An amphiphilic conjugate approach toward the design and synthesis of betulinic acid-polyphenol conjugates as inhibitors of the HIV-1 gp41 fusion core formation

ChemMedChem

Volumn 6, Issue 9, 2011, Pages 1654-1664

  Liu, Yan ^a   Ke, Zhuofeng ^b   Wu, Kwok Yiu ^a   Liu, Shuwen ^c   Chen, Wen Hua ^c   Jiang, Shibo ^d   Jiang, Zhi Hong ^a,c  

^a HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

^b KYOTO UNIVERSITY   (Japan)

^c SOUTHERN MEDICAL UNIVERSITY   (China)

^d NEW YORK BLOOD CENTER   (United States)

Author keywords

Conjugates; Drug design; Fusion entry inhibitors; HIV 1 gp41; Molecular modeling

Indexed keywords

3 (3,4 DIACETOXYPHENYL) N [6 [(3BETA ACETOXYLUP 20(29) EN 28 OYL)AMINO]HEXYL]ACRYLAMIDE; 3 (3,4 DIACETOXYPHENYL) N [6 [(3BETA HYDROXYLUP 20(29) EN 28 OYL)AMINO]HEXYL]ACRYLAMIDE; 3 (3,4 DIACETOXYPHENYL) N [7 [(3BETA ACETOXYLUP 20(29) EN 28 OYL)AMINO]HEXYL]ACRYLAMIDE; 3 (3,4 DIACETOXYPHENYL) N [7 [(3BETA HYDROXYLUP 20(29) EN 28 OYL)AMINO]HEPTYL]ACRYLAMIDE; 3 (3,4 DIHYDROXYPHENYL) N [6 [(3BETA ACETOXYLUP 20(29) EN 28 OYL)AMINO]HEPTYL]ACRYLAMIDE; 3 (3,4 DIHYDROXYPHENYL) N [6 [(3BETA ACETOXYLUP 20(29) EN 28 OYL)AMINO]HEXYL]ACRYLAMIDE; 3 (3,4 DIHYDROXYPHENYL) N [6 [(3BETA HYDROXYLUP 20(29) EN 28 OYL)AMINO]HEPTYL]ACRYLAMIDE; 3 (3,4 DIHYDROXYPHENYL) N [6 [(3BETA HYDROXYLUP 20(29) EN 28 OYL)AMINO]HEXYL]ACRYLAMIDE; 3,4,5 TRIACETOXY N [6 [(3BETA ACETOXYLUP 20(29) EN 28 OYL)AMINO]HEXYL]BENZAMIDE; 3,4,5 TRIACETOXY N [7 [(3BETA ACETOXYLUP 20(29) EN 28 OYL)AMINO]HEPTYL]BENZAMIDE; 3,4,5 TRIACETOXY N [7 [(3BETA HYDROXYLUP 20(29) EN 28 OYL)AMINO]HEPTYL]BENZAMIDE; 3,4,5 TRIHYDROXY N [6 [(3BETA ACETOXYLUP 20(29) EN 28 OYL)AMINO]HEXYL]BENZAMIDE; 3,4,5 TRIHYDROXY N [6 [(3BETA HYDROXYLUP 20(29) EN 28 OYL)AMINO]HEPTYL]BENZAMIDE; 3,4,5 TRIHYDROXY N [6 [(3BETA HYDROXYLUP 20(29) EN 28 OYL)AMINO]HEXYL]BENZAMIDE; 3,4,5 TRIHYDROXY N [6 [(3BETA HYDROXYLUPAN 20(29) EN 28 OYL)AMINO]HEXYL]BENZAMIDE; 3,4,5 TRIHYDROXY N [7 [(3BETA ACETOXYLUP 20(29) EN 28 OYL)AMINO]HEPTYL]BENZAMIDE; 3,4,5 TRIHYDROXY N [7 [(3BETA HYDROXYLUPAN 20(29) EN 28 OYL)AMINO]HEXYL]BENZAMIDE; ACRYLAMIDE DERIVATIVE; BENZAMIDE DERIVATIVE; BETULIC ACID; GLYCOPROTEIN GP 41; HUMAN IMMUNODEFICIENCY VIRUS FUSION INHIBITOR; POLYPHENOL; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; BINDING AFFINITY; DRUG CONJUGATION; DRUG DESIGN; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ALGORITHMS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HIV ENVELOPE PROTEIN GP41; HIV FUSION INHIBITORS; HIV INFECTIONS; HUMANS; HYDROGEN BONDING; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MODELS, MOLECULAR; POLYPHENOLS; TRITERPENES;

EID: 80052093762     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201100149     Document Type: Article

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