAN; METHODOLOGY; OSMOLARITY; PH;

CALCIUM; CARIOSTATIC AGENTS; CASEINS; DENTAL ENAMEL; ELECTRON PROBE MICROANALYSIS; FLUORIDES; HUMANS; HYDROGEN-ION CONCENTRATION; OSMOLAR CONCENTRATION; PHOSPHATES; TOOTH REMINERALIZATION;

EID: 42449164656     PISSN: 00086568     EISSN: None     Source Type: Journal    
DOI: 10.1159/000113161     Document Type: Article

References (51)

1. Angmar V, Carlstrom D, Glas JE: Studies on the ultrastructure of dental enamel. J Ultrastruct Res 1963;8:12-23.
2. Backer Dirks O: Posteruptive changes in dental enamel. J Dent Res 1966;45:503-511.
3. Bates RG: First disassociation constant of phosphoric acid from 0 to 60°C: Limitations of the electromotive force method for moderately strong acids. J Res Natl Bur Std 1951;47: 127-134.
4. Bates R, Acree S: pH values of certain phosphatechloride mixtures and the second dissociation constant of phosphoric acid from 0 to 60°C. J Res Natl Bur Std 1943;30:129.
5. Bjerrum N: Electrometric measurements with the hydrogen electrode on mixtures of acids and bases with salts: the dissociation constants of water, phosphoric acid, citric acid and glycine. Kg Danske Videnskab Selskab Math Fys Medd 1929;9:5-206.
6. Borggreven JM, van Dijk JW, Driessens FC: Effect of mono- and divalent ions on diffusion and binding in bovine tooth enamel. Arch Oral Biol 1981;26:663-669.
7. Broene HH, deVries T: The thermodynamics of aqueous hydrofluoric acid solutions. J Am ChemSoc 1947;69:1644-1646.
8. Burke EJ, Moreno EC: Diffusion fluxes of tritiated water across human enamel membranes. Arch Oral Biol 1975;20:327-332.
9. Cai F, Manton DJ, Shen P, Walker GD, Cross KJ, Yuan Y, Reynolds C, Reynolds EC: Effect of citric acid and casein phosphopeptide-amorphous calcium phosphate to a sugar-free chewing gum on enamel remineralization in situ. Caries Res 2007;41:377-383.
10. Cai F, Shen P, Morgan MV, Reynolds EC: Remineralization of enamel subsurface lesions in situ by sugar-free lozenges containing casein phosphopeptide-amorphous calcium phosphate. Aust Dent J 2003;48:240-243.
11. Chu JS, Fox JL, Higuchi WI, Nash WP: Electron probe micro-analysis for subsurface demineralization and remineralization of dental enamel. J Dent Res 1989;68:26-31.
12. Chughtai A, Marshall R, Nancollas GH: Complexes in calcium phosphate solutions. J Phys Chem 1968;72:208-211.
13. Connick RE, Tsao MS: Complexing of magnesium ion by fluoride ion. J Am Chem Soc 1954;76:5311-5314.
14. Cross KJ, Huq NL, Palamara JE, Perich JW, Reynolds EC: Physicochemical characterization of casein phosphopeptide-amorphous calcium phosphate nanocomplexes. J Biol Chem 2005;280:15362-15369.
15. Cross KJ, Huq NL, Stanton DP, Sum M, Reynolds EC: NMR studies of a novel calcium, phosphate and fluoride delivery vehiclealpha(S1)-casein(59-79) by stabilized amorphous calcium fluoride phosphate nano-complexes. Biomaterials 2004; 25:5061-5069.
16. Davies CW, Hoyle BE: The dissociation constant of calcium hydroxide. J Chem Soc 1951;1: 233-234.
17. de Rooij JF, Nancollas GH: The formation and remineralization of artificial white spot lesions: a constant composition approach. J Dent Res 1984;63:864-867.
18. Dibdin GH: The water in human dental enamel and its diffusional exchange measured by clearance of tritiated water from enamel slabs of varying thickness. Caries Res 1993; 27:81-86.
19. Driessens FCM: Mineral Aspects of Dentistry. Monogr Oral Sci. Basel, Karger, 1982, vol 10.
20. Elliott JC: Structure and Chemistry of the Apatites and Other Calcium Orthophosphates. London, Elsevier, 1994.
21. Featherstone JD, Rodgers BE, Smith MW: Physicochemical requirements for rapid remineralization of early carious lesions. Caries Res 1981;15:221-235.
22. Gray JA: Kinetics of enamel dissolution during formation of incipient caries-like lesions. Arch Oral Biol 1966;11:397-421.
23. Gregory TM, Moreno EC, Brown WE: Solubility of dicalcium phosphate dihydrate in the system calcium hydroxide - orthophosphoric acid - water at 5, 15, 25, and 37.5°C. J Res Natl Bur Std 1970;74A:461.
24. Holly FJ, Gray JA: Mechanism for incipient carious lesion growth utilizing a physical model based on diffusion concepts. Arch Oral Biol 1968;13:319-334.
25. Iijima Y, Cai F, Shen P, Walker G, Reynolds C, Reynolds EC: Acid resistance of enamel sub-surface lesions remineralized by a sugar-free chewing gum containing casein phosphopeptide-amorphous calcium phosphate. Caries Res 2004;38:551-556.
26. Iijima Y, Takagi O, Ruben J, Arends J: In vitro remineralization of in vivo and in vitro formed enamel lesions. Caries Res 1999;33: 206-213.
27. Itaya K, Ui M: A new micromethod for the colorimetric determination of inorganic phosphate. Clin Chim Acta 1966;14:361-366.
28. Koulourides T, Feagin F, Pigman W: Remineralization of dental enamel by saliva in vitro. Ann NY Acad Sci 1965;131:751-757.
29. LeGeros RZ: Calcium Phosphates in Oral Biology and Medicine. Monogr Oral Sci. Basel, Karger, 1991, vol 15.
30. Martell AE, Smith RM: Critical Stability Constants: Other Organic Ligands. New York, Plenum Press, 1977.
31. McCann H: The solubility of fluorapatite and its relationship to that of calcium fluoride. Arch Oral Biol 1968;13:987-1001.
32. 3OH) in the system calcium hydroxide-phosphoric acid-water at 5, 15, 25 and 37°C. J Res Natl Bur Std 1977;81A:273-281.
33. Meyer JL, Eanes ED: A thermodynamic analysis of the amorphous to crystalline calcium phosphate transformation. Calcif Tissue Res 1978;25:59-68.
34. Milnar FJ: Considering biomodification and remineralization techniques as adjuncts to vital tooth-bleaching regimens. Compend Contin Educ Dent 2007;28:234-236, 238-240.
35. Morgan MV, Adams GG, Bailey DL, Tsao CE, Reynolds EC: CPP-ACP gum slows progression and enhances regression of dental caries (abstract). J Dent Res 2006;85(special issue B):2445.
36. Oshiro M., Yamaguchi K, Takamizawa T, Inage H, Watanabe T, Irokawa A, Ando S, Miyazaki M: Effect of CPP-ACP paste on tooth mineralization: an FE-SEM study. J Oral Sci 2007;49:115-120.
37. Papas A, Russell D, Singh M, Stack K, Kent R, Triol C, Winston A: Double-blind clinical trial of a reminerali zing dentifrice in the prevention of caries in a radiation therapy population. Gerodontology 1999;16:2-10.
38. Petersson LG, Odelius H, Lodding A, Larsson SJ, Frostell G: Ion probe study of fluorine gradients in the outermost layers of human enamel. J Dent Res 1976;55:980-990.
39. Rahiotis C, Vougiouklakis G: Effect of a CPP-ACP agent on the demineralization and remineralization of dentine in vitro. J Dent 2007;35:695-698.
40. Reynolds EC: Calcium phosphopeptide complexes. US Patent 6,780,844, 1997a.
41. Reynolds EC: Remineralization of enamel sub-surface lesions by casein phosphopeptidestabilized calcium phosphate solutions. J Dent Res 1997b;76:1587-1595.
42. Reynolds EC: Anticariogenic complexes of amorphous calcium phosphate stabilized by casein phosphopeptides: a review. Spec Care Dentist 1998;18:8-16.
43. Reynolds EC, Cai F, Shen P, Walker G: Retention in plaque and remineralization of enamel lesions by various forms of calcium in a mouth-rinse or sugar-free chewing gum. J Dent Res 2003;83:206-211.
44. Shen P, Cai F, Nowicki A, Vincent J, Reynolds EC: Remineralization of enamel subsurface lesions by sugar-free chewing gum containing casein phosphopeptide-amorphous calcium phosphate. J Dent Res 2001;80:2066-2070.
45. 2O. J Dent Res 1983;62:398-400.
46. Silverstone LM: Remineralization phenomena. Caries Res 1977;11(suppl 1):59-84.
47. ten Bosch J, Angmar-Mansson B: A review of quantitative methods for studies of mineral content of intra-oral incipient caries lesions. J Dent Res 1991;70:2-14.
48. ten Cate JM, Arends J: Remineralization of artificial enamel lesions in vitro. Caries Res 1977;11:277-286.
49. ten Cate JM, van Loveren C: Fluoride mechanisms. Dent Clin North Am 1999;43:713-742.
50. White D: Use of synthetic polymer gels for artificial carious lesion preparation. Caries Res 1987;21:228-242.
51. Yamaguchi K, Miyazaki M, Takamizawa T, Inage H, Moore BK: Effect of CPP-ACP paste on mechanical properties of bovine enamel as determined by an ultrasonic device. J Dent 2006;34:230-236.