Accurate determination of the anticancer prodrug simmitecan and its active metabolite chimmitecan in various plasma samples based on immediate deactivation of blood carboxylesterases

Journal of Chromatography A

Volumn 1218, Issue 38, 2011, Pages 6646-6653

  Hu, Zheyi ^a,b   Sun, Yan ^a,b   Du, Feifei ^a   Niu, Wei ^a   Xu, Fang ^a   Huang, Yuxing ^a,c   Li, Chuan ^a,b  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c TIANJIN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Bis(4 nitrophenyl)phosphate; Camptothecin; Carboxylesterase; Chimmitecan; Irinotecan; Matrix effects; Prodrug; Pulse gradient chromatography; Simmitecan

Indexed keywords

BIS(4-NITROPHENYL) PHOSPHATE; CAMPTOTHECINS; CARBOXYLESTERASES; CHIMMITECAN; GRADIENT CHROMATOGRAPHY; IRINOTECAN; MATRIX EFFECTS; PRODRUGS; SIMMITECAN;

ACETONITRILE; CHROMATOGRAPHY; ELECTROSPRAY IONIZATION; ESTERIFICATION; ESTERS; GRADIENT METHODS; MAMMALS; MASS SPECTROMETRY; METABOLISM; METABOLITES;

BLOOD;

ACETONITRILE; ANTINEOPLASTIC AGENT; BIS(4 NITROPHENYL) PHOSPHATE; CAMPTOTHECIN; CARBOXYLESTERASE; CHIMMITECAN; DRUG METABOLITE; IRINOTECAN; PRODRUG; SIMMITECAN; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CHROMATOGRAPHY; CONTROLLED STUDY; DISTRIBUTION VOLUME; DOG; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DETERMINATION; DRUG DOSE COMPARISON; DRUG HALF LIFE; DRUG HYDROLYSIS; DRUG STABILITY; DRUG STRUCTURE; DRUG TRANSFORMATION; ELECTROSPRAY; ENZYME INACTIVATION; ENZYME INHIBITION; HEMOLYSIS; HUMAN; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; MOUSE; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; PRECIPITATION; PRIORITY JOURNAL; PULSE GRADIENT CHROMATOGRAPHY; QUANTITATIVE ANALYSIS; RAT; RELIABILITY; SINGLE DRUG DOSE; SPECIES DIFFERENCE; SUPERNATANT; TANDEM MASS SPECTROMETRY;

ANIMALS; ANTINEOPLASTIC AGENTS; CAMPTOTHECIN; CARBOXYLIC ESTER HYDROLASES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; ENZYME INHIBITORS; MALE; MICE; MICE, NUDE; PRODRUGS; RATS; RATS, SPRAGUE-DAWLEY; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

CANIS FAMILIARIS; MUS MUSCULUS; RATTUS;

EID: 80052086870     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2011.07.042     Document Type: Article

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