Thiopental inhibits function of different inward rectifying potassium channel isoforms by a similar mechanism

European Journal of Pharmacology

Volumn 638, Issue 1-3, 2010, Pages 33-41

  López Izquierdo, Angélica ^a   Ponce Balbuena, Daniela ^a   Ferrer, Tania ^a   Rodríguez Menchaca, Aldo A ^a   Sánchez Chapula, José A ^a  

^a UNIVERSIDAD DE COLIMA   (Mexico)

Author keywords

Inward rectifier potassium channel; PIP2; Thiopental

Indexed keywords

INWARDLY RECTIFYING POTASSIUM CHANNEL; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR2.1; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; THIOPENTAL; ISOPROTEIN;

ARTICLE; CELL STRAIN HEK293; CONCENTRATION RESPONSE; CONTROLLED STUDY; INHIBITION KINETICS; PATCH CLAMP; POINT MUTATION; PRIORITY JOURNAL; WHOLE CELL; ANTAGONISTS AND INHIBITORS; DOSE RESPONSE; DRUG EFFECTS; DRUG INTERACTION; GENETICS; HUMAN; MEMBRANE POTENTIAL; PATCH CLAMP TECHNIQUE; TRANSFORMED CELL LINE;

CELL LINE, TRANSFORMED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; HUMANS; MEMBRANE POTENTIALS; PATCH-CLAMP TECHNIQUES; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; POINT MUTATION; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTEIN ISOFORMS; THIOPENTAL;

EID: 77953541025     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.04.026     Document Type: Article

References (38)

1. Amar D., Shamoon H., Lazar E.J., Frishman W.H. Acute hyperglycaemic effect of anaesthetic induction with thiopentone. Acta Anaesthesiol. Scand. 1993, 37:571-574.
2. + channels and insulin secretion: their role in health and disease. Diabetologia 1999, 42:903-919.
3. Atlee J.L. Perioperative cardiac dysrhythmias: diagnosis and management. Anesthesiology 1997, 86:1397-1424.
4. Brandon R.A., Baggot J.D. The pharmacokinetics of thiopentone. J. Vet. Pharmacol. Ther. 1981, 4:79-85.
5. Carnes C.A., Muir W.W., Van Wagoner D.R. Effect of intravenous anesthetics on inward rectifier potassium current in rat and human ventricular myocytes. Anesthesiology 1997, 87:327-334.
6. Du X., Zhang H., Lopes C., Mirshahi T., Rohacs T., Logothetis D.E. Characteristic interactions with phosphatidylinositol 4, 5-bisphosphate determine regulation of Kir channels by diverse modulators. J. Biol. Chem. 2004, 279:37271-37281.
7. Franks N.P. Molecular targets underlying general anaesthesia. Br. J. Pharmacol. 2006, 147(Suppl 1):S72-81.
8. Franks N.P., Lieb W.R. Molecular and cellular mechanisms of general anaesthesia. Nature 1994, 367:607-614.
9. Hamill O.P., Marty A., Neher E., Sakmann B., Sigworth F.J. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Arch. 1981, 391:85-100.
10. Heath B.M., Terrar D.A. The deactivation kinetics of the delayed rectifier components IKr and IKs in guinea-pig isolated ventricular myocytes. Exp. Physiol. 1996, 81:605-621.
11. Hilgemann D.W., Feng S., Nasuhoglu C. The complex and intriguing lives of PIP2 with ion channels and transporters. Sci. STKE 2001, RE19. 2001.
12. Huang C.L., Feng S., Hilgemann D.W. Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gbetagamma. Nature 1998, 391:803-806.
13. Karschin A., Brockhaus J., Ballanyi K. KATP channel formation by the sulphonylurea receptors SUR1 with Kir6.2 subunits in rat dorsal vagal neurons in situ. J. Physiol. 1998, 509(Pt 2):339-346.
14. + channels and voltage-activated currents in CRI-G1 insulin-secreting cells. Br. J. Pharmacol. 1991, 103:2021-2029.
15. + channel. J. Physiol. 2001, 531:645-660.
16. Liu B., Jia Z., Geng X., Bei J., Zhao Z., Jia Q., Zhang H. Selective inhibition of Kir currents by antihistamines. Eur. J. Pharmacol. 2007, 558:21-26.
17. Lopatin A.N., Nichols C.G. Inward rectifiers in the heart: an update on I(K1). J. Mol. Cell Cardiol. 2001, 33:625-638.
18. Lopes C.M., Zhang H., Rohacs T., Jin T., Yang J., Logothetis D.E. Alterations in conserved Kir channel-PIP2 interactions underlie channelopathies. Neuron 2002, 34:933-944.
19. Lundbaek J.A. Lipid bilayer-mediated regulation of ion channel function by amphiphilic drugs. J. Gen. Physiol. 2008, 131:421-429.
20. Martynyuk A.E., Morey T.E., Raatikainen M.J., Seubert C.N., Dennis D.M. Ionic mechanisms mediating the differential effects of methohexital and thiopental on action potential duration in guinea pig and rabbit isolated ventricular myocytes. Anesthesiology 1999, 90:156-164.
21. McConachie I., Keaveny J.P., Healy T.E., Vohra S., Million L. Effect of anaesthesia on the QT interval. Br. J. Anaesth. 1989, 63:558-560.
22. Nishida M., MacKinnon R. Structural basis of inward rectification: cytoplasmic pore of the G protein-gated inward rectifier GIRK1 at 1.8 A resolution. Cell 2002, 111:957-965.
23. + conductance of myocardium. J. Pharmacol. Exp. Ther. 1993, 265:358-365.
24. Park W.K., Lynch C. Propofol and thiopental depression of myocardial contractility. A comparative study of mechanical and electrophysiologic effects in isolated guinea pig ventricular muscle. Anesth. Analg. 1992, 74:395-405.
25. Pegan S., Arrabit C., Zhou W., Kwiatkowski W., Collins A., Slesinger P.A., Choe S. Cytoplasmic domain structures of Kir2.1 and Kir3.1 show sites for modulating gating and rectification. Nat. Neurosci. 2005, 8:279-287.
26. + 2.x family of inward rectifier channels by interfering with phosphatidylinositol 4, 5-bisphosphate-channel interactions. J. Pharmacol. Exp. Ther. 2009, 331:563-573.
27. Rodriguez-Menchaca A.A., Navarro-Polanco R.A., Ferrer-Villada T., Rupp J., Sachse F.B., Tristani-Firouzi M., Sanchez-Chapula J.A. The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:1364-1368.
28. Rusy B.F., Komai H. Anesthetic depression of myocardial contractility: a review of possible mechanisms. Anesthesiology 1987, 67:745-766.
29. Sakai F., Hiraoka M., Amaha K. Comparative actions of propofol and thiopentone on cell membranes of isolated guineapig ventricular myocytes. Br. J. Anaesth. 1996, 77:508-516.
30. Schulze D., Krauter T., Fritzenschaft H., Soom M., Baukrowitz T. Phosphatidylinositol 4, 5-bisphosphate (PIP2) modulation of ATP and pH sensitivity in Kir channels. A tale of an active and a silent PIP2 site in the N terminus. J. Biol. Chem. 2003, 278:10500-10505.
31. Suh B.C., Hille B. Regulation of ion channels by phosphatidylinositol 4, 5-bisphosphate. Curr. Opin. Neurobiol. 2005, 15:370-378.
32. Tanelian D.L., Kosek P., Mody I., MacIver M.B. The role of the GABAA receptor/chloride channel complex in anesthesia. Anesthesiology 1993, 78:757-776.
33. Trudell J.R., Bertaccini E. Molecular modelling of specific and non-specific anaesthetic interactions. Br. J. Anaesth. 2002, 89:32-40.
34. Wang Z., Yue L., White M., Pelletier G., Nattel S. Differential distribution of inward rectifier potassium channel transcripts in human atrium versus ventricle. Circulation 1998, 98:2422-2428.
35. + channels. Nat. Neurosci. 2003, 6:811-818.
36. Xie L.H., John S.A., Ribalet B., Weiss J.N. Long polyamines act as cofactors in PIP2 activation of inward rectifier potassium (Kir2.1) channels. J. Gen. Physiol. 2005, 126:541-549.
37. Yang C.X., Zhang X.B., Gong N., Wang M.Y., Xu T.L. Differential effects of thiopental and pentobarbital on spinal GABA(A) receptors. Neurochem. Res. 2008, 33:2159-2165.
38. Zhao Z., Liu B., Zhang G., Jia Z., Jia Q., Geng X., Zhang H. Molecular basis for genistein-induced inhibition of Kir2.3 currents. Pflügers Arch. 2008, 456:413-423.