Inhibition of macrophage activation and suppression of graft rejection by DTCM-glutarimide, a novel piperidine derived from the antibiotic 9-methylstreptimidone

Inflammation Research

Volumn 60, Issue 9, 2011, Pages 879-888

  Takeiri, Masatoshi ^a   Tachibana, Miyuki ^a   Kaneda, Ayumi ^a   Ito, Ayumi ^a   Ishikawa, Yuichi ^a   Nishiyama, Shigeru ^a   Goto, Ryoichi ^b   Yamashita, Kenichiro ^b   Shibasaki, Susumu ^b   Hirokata, Gentaro ^b   Ozaki, Michitaka ^b   Todo, Satoru ^b   Umezawa, Kazuo ^a  

^a KEIO UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

Author keywords

AP 1; DTCM glutarimide; Heart transplantation; LPS; Mixed lymphocyte reaction

Indexed keywords

3 [(DODECYLTHIOCARBONYL)METHYL]GLUTARIMIDE; 9 METHYLSTREPTIMIDONE; ANTIBIOTIC AGENT; CYCLOOXYGENASE 2; GLUTARIMIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN C FOS; PROTEIN C JUN; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CARDIAC GRAFT REJECTION; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE RELEASE; DONOR; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; GRAFT RECIPIENT; GRAFT SURVIVAL; HEART TRANSPLANTATION; HISTOPATHOLOGY; MACROPHAGE ACTIVATION; MALE; MIXED LYMPHOCYTE CULTURE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SPLEEN CELL; SURVIVAL TIME;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CYCLOOXYGENASE 2; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MOLECULAR STRUCTURE; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; PIPERIDONES; PROTO-ONCOGENE PROTEINS C-FOS; TRANSCRIPTION FACTOR AP-1;

EID: 80052054102     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-011-0348-z     Document Type: Article

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