Hemodynamic effect of the nitroxide superoxide dismutase mimics

Free Radical Biology and Medicine

Volumn 27, Issue 5-6, 1999, Pages 529-535

  Hahn, Stephen M ^a   Sullivan, Francis J ^b   Deluca, Anne Marie ^b   Bacher, John D ^c   Liebmann, James ^b   Krishna, Murali C ^b   Coffin, Deborah ^b   Mitchell, James B ^b  

^a National Centre for Research Resources   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Free radical; Hypotension; Nitric oxide; Nitroxides; SOD mimics; Swine

Indexed keywords

3 CARBAMOYL 2,2,5,5 TETRAMETHYL 3 PYRROLINE 1 OXYL; NITROXIDE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; TEMPOL;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FEMALE; HEMODYNAMICS; HYPOTENSION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; SWINE; TACHYCARDIA; VASODILATATION;

ANIMALS; BLOOD PRESSURE; CYCLIC N-OXIDES; HEART RATE; HEMODYNAMIC PROCESSES; HYPOTENSION; NITRIC OXIDE; PYRROLIDINES; RADIATION-PROTECTIVE AGENTS; REACTIVE OXYGEN SPECIES; SKIN TEMPERATURE; SPIN LABELS; SUPEROXIDE DISMUTASE; SWINE; SWINE, MINIATURE; TACHYCARDIA; VASCULAR RESISTANCE; VASODILATOR AGENTS;

CYGNUS; SUIDAE; SUS SCROFA;

EID: 0032856649     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(99)00099-4     Document Type: Article

References (27)

1. McConnell H.M. Molecular motion in biological membranes. Berliner L.J. Spin labelling theory and applications. 1976;525-560 Academic Press, New York.
2. Swartz H.M., Pals M., Sentjurc M., Morse P.D. Hypoxia sensitive NMR contrast agents. Magn. Reson. M. 3:1986;169-174.
3. Mitchell J.B., Samuni A., Krishna M.C., DeGraff W.G., Ahn M.S., Samuni U., Russo A. Biologically active metal-independent superoxide dismutase mimics. Biochemistry. 29:1990;2802-2807.
4. Samuni A., Mitchell J.B., DeGraff W., Krishna C.M., Samuni U., Russo A. Nitroxide SOD-mimics Modes of action . Free Radic. Res. Commun. 12-13:1991;187-194.
5. Mitchell J.B., DeGraff W., Kaufman D., Krishna M.C., Samuni A., Finkelstein E., Ahn M.S., Hahn S.M., Gamson J., Russo A. Inhibition of oxygen-dependent radiation-induced damage by the nitroxide superoxide dismutase mimic, Tempol. Arch. Biochem. Biophys. 289:1991;62-70.
6. Hahn S.M., Wilson L., Krishna C.M., Liebmann J., DeGraff W., Gamson J., Samuni A., Venzon D., Mitchell J.B. Identification of nitroxide radioprotectors. Radiat. Res. 132:1992;87-93.
7. Hahn S.M., Tochner Z., Krishna C.M., Glass J., Wilson L., Samuni A., Sprague M., Venzon D., Glatstein E., Mitchell J.B., Russo A. Tempol, a stable free radical, is a novel murine radiation protector. Cancer Res. 52:1992;1750-1753.
8. Hahn S.M., DeLuca A.M., Coffin D., Krishna C.M., Mitchell J.B. In vivo radioprotection and effects on blood pressure of the stable free radical nitroxides. Int. J. Radiat. Oncol. Biol. Phys. 12:1998;839-842.
9. Hahn S.M., Sullivan F.J., DeLuca A.M., Krishna C.M., Wersto N., Venzon D., Russo A., Mitchell J.B. Evaluation of tumor radioprotection in a murine tumor model. Free Radic. Biol. Med. 22:1997;1211-1216.
10. Kuppusamy P., Afeworki M., Shankar R.A., Coffin D., Krishna M.C., Hahn S.M., Mitchell J.B., Zweier J.L. In vivo electron paramagnetic resonance imaging of tumor heterogeneity and oxygenation in a murine model. Cancer Res. 58:1998;1562-1568.
11. Hahn S.M., Lepinski D.L., DeLuca A.M., Mitchell J.B., Pellmar T.C. Neurophysiological consequences of nitroxide anti-oxidants. Can. J. Physiol. Pharmacol. 73:1995;399-403.
12. Swartz H.M. Principles of the metabolism of nitroxides and their implications for spin trapping. Free Radic. Res. Commun. 9:1990;399-405.
13. Singh R.J., Hogg N., Mchaouab H.S., Kalyanaraman B. Physical and chemical interactions between nitric oxide and nitroxides. Biochim. Biophys. Acta. 1201:1994;437-441.
14. Samuni A., Godinger D., Aronovitch J., Russo A., Mitchell J.B. Nitroxides block DNA scission and protect cells from oxidative damage. Biochemistry. 30:1991;555-561.
15. Samuni A., Krishna C.M., Riesz P., Finkelstein E., Russo A. A novel metal-free low molecular weight superoxide dismutase mimic. J. Biol. Chem. 263:1988;17921-17924.
16. Samuni A., Krishna C.M., Riesz P., Finkelstein E., Russo A. Superoxide reaction with nitroxide spin-adducts. Free Rad. Biol. Med. 6:1989;141-148.
17. Panza J.A. Endothelial dysfunction in essential hypertension. Clin. Cardiol. 20:1997;26-33.
18. Jun T., Ke-yan F., Catalano M. Increased superoxide anion production in humans a possible mechanism for the pathogenesis of hypertension . J. Hum. Hypertens. 10:1996;305-309.
19. Sozmen B., Kazaz C., Taskiran D., Tuzun S., Sozmen E.Y. Effect of N-dicyclopropylmethyl-amino-2-oxazoline (S-3341) on antioxidant status and nitric oxide in hypertensive patients. Curr. Med. Res. Opin. 14:1998;89-96.
20. Schnackenberg C.G., Welch W.J., Wilcox C.S. Normalization of blood pressure and renal vascular resistance in SHR with a membrane-permeable superoxide dismutase mimetic role of nitric oxide . Hypertension. 32:1998;59-64.
21. Bouloumie A., Bauersachs J., Linz W., Scholkens B.A., Wiemer G., Fleming I., Busse R. Endothelial dysfunction coincides with an enhanced nitric oxide synthase expression and superoxide anion production. Hypertension. 30:1997;934-941.
22. Konorev E.A., Baker J.E., Joseph J., Kalyanaraman B. Vasodilatory and toxic effects of spin traps on aerobic cardiac function. Free Radic. Biol. Med. 14:1993;127-137.
23. Konorev E.A., Tarpey M.M., Joseph J., Baker J.E., Kalyanaraman B. Nitronyl nitroxides as probes to study the mechanism of vasodilatory action of nitrovasodilators, nitrone spin traps, and nitroxides role of nitric oxide . Free Radic. Biol. Med. 18:1995;169-177.
24. Krishna M.C., Grahame D.A., Samuni A., Mitchell J.B., Russo A. Oxoammonium cation intermediate in the nitroxide-catalyzed dismutation of superoxide. Proc. Natl. Acad. Sci. 89:1992;5537-5541.
25. Krishna M.C., Samuni A., Taira J., Goldstein S., Mitchell J.B., Russo A. Stimulation by nitroxides of catalase-like activity of hemeproteins. J. Biol. Chem. 271:1996;26018-26025.
26. Wink D.A., Hanbauer I., Laval F., Cook J.A., Krishna M.C., Mitchell J.B. Nitric oxide protects against the cytotoxic effects of reactive oxygen species. Ann. NY Acad. Sci. 738:1994;265-278.
27. Zollner S., Haseloff R.F., Kirilyuk I.A., Blasig E., Rubanyi G.M. Nitroxides increase the detectable amount of nitric oxide released from endothelial cells. J. Biol. Chem. 272:1997;23076-23080.