Discriminative stimulus properties of GABA A receptor positive allosteric modulators TPA023, ocinaplon and NG2-73 in rats trained to discriminate chlordiazepoxide or zolpidem

European Journal of Pharmacology

Volumn 668, Issue 1-2, 2011, Pages 190-193

  Vinkers, Christiaan H ^a,b   Olivier, Berend ^a,c   Hanania, Taleen ^d   Min, Wenzhong ^d   Schreiber, Rudy ^e   Hopkins, Seth C ^e   Campbell, Una ^e   Paterson, Neil ^d  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d PSYCHOGENICS INC   (United States)

^e DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

; (Rat); Abuse liability; Alpha subunit; Benzodiazepine; Dependence; Drug discrimination; GABA; TPA 023

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR ALPHA1; 7 (1,1 DIMETHYLETHYL) 6 (2 ETHYL 2H 1,2,4 TRIAZOL 3 YLMETHOXY) 3 (2 FLUOROPHENYL) 1,2,4 TRIAZOLO[4,3 B]PYRIDAZINE; ADIPIPLON; CHLORDIAZEPOXIDE; GABAERGIC RECEPTOR AFFECTING AGENT; NG 2 73; OCINAPLON; TPA 023; UNCLASSIFIED DRUG; ZOLPIDEM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG DISCRIMINATION; DRUG EFFECT; DRUG EFFICACY; DRUG RECEPTOR BINDING; DRUG RESPONSE; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; VALIDATION STUDY;

ALLOSTERIC REGULATION; ANIMALS; ANTI-ANXIETY AGENTS; BEHAVIOR, ANIMAL; CHLORDIAZEPOXIDE; CONDITIONING (PSYCHOLOGY); HYPNOTICS AND SEDATIVES; LIGANDS; MALE; PYRIDAZINES; PYRIDINES; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; SUBSTRATE SPECIFICITY; TRIAZOLES;

EID: 80052066952     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.06.054     Document Type: Article

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