4-aminopyridine induces apoptosis of human acute myeloid leukemia cells via increasing [Ca 2+ ]i through P 2 X 7 receptor pathway

Cellular Physiology and Biochemistry

Volumn 28, Issue 2, 2011, Pages 199-208

  Wang, Wei ^a   Xiao, Jianbing ^a   Adachi, Masaaki ^a,b   Liu, Zhiyu ^a   Zhou, Jin ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b SAPPORO MEDICAL UNIVERSITY   (Japan)

Author keywords

4 aminopyridine; Acute myeloid leukemia; Apoptosis; Mitochondria; Purinergic receptors

Indexed keywords

4 AMINOPYRIDINE; CALCIUM ION; CASPASE 3; CASPASE 9; MESSENGER RNA; PURINERGIC P2X7 RECEPTOR; SMALL INTERFERING RNA;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE MONOCYTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CANCER INHIBITION; CELL DISRUPTION; CELL STRAIN HL 60; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE SILENCING; HUMAN; HUMAN CELL; IC 50; LEUKEMIA CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; POTASSIUM CURRENT; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; TIME;

EID: 80052091343     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000331731     Document Type: Article

References (37)

1. Deschler B, Lübbert M: Acute myeloid leukemia: epidemiology and etiology. Cancer 2006;107:2099-20107.
2. Smits EL, Berneman ZN, Van Tendeloo VF: Immunotherapy of acute myeloid leukemia: current approaches. Oncologist 2009;14:240-252.
3. Büchner T, Hiddemann W, Wörmann B, Löffler H, Gassmann W, Haferlach T, Fonatsch C, Haase D, Schoch C, Hossfeld D, Lengfelder E, Aul C, Heyll A, Maschmeyer G, Ludwig WD, Sauerland MC, Heinecke A: Double induction strategy for acute myeloid leukemia:the effect of high-dose cytarabine with mitoxantrone instead of standard-dose cytarabine with daunorubicin and 6-thioguanine: a randomized trial by the German AML Cooperative Group. Blood 1999;93:4116-4124. (Pubitemid 29279253)
4. Tallman MS, Gilliland DG, Rowe JM: Drug therapy for acute myeloid leukemia. Blood 2005;106:1154-1163. (Pubitemid 41130866)
5. Gojo I, Jiemjit A, Trepel JB, Sparreboom A, asg WD, Rollins S, Tidwell ML, Greer J, Chung EJ, Lee MJ, Gore SD, Sausville EA, Zwiebel J, Karp JE: Phase 1 and pharmacologic study of MS-275, a histone deacetylase inhibitor, in adults with refractory and relapsed acute leukemias. Blood 2007;109:2781-2790. (Pubitemid 46482071)
6. Harousseau JL, Cahn JY, Pignon B, Witz F, Milpied N, Delain M, Lioure B, Lamy T, Desablens B, Guilhot F, Caillot D, Abgrall JF, Francois S, Briere J, Guyotat D, Casassus P, Audhuy B, Tellier Z, Hurteloup P, Herve P: Comparison of autologous bone marrow transplantation and intensive chemotherapy as postremission therapy in adult acute myeloid leukemia. The Groupe Ouest Est Leucemies Aigues Myeloblastiques (GOELAM). Blood 1997;90:2978-2986. (Pubitemid 27444191)
7. Sternberg DW, Aird W, Neuberg D, Thompson L, MacNeill K, Amrein P, Shulman LN: Treatment of patients with recurrent and primary refractory acute myelogenous leukemia using mitoxantrone and intermediate-dose cytarabine: a pharmacologically based regimen. Cancer 2000;88:2037-2041. (Pubitemid 30233204)
8. Rouzaire-Dubois B, Gerard V, Dubois JM: Involvement of K+ channels in the quercetin-induced inhibition of neuroblastoma cell growth. Pflugers Arch 1993;423:202-205. (Pubitemid 23137293)
9. Fieber LA, Gonzalez DM, Wallace MR, Muir D: Delayed rectifier K+ currents in NF1 Schwann cells. Pharmacological block inhibits proliferation. Neurobiol Dis 2003;13:136-146. (Pubitemid 36793978)
10. Nilius B, Wohlrab W: Potassium channels and regulation of proliferation of human melanoma cells. J Physiol Lond 1992;445:537-48.
11. Rybalchenko V, Prevarskaya N, Van Coppenolle F, Legrand G, Lemonnier L, Le Bourhis X, Skryma R: Verapamil inhibits proliferation of LNCaP human prostate cancer cells influencing K+ channel gating. Mol Pharmacol 2001;59:1376-1387. (Pubitemid 32510101)
12. Chin LS, Park CC, Zitnay KM, Sinha M, Dipatri AJJR, Perillan P, Simard JM: 4-Aminopyridine causes apoptosis and blocks an outward rectifier K+ channel in malignant astrocytoma cell lines. J Neurosci Res 1997;48:122-127. (Pubitemid 27181337)
13. Cabado AG, Alfonso A, Vieytes MR, González M, Botana MA, Botana LM: Crosstalk between cytosolic pH and intracellular calcium in human lymphocytes: effect of 4-aminopyridin, ammoniun chloride and ionomycin. Cell Signal 2000;12:573-581.
14. + entry induced by rapid cytosolic alkalinization in Jurkat T-lymphocytes. Biochem J 1994;301:83-88.
15. + influx mediates apoptosis induced by 4-aminopyridine, a K+ channel blocker, in HepG2 human hepatoblastoma cells. Pharmacol 200;60:74-81.
16. Harman AW, Maxwell MJ:An evaluation of the role of calcium in cell injury. Annu Rev Pharmacol Toxicol 1995;35:129-114.
17. Distelhorst CW, Dubyak G: Role of calcium in glucocorticosteroid-induced apoptosis of thymocytes and lymphoma cells: Resurrection of old theories by new findings. Blood 1998;91:731-734. (Pubitemid 28078272)
18. Lajdova I, Chorvat D, Spustova V, Chorvatova A: 4-Aminopyridine activates calcium influx through modulation of the pore-forming purinergic receptor in human peripheral blood mononuclear cells. Can J Physiol Pharmacol 2004;82:50-56. (Pubitemid 38420837)
19. Xu B, Wilson BA, Lu L: Induction of human myeloblastic ML-1 cell G1 arrest by suppression of K+ channel activity. Am J Physiol 1996;271:C2037-2044.
20. Wang W, Adachi M, Kawamura R, Sakamoto H, Hayashi T, Ishida T, Imai K, Shinomura Y: Parthenolide-induced apoptosis in multiple myeloma cells involves reactive oxygen species generation and cell sensitivity depends on catalase activity. Apoptosis 2006;11:2225-2235. (Pubitemid 44885398)
21. Schmitt CA, Rosenthal CT, Lowe SW: Genetic analysis of chemoresistance in primary murine lymphomas. Nat Med 2000;6:1029-1035.
22. Thornberry NA, Rano TA, Peterson EP, Rasper DM, Timkey T, Garcia-Calvo M, Houtzager VM, Nordstrom PA, Roy S, Vaillancourt JP, Chapman KT, Nicholson DW: A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis. J Biol Chem 1997;272:17907-11. (Pubitemid 27306365)
23. Degterev A, Boyce M, Yuan J: A decade of caspases. Oncogene 2003;22:8543-8567. (Pubitemid 38028527)
24. Wang L, Xu B, White RE, Lu L: Effects of arsenic trioxide on voltage-gated potassium channels and on cell proliferation of human multiple myeloma cells. Chin Med J 2007;120:1266-1269.
25. Zhang XJ, Zheng GG, Ma XT, Yang YH, Li G, Rao Q, Nie K, Wu KF: Expression of P2X7 in human hematopoietic cell lines and leukemia patients. Leuk Res 2004;28:1313-1322. (Pubitemid 39314411)
26. Jahani-Asl A, Germain M, Slack RS: Mitochondria: joining forces to thwart cell death. Biochim Biophys Acta 2010;1802:162-6.
27. Spitzner M, Ousingsawat J, Scheidt K, Kunzelmann K, Schreiber R: Voltagegated K+ channels support proliferation of colonic carcinoma cells. FASEB J 2007;21:35-44. (Pubitemid 46052543)
28. Pillozzi S, Brizzi MF, Bernabei PA, Bartolozzi B, Caporale R, Basile V, Boddi V, Pegoraro L, Becchetti A, Arcangeli A: VEGFR-1 (FLT-1), beta1 integrin, and hERG K+ channel for a macromolecular signaling complex in acute myeloid leukemia: role in cell migration and clinical outcome. Blood 2007;110:1238-1250. (Pubitemid 47281422)
29. Pillozzi S, Brizzi MF, Balzi M, Crociani O, Cherubini A, Guasti L, Bartolozzi B, Becchetti A, Wanke E, Bernabei PA, Olivotto M, Pegoraro L, Arcangeli A: HERG potassium channels are constitutively expressed in primary human acute myeloid leukemias and regulate cell proliferation of normal and leukemic hemopoietic progenitors. Leukemia 2002;16:1791-1798.
30. Jang SH, Kang KS, Ryu PD, Lee SY: Kv1.3 voltage-gated K(+) channel subunit as a potential diagnostic marker and therapeutic target for breast cancer. BMB Rep 2009;42:535-539.
31. Pardo LA: Voltage-gated potassium channels in cell proliferation. Physiology (Bethesda). 2004;19:285-292. (Pubitemid 39472640)
32. Ishikawa T, Eckman DM, Keef KD: Characterization of delayed rectifier K+ currents in rabbit coronary artery cells near resting membrane potential. Can J Physiol Pharmacol 1997;75:1116-1122. (Pubitemid 27504781)
33. Shimoda LA, Sylvester JT, Sham JS: Inhibition of voltage-gated K+ current in rat intrapulmonary arterial myocytes by endothelin-1. Am J Physiol 1998;274:L842-853.
34. Chung S, Joe E, Soh H, Lee MY, Bang HW: Delayed rectifier potassium currents induced in activated rat microglia set the resting membrane potential. Neurosci Lett 1998;242:73-76. (Pubitemid 28082996)
35. Green DR, Reed JC: Mitochondria and apoptosis. Science 1998;281:1309-1312. (Pubitemid 28406816)
36. Dong DL, Wang QH, Yue P, Jiao JD, Gu RM, Yang BF: Indapamide induces apoptosis of GH3 pituitary cells independently of its inhibition of voltage-dependent K+ currents. Eur J Pharmacol 2006;536:78-84.
37. Wu ZZ, Li DP, Chen SR, Pan HL: Aminopyridines potentiate synaptic and neuromuscular transmission by targeting the voltage-activated calcium channel beta subunit. J Biol Chem 2009;284:36453-36461.