Comparison of autologous bone marrow transplantation and intensive chemotherapy as postremission therapy in adult acute myeloid leukemia

Blood

Volumn 90, Issue 8, 1997, Pages 2978-2986

  Harousseau, Jean Luc ^a   Cahn, Jean Yves ^b   Pignon, Bernard ^b   Witz, Francis ^b   Milpied, Noël ^b   Delain, Martine ^b   Lioure, Bruno ^b   Lamy, Thierry ^b   Desablens, Bernard ^b   Guilhot, François ^b   Caillot, Denis ^b   Abgrall, Jean François ^b   François, Sylvie ^b   Briere, Jean ^b   Guyotat, Denis ^b   Casassus, Philippe ^b   Audhuy, Bruno ^b   Tellier, Zéra ^b   Hurteloup, Patrick ^b   Herve, Patrick ^b  

^a HÔTEL DIEU   (France)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMSACRINE; ANTHRACYCLINE ANTIBIOTIC AGENT; BUSULFAN; CYCLOPHOSPHAMIDE; CYTARABINE; ETOPOSIDE; IDARUBICIN; ZORUBICIN;

ACUTE GRANULOCYTIC LEUKEMIA; ADOLESCENT; ADULT; ALLOGENIC BONE MARROW TRANSPLANTATION; ARTICLE; AUTOLOGOUS BONE MARROW TRANSPLANTATION; BONE MARROW BIOPSY; CANCER CHEMOTHERAPY; CANCER SURVIVAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HLA MATCHING; HOSPITALIZATION; HUMAN; HUMAN CELL; HUMAN TISSUE; LEUKEMIA REMISSION; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; PROGNOSIS; RANDOMIZED CONTROLLED TRIAL; THROMBOCYTOPENIA; TREATMENT OUTCOME;

ACUTE DISEASE; ADOLESCENT; ADULT; ANTIBIOTICS, ANTINEOPLASTIC; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BONE MARROW TRANSPLANTATION; CYTARABINE; DAUNORUBICIN; HUMANS; IDARUBICIN; LEUKEMIA, MYELOID; MIDDLE AGED; MULTIVARIATE ANALYSIS; OUTCOME ASSESSMENT (HEALTH CARE); PROGNOSIS; REMISSION INDUCTION;

EID: 9844244021     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (62)

1. Mayer RJ: Allogenic transplantation versus intensive chemotherapy in first remission acute leukemia: Is there a "best choice." J Clin Oncol 6:1532, 1988
2. Löwenberg B: Post remission treatment of acute myelogenous leukemia. N Engl J Med 332:260, 1993
3. Gale RP, Armitage JO, Butturini A: Is there a role for autotransplant in acute leukemia? Bone Marrow Transplant 4:217, 1989
4. Gale R, Champlin R: How does marrow transplantation cure leukemia. Lancet 2:28, 1984
5. Horowitz, MM, Gale RP, Sondel PM, Goldman JM, Kersey J, Kolb HJ, Rimm AA, Ringden O, Rozman C, Speck B: Graft-versus leukemia reaction after bone marrow transplantation. Blood 75:555, 1990
6. Burnett AK, Tansey P, Watkins R, Alcorn M, Maharaj D, Singer CR, Mackinnon S, Mac Donald GA, Robertson AG: Transplantation of unpurged autologous bone marrow transplantation in acute myeloid leukaemia in first remission. Lancet 2:1068, 1984
7. Beelen DW, Quabeck K, Graeven U, Sayer HG, Mahmoud HK, Schaefe UW: Acute toxicity and first clinical results of intensive postinduction therapy using a modified busulfan and cyclophosphamide regimen with autologous bone marrow rescue in first remission of acute myeloid leukemia. Blood 74:1507, 1989
8. Mac Millan AK, Goldstone AH, Linch DC, Gribben JG, Patterson KG, Richards JDM, Franklin I, Boughton BJ, Milligan DW, Leyland M, Hutchinson RM, Newland AC: High dose chemotherapy and autologous bone marrow transplantation in acute myeloid leukemia. Blood 76:480, 1990
9. Cahn JY, Herve P, Flesch M, Plouvier E, Noir A, Racadot E, Montcuquet P, Behar C, Pignon B, Boilletot A, Lutz P, Henon P, Rozenbaum A, Peters A, Leconte Des Floris R: Autologous bone marrow transplantation for acute leukemia in first remission: A pilot study of 33 cases. Br J Haematol 63:457, 1986
10. Yeager AM, Keizer H, Santos GW, Saral R, Colvin OM, Stuart RK, Braine HG, Burke PJ, Ambinder RF, Burns WH, Fuller DJ, Davis JM, Karp JE, May WS, Rowley SD: Autologous bone marrow transplantation in patients with acute non lymphocytic leukemia using ex vivo marrow treatment with alpha-hydroxy-peroxycyclophosphamide. N Engl J Med 315:141, 1986
11. Gorin NC, Douay L, Laporte JP, Lopez M, Mary JY, Najman A, Salmon C, Aegerter P, Stachowiak J, David R, Pene F, Kantor G, Deloux J, Duhamel E, Van Den Akker J, Gerota J, Parlier Y, Duhamel G: Autologous bone marrow transplantation using marrow incubated with ASTA Z 7557 in adult acute leukemia. Blood 67:1367, 1986
12. Korbling M, Hunstein W, Fliedner JM, Cayeux S, Dorken B, Fehrentz D, Haas R, Ho AD, Keilhoz U, Knauf W, Konig A, Mende U, Pezzutto A, Von Reumon J, Wolf GK, Wannenmacher M, Zumwinkel K, Rother K: Disease free survival after autologous bone marrow transplantation in patients with acute myelocytic leukemia. Blood 74:1898, 1989
13. Sanz MA, De La Rubia J, Sanz GF, Martin G, Martinez J, Jarque I, Sempere A, Gomis F, Senent L, Angeles Soler M, Lopez F, Jesus Arilla M, Carpio N, Guinot M, Palau J, Tudela M, Marty ML: Busulfan plus cyclophosphamide followed by autologous blood stem cell transplantation for patients with acute myeloblastic leukemia in first complete remission: A report form a single institution. J Clin Oncol 11:1161, 1993
14. Gorin NC, Aegerter P, Auvert B, Meloni G, Goldstone AH, Burnett A, Carella A, Korbling M, Herve P, Maraninchi O, Lowenberg R, Verdonck LF, De Planque M, Hermans J, Helbig W, Porcellini A, Rizzoli V, Alessandrino EP, Franklin IM, Reiffers J, Colleselli P, Goldman JM: Autologous bone marrow transplantation for acute myelocytic leukemia in first remission: A European survey of the role of marrow purging. Blood 75:1606, 1990
15. Cassileth PA, Begg CB, Silber R: Prolonged unmaintained remission after intensive consolidation therapy in adult acute non lympocytic leukemia. Cancer Treat Rep 71:137, 1987
16. Champlin R, Ho W, Winston D, Decker D, Greenberg P, Burnison M, Holly FE, Gale RP: Treatment of adults with acute myelogenous leukemia: Prospective evaluation of high dose cytarabine in consolidation chemotherapy and with bone marrow transplantation. Semin Oncol 14:1, 1987 (suppl)
17. Preisler HD, Raza A, Early A: Intensive remission consolidation therapy in the treatment of acute non lymphocytic leukemia. Br J Haematol 5:722, 1987
18. Tallman MS, Appelbaum FR, Amos D, Goldberg RS, Livingston RB, Mortimer J, Weiden PL, Thomas ED: Evaluation of intensive post remission chemotherapy for adults with acute non lymphocytic leukemia using high dose cytosine arabinoside with L-asparaginase and amsacrine with etoposide. J Clin Oncol 5:918, 1987
19. Tricot G, Boogaerts MA, Vlietiwck R, Emonds MP, Verwilgen RL: The role of intensive remission induction and consolidation therapy in patients with acute myeloid leukemia. Br J Haematol 66:37, 1987
20. Geller RB, Burke PJ, Karp JE, Humphrey RL, Braine HG, Tucken RW, Fox MG, Zahurok M, Morell L, Hall KL, Piantadusi S: A two-step timed sequential treatment for acute myelocytic leukemia. Blood 74:1499, 1989
21. Wolff SN, Herzig RH, Fay JW: High-dose cytarabine and daunorubicine as consolidation therapy for acute myeloid leukemia in first remission: Long term follow up and results. J Clin Oncol 66:37, 1989
22. Harousseau JL, Milpied N, Briere J, Desablens B, Leprise PY, Ifrah N, Ghandour C, Casassus P: Double intensive consolidation chemotherapy in adult acute myeloid leukemia. J Clin Oncol 9:1432, 1991
23. Zittoun RA, Mandelli F, Willemze R, Dewitte T, Labar B, Resegotti L, Leoni F, Damasio E, Visani G, Papa G, Caronia F, Hayat M, Stryckmans P, Rotoli B, Leoni P, Peetermans ME, Dardenne M, Vegna ML, Petti MC, Solbu G, Suciu S: Autologous or allogeneic bone marrow transplantation compared with intensive chemotherapy in acute myelogenous leukemia. N Engl J Med 322:217, 995
24. Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DAG, Gralnick HR, Sultan C: Proposed revised criteria for the classification of acute myeloid leukemia: A report of the French-American-British Cooperative Group. Ann Intern Med 103:626, 1985
25. Keating MJ, Smith TL, Kantarjian H, Cork A, Walters R, Trujillo JM, Mc Credie KB, Gehan EA, Freireich EJ: Cytogenetic pattern in acute myelogenous leukemia: A major reproducible determinant of outcome. Leukemia 2:403, 1988
26. Schiffer CA, Lee EJ, Tomiyasu T, Wiernik PH, Testa JR: Prognostic impact of cytogenetic abnormalities in patients with de novo acute non lymphocytic leukemia. Blood 73:263, 1989
27. Morisson FS, Kopecky KJ, Head DR, Athens JW, Balcerzak SP, Gumbart C, Dabich L, Costanzi JJ, Coltman CA, Saiki JH, Hussein KK, Fabian CJ, Appelbaum FR: Late intensification with POMP chemotherapy prolongs survival in acute myelogenous leukemia. Results of Southwest Oncology Group Study of rubidazone versus adriamycin for remission induction, prophylactic intrathecal therapy, late intensification, and levamisole maintenance. Leukemia 6:708, 1992
28. Santos GW, Tutschka PJ, Broxmeyer R, Saral R, Beschorner WE, Bias WB, Braine H, Burns WH, Elfenbein GJ, Kaizer H, Melitis D, Sensenbrenner LL, Stuart RK, Yeager AM: Marrow transplantation for acute non lymphocytic leukemia with busulfan and cyclophosphamide. N Engl J Med 309:1347, 1983
29. Buyse ME, Staquet MJ, Sylvester RJ (eds): Cancer Clinical Trials: Methods and Practice. Oxford, UK, Oxford, 1984, p 337
30. Kruskal WH, Wallis WA: Use of ranks in one-criterion variance analysis. J Am Stat Assoc 47:583, 1952
31. Kaplan E, Meier P: Non parametric estimation from incomplete observations. J Am Stat Assoc 53:457, 1985
32. Peto R, Peto J: Asymptotically efficient rank invariant test procedures. J R Stat Soc (A) 135:185, 1972
33. Armitage P, Berry G: Statistical Methods in Medical Research (ed 2). Oxford, UK, Blackwell Scientific, 1987
34. Peto R, Pike MC, Armitage P, Breslow NE, Cox DR, Howard SV, Mantel N, Mc Pherson K, Peto J, Smith G: Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples. Br J Cancer 35:1, 1977
35. Mayer RJ, Davis RB, Schiffer CA, Berg DT, Powell BL, Schulman P, Omura GA, Moore JO, Mc Intyre OR, Frei E III: Intensive post remission chemotherapy in adults with acute myeloid leukemia. N Engl J Med 331:896, 1994
36. Ferrant A, Doyen C, Delannoy A, Cornu G, Martiat P, Latinne D, De Bruyere M, Bosly A, Michaux JL, Sokal G: Allogeneic or autologous bone marrow transplantation for acute non-lymphocytic leukemia in first remission. Bone Marrow Transplant 7:303, 1991
37. Estey E: Use of colony-stimulating factors in the treatment of acute myeloid leukemia. Blood 83:2015, 1994
38. Harousseau JL, Wu D: The use of GM-CSF and G-CSF in the treatment of acute leukemias. Leuk Lymphoma 18:405, 1994
39. Reiffers J, Gaspard MH, Maraninchi D, Michallet M, Marit G, Stoppa AM, Corront B, David B, Gastaut JA, Sotto JJ, Broustet A, Carcassonne Y, Hollard D: Comparison of allogenic or autologous bone marrow transplantation and chemotherapy in patients with acute myeloid leukaemia in first remission: A prospective controlled trial. Br J Harematol 72:57, 1989
40. Reiffers J, Stoppa AM, Attal M, Michallet M, Marit G, Blaise D, Huguet F, Corront B, Cony-Makhoul P, Montastruc M, Gastaut JA, Laurent G, Molina L, Broustet A, Maraninchi D, Pris J, Hollard D, Faberes A: Autologous stem cell transplantation versus chemotherapy for adult patients with acute myeloid leukemia in first remission: The BGMT experience. Nouv Rev Fr Hematol 35:17, 1993
41. Lowenberg B, Verdonck LJ, Dekker AW, Willemze R, Zwaan FE, De Plancque M, Abels J, Sonneveld P, Van Der Lelie J, Goudsmidt K, Van Putten WLJ, Sizoo W, Hagenbeek A, De Gast GL: Autologous bone marrow transplantation in acute myeloid leukemia in first remission: Results of a Dutch prospective study. J Clin Oncol 8:287, 1990
42. Storb R, Deeg HJ, Whitehead J, Appelbaum F, Beatty P, Bensinger W, Buckner CD, Clift R, Doney K, Farewell V, Hansen J, Hill R, Lum L, Martin P, Mc Guffin R, Sanders J, Stewart P, Sullivan K, Witherspoon R, Yee G, Thomas ED: Methotrexate and cyclosporine compared with cyclosporine alone for prophylaxis of graft versus host disease after marrow transplantation for leukemia. N Engl J Med 314:729, 1986
43. Aurer I, Gale RP: Are new conditioning regimens for transplants in acute myelogenous leukemia better. Bone Marrow Transplant 7:255, 1991
44. Sierra J, Brunet S, Granena A, Olive T, Bueno J, Ribera JM, Petit J, Besses C, Llorente A, Guardia R, Macia J, Rovira M, Badell I, Vela E, Diaz De Heredia C, Vivanlos P, Carreras S, Feliv E, Montserrat E, Julia A, Cubelis J, Rozman C, Domingo A, Ortega JJ: Feasibility and results of bone marrow transplantation after remission induction and intensification chemotherapy in de novo acute myeloid leukemia. J Clin Oncol 14:1353, 1996
45. Ravindranath Y, Yeager AM, Chang MN, Steuber CP, Krischer J, Graham-Pole J, Carroll A, Inove S, Camitta B, Weinstein HJ: Autologous bone marrow transplantation versus intensive consolidation chemotherapy for acute myeloid leukemia in childhood. N Engl J Med 334:1428, 1996
46. Burnett AK, Goldstone AH, Stevens RF, Hann JM, Rees JK, Wheatley K, Gray RG: The role of BMT in addition to intensive chemotherapy in AML in first CR. Results of the MRC AML-10 trial. Blood 84:252a, 1994 (abstr, suppl 1)
47. Cassileth PA, Lynch E, Hines JD, Oken MM, Mazza JJ, Bennett JM, Mc Glave PB, Edelstein M, Harrington DP, O'Conneil MJ: Varying intensity of postremission therapy in acute myeloid leukemia. Blood 79:1924, 1992
48. Berman E, Heller G, Santorsa J, McKenzie S, Gee T, Kempin S, Gulati S, Andreeff M, Kolitz J, Gabrilove J, Reich L, Mayer K, Keefe D, Trainor K, Schluger A, Penenberg D, Raymond V, O'Reilly R, Jhanwar S, Young C, Clarkson B: Results of randomized trial comparing idarubicin and cytosine arabinoside with daunorubicin and cytosine arabinoside in adult patients with newly diagnosed acute myelogenous leukemia. Blood 77:666, 1991
49. Wiernik PH, Banks PLC, Case DC, Arlin ZA, Periman PO, Todd MB, Ritch PS, Enck RE, Weitberg AB: Cytarabine plus Idarubicin or daunorubicin as induction and consolidation therapy for previously untreated adult patients with acute myeloid leukemia. Blood 79:313, 1992
50. Vogler WR, Velez-Garcia E, Weiner RS, Flaum MA, Bartolucci AA, Omura GA, Gerber MC, Banks PLC: A phase III trial comparing idarubicin and daunorubicin in combination with cytarabine in acute myelogenous leukemia: A Southeastern Cancer Study Group study. J Clin Oncol 10:1103, 1992
51. Keating MJ, Gehan EA, Smith TL, Estey EH, Walters RS, Katarjian HM, Mc Credie KB, Freireich EJ: A strategy for evaluation of new treatments in untreated patients: Application to a clinical trial of AMSA for acute leukemia. J Clin Oncol 5:710, 1987
52. Berman E, Arlin ZA, Gaynor J, Miller W, Gee T, Kempin SJ, Mertelsmann R, Andreeff M, Reich L, Nahmias N, Clarkson B: Comparative trial of cytarabine and thioguanine in combination with amsacrine or daunorubicin in patients with untreated acute non lymphocytic leukemia: Results of the L-16M protocol. Leukemia 3:115, 1989
53. O'Dwyer PJ, Leyland-Jones B, Alonso MT, Marsoni S, Wittes RE: Etoposide (VP16-213) current status of an active anticancer drug. N Engl J Med 312:692, 1985
54. Meloni G, De Fabritiis P, Petti MC, Mandelli F: BAVC regimen and autologous bone marrow transplantation in patients with acute myelogenous leukemia in second remission. Blood 75:2282, 1990
55. Petersen FB, Lynch MHE, Clift RA, Appelbaum FR, Sanders JE, Bensinger WI, Benyunes MC, Doney K, Fefer A, Martin P, Storb R, Rowley S, Sullivan KM, Witherspoon R, Weiden P, Thomas ED, Fisher L, Hansen JA, Buckner CD: Autologous marrow transplantation for patients with acute myeloid leukemia in untreated first relapse or in second complete remission. J Clin Oncol 11:1355, 1993
56. Demirer T, Buckner CD, Appelbaum FR, Petersen FB, Rowley S, Weaver CH, Lilleby K, Sanders J, Chaunley T, Storb R, Schiffman K, Benyumes MC, Fefer A, Montgomery P, Bensinger WI: Rapid engraftment after autologous transplantation utilizing marrow and recombinant granulocyte colony-stimulating factor-mobilized peripheral blood stem cells in patients with acute myelogenous leukemia. Bone Marrow Transplant 15:915, 1995
57. Korbling M, Fliedner TM, Holle R: Autologous blood stem ceU versus purged marrow transplantation in stantard risk AML: Influence of source and cell composition of the autograft on hemopoietic reconstitution and disease-free survival. Bone Marrow Transplant 7:349, 1991
58. Reiffers J, Korbling M, Labopin M, Gorin NC: Autologous blood stem cell transplantation versus autologous bone marrow transplantation for acute myeloid leukemia in first complete remission. Int J Cell Cloning 10:111, 1992
59. Bishop JF, Matthew JP, Young GA, Szer J, Gillett A, Joshua D, Bradstock K, Enwo A, Wolff MM, Fox R, Cobcroft R, Herrmann R, Van Der Neyden M, Lowenthal RM, Page F, Garson OM, Juneja S: Randomized study of high-dose cytarabine in induction in acute myeloid leukemia. Blood 87:1710, 1996
60. Woods WG, Kobrinsky N, Buckley JD, Won Lee J, Sanders J, Neudorf S, Gold S, Barnard DR, De Swarte J, Dusenberry K, Kalousek D, Arthur DC, Lange BJ: Timed-sequential induction therapy improves postremission outcome in acute myeloid leukemia: A report from the Children's Cancer Group. Blood 87:4979, 1996
61. Solary E, Witz B, Caillot D, Moreau P, Desablens B, Cahn JY, Sadoun A, Pignon B, Berthou C, Maloisel F, Guyotat D, Casassus P, Ifrah N, Lamy Y, Audhuy B, Colombat P, Harousseau JL: Combination of quinine as a potential reversing agent with mitoxantrone and cytarabine for the treatment of acute leukemias: A randomized multicenter study. Blood 88:1198, 1996
62. Hurd DD: Postremission therapy for the younger adult patients with acute myelogenous leukemia: Defining a role for transplantation. J Clin Oncol 11:1636, 1993