Treatment with docosahexaenoic acid, but not eicosapentaenoic acid, delays Ca2+-induced mitochondria permeability transition in normal and hypertrophied myocardium

Journal of Pharmacology and Experimental Therapeutics

Volumn 335, Issue 1, 2010, Pages 155-162

  Khairallah, Ramzi J ^a   O'Shea, Karen M ^a   Brown, Bethany H ^a   Khanna, Nishanth ^a   Des Rosiers, Christine ^b   Stanley, William C ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b MONTREAL HEART INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; DOCOSAHEXAENOIC ACID; FISH OIL; ICOSAPENTAENOIC ACID; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; PHOSPHOLIPID; ARACHIDONIC ACID; FATTY ACID; MESSENGER RNA; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALORIC INTAKE; CONTROLLED STUDY; DIETARY INTAKE; ECHOCARDIOGRAPHY; GENE EXPRESSION; HEART FAILURE; HEART FUNCTION; HEART LEFT VENTRICLE MASS; HEART VENTRICLE HYPERTROPHY; MALE; MITOCHONDRIAL PERMEABILITY; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; BIOSYNTHESIS; CARDIOMEGALY; DIET; DIET SUPPLEMENTATION; DRUG EFFECTS; ECHOGRAPHY; ELECTROCARDIOGRAPHY; HEART MITOCHONDRION; HEART MUSCLE; ISOLATION AND PURIFICATION; METABOLISM; OXYGEN CONSUMPTION; PERMEABILITY; WISTAR RAT;

ANIMALS; ARACHIDONIC ACID; CALCIUM; CARDIOMEGALY; DIET; DIETARY SUPPLEMENTS; DOCOSAHEXAENOIC ACIDS; EICOSAPENTAENOIC ACID; ELECTROCARDIOGRAPHY; FATTY ACIDS; MALE; MITOCHONDRIA, HEART; MYOCARDIUM; OXYGEN CONSUMPTION; PERMEABILITY; PHOSPHOLIPIDS; RATS; RATS, WISTAR; RNA, MESSENGER; TRIGLYCERIDES;

EID: 77957236105     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.110.170605     Document Type: Article

References (23)

1. Baines CP (2009) The molecular composition of the mitochondrial permeability transition pore. J Mol Cell Cardiol 46:850-857.
2. Bugger H, Schwarzer M, Chen D, Schrepper A, Amorim PA, Schoepe M, Nguyen TD, Mohr FW, Khalimonchuk O, Weimer BC, et al. (2010) Proteomic remodelling of mitochondrial oxidative pathways in pressure overload-induced heart failure. Cardiovasc Res 85:376-384.
3. Chess DJ, Khairallah RJ, O'Shea KM, Xu W, and Stanley WC (2009) A high-fat diet increases adiposity but maintains mitochondrial oxidative enzymes without affecting development of heart failure with pressure overload. Am J Physiol Heart Circ Physiol 297:H1585-H1593.
4. Chess DJ, Xu W, Khairallah R, O'Shea KM, Kop WJ, Azimzadeh AM, and Stanley WC (2008) The antioxidant tempol attenuates pressure overload-induced cardiac hypertrophy and contractile dysfunction in mice fed a high-fructose diet. Am J Physiol Heart Circ Physiol 295:H2223-H2230.
5. Duda MK, O'Shea KM, and Stanley WC (2009a) Omega-3 polyunsaturated fatty acid supplementation for the treatment of heart failure: mechanisms and clinical potential. Cardiovasc Res 84:33-41.
6. Duda MK, O'Shea KM, Lei B, Barrows BR, Azimzadeh AM, McElfresh TE, Hoit BD, Kop WJ, and Stanley WC (2007) Dietary supplementation with omega-3 PUFA increases adiponectin and attenuates ventricular remodeling and dysfunction with pressure overload. Cardiovasc Res 76:303-310.
7. Duda MK, O'Shea KM, Tintinu A, Xu W, Khairallah RJ, Barrows BR, Chess DJ, Azimzadeh AM, Harris WS, Sharov VG, et al. (2009b) Fish oil, but not flaxseed oil, decreases inflammation and prevents pressure overload-induced cardiac dysfunction. Cardiovasc Res 81:319-327.
8. GISSI-HF Investigators, Tavazzi L, Maggioni AP, Marchioli R, Barlera S, Franzosi MG, Latini R, Lucci D, Nicolosi GL, Porcu M, et al. (2008) Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial. Lancet 372:1223-1230.
9. Halestrap AP (2009) What is the mitochondrial permeability transition pore? J Mol Cell Cardiol 46:821-831.
10. Javadov S and Karmazyn M (2007) Mitochondrial permeability transition pore opening as an endpoint to initiate cell death and as a putative target for cardioprotection. Cell Physiol Biochem 20:1-22.
11. Kang PM, Yue P, Liu Z, Tarnavski O, Bodyak N, and Izumo S (2004) Alterations in apoptosis regulatory factors during hypertrophy and heart failure. Am J Physiol Heart Circ Physiol 287:H72-H80.
12. Khairallah RJ, Sparagna GC, Khanna N, O'Shea KM, Hecker PA, Kristian T, Fiskum G, Des Rosiers C, Polster BM, and Stanley WC (2010) Dietary supplementation with docosahexaenoic acid, but not eicosapentanoic acid, dramatically alters cardiac mitochondrial phospholipid fatty acid composition and prevents permeability transition. Biochim Biophys Acta 1797:1555-1562.
13. 2+-induced mitochondrial permeability transition. J Pharmacol Exp Ther 321:707-715.
14. Levy D, Garrison RJ, Savage DD, Kannel WB, and Castelli WP (1990) Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med 322:1561-1566.
15. Marcil M, Ascah A, Matas J, Bélanger S, Deschepper CF, and Burelle Y (2006) Compensated volume overload increases the vulnerability of heart mitochondria without affecting their functions in the absence of stress. J Mol Cell Cardiol 41:998-1009.
16. Mozaffarian D, Bryson CL, Lemaitre RN, Burke GL, and Siscovick DS (2005) Fish intake and risk of incident heart failure. J Am Coll Cardiol 45:2015-2021. (Pubitemid 40814125)
17. Neubauer S (2007) The failing heart-an engine out of fuel. N Engl J Med 356:1140-1151.
18. Okere IC, Young ME, McElfresh TA, Chess DJ, Sharov VG, Sabbah HN, Hoit BD, Ernsberger P, Chandler MP, and Stanley WC (2006) Low carbohydrate/high-fat diet attenuates cardiac hypertrophy, remodeling, and altered gene expression in hypertension. Hypertension 48:1116-1123.
19. 2+-induced permeability transition. J Mol Cell Cardiol 47:819-827.
20. Penzo D, Petronilli V, Angelin A, Cusan C, Colonna R, Scorrano L, Pagano F, Prato M, Di Lisa F, and Bernardi P (2004) Arachidonic acid released by phospholipase A(2) activation triggers Ca(2+)-dependent apoptosis through the mitochondrial pathway. J Biol Chem 279:25219-25225.
21. Shah KB, Duda MK, O'Shea KM, Sparagna GC, Chess DJ, Khairallah RJ, Robillard-Frayne I, Xu W, Murphy RC, Des Rosiers C, et al. (2009) The cardioprotective effects of fish oil during pressure overload are blocked by high fat intake: role of cardiac phospholipid remodeling. Hypertension 54:605-611.
22. Stanley WC, Recchia FA, and Lopaschuk GD (2005) Myocardial substrate metabolism in the normal and failing heart. Physiol Rev 85:1093-1129.
23. Williams SD and Gottlieb RA (2002) Inhibition of mitochondrial calcium-independent phospholipase A2 (iPLA2) attenuates mitochondrial phospholipid loss and is cardioprotective. Biochem J 362:23-32.