Olfactory memory is impaired in a triple transgenic model of Alzheimer disease

Behavioural Brain Research

Volumn 224, Issue 2, 2011, Pages 408-412

  Cassano, Tommaso ^a   Romano, Adele ^b   Macheda, Teresa ^a   Colangeli, Roberto ^b   Cimmino, Concetta Stefania ^a   Petrella, Antonio ^c   LaFerla, Frank M ^d   Cuomo, Vincenzo ^b   Gaetani, Silvana ^b  

^a UNIVERSITY OF FOGGIA   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c Puglia and Basilicata Experimental Zooprophylactic Institute   (Italy)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alzheimer's disease; Olfactory circuitry; Olfactory memory; Social transmission of food preference; Triple transgenic model of AD

Indexed keywords

AMYLOID BETA PROTEIN; TAU PROTEIN;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CONTROLLED STUDY; DISEASE MODEL; DISEASE SEVERITY; ENTORHINAL CORTEX; FOOD PREFERENCE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INFORMATION PROCESSING; MOUSE; NONHUMAN; ODOR; OLFACTORY BULB; OLFACTORY MEMORY; ORBITAL CORTEX; PRIORITY JOURNAL; PYRIFORM CORTEX; SMELLING DISORDER; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; DEFECATION; FOOD; FOOD PREFERENCES; HIPPOCAMPUS; HUMANS; IMMUNOHISTOCHEMISTRY; MEMORY; MICE; MICE, TRANSGENIC; MOTOR ACTIVITY; OLFACTORY BULB; OLFACTORY PATHWAYS; PRESENILIN-1; SMELL; TAU PROTEINS;

EID: 80051799632     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2011.06.029     Document Type: Article

References (20)

1. Querfurth H.W., LaFerla F.M. Alzheimer's disease. N Engl J Med 2010, 362:329-344.
2. Mesholam R.I., Moberg P.J., Mahr R.N., Doty R.L. Olfaction in neurodegenerative disease: a meta-analysis of olfactory functioning in Alzheimer's and Parkinson's diseases. Arch Neurol 1998, 55(1):84-90.
3. Brennan P.A., Keverne E.B. Neural mechanisms of mammalian olfactory learning. Prog Neurobiol 1997, 51(4):457-481.
4. Royet J.P., Croisile B., Williamson-Vasta R., Hibert O., Serclerat D., Guerin J. Rating of different olfactory judgements in Alzheimer's disease. Chem Senses 2001, 26(4):409-417.
5. Davis P., Morris J., White D. The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer's disease. Neurobiol Aging 1991, 12:295-312.
6. Doty R.L., Shaman P., Applebaum S.L., Giberson R., Siksorski L., Rosenberg L. Smell identification ability: changes with age. Science 1984, 226(4681):1441-1443.
7. Serby M., Larson P., Kalkstein D. The nature and course of olfactory deficits in Alzheimer's disease. Am J Psychiatry 1991, 148(3):357-360.
8. Wesson D.W., Levy E., Nixon R.A., Wilson D.A. Olfactory dysfunction correlates with amyloid-beta burden in an Alzheimer's disease mouse model. J Neurosci 2010, 30(2):505-514.
9. Oddo S., Caccamo A., Shepherd J.D., Murphy M.P., Golde T.E., Kayed R., et al. Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron 2003, 39(3):409-421.
10. Kitazawa M., Oddo S., Yamasaki T.R., Green K.N., LaFerla F.M. Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease. J Neurosci 2005, 25(39):8843-8853.
11. Galef B.G., Iliffe C.P., Whiskin E.E. Social influences on rats' (Rattus norvegicus) preferences for flavored foods, scented nest materials, and odors associated with harborage sites: are flavored food special?. J Comp Psychol 1994, 108(3):266-273.
12. Burne T.H., Johnston A.N., Wilkinson L.S., Kendrick K.M. Effects of anesthetic agents on socially transmitted olfactory memories in mice. Neurobiol Learn Mem 2010, 93(2):268-274.
13. Steiner R.A., Hohmann J.G., Holmes A., Wrenn C.C., Cadd G., Jureus A., et al. Galanin transgenic mice display cognitive and neurochemical deficits characteristic of Alzheimer's disease. Proc Natl Acad Sci USA 2001, 98(7):4184-4189.
14. Lambourne S.L., Sellers L.A., Bush T.G., Choudhury S.K., Emson P.C., Suh Y.H., Wilkinson L.S. Increased tau phosphorylation on mitogen-activated protein kinase consensus sites and cognitive decline in transgenic models for Alzheimer's disease and FTDP-17: evidence for distinct molecular processes underlying tau abnormalities. Mol Cell Biol 2005, 25(1):278-293.
15. Wrenn C.C., Harris A.P., Saavedra M.C., Crawley J.N. Social transmission of food preference in mice: methodology and application of galanin-overexpression transgenic mice. Behav Neurosci 2003, 117(1):21-31.
16. 1 receptor agonist, R(+)WIN55,212-2, with a reduced incidence of spike-wave discharges. Epilepsia 2010, 51(8):1511-1521.
17. Hsiao K., Chapman P., Nilsen S., Eckman C., Harigaya Y., Younkin S., et al. Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 1996, 274(5284):99-102.
18. Lehman E.J., Kulnane L.S., Lamb B.T. Alterations in beta-amyloid production and deposition in brain regions of two transgenic models. Neurobiol Aging 2003, 24(5):645-653.
19. Billings L.M., Oddo S., Green K.N., McGaugh J.L., LaFerla F.M. Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice. Neuron 2005, 45(5):675-688.
20. Gerlai R., Clayton N.S. Analysing hippocampal function in transgenic mice: an ethological perspective. Trends Neurosci 1999, 22(2):47-51.