Discovery of a potent and short-acting oral calcilytic with a pulsatile secretion of parathyroid hormone

ACS Medicinal Chemistry Letters

Volumn 2, Issue 3, 2011, Pages 238-242

  Shinagawa, Yuko ^a   Inoue, Teruhiko ^a   Katsushima, Takeo ^a   Kiguchi, Toshihiro ^a   Ikenogami, Taku ^a   Ogawa, Naoki ^a   Fukuda, Kenji ^a   Hirata, Kazuyuki ^a   Harada, Kazuhito ^a   Takagi, Masaki ^a   Nakagawa, Takashi ^a   Kimura, Shuichi ^a   Matsuo, Yushi ^a   Maekawa, Mariko ^a   Hayashi, Mikio ^a   Soejima, Yuki ^a   Takahashi, Mitsuru ^a   Shindo, Masanori ^a   Hashimoto, Hiromasa ^a  

^a JAPAN TOBACCO INC   (Japan)

Author keywords

calcilytics; Calcium sensing receptor (CaSR) antagonist; cytochrome P450 inhibition; osteoporosis; PTH; short acting

Indexed keywords

2 CHLORO 6 [3 [1,1 DIMETHYL 2 (2 NAPHTHYL)ETHYLAMINO] 2 HYDROXYPROPOXY]BENZONITRILE; AMINE; BIPHENYLCARBOXYLIC ACID; CALCIUM ANTAGONIST; CALCIUM SENSING RECEPTOR ANTAGONIST; CARBOXYLIC ACID DERIVATIVE; CYTOCHROME P450 2D6; HEMISULFATE; JTT 305; PARATHYROID HORMONE; PROPANEDIOL DERIVATIVE; RONACALERET; SULFUR ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG POTENCY; ENZYME INHIBITION; INJECTION; LIPOPHILICITY; LOW DRUG DOSE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PARATHYROID HORMONE RELEASE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT; TIME TO MAXIMUM PLASMA CONCENTRATION;

RATTUS;

EID: 79952669929     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml100268k     Document Type: Article

References (25)

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