DHA protects against zinc mediated alterations in neuronal cellular bioenergetics

Cellular Physiology and Biochemistry

Volumn 28, Issue 1, 2011, Pages 157-162

  McGee, Sean L ^a   Sadli, Nadia ^b   Morrison, Shona ^a   Swinton, Courtney ^a   Suphioglu, Cenk ^b  

^a DEAKIN UNIVERSITY   (Australia)

^b DEAKIN UNIVERSITY   (Australia)

Author keywords

Bioenergetics; DHA; Docosahexaenoic acid; Human neuronal cells; Mitochondrial function; Zinc

Indexed keywords

ADENOSINE TRIPHOSPHATE; DOCOSAHEXAENOIC ACID; ZINC;

ARTICLE; BIOENERGY; CELL PROTECTION; GLYCOLYSIS; HUMAN; HUMAN CELL; KERATINOCYTE; LONG TERM EXPOSURE; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; NERVE CELL; NEUROBLASTOMA CELL; OXYGEN CONSUMPTION; PRIORITY JOURNAL;

EID: 80051964815     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000331724     Document Type: Article

References (21)

1. Li YV, Hough CJ, Sarvey JM: Do we need zinc to think? Sci STKE 2003;2003:pe19.
2. Weiss JH, Sensi SL, Koh JY: Zn2+: a novel ionic mediator of neural injury in brain disease. Trends Pharmacol Sci 2000;21:395-401.
3. Dineley KE, Votyakova TV, Reynolds IJ: Zinc inhibition of cellular energy production: implications for mitochondria and neurodegeneration. J Neurochem 2003;85:563-570. (Pubitemid 36534479)
4. Ikeda T, Kimura K, Morioka S, Tamaki N: Inhibitory effects of Zn2+ on muscle glycolysis and their reversal by histidine. J Nutr Sci Vitaminol (Tokyo) 1980;26:357-366. (Pubitemid 11160240)
5. Brown AM, Kristal BS, Effron MS, Shestopalov AI, Ullucci PA, Sheu KF, Blass JP, Cooper AJ: Zn2+ inhibits alphaketoglutarate-stimulated mitochondrial respiration and the isolated alphaketoglutarate dehydrogenase complex. J Biol Chem 2000;275:13441-13447. (Pubitemid 30257407)
6. Skulachev VP, Chistyakov VV, Jasaitis AA, Smirnova EG: Inhibition of the respiratory chain by zinc ions. Biochem Biophys Res Commun 1967;26:1-6.
7. Suphioglu C, De Mel D, Kumar L, Sadli N, Freestone D, Michalczyk A, Sinclair A, Ackland ML: The omega-3 fatty acid, DHA, decreases neuronal cell death in association with altered zinc transport. FEBS Lett 2010;584:612-618.
8. Suphioglu C, Sadli N, Coonan D, Kumar L, De Mel D, Lesheim J, Sinclair AJ, Ackland L: Zinc and DHA have opposing effects on the expression levels of histones H3 and H4 in human neuronal cells. Br J Nutr 2010;103:344-351.
9. Svennerholm L: Distribution and fatty acid composition of phosphoglycerides in normal human brain. J Lipid Res 1968;9:570-579.
10. Chapkin RS, McMurray DN, Davidson LA, Patil BS, Fan YY, Lupton JR: Bioactive dietary long-chain fatty acids: emerging mechanisms of action. Br J Nutr 2008;100:1152-1157.
11. Calon F, Lim GP, Yang F, Morihara T, Teter B, Ubeda O, Rostaing P, Triller A, Salem N Jr, Ashe KH, Frautschy SA, Cole GM: Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model. Neuron 2004;43:633-645. (Pubitemid 39179724)
12. Lim GP, Calon F, Morihara T, Yang F, Teter B, Ubeda O, Salem N, Frautschy SA, Cole GM: A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model. J Neurosci 2005;25:3032-3040. (Pubitemid 40463537)
13. Nicholls DG: Spare respiratory capacity, oxidative stress and excitotoxicity. Biochem Soc Trans 2009;37:1385-1388.
14. Sheline CT, Behrens MM, Choi DW: Zinc-induced cortical neuronal death: contribution of energy failure attributable to loss of NAD+ and inhibition of glycolysis. J Neurosci 2000;20:3139-3146. (Pubitemid 30263130)
15. Link TA, von Jagow G: Zinc ions inhibit the QP center of bovine heart mitochondrial bc1 complex by blocking a protonatable group. J Biol Chem 1995;270:25001-25006.
16. Lorusso M, Cocco T, Sardanelli AM, Minuto M, Bonomi F, Papa S: Interaction of Zn2+ with the bovine-heart mitochondrial bc1 complex. Eur J Biochem 1991;197:555-561.
17. Jiang D, Sullivan PG, Sensi SL, Steward O, Weiss JH: Zn2+ induces permeability transition pore opening and release of pro-apoptotic peptides from neuronal mitochondria. J Biol Chem 2001;276:47524-47529.
18. Pedersen PL: Transport ATPases into the year 2008: a brief overview related to types, structures, functions and roles in health and disease. J Bioenerg Biomembr 2007;39:349-355.
19. Khairallah RJ, O'Shea KM, Brown BH, Khanna N, Des Rosiers C, Stanley WC: Treatment with docosahexaenoic acid, but not eicosapentaenoic acid, delays Ca2+-induced mitochondria permeability transition in normal and hypertrophied myocardium. J Pharmacol Exp Ther 2010;335:155-162.
20. Khairallah RJ, Sparagna GC, Khanna N, O'Shea KM, Hecker PA, Kristian T, Fiskum G, Des Rosiers C, Polster BM, Stanley WC: Dietary supplementation with docosahexaenoic acid, but not eicosapentaenoic acid, dramatically alters cardiac mitochondrial phospholipid fatty acid composition and prevents permeability transition. Biochim Biophys Acta 2010;1797:1555-1562.
21. Devinney MJ, Malaiyandi LM, Vergun O, DeFranco DB, Hastings TG, Dineley KE: A comparison of Zn2+-and Ca2+-triggered depolarization of liver mitochondria reveals no evidence of Zn2+-induced permeability transition. Cell Calcium 2009;45:447-455.