Selective inhibition of the K ir2 family of inward rectifier potassium channels by a small molecule probe: The discovery, SAR, and pharmacological characterization of ML133

ACS Chemical Biology

Volumn 6, Issue 8, 2011, Pages 845-856

  Wang, Hao Ran ^a   Wu, Meng ^a   Yu, Haibo ^a   Long, Shunyou ^a   Stevens, Amy ^a   Engers, Darren W ^b   Sackin, Henry ^c   Daniels, J Scott ^b   Dawson, Eric S ^b   Hopkins, Corey R ^b   Lindsley, Craig W ^b   Li, Min ^a   McManus, Owen B ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELASTROL; CHLOROQUINE; GAMBOGIC ACID; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR2.1; MEPYRAMINE; ML 133; ML133; POTASSIUM CHANNEL BLOCKING AGENT; TAMOXIFEN; THIOPENTAL; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG POTENCY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; HUMAN TISSUE; IC 50; MODEL; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; DRUG DESIGN; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; POTASSIUM CHANNELS, INWARDLY RECTIFYING; SEQUENCE ALIGNMENT; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80052015441     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb200146a     Document Type: Article

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