메뉴 건너뛰기




Volumn 60, Issue 4, 2011, Pages 397-407

Living in a dangerous world decreases maternal care: A study in serotonin transporter knockout mice

Author keywords

5 HTT knockout mice; Adaptation; Anxiety; Behavioral profile; Corticosterone; Early adversity; Maternal care; Maternal effects; Prenatal stress

Indexed keywords

CORTICOSTERONE; SEROTONIN TRANSPORTER;

EID: 80052160542     PISSN: 0018506X     EISSN: 10956867     Source Type: Journal    
DOI: 10.1016/j.yhbeh.2011.07.006     Document Type: Article
Times cited : (28)

References (112)
  • 2
    • 0032100238 scopus 로고    scopus 로고
    • Do early-life events permanently alter behavioral and hormonal responses to stressors?
    • Anisman H., Zaharia M.D., Meaney M.J., Merali Z. Do early-life events permanently alter behavioral and hormonal responses to stressors?. Int. J. Dev. Neurosci. 1998, 16:149-164.
    • (1998) Int. J. Dev. Neurosci. , vol.16 , pp. 149-164
    • Anisman, H.1    Zaharia, M.D.2    Meaney, M.J.3    Merali, Z.4
  • 3
    • 0015163387 scopus 로고
    • Prenatal psychological stress and offspring behavior in rats and mice
    • Archer J.E., Blackman D.E. Prenatal psychological stress and offspring behavior in rats and mice. Dev. Psychobiol. 1971, 4:193-248.
    • (1971) Dev. Psychobiol. , vol.4 , pp. 193-248
    • Archer, J.E.1    Blackman, D.E.2
  • 4
    • 18044385348 scopus 로고    scopus 로고
    • Is mom too sensitive? Impact of maternal stress during gestation
    • Bale T.L. Is mom too sensitive? Impact of maternal stress during gestation. Front. Neuroendocrinol. 2005, 26:41-49.
    • (2005) Front. Neuroendocrinol. , vol.26 , pp. 41-49
    • Bale, T.L.1
  • 5
    • 0016043306 scopus 로고
    • Plasma corticosterone levels during pregnancy in the mouse: the relative contributions of the adrenal glands and foeto-placental units
    • Barlow S.M., Morrison P.J., Sullivan F.M. Plasma corticosterone levels during pregnancy in the mouse: the relative contributions of the adrenal glands and foeto-placental units. J. Endocrinol. 1974, 60:473-483.
    • (1974) J. Endocrinol. , vol.60 , pp. 473-483
    • Barlow, S.M.1    Morrison, P.J.2    Sullivan, F.M.3
  • 6
    • 0030781583 scopus 로고    scopus 로고
    • Further pharmacological validation of the BALB/c neophobia in the free exploratory paradigm as an animal model of trait anxiety
    • Belzung C., Berton F. Further pharmacological validation of the BALB/c neophobia in the free exploratory paradigm as an animal model of trait anxiety. Behav. Pharmacol. 1997, 8:541-548.
    • (1997) Behav. Pharmacol. , vol.8 , pp. 541-548
    • Belzung, C.1    Berton, F.2
  • 7
    • 0031978809 scopus 로고    scopus 로고
    • Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine ("Ecstasy") in serotonin transporter-deficient mice
    • Bengel D., Murphy D.L., Andrews A.M., Wichems C.H., Feltner D., Heils A., Mössner R., Westphal H., Lesch K.-P. Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine ("Ecstasy") in serotonin transporter-deficient mice. Mol. Pharmacol. 1998, 53:649-655.
    • (1998) Mol. Pharmacol. , vol.53 , pp. 649-655
    • Bengel, D.1    Murphy, D.L.2    Andrews, A.M.3    Wichems, C.H.4    Feltner, D.5    Heils, A.6    Mössner, R.7    Westphal, H.8    Lesch, K.-P.9
  • 8
    • 70350223525 scopus 로고    scopus 로고
    • Childhood maltreatment, intervening variables, and adult psychological difficulties in women: an overview
    • Briere J., Jordan C.E. Childhood maltreatment, intervening variables, and adult psychological difficulties in women: an overview. Trauma Violence Abuse 2009, 10:375-388.
    • (2009) Trauma Violence Abuse , vol.10 , pp. 375-388
    • Briere, J.1    Jordan, C.E.2
  • 9
    • 78349310407 scopus 로고    scopus 로고
    • Chronic corticosterone during pregnancy and postpartum affects maternal care, cell proliferation and depressive-like behavior in the dam
    • Brummelte S., Galea L.A.M. Chronic corticosterone during pregnancy and postpartum affects maternal care, cell proliferation and depressive-like behavior in the dam. Horm. Behav. 2010, 58:769-779.
    • (2010) Horm. Behav. , vol.58 , pp. 769-779
    • Brummelte, S.1    Galea, L.A.M.2
  • 10
    • 0027407657 scopus 로고
    • Effects of postnatal stress on dopamine mesolimbic system responses to aversive experiences in adult life
    • Cabib S., Puglisi-Allegra S., D'Amato F.R. Effects of postnatal stress on dopamine mesolimbic system responses to aversive experiences in adult life. Brain Res. 1993, 604:232-239.
    • (1993) Brain Res. , vol.604 , pp. 232-239
    • Cabib, S.1    Puglisi-Allegra, S.2    D'Amato, F.R.3
  • 11
    • 1642483651 scopus 로고    scopus 로고
    • Emotional reactivity in mice may not be inherited but influenced by parent
    • Calatayud F., Coubard S., Belzung C. Emotional reactivity in mice may not be inherited but influenced by parent. Physiol. Behav. 2004, 80:465-474.
    • (2004) Physiol. Behav. , vol.80 , pp. 465-474
    • Calatayud, F.1    Coubard, S.2    Belzung, C.3
  • 12
    • 0032574785 scopus 로고    scopus 로고
    • Maternal care during infancy regulates the development of neural systems mediating the expression of fearfulness in the rat
    • Caldji C., Tannenbaum B., Sharma S., Francis D., Plotsky P.M., Meaney M.J. Maternal care during infancy regulates the development of neural systems mediating the expression of fearfulness in the rat. Proc. Natl. Acad. Sci. U.S.A. 1998, 95:5335-5340.
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 5335-5340
    • Caldji, C.1    Tannenbaum, B.2    Sharma, S.3    Francis, D.4    Plotsky, P.M.5    Meaney, M.J.6
  • 13
    • 33644749610 scopus 로고    scopus 로고
    • Identifying interactions between genes and early environment in the mouse
    • Carola V., Frazzetto G., Gross C. Identifying interactions between genes and early environment in the mouse. Genes Brain Behav. 2006, 5:189-199.
    • (2006) Genes Brain Behav. , vol.5 , pp. 189-199
    • Carola, V.1    Frazzetto, G.2    Gross, C.3
  • 14
    • 41449111073 scopus 로고    scopus 로고
    • Identifying molecular substrates in a mouse model of the serotonin transporter×environment risk factor for anxiety and depression
    • Carola V., Frazzetto G., Pascucci T., Audero E., Puglisi-Allegra S., Cabib S., Lesch K.-P., Gross C. Identifying molecular substrates in a mouse model of the serotonin transporter×environment risk factor for anxiety and depression. Biol. Psychiatry 2008, 63:840-846.
    • (2008) Biol. Psychiatry , vol.63 , pp. 840-846
    • Carola, V.1    Frazzetto, G.2    Pascucci, T.3    Audero, E.4    Puglisi-Allegra, S.5    Cabib, S.6    Lesch, K.-P.7    Gross, C.8
  • 15
    • 29444447606 scopus 로고    scopus 로고
    • MIT Press, Cambridge/MA, C.S. Carter, L. Ahnert, K.E. Grossmann, S.B. Hrdy, M.E. Lamb, S.W. Porges, N. Sachser (Eds.)
    • Attachment and Bonding: A New Synthesis 2005, MIT Press, Cambridge/MA. C.S. Carter, L. Ahnert, K.E. Grossmann, S.B. Hrdy, M.E. Lamb, S.W. Porges, N. Sachser (Eds.).
    • (2005) Attachment and Bonding: A New Synthesis
  • 17
    • 43049156118 scopus 로고    scopus 로고
    • Epigenetic mechanisms and the transgenerational effects of maternal care
    • Champagne F.A. Epigenetic mechanisms and the transgenerational effects of maternal care. Front. Neuroendocrinol. 2008, 29:386-397.
    • (2008) Front. Neuroendocrinol. , vol.29 , pp. 386-397
    • Champagne, F.A.1
  • 18
    • 77951452018 scopus 로고    scopus 로고
    • Epigenetic influence of social experiences across the lifespan
    • Champagne F.A. Epigenetic influence of social experiences across the lifespan. Dev. Psychobiol. 2010, 52:299-311.
    • (2010) Dev. Psychobiol. , vol.52 , pp. 299-311
    • Champagne, F.A.1
  • 19
  • 20
    • 0041733266 scopus 로고    scopus 로고
    • Variations in maternal care in the rat as a mediating influence for the effects of environment on development
    • Champagne F.A., Francis D.D., Mar A., Meaney M.J. Variations in maternal care in the rat as a mediating influence for the effects of environment on development. Physiol. Behav. 2003, 79:359-371.
    • (2003) Physiol. Behav. , vol.79 , pp. 359-371
    • Champagne, F.A.1    Francis, D.D.2    Mar, A.3    Meaney, M.J.4
  • 21
    • 33745476901 scopus 로고    scopus 로고
    • Stress during gestation alters postpartum maternal care and the development of the offspring in a rodent model
    • Champagne F.A., Meaney M.J. Stress during gestation alters postpartum maternal care and the development of the offspring in a rodent model. Biol. Psychiatry 2006, 59:1227-1235.
    • (2006) Biol. Psychiatry , vol.59 , pp. 1227-1235
    • Champagne, F.A.1    Meaney, M.J.2
  • 22
    • 22144482385 scopus 로고    scopus 로고
    • Differential adaptive responses to chronic stress of maternally stressed male mice offspring
    • Chung S., Son G.H., Park S.H., Park E., Lee K.H., Geum D., Kim K. Differential adaptive responses to chronic stress of maternally stressed male mice offspring. Endocrinology 2005, 146:3202-3210.
    • (2005) Endocrinology , vol.146 , pp. 3202-3210
    • Chung, S.1    Son, G.H.2    Park, S.H.3    Park, E.4    Lee, K.H.5    Geum, D.6    Kim, K.7
  • 23
    • 43549108995 scopus 로고    scopus 로고
    • Effects of rat odour and shelter on maternal behaviour in C57BL/6 dams and on fear and stress responses in their adult offspring
    • Coutellier L., Friedrich A.-C., Failing K., Marashi V., Würbel H. Effects of rat odour and shelter on maternal behaviour in C57BL/6 dams and on fear and stress responses in their adult offspring. Physiol. Behav. 2008, 94:393-404.
    • (2008) Physiol. Behav. , vol.94 , pp. 393-404
    • Coutellier, L.1    Friedrich, A.-C.2    Failing, K.3    Marashi, V.4    Würbel, H.5
  • 24
    • 0019199013 scopus 로고
    • Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines
    • Crawley J., Goodwin F.K. Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines. Pharmacol. Biochem. Behav. 1980, 13:167-170.
    • (1980) Pharmacol. Biochem. Behav. , vol.13 , pp. 167-170
    • Crawley, J.1    Goodwin, F.K.2
  • 25
    • 0019823545 scopus 로고
    • Neuropharmacologic specificity of a simple animal model for the behavioral actions of benzodiazepines
    • Crawley J.N. Neuropharmacologic specificity of a simple animal model for the behavioral actions of benzodiazepines. Pharmacol. Biochem. Behav. 1981, 15:695-699.
    • (1981) Pharmacol. Biochem. Behav. , vol.15 , pp. 695-699
    • Crawley, J.N.1
  • 28
    • 0017806658 scopus 로고
    • Perinatal changes in plasma and adrenal corticosterone and aldosterone concentrations in the mouse
    • Dalle M., Giry J., Gay M., Delost P. Perinatal changes in plasma and adrenal corticosterone and aldosterone concentrations in the mouse. J. Endocrinol. 1978, 76:303-309.
    • (1978) J. Endocrinol. , vol.76 , pp. 303-309
    • Dalle, M.1    Giry, J.2    Gay, M.3    Delost, P.4
  • 29
    • 0031657177 scopus 로고    scopus 로고
    • Long-term effects of postnatal manipulation on emotionality are prevented by maternal anxiolytic treatment in mice
    • D'Amato F.R., Cabib S., Ventura R., Orsini C. Long-term effects of postnatal manipulation on emotionality are prevented by maternal anxiolytic treatment in mice. Dev. Psychobiol. 1998, 32:225-234.
    • (1998) Dev. Psychobiol. , vol.32 , pp. 225-234
    • D'Amato, F.R.1    Cabib, S.2    Ventura, R.3    Orsini, C.4
  • 30
    • 0010470437 scopus 로고
    • Prenatal maternal stress in mice. Differential effects on behavior
    • DeFries J.C. Prenatal maternal stress in mice. Differential effects on behavior. J. Hered. 1964, 55:289-295.
    • (1964) J. Hered. , vol.55 , pp. 289-295
    • DeFries, J.C.1
  • 31
    • 0002452002 scopus 로고
    • Effects of exposure to stressors in early life upon later behavioural and biological processes
    • Oxford University Press, New York, L. Levi (Ed.)
    • Denenberg V.H. Effects of exposure to stressors in early life upon later behavioural and biological processes. Society, Stress, and Disease: Childhood and Adolescence 1975, 269-281. Oxford University Press, New York. L. Levi (Ed.).
    • (1975) Society, Stress, and Disease: Childhood and Adolescence , pp. 269-281
    • Denenberg, V.H.1
  • 32
    • 0026048383 scopus 로고
    • Selectivity in paternal and infanticidal responses by male mice: effects of relatedness, location, and previous sexual partners
    • Elwood R.W., Kennedy H.F. Selectivity in paternal and infanticidal responses by male mice: effects of relatedness, location, and previous sexual partners. Behav. Neural Biol. 1991, 56:129-147.
    • (1991) Behav. Neural Biol. , vol.56 , pp. 129-147
    • Elwood, R.W.1    Kennedy, H.F.2
  • 34
    • 0036854608 scopus 로고    scopus 로고
    • Effects of prenatal stress on stress-induced changes in behavior and macrophage activity of mice
    • Fonseca E.S., Massoco C.O., Palermo-Neto J. Effects of prenatal stress on stress-induced changes in behavior and macrophage activity of mice. Physiol. Behav. 2002, 77:205-215.
    • (2002) Physiol. Behav. , vol.77 , pp. 205-215
    • Fonseca, E.S.1    Massoco, C.O.2    Palermo-Neto, J.3
  • 35
    • 0033527727 scopus 로고    scopus 로고
    • Nongenomic transmission across generations of maternal behavior and stress responses in the rat
    • Francis D., Diorio J., Liu D., Meaney M.J. Nongenomic transmission across generations of maternal behavior and stress responses in the rat. Science 1999, 286:1155-1158.
    • (1999) Science , vol.286 , pp. 1155-1158
    • Francis, D.1    Diorio, J.2    Liu, D.3    Meaney, M.J.4
  • 36
    • 0027141033 scopus 로고
    • The free-exploratory paradigm: an effective method for measuring neophobic behaviour in mice and testing potential neophobia-reducing drugs
    • Griebel G., Belzung C., Misslin R., Vogel E. The free-exploratory paradigm: an effective method for measuring neophobic behaviour in mice and testing potential neophobia-reducing drugs. Behav. Pharmacol. 1993, 4:637-644.
    • (1993) Behav. Pharmacol. , vol.4 , pp. 637-644
    • Griebel, G.1    Belzung, C.2    Misslin, R.3    Vogel, E.4
  • 37
    • 3042719619 scopus 로고    scopus 로고
    • The developmental origins of anxiety
    • Gross C., Hen R. The developmental origins of anxiety. Nat. Rev. Neurosci. 2004, 5:545-552.
    • (2004) Nat. Rev. Neurosci. , vol.5 , pp. 545-552
    • Gross, C.1    Hen, R.2
  • 38
    • 79952705355 scopus 로고    scopus 로고
    • Glucocorticoids, prenatal stress and the programming of disease
    • Harris A., Seckl J. Glucocorticoids, prenatal stress and the programming of disease. Horm. Behav. 2011, 59:279-289.
    • (2011) Horm. Behav. , vol.59 , pp. 279-289
    • Harris, A.1    Seckl, J.2
  • 40
    • 80051929731 scopus 로고    scopus 로고
    • Consequences of serotonin transporter genotype and early adversity on behavioral profile - pathology or adaptation?
    • Heiming R.S., Sachser N. Consequences of serotonin transporter genotype and early adversity on behavioral profile - pathology or adaptation?. Front. Neurosci. 2010, 4:187.
    • (2010) Front. Neurosci. , vol.4 , pp. 187
    • Heiming, R.S.1    Sachser, N.2
  • 41
    • 0029867314 scopus 로고    scopus 로고
    • A review of the validity and variability of the elevated plus-maze as an animal model of anxiety
    • Hogg S. A review of the validity and variability of the elevated plus-maze as an animal model of anxiety. Pharmacol. Biochem. Behav. 1996, 54:21-30.
    • (1996) Pharmacol. Biochem. Behav. , vol.54 , pp. 21-30
    • Hogg, S.1
  • 42
    • 0034985694 scopus 로고    scopus 로고
    • Targeted gene mutation approaches to the study of anxiety-like behavior in mice
    • Holmes A. Targeted gene mutation approaches to the study of anxiety-like behavior in mice. Neurosci. Biobehav. Rev. 2001, 25:261-273.
    • (2001) Neurosci. Biobehav. Rev. , vol.25 , pp. 261-273
    • Holmes, A.1
  • 43
    • 0345305849 scopus 로고    scopus 로고
    • Abnormal anxiety-related behavior in serotonin transporter null mutant mice: the influence of genetic background
    • Holmes A., Li Q., Murphy D.L., Gold E., Crawley J.N. Abnormal anxiety-related behavior in serotonin transporter null mutant mice: the influence of genetic background. Genes Brain Behav. 2003, 2:365-380.
    • (2003) Genes Brain Behav. , vol.2 , pp. 365-380
    • Holmes, A.1    Li, Q.2    Murphy, D.L.3    Gold, E.4    Crawley, J.N.5
  • 44
    • 0242391960 scopus 로고    scopus 로고
    • Abnormal behavioral phenotypes of serotonin transporter knockout mice: parallels with human anxiety and depression
    • Holmes A., Murphy D.L., Crawley J.N. Abnormal behavioral phenotypes of serotonin transporter knockout mice: parallels with human anxiety and depression. Biol. Psychiatry 2003, 54:953-959.
    • (2003) Biol. Psychiatry , vol.54 , pp. 953-959
    • Holmes, A.1    Murphy, D.L.2    Crawley, J.N.3
  • 45
    • 79952012111 scopus 로고    scopus 로고
    • Looking on the bright side of serotonin transporter gene variation
    • Homberg J.R., Lesch K.-P. Looking on the bright side of serotonin transporter gene variation. Biol. Psychiatry 2011, 69:513-519.
    • (2011) Biol. Psychiatry , vol.69 , pp. 513-519
    • Homberg, J.R.1    Lesch, K.-P.2
  • 46
    • 0035207885 scopus 로고    scopus 로고
    • Development of adult ethanol preference and anxiety as a consequence of neonatal maternal separation in Long Evans rats and reversal with antidepressant treatment
    • Huot R.L., Thrivikraman K.V., Meaney M.J., Plotsky P.M. Development of adult ethanol preference and anxiety as a consequence of neonatal maternal separation in Long Evans rats and reversal with antidepressant treatment. Psychopharmacology 2001, 158:366-373.
    • (2001) Psychopharmacology , vol.158 , pp. 366-373
    • Huot, R.L.1    Thrivikraman, K.V.2    Meaney, M.J.3    Plotsky, P.M.4
  • 47
    • 4243093999 scopus 로고    scopus 로고
    • Delayed effects of chronic variable stress during peripubertal-juvenile period on hippocampal morphology and on cognitive and stress axis functions in rats
    • Isgor C., Kabbaj M., Akil H., Watson S.J. Delayed effects of chronic variable stress during peripubertal-juvenile period on hippocampal morphology and on cognitive and stress axis functions in rats. Hippocampus 2004, 14:636-648.
    • (2004) Hippocampus , vol.14 , pp. 636-648
    • Isgor, C.1    Kabbaj, M.2    Akil, H.3    Watson, S.J.4
  • 49
    • 16244422993 scopus 로고    scopus 로고
    • The effects of prenatal social stress on behaviour: mechanisms and function
    • Kaiser S., Sachser N. The effects of prenatal social stress on behaviour: mechanisms and function. Neurosci. Biobehav. Rev. 2005, 29:283-294.
    • (2005) Neurosci. Biobehav. Rev. , vol.29 , pp. 283-294
    • Kaiser, S.1    Sachser, N.2
  • 50
    • 64949121183 scopus 로고    scopus 로고
    • Effects of prenatal social stress on offspring development: pathology or adaptation?
    • Kaiser S., Sachser N. Effects of prenatal social stress on offspring development: pathology or adaptation?. Curr. Dir. Psychol. Sci. 2009, 18:118-121.
    • (2009) Curr. Dir. Psychol. Sci. , vol.18 , pp. 118-121
    • Kaiser, S.1    Sachser, N.2
  • 53
    • 0036297593 scopus 로고    scopus 로고
    • Glucocorticoid hormones and early brain development in schizophrenia
    • Koenig J.I., Kirkpatrick B., Lee P. Glucocorticoid hormones and early brain development in schizophrenia. Neuropsychopharmacology 2002, 27:309-318.
    • (2002) Neuropsychopharmacology , vol.27 , pp. 309-318
    • Koenig, J.I.1    Kirkpatrick, B.2    Lee, P.3
  • 54
    • 0036627586 scopus 로고    scopus 로고
    • The role of prenatal stress in the etiology of developmental behavioural disorders
    • Kofman O. The role of prenatal stress in the etiology of developmental behavioural disorders. Neurosci. Biobehav. Rev. 2002, 26:457-470.
    • (2002) Neurosci. Biobehav. Rev. , vol.26 , pp. 457-470
    • Kofman, O.1
  • 55
    • 0018574002 scopus 로고
    • Loss of tissue sensitivity to growth hormone during maternal deprivation in rats
    • Kuhn C.M., Evoniuk G., Schanberg S.M. Loss of tissue sensitivity to growth hormone during maternal deprivation in rats. Life Sci. 1979, 25:2089-2097.
    • (1979) Life Sci. , vol.25 , pp. 2089-2097
    • Kuhn, C.M.1    Evoniuk, G.2    Schanberg, S.M.3
  • 56
    • 0032098468 scopus 로고    scopus 로고
    • Responses to maternal separation: mechanisms and mediators
    • Kuhn C.M., Schanberg S.M. Responses to maternal separation: mechanisms and mediators. Int. J. Dev. Neurosci. 1998, 16:261-270.
    • (1998) Int. J. Dev. Neurosci. , vol.16 , pp. 261-270
    • Kuhn, C.M.1    Schanberg, S.M.2
  • 57
    • 77954429466 scopus 로고    scopus 로고
    • Faecal glucocorticoid metabolites: how to express yourself - comparison of absolute amounts versus concentrations in samples from a study in laboratory rats
    • Lepschy M., Touma C., Palme R. Faecal glucocorticoid metabolites: how to express yourself - comparison of absolute amounts versus concentrations in samples from a study in laboratory rats. Lab. Anim. 2010, 44:192-198.
    • (2010) Lab. Anim. , vol.44 , pp. 192-198
    • Lepschy, M.1    Touma, C.2    Palme, R.3
  • 58
    • 30644479033 scopus 로고    scopus 로고
    • Genetic alterations of the murine serotonergic gene pathway: the neurodevelopmental basis of anxiety
    • Lesch K.P. Genetic alterations of the murine serotonergic gene pathway: the neurodevelopmental basis of anxiety. Handb. Exp. Pharmacol. 2005, 169:71-112.
    • (2005) Handb. Exp. Pharmacol. , vol.169 , pp. 71-112
    • Lesch, K.P.1
  • 59
    • 79958139576 scopus 로고    scopus 로고
    • When the serotonin transporter gene meets adversity: the contribution of animal models to understanding epigenetic mechanisms in affective disorders and resilience
    • Lesch K.-P. When the serotonin transporter gene meets adversity: the contribution of animal models to understanding epigenetic mechanisms in affective disorders and resilience. Curr. Top. Behav. Neurosci. 2011, 7:251-280.
    • (2011) Curr. Top. Behav. Neurosci. , vol.7 , pp. 251-280
    • Lesch, K.-P.1
  • 61
    • 0028686648 scopus 로고
    • The ontogeny of the hypothalamic-pituitary-adrenal axis. The influence of maternal factors
    • Levine S. The ontogeny of the hypothalamic-pituitary-adrenal axis. The influence of maternal factors. Ann. N. Y. Acad. Sci. 1994, 746:275-288.
    • (1994) Ann. N. Y. Acad. Sci. , vol.746 , pp. 275-288
    • Levine, S.1
  • 62
    • 0002487593 scopus 로고
    • Critical period for effects of infantile experience on maturation of stress response
    • Levine S., Lewis G.W. Critical period for effects of infantile experience on maturation of stress response. Science 1959, 129:42-43.
    • (1959) Science , vol.129 , pp. 42-43
    • Levine, S.1    Lewis, G.W.2
  • 63
    • 0025321231 scopus 로고
    • Ethologically-based animal models of anxiety disorders
    • Lister R.G. Ethologically-based animal models of anxiety disorders. Pharmacol. Ther. 1990, 46:321-340.
    • (1990) Pharmacol. Ther. , vol.46 , pp. 321-340
    • Lister, R.G.1
  • 66
    • 0032836473 scopus 로고    scopus 로고
    • Male olfactory cues affect mothers' behavior in mice: effects of benzodiazepines
    • Mandillo S., D'Amato F.R. Male olfactory cues affect mothers' behavior in mice: effects of benzodiazepines. Psychopharmacology 1999, 146:297-302.
    • (1999) Psychopharmacology , vol.146 , pp. 297-302
    • Mandillo, S.1    D'Amato, F.R.2
  • 67
    • 60249096516 scopus 로고    scopus 로고
    • Predation threat exerts specific effects on rat maternal behaviour and anxiety-related behaviour of male and female offspring
    • Mashoodh R., Sinal C.J., Perrot-Sinal T.S. Predation threat exerts specific effects on rat maternal behaviour and anxiety-related behaviour of male and female offspring. Physiol. Behav. 2009, 96:693-702.
    • (2009) Physiol. Behav. , vol.96 , pp. 693-702
    • Mashoodh, R.1    Sinal, C.J.2    Perrot-Sinal, T.S.3
  • 68
    • 0034002776 scopus 로고    scopus 로고
    • Antenatal glucocorticoids and programming of the developing CNS
    • Matthews S.G. Antenatal glucocorticoids and programming of the developing CNS. Pediatr. Res. 2000, 47:291-300.
    • (2000) Pediatr. Res. , vol.47 , pp. 291-300
    • Matthews, S.G.1
  • 69
    • 63649130425 scopus 로고    scopus 로고
    • Serotonin transporter gene variation, infant abuse, and responsiveness to stress in rhesus macaque mothers and infants
    • McCormack K., Newman T.K., Higley J.D., Maestripieri D., Sanchez M.M. Serotonin transporter gene variation, infant abuse, and responsiveness to stress in rhesus macaque mothers and infants. Horm. Behav. 2009, 55:538-547.
    • (2009) Horm. Behav. , vol.55 , pp. 538-547
    • McCormack, K.1    Newman, T.K.2    Higley, J.D.3    Maestripieri, D.4    Sanchez, M.M.5
  • 70
    • 33846128770 scopus 로고    scopus 로고
    • Evidence for non-genomic transmission of ecological information via maternal behavior in female rats
    • McLeod J., Sinal C.J., Perrot-Sinal T.S. Evidence for non-genomic transmission of ecological information via maternal behavior in female rats. Genes Brain Behav. 2007, 6:19-29.
    • (2007) Genes Brain Behav. , vol.6 , pp. 19-29
    • McLeod, J.1    Sinal, C.J.2    Perrot-Sinal, T.S.3
  • 71
    • 0034928759 scopus 로고    scopus 로고
    • Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations
    • Meaney M.J. Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. Annu. Rev. Neurosci. 2001, 24:1161-1192.
    • (2001) Annu. Rev. Neurosci. , vol.24 , pp. 1161-1192
    • Meaney, M.J.1
  • 72
    • 0022366241 scopus 로고
    • The effects of early postnatal handling on hippocampal glucocorticoid receptor concentrations: temporal parameters
    • Meaney M.J., Aitken D.H. The effects of early postnatal handling on hippocampal glucocorticoid receptor concentrations: temporal parameters. Brain Res. 1985, 354:301-304.
    • (1985) Brain Res. , vol.354 , pp. 301-304
    • Meaney, M.J.1    Aitken, D.H.2
  • 73
    • 33845342923 scopus 로고    scopus 로고
    • Effects of repeated maternal separation on anxiety- and depression-related phenotypes in different mouse strains
    • Millstein R.A., Holmes A. Effects of repeated maternal separation on anxiety- and depression-related phenotypes in different mouse strains. Neurosci. Biobehav. Rev. 2007, 31:3-17.
    • (2007) Neurosci. Biobehav. Rev. , vol.31 , pp. 3-17
    • Millstein, R.A.1    Holmes, A.2
  • 74
    • 79955483996 scopus 로고    scopus 로고
    • Prenatal stress induces anxiety-like behavior together with the disruption of central serotonin neurons in mice
    • Miyagawa K., Tsuji M., Fujimori K., Saito Y., Takeda H. Prenatal stress induces anxiety-like behavior together with the disruption of central serotonin neurons in mice. Neurosci. Res. 2011, 70:111-117.
    • (2011) Neurosci. Res. , vol.70 , pp. 111-117
    • Miyagawa, K.1    Tsuji, M.2    Fujimori, K.3    Saito, Y.4    Takeda, H.5
  • 75
    • 0021249437 scopus 로고
    • Maternal contributions to the development of masculine sexual behavior in laboratory rats
    • Moore C.L. Maternal contributions to the development of masculine sexual behavior in laboratory rats. Dev. Psychobiol. 1984, 17:347-356.
    • (1984) Dev. Psychobiol. , vol.17 , pp. 347-356
    • Moore, C.L.1
  • 76
    • 0031680550 scopus 로고    scopus 로고
    • The adaptive significance of maternal effects
    • Mousseau T.A., Fox C.W. The adaptive significance of maternal effects. Trends Ecol. Evol. 1998, 13:403.
    • (1998) Trends Ecol. Evol. , vol.13 , pp. 403
    • Mousseau, T.A.1    Fox, C.W.2
  • 77
    • 54049086269 scopus 로고    scopus 로고
    • Sex-specific programming of offspring emotionality after stress early in pregnancy
    • Mueller B.R., Bale T.L. Sex-specific programming of offspring emotionality after stress early in pregnancy. J. Neurosci. 2008, 28:9055-9065.
    • (2008) J. Neurosci. , vol.28 , pp. 9055-9065
    • Mueller, B.R.1    Bale, T.L.2
  • 79
    • 33646825971 scopus 로고    scopus 로고
    • Effects of perinatal stress on the anxiety-related behavior of the adolescence mouse
    • Nishio H., Tokumo K., Hirai T. Effects of perinatal stress on the anxiety-related behavior of the adolescence mouse. Int. J. Dev. Neurosci. 2006, 24:263-268.
    • (2006) Int. J. Dev. Neurosci. , vol.24 , pp. 263-268
    • Nishio, H.1    Tokumo, K.2    Hirai, T.3
  • 80
    • 36048941028 scopus 로고    scopus 로고
    • Effects of prenatal stress on motor performance and anxiety behavior in Swiss mice
    • Pallarés M., Scacchi Bernasconi P., Feleder C., Cutrera R.A. Effects of prenatal stress on motor performance and anxiety behavior in Swiss mice. Physiol. Behav. 2007, 92:951-956.
    • (2007) Physiol. Behav. , vol.92 , pp. 951-956
    • Pallarés, M.1    Scacchi Bernasconi, P.2    Feleder, C.3    Cutrera, R.A.4
  • 81
    • 34848857007 scopus 로고    scopus 로고
    • Early life stress effects on adult stress-induced corticosterone secretion and anxiety-like behavior in the C57BL/6 mouse are not as robust as initially thought
    • Parfitt D.B., Walton J.R., Corriveau E.A., Helmreich D.L. Early life stress effects on adult stress-induced corticosterone secretion and anxiety-like behavior in the C57BL/6 mouse are not as robust as initially thought. Horm. Behav. 2007, 52:417-426.
    • (2007) Horm. Behav. , vol.52 , pp. 417-426
    • Parfitt, D.B.1    Walton, J.R.2    Corriveau, E.A.3    Helmreich, D.L.4
  • 83
    • 0027195888 scopus 로고
    • Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats
    • Plotsky P.M., Meaney M.J. Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats. Mol. Brain Res. 1993, 18:195-200.
    • (1993) Mol. Brain Res. , vol.18 , pp. 195-200
    • Plotsky, P.M.1    Meaney, M.J.2
  • 84
    • 1642315257 scopus 로고    scopus 로고
    • Dopamine release in response to a psychological stress in humans and its relationship to early life maternal care: a positron emission tomography study using [11C]raclopride
    • Pruessner J.C., Champagne F., Meaney M.J., Dagher A. Dopamine release in response to a psychological stress in humans and its relationship to early life maternal care: a positron emission tomography study using [11C]raclopride. J. Neurosci. 2004, 24:2825-2831.
    • (2004) J. Neurosci. , vol.24 , pp. 2825-2831
    • Pruessner, J.C.1    Champagne, F.2    Meaney, M.J.3    Dagher, A.4
  • 85
    • 0038069368 scopus 로고    scopus 로고
    • Long-term neurobehavioural impact of the postnatal environment in rats: manipulations, effects and mediating mechanisms
    • Pryce C.R., Feldon J. Long-term neurobehavioural impact of the postnatal environment in rats: manipulations, effects and mediating mechanisms. Neurosci. Biobehav. Rev. 2003, 27:57-71.
    • (2003) Neurosci. Biobehav. Rev. , vol.27 , pp. 57-71
    • Pryce, C.R.1    Feldon, J.2
  • 86
    • 33645854064 scopus 로고    scopus 로고
    • Exposure to repetitive versus varied stress during prenatal development generates two distinct anxiogenic and neuroendocrine profiles in adulthood
    • Richardson H.N., Zorrilla E.P., Mandyam C.D., Rivier C.L. Exposure to repetitive versus varied stress during prenatal development generates two distinct anxiogenic and neuroendocrine profiles in adulthood. Endocrinology 2006, 147:2506-2517.
    • (2006) Endocrinology , vol.147 , pp. 2506-2517
    • Richardson, H.N.1    Zorrilla, E.P.2    Mandyam, C.D.3    Rivier, C.L.4
  • 87
    • 0037498259 scopus 로고    scopus 로고
    • Anxiety and fear behaviors in adult male and female C57BL/6 mice are modulated by maternal separation
    • Romeo R.D., Mueller A., Sisti H.M., Ogawa S., McEwen B.S., Brake W.G. Anxiety and fear behaviors in adult male and female C57BL/6 mice are modulated by maternal separation. Horm. Behav. 2003, 43:561-567.
    • (2003) Horm. Behav. , vol.43 , pp. 561-567
    • Romeo, R.D.1    Mueller, A.2    Sisti, H.M.3    Ogawa, S.4    McEwen, B.S.5    Brake, W.G.6
  • 88
    • 0004102213 scopus 로고    scopus 로고
    • Anwendung statistischer Methoden. Springer-Verlag, Berlin, L. Sachs (Ed.)
    • Angewandte Statistik 1999, Anwendung statistischer Methoden. Springer-Verlag, Berlin. L. Sachs (Ed.).
    • (1999) Angewandte Statistik
  • 89
    • 79957493068 scopus 로고    scopus 로고
    • Adaptive modulation of behavioural profiles by social stress during early phases of life and adolescence
    • Sachser N., Hennessy M.B., Kaiser S. Adaptive modulation of behavioural profiles by social stress during early phases of life and adolescence. Neurosci. Biobehav. Rev. 2011, 35:1518-1533.
    • (2011) Neurosci. Biobehav. Rev. , vol.35 , pp. 1518-1533
    • Sachser, N.1    Hennessy, M.B.2    Kaiser, S.3
  • 90
    • 0023488867 scopus 로고
    • Sensory deprivation stress and supplemental stimulation in the rat pup and preterm human neonate
    • Schanberg S.M., Field T.M. Sensory deprivation stress and supplemental stimulation in the rat pup and preterm human neonate. Child Dev. 1987, 58:1431-1447.
    • (1987) Child Dev. , vol.58 , pp. 1431-1447
    • Schanberg, S.M.1    Field, T.M.2
  • 91
    • 10344226154 scopus 로고    scopus 로고
    • Prenatal glucocorticoids and long-term programming
    • Seckl J.R. Prenatal glucocorticoids and long-term programming. Eur. J. Endocrinol. 2004, 151:U49-U62.
    • (2004) Eur. J. Endocrinol. , vol.151
    • Seckl, J.R.1
  • 92
    • 34249316880 scopus 로고    scopus 로고
    • Mechanisms of disease: glucocorticoids, their placental metabolism and fetal 'programming' of adult pathophysiology
    • Seckl J.R., Holmes M.C. Mechanisms of disease: glucocorticoids, their placental metabolism and fetal 'programming' of adult pathophysiology. Nat. Clin. Pract. Endocrinol. Metab. 2007, 3:479-488.
    • (2007) Nat. Clin. Pract. Endocrinol. Metab. , vol.3 , pp. 479-488
    • Seckl, J.R.1    Holmes, M.C.2
  • 93
    • 35348868631 scopus 로고    scopus 로고
    • Association between the recombinant human serotonin transporter linked promoter region polymorphism and behavior in rhesus macaques during a separation paradigm
    • Spinelli S., Schwandt M.L., Lindell S.G., Newman T.K., Heilig M., Suomi S.J., Higley J.D., Goldman D., Barr C.S. Association between the recombinant human serotonin transporter linked promoter region polymorphism and behavior in rhesus macaques during a separation paradigm. Dev. Psychopathol. 2007, 19:977-987.
    • (2007) Dev. Psychopathol. , vol.19 , pp. 977-987
    • Spinelli, S.1    Schwandt, M.L.2    Lindell, S.G.3    Newman, T.K.4    Heilig, M.5    Suomi, S.J.6    Higley, J.D.7    Goldman, D.8    Barr, C.S.9
  • 94
    • 31144432426 scopus 로고    scopus 로고
    • Attachment and development: a prospective, longitudinal study from birth to adulthood
    • Sroufe L.A. Attachment and development: a prospective, longitudinal study from birth to adulthood. Attach Hum. Dev. 2005, 7:349-367.
    • (2005) Attach Hum. Dev. , vol.7 , pp. 349-367
    • Sroufe, L.A.1
  • 95
    • 36949041037 scopus 로고    scopus 로고
    • Gene-by-environment (serotonin transporter and childhood maltreatment) interaction for anxiety sensitivity, an intermediate phenotype for anxiety disorders
    • Stein M.B., Schork N.J., Gelernter J. Gene-by-environment (serotonin transporter and childhood maltreatment) interaction for anxiety sensitivity, an intermediate phenotype for anxiety disorders. Neuropsychopharmacology 2008, 33:312-319.
    • (2008) Neuropsychopharmacology , vol.33 , pp. 312-319
    • Stein, M.B.1    Schork, N.J.2    Gelernter, J.3
  • 96
    • 0027422805 scopus 로고
    • Maternal regulation of the hypothalamic-pituitary-adrenal axis in the infant rat: the roles of feeding and stroking
    • Suchecki D., Rosenfeld P., Levine S. Maternal regulation of the hypothalamic-pituitary-adrenal axis in the infant rat: the roles of feeding and stroking. Dev. Brain Res. 1993, 75:185-192.
    • (1993) Dev. Brain Res. , vol.75 , pp. 185-192
    • Suchecki, D.1    Rosenfeld, P.2    Levine, S.3
  • 97
    • 0347090594 scopus 로고    scopus 로고
    • Analyzing corticosterone metabolites in fecal samples of mice: a noninvasive technique to monitor stress hormones
    • Touma C., Palme R., Sachser N. Analyzing corticosterone metabolites in fecal samples of mice: a noninvasive technique to monitor stress hormones. Horm. Behav. 2004, 45:10-22.
    • (2004) Horm. Behav. , vol.45 , pp. 10-22
    • Touma, C.1    Palme, R.2    Sachser, N.3
  • 98
    • 0037442105 scopus 로고    scopus 로고
    • Effects of sex and time of day on metabolism and excretion of corticosterone in urine and feces of mice
    • Touma C., Sachser N., Möstl E., Palme R. Effects of sex and time of day on metabolism and excretion of corticosterone in urine and feces of mice. Gen. Comp. Endocrinol. 2003, 130:267-278.
    • (2003) Gen. Comp. Endocrinol. , vol.130 , pp. 267-278
    • Touma, C.1    Sachser, N.2    Möstl, E.3    Palme, R.4
  • 99
    • 0024158498 scopus 로고
    • Thigmotaxis as a test for anxiolytic activity in rats
    • Treit D., Fundytus M. Thigmotaxis as a test for anxiolytic activity in rats. Pharmacol. Biochem. Behav. 1988, 31:959-962.
    • (1988) Pharmacol. Biochem. Behav. , vol.31 , pp. 959-962
    • Treit, D.1    Fundytus, M.2
  • 100
    • 0030960905 scopus 로고    scopus 로고
    • Prenatal stress induces high anxiety and postnatal handling induces low anxiety in adult offspring: correlation with stress-induced corticosterone secretion
    • Vallée M., Mayo W., Dellu F., Le Moal M., Simon H., Maccari S. Prenatal stress induces high anxiety and postnatal handling induces low anxiety in adult offspring: correlation with stress-induced corticosterone secretion. J. Neurosci. 1997, 17:2626-2636.
    • (1997) J. Neurosci. , vol.17 , pp. 2626-2636
    • Vallée, M.1    Mayo, W.2    Dellu, F.3    Le Moal, M.4    Simon, H.5    Maccari, S.6
  • 101
    • 0032402170 scopus 로고    scopus 로고
    • Maternal deprivation effect on the infant's neural stress markers is reversed by tactile stimulation and feeding but not by suppressing corticosterone
    • van Oers H.J.J., de Kloet E.R., Whelan T., Levine S. Maternal deprivation effect on the infant's neural stress markers is reversed by tactile stimulation and feeding but not by suppressing corticosterone. J. Neurosci. 1998, 18:10171-10179.
    • (1998) J. Neurosci. , vol.18 , pp. 10171-10179
    • van Oers, H.J.J.1    de Kloet, E.R.2    Whelan, T.3    Levine, S.4
  • 102
    • 34248577678 scopus 로고    scopus 로고
    • Opposite effects of maternal separation on intermale and maternal aggression in C57BL/6 mice: link to hypothalamic vasopressin and oxytocin immunoreactivity
    • Veenema A.H., Bredewold R., Neumann I.D. Opposite effects of maternal separation on intermale and maternal aggression in C57BL/6 mice: link to hypothalamic vasopressin and oxytocin immunoreactivity. Psychoneuroendocrinology 2007, 32:437-450.
    • (2007) Psychoneuroendocrinology , vol.32 , pp. 437-450
    • Veenema, A.H.1    Bredewold, R.2    Neumann, I.D.3
  • 103
    • 0020034868 scopus 로고
    • The regulation of infanticide and parental behavior: implications for reproductive success in male mice
    • vom Saal F.S., Howard L.S. The regulation of infanticide and parental behavior: implications for reproductive success in male mice. Science 1982, 215:1270-1272.
    • (1982) Science , vol.215 , pp. 1270-1272
    • vom Saal, F.S.1    Howard, L.S.2
  • 104
    • 0030028787 scopus 로고    scopus 로고
    • Neonatal deprivation of maternal touch may suppress ornithine decarboxylase via downregulation of the proto-oncogenes c-myc and max
    • Wang S., Bartolome J.V., Schanberg S.M. Neonatal deprivation of maternal touch may suppress ornithine decarboxylase via downregulation of the proto-oncogenes c-myc and max. J. Neurosci. 1996, 16:836-842.
    • (1996) J. Neurosci. , vol.16 , pp. 836-842
    • Wang, S.1    Bartolome, J.V.2    Schanberg, S.M.3
  • 105
    • 0033834593 scopus 로고    scopus 로고
    • Effects of prenatal stress on defensive withdrawal behavior and corticotropin releasing factor systems in rat brain
    • Ward H.E., Johnson E.A., Salm A.K., Birkle D.L. Effects of prenatal stress on defensive withdrawal behavior and corticotropin releasing factor systems in rat brain. Physiol. Behav. 2000, 70:359-366.
    • (2000) Physiol. Behav. , vol.70 , pp. 359-366
    • Ward, H.E.1    Johnson, E.A.2    Salm, A.K.3    Birkle, D.L.4
  • 106
    • 51449122281 scopus 로고    scopus 로고
    • Maternal behaviour in Mus musculus sp.: An ethological review
    • Weber E.M., Olsson I.A.S. Maternal behaviour in Mus musculus sp.: An ethological review. Appl. Anim. Behav. Sci. 2008, 114:1-22.
    • (2008) Appl. Anim. Behav. Sci. , vol.114 , pp. 1-22
    • Weber, E.M.1    Olsson, I.A.S.2
  • 107
    • 77950945886 scopus 로고    scopus 로고
    • Early life stress increases anxiety-like behavior in Balbc mice despite a compensatory increase in levels of postnatal maternal care
    • Wei L., David A., Duman R.S., Anisman H., Kaffman A. Early life stress increases anxiety-like behavior in Balbc mice despite a compensatory increase in levels of postnatal maternal care. Horm. Behav. 2010, 57:396-404.
    • (2010) Horm. Behav. , vol.57 , pp. 396-404
    • Wei, L.1    David, A.2    Duman, R.S.3    Anisman, H.4    Kaffman, A.5
  • 108
    • 67649351968 scopus 로고    scopus 로고
    • Family relationships in childhood and common psychiatric disorders in later life: systematic review of prospective studies
    • Weich S., Patterson J., Shaw R., Stewart-Brown S. Family relationships in childhood and common psychiatric disorders in later life: systematic review of prospective studies. Br. J. Psychiatry 2009, 194:392-398.
    • (2009) Br. J. Psychiatry , vol.194 , pp. 392-398
    • Weich, S.1    Patterson, J.2    Shaw, R.3    Stewart-Brown, S.4
  • 109
    • 0034749488 scopus 로고    scopus 로고
    • Alterations induced by gestational stress in brain morphology and behaviour of the offspring
    • Weinstock M. Alterations induced by gestational stress in brain morphology and behaviour of the offspring. Prog. Neurobiol. 2001, 65:427-451.
    • (2001) Prog. Neurobiol. , vol.65 , pp. 427-451
    • Weinstock, M.1
  • 110
    • 45849128326 scopus 로고    scopus 로고
    • The long-term behavioural consequences of prenatal stress
    • Weinstock M. The long-term behavioural consequences of prenatal stress. Neurosci. Biobehav. Rev. 2008, 32:1073-1086.
    • (2008) Neurosci. Biobehav. Rev. , vol.32 , pp. 1073-1086
    • Weinstock, M.1
  • 111
    • 0035180462 scopus 로고    scopus 로고
    • Prenatal stress, glucocorticoids and the programming of the brain
    • Welberg L.A.M., Seckl J.R. Prenatal stress, glucocorticoids and the programming of the brain. J. Neuroendocrinol. 2001, 13:113-128.
    • (2001) J. Neuroendocrinol. , vol.13 , pp. 113-128
    • Welberg, L.A.M.1    Seckl, J.R.2
  • 112
    • 0033624912 scopus 로고    scopus 로고
    • Inhibition of 11beta-hydroxysteroid dehydrogenase, the foeto-placental barrier to maternal glucocorticoids, permanently programs amygdala GR mRNA expression and anxiety-like behaviour in the offspring
    • Welberg L.A.M., Seckl J.R., Holmes M.C. Inhibition of 11beta-hydroxysteroid dehydrogenase, the foeto-placental barrier to maternal glucocorticoids, permanently programs amygdala GR mRNA expression and anxiety-like behaviour in the offspring. Eur. J. Neurosci. 2000, 12:1047-1054.
    • (2000) Eur. J. Neurosci. , vol.12 , pp. 1047-1054
    • Welberg, L.A.M.1    Seckl, J.R.2    Holmes, M.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.