Study of the efficacy of toothpaste containing casein phosphopeptide in the prevention of dental caries: A randomized controlled trial in 12- to 15-year-old high caries risk children in Bangalore, India

Caries Research

Volumn 43, Issue 6, 2009, Pages 430-435

  Rao, S K ^a,e   Bhat, G S ^b   Aradhya, S ^c   Devi, A ^d   Bhat, M ^a  

^a MANIPAL COLLEGE OF DENTAL SCIENCES   (India)

^b Karnataka Veterinary Animal and Fisheries Sciences University   (India)

^c Oxford Dental College   (India)

^d V S Dental College and Hospital   (India)

^e NONE   (India)

Author keywords

Casein phosphopeptide; Children; Clinical trial; Dental caries; Dentifrices; Fluoride; Prevention; Randomized controlled trial

Indexed keywords

ANTICARIES AGENT; CASEIN; FLUORIDE; FLUOROPHOSPHATE; PHOSPHATE; PLACEBO; TOOTHPASTE;

ADOLESCENT; ARTICLE; CHILD; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DENTAL CARIES; FEMALE; FOLLOW UP; HEALTH SURVEY; HUMAN; INDIA; MALE; MOUTH HYGIENE; RANDOMIZED CONTROLLED TRIAL; TOOTH BRUSHING; TREATMENT OUTCOME;

ADOLESCENT; CARIOSTATIC AGENTS; CASEINS; CHILD; DENTAL CARIES; DENTAL CARIES SUSCEPTIBILITY; DMF INDEX; FEMALE; FLUORIDES; FOLLOW-UP STUDIES; HUMANS; INDIA; MALE; ORAL HYGIENE; ORAL HYGIENE INDEX; PHOSPHATES; PLACEBOS; TOOTHBRUSHING; TOOTHPASTE; TREATMENT OUTCOME;

EID: 70350393399     PISSN: 00086568     EISSN: None     Source Type: Journal    
DOI: 10.1159/000252976     Document Type: Article

References (24)

1. Andlaw RJ: Oral hygiene and dental caries: a review. Int Dent J 1978; 28: 1-6.
2. Bavetta LA, McClure FJ: Protein factors and experimental rat caries. J Nutr 1957; 63: 107-117.
3. Bellini HT, Arneberg P, Von Der Fehr FR: Oral hygiene and caries: a review. Acta Odontol Scand 1981; 39: 257-265.
4. Ferrazzano GF, Cantile T, Quarto M, Ingenito A, Chianese L, Addeo F: Protective effect of yogurt extract on dental enamel demineralization in vitro. Austr Dent J 2008; 53: 314-319.
5. Greene JC, Vermillion JR: The Oral Hygiene Index: a method to determine oral hygiene status. J Am Dent Assoc 1960; 61: 172-179.
6. Guggenheim B, Neeser JR, Golliard M, Schüpbach P: Salivary pellicle modified by milk components mediates caries protection. Caries Res 1994; 28: 182.
7. Holloway PJ, Shaw JH, Sweeney EA: Effects of various sucrose-casein ratios in purified diets on the teeth and supporting structures of rats. Arch Oral Biol 1961; 3: 185-200.
8. Marinho VCC, Higgins JPT, Logan S, Sheiham A: Topical fluoride (toothpastes, mouthrinses, gels or varnishes) for preventing dental caries in children and adolescents. Cochrane Database Syst Rev 2003; 4:CD002782.
9. Mergele M: Report II: an unsupervised brushing study on subjects residing in a community with fluoride in water. Acad Med NJ Bull 1968; 14: 251-255.
10. Mishra D, Singh HP: Kuppuswamy's socioeconomic status scale-a revision. Indian J Pediatr 2003;70:273-274.
11. Murray JJ: The Prevention of Dental Disease. Oxford, Oxford University Press, 1989.
12. Reynolds EC: The prevention of enamel sub-surface demineralization of bovine enamel and change in plaque composition by casein in an intra-oral model. J Dent Res 1987; 66: 1120-1127.
13. Reynolds EC, Del Rio A: Effects of casein and whey protein solutions on caries experience and feeding patterns of the rat. Arch Oral Biol 1984; 29: 927-933.
14. Reynolds EC, Riley PF: Protein dissimilation by human salivary-sediment bacteria. J Dent Res 1989; 68: 124-129.
15. Schüpbach P, Neeser JR, Golliard M, Rouvet M, Guggenheim B: Incorporation of caseinoglycomacropeptide and caseinophosphopeptide into salivary pellicle inhibits adherence of mutans streptococci. J Dent Res 1996; 75: 1779-1788.
16. Schweigert BS, Potts E, Shaw JH, Zepplin M, Phillips PH: Dental caries in cotton rat. VIII. Further studies on the dietary effects of carbohydrate, protein and fat on the incidence and extent of carious lesions. J Nutr 1946a; 32: 405-412.
17. Schweigert BS, Shaw JH, Zepplin M, Elvehjem CA: Dental caries in the cotton rat. VI. The effect of the amount of protein, fat and carbohydrate in the diet on the incidence and extent of carious lesions. J Nutr 1946b;31: 439-447.
18. Shaw JH: Effects of dietary composition on tooth decay in albino rat. J Nutr 1950; 41: 13-23.
19. Sutcliffe P: Oral cleanliness and dental caries; in Murray JJ (ed): The Prevention of Dental Disease. Oxford, Oxford University Press, 1983, pp 159-174.
20. Swaisgood HE: Chemistry of milk proteins; in Fox PF (ed): Developments in Dairy Chemistry 1. London, Applied Science Publishers, 1982.
21. Torell P, Ericsson Y: Two-year clinical tests with different methods of local caries preventive fluoride application in Swedish school children. Acta Odontol Scand 1965; 23: 287-322.
22. Twetman S, Axelsson S, Dahlgren H, Holm AK, Källestål C, Lagerlöf F, Lingström P, Mejàre I, Nordenram G, Norlund A, Petersson LG, Söder B: Caries-preventive effect of fluoride toothpaste: a systematic review. Acta Odontol Scand 2003; 61: 347-355. (Pubitemid 38082336)
23. Vernon PG, Huntington E, Singleton SJ: An intra-oral model to monitor the effect of a dentifrice on surface softening of enamel in-situ (abstract). J Dent Res 1992; 71: 597.
24. World Health Organization: Oral Health Surveys, Basic Methods, ed 3. Geneva, WHO, 1987.