Apolipoprotein A1/C3/A5 haplotypes and serum lipid levels

Lipids in Health and Disease

Volumn 10, Issue , 2011, Pages

  Yin, Rui Xing ^a   Li, Yi Yang ^a,b   Lai, Chao Qiang ^c  

^a GUANGXI MEDICAL UNIVERSITY   (China)

^b Guangxi Minzu Hospital   (China)

^c TUFTS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN A1; APOLIPOPROTEIN A5; APOLIPOPROTEIN C3; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; APOA5 PROTEIN, HUMAN; APOLIPOPROTEIN A; LIPID;

ADULT; AGED; ALCOHOL CONSUMPTION; ARTICLE; BLOOD PRESSURE; BODY MASS; BODY WEIGHT; CHINESE; CHOLESTEROL BLOOD LEVEL; CIGARETTE SMOKING; ENVIRONMENTAL FACTOR; FEMALE; GEL ELECTROPHORESIS; GENE FREQUENCY; GENE SEQUENCE; GENETIC ASSOCIATION; GENOTYPE; HAPLOTYPE; HUMAN; LIPID BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; MALE; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; TRIACYLGLYCEROL BLOOD LEVEL; ADOLESCENT; AMINO ACID SUBSTITUTION; BLOOD; CHINA; DNA SEQUENCE; GENE LINKAGE DISEQUILIBRIUM; GENETICS; MIDDLE AGED; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AMINO ACID SUBSTITUTION; APOLIPOPROTEIN A-I; APOLIPOPROTEIN C-III; APOLIPOPROTEINS A; BASE SEQUENCE; CHINA; CHOLESTEROL, HDL; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; HAPLOTYPES; HUMANS; LINKAGE DISEQUILIBRIUM; LIPIDS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POLYMORPHISM, SINGLE NUCLEOTIDE; SEQUENCE ANALYSIS, DNA; YOUNG ADULT;

EID: 80051792295     PISSN: None     EISSN: 1476511X     Source Type: Journal    
DOI: 10.1186/1476-511X-10-140     Document Type: Article

References (71)

1. Diet, serum cholesterol, and death from coronary heart disease. The Western Electric study. Shekelle RB, Shryock AM, Paul O, Lepper M, Stamler J, Liu S, Raynor WJ Jr, N Engl J Med 1981 304 65 70 10.1056/NEJM198101083040201 7442730 (Pubitemid 11170309)
2. Plasma triglyceride as a risk factor for coronary heart disease. The epidemiologic evidence and beyond. Austin MA, Am J Epidemiol 1989 129 249 59 2643302 (Pubitemid 19046992)
3. Low-density lipoprotein triglycerides associated with low-grade systemic inflammation, adhesion molecules, and angiographic coronary artery disease: the Ludwigshafen Risk and Cardiovascular Health study. März W, Scharnagl H, Winkler K, Tiran A, Nauck M, Boehm BO, Winkelmann BR, Circulation 2004 110 3068 74 10.1161/01.CIR.0000146898.06923.80 15505088 (Pubitemid 39492000)
4. Comparison of the plasma levels of apolipoproteins B and A-1, and other risk factors in men and women with premature coronary artery disease. Kwiterovich PO Jr, Coresh J, Smith HH, Bachorik PS, Derby CA, Pearson TA, Am J Cardiol 1992 69 1015 21 10.1016/0002-9149(92)90856-T 1561971 (Pubitemid 23058996)
5. Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: a meta-analysis of population-based prospective studies. Hokanson JE, Austin MA, J Cardiovasc Risk 1996 3 213 319 10.1097/00043798-199604000-00014 8836866
6. Interactions of the apolipoprotein A5 gene polymorphisms and alcohol consumption on serum lipid levels. Yin RX, Li YY, Liu WY, Zhang L, Wu JZ, PLoS ONE 2011 6 17954 10.1371/journal.pone.0017954 21423763
7. Genetic and environmental influences on serum lipid levels in twins. Heller DA, de Faire U, Pedersen NL, Dahlén G, McClearn GE, N Engl J Med 1993 328 1150 6 10.1056/NEJM199304223281603 8455681 (Pubitemid 23105752)
8. Associations of the apolipoprotein A-I gene polymorphism and serum lipid levels in the Guangxi Hei Yi Zhuang and Han populations. Li Y, Yin R, Zhou Y, Deng Y, Yang D, Pan S, Lin W, Int J Mol Med 2008 21 753 64 18506369
9. Modulation of lipoprotein lipase activity by apolipoproteins. Wang C, McConathy WJ, Kloer HU, Alaupovic P, J Clin Invest 1985 75 384 90 10.1172/JCI111711 3973011
10. The novel apolipoprotein A5 is present in human serum, is associated with VLDL, HDL, and chylomicrons, and circulates at very low concentrations compared with other apolipoproteins. O'Brien PJ, Alborn WE, Sloan HJ, Ulmer M, Boodhoo A, Knierman MD, Schultze AE, Konrad1 RJ, Clin Chem 2005 51 351 9 10.1373/clinchem.2004.040824 15528295 (Pubitemid 40175805)
11. Human apolipoprotein AI-CIII gene complex is located on chromosome 11. Bruns GA, Karanthasis SK, Breslow JL, Arteriosclerosis 1984 4 97 102 10.1161/01.ATV.4.2.97 6422919 (Pubitemid 14152887)
12. An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing. Pennacchio LA, Olivier M, Hubacek JA, Cohen JC, Cox DR, Fruchart JC, Krauss RM, Rubin EM, Science 2001 294 169 73 10.1126/science.1064852 11588264 (Pubitemid 32952971)
13. Restriction fragment length polymorphisms of the apolipoprotein A-I, C-III, A-IV gene locus. Relationships with lipids, apolipoproteins, and premature coronary artery disease. Ordovas JM, Civeira F, Genest J Jr, Craig S, Robbins AH, Meade T, Pocovi M, Frossard PM, Masharani U, Wilson PW, Salem DN, Ward RH, Schaefer EJ, Atherosclerosis 1991 87 75 86 10.1016/0021-9150(91)90234-T 1678604
14. Association between genetic variations of apo AI-CIII-AIV cluster gene and hypertriglyceridemic subjects. Hong SH, Park WH, Lee CC, Song JH, Kim JQ, Clin Chem 1997 43 13 7 8990215 (Pubitemid 27024383)
15. Linkage disequilibrium of the Apo AI-CIII-AIV gene cluster and their relationship to plasma triglyceride, apolipoprotein AI and CIII levels in Koreans. Song J, Park JW, Park H, Kim JQ, Mol Cells 1998 8 12 8 9571626 (Pubitemid 128490208)
16. Relative contribution of variation within the APOC3/A4/A5 gene cluster in determining plasma triglycerides. Talmud PJ, Hawe E, Martin S, Olivier M, Miller GJ, Rubin EM, Pennacchio LA, Humphries SE, Hum Mol Genet 2002 11 3039 46 10.1093/hmg/11.24.3039 12417525 (Pubitemid 35414817)
17. Association of the APOLIPOPROTEIN A1/C3/A4/A5 gene cluster with triglyceride levels and LDL particle size in familial combined hyperlipidemia. Mar R, Pajukanta P, Allayee H, Groenendijk M, Dallinga-Thie G, Krauss RM, Sinsheimer JS, Cantor RM, de Bruin TW, Lusis AJ, Circ Res 2004 94 993 9 10.1161/01.RES.0000124922.61830.F0 15001527 (Pubitemid 38490078)
18. Linkage and association between distinct variants of the APOA1/C3/A4/A5 gene cluster and familial combined hyperlipidemia. Eichenbaum-Voline S, Olivier M, Jones EL, Naoumova RP, Jones B, Gau B, Patel HN, Seed M, Betteridge DJ, Galton DJ, Rubin EM, Scott J, Shoulders CC, Pennacchio LA, Arterioscler Thromb Vasc Biol 2004 24 167 74 10.1161/01.ATV.0000099881.83261.D4 14551155 (Pubitemid 38082429)
19. Impact of APOA5/A4/C3 genetic polymorphisms on lipid variables and cardiovascular disease risk in French men. Dallongeville J, Cottel D, Montaye M, Codron V, Amouyel P, Helbecque N, Int J Cardiol 2006 106 152 6 10.1016/j.ijcard.2004.10.065 16321685 (Pubitemid 41728931)
20. Evidence for consistent intragenic and intergenic interactions between SNP effects in the APOA1/C3/A4/A5 gene cluster. Hamon SC, Kardia SL, Boerwinkle E, Liu K, Klos KL, Clark AG, Sing CF, Hum Hered 2006 61 87 96 10.1159/000093384 16710093 (Pubitemid 43883126)
21. Consistent effects of genes involved in reverse cholesterol transport on plasma lipid and apolipoprotein levels in CARDIA participants. Klos KL, Sing CF, Boerwinkle E, Hamon SC, Rea TJ, Clark A, Fornage M, Hixson JE, Arterioscler Thromb Vasc Biol 2006 26 1828 36 10.1161/01.ATV.0000231523.19199.45 16763159 (Pubitemid 44305337)
22. Associations of the apolipoprotein A1/C3/A4/A5 gene cluster with triglyceride and HDL cholesterol levels in women with type 2 diabetes. Qi L, Liu S, Rifai N, Hunter D, Hu FB, Atherosclerosis 2007 192 204 10 10.1016/j.atherosclerosis.2006.05.006 16781717 (Pubitemid 46602299)
23. Genetic studies on the APOA1-C3-A5 gene cluster in Asian Indians with premature coronary artery disease. Shanker J, Perumal G, Rao VS, Khadrinarasimhiah NB, John S, Hebbagodi S, Mukherjee M, Kakkar VV, Lipids Health Dis 2008 7 33 10.1186/1476-511X-7-33 18801202
24. Effects of variations in the APOA1/C3/A4/A5 gene cluster on different parameters of postprandial lipid metabolism in healthy young men. Delgado-Lista J, Perez-Jimenez F, Ruano J, Perez-Martinez P, Fuentes F, Criado-Garcia J, Parnell LD, Garcia-Rios A, Ordovas JM, Lopez-Miranda J, J Lipid Res 2010 51 63 73 10.1194/jlr.M800527-JLR200 19592705
25. Associations of polymorphisms in the apolipoprotein A1/C3/A4/A5 gene cluster with familial combined hyperlipidaemia in Hong Kong Chinese. Liu ZK, Hu M, Baum L, Thomas GN, Tomlinson B, Atherosclerosis 2010 208 427 32 10.1016/j.atherosclerosis.2009.08.013 19732897
26. Haplotypes of the ApoA-I/C-III/A-IV gene cluster and familial combined hyperlipidemia. Tahvanainen E, Pajukanta P, Porkka K, Nieminen S, Ikävalko L, Nuotio I, Taskinen MR, Peltonen L, Ehnholm C, Arterioscler Thromb Vasc Biol 1998 18 1810 7 10.1161/01.ATV.18.11.1810 9812922 (Pubitemid 28521073)
27. Haplotypes in the APOA1-C3-A4-A5 gene cluster affect plasma lipids in both humans and baboons. Wang QF, Liu X, O'Connell J, Peng Z, Krauss RM, Rainwater DL, VandeBerg JL, Rubin EM, Cheng JF, Pennacchio LA, Hum Mol Genet 2004 13 1049 56 10.1093/hmg/ddh121 15044382 (Pubitemid 38702191)
28. Haplotype analysis of the apolipoprotein gene cluster on human chromosome 11. Olivier M, Wang X, Cole R, Gau B, Kim J, Rubin EM, Pennacchio LA, Genomics 2004 83 912 23 10.1016/j.ygeno.2003.11.016 15081120 (Pubitemid 38469930)
29. APOA1/C3/A5 haplotype and risk of hypertriglyceridemia in Taiwanese. Chien KL, Fang WH, Wen HC, Lin HP, Lin YL, Lin SW, Wu JH, Kao JT, Clin Chim Acta 2008 390 56 62 10.1016/j.cca.2007.12.014 18206649
30. Genetic association study of APOA1/C3/A4/A5 gene cluster and haplotypes on triglyceride and HDL cholesterol in a community-based population. Chien KL, Chen MF, Hsu HC, Su TC, Chang WT, Lee CM, Lee YT, Clin Chim Acta 2008 388 78 83 10.1016/j.cca.2007.10.006 17964293 (Pubitemid 350266570)
31. Genetic analysis of a polymorphism in the human apolipoprotein A-I gene promoter: effect on plasma HDL-cholesterol levels. Barre DE, Guerra R, Verstraete R, Wang Z, Grundy SM, Cohen JC, J Lipid Res 1994 35 1292 6 7964190 (Pubitemid 24209403)
32. APOA1/C3/A4 gene cluster variability and lipid levels in Brazilian children. de Franca E, Alves JG, Hutz MH, Braz J Med Biol Res 2005 38 535 41 15962178 (Pubitemid 40692001)
33. Lack of association of the apolipoprotein A-I-C-III-A-IV gene XmnI and SstI polymorphisms and of the lipoprotein lipase gene mutations in familial combined hyperlipoproteinemia in French Canadian subjects. Marcil M, Boucher B, Gagné E, Davignon J, Hayden M, Genest J Jr, J Lipid Res 1996 37 309 19 9026529
34. Lack of association between genetic variations of apo A-I-C-III-A-IV gene cluster and myocardial infarction in a sample of European male: ECTIM study. Kee F, Amouyel P, Fumeron F, Arveiler D, Cambou JP, Evans A, Cambien F, Fruchart JC, Ducimetière P, Dallongeville J, Atherosclerosis 1999 145 187 95 10.1016/S0021-9150(99)00066-0 10428310 (Pubitemid 29292715)
35. Plasma triglyceride and HDL-cholesterol concentrations in Vietnamese girls are affected by lipoprotein lipase, but not apolipoprotein CIII polymorphism. Thu NN, Mai TT, Ohmori R, Kuroki M, Chuyen NV, Hung NT, Kawakami M, Kondo K, J Nutr 2006 136 1488 92 16702309 (Pubitemid 43765350)
36. Apolipoprotein A-I/C-III/A-IV SstI and apolipoprotein B XbaI polymorphisms do not affect early functional and structural changes in atherosclerosis: the Cardiovascular Risk in Young Finns study. Nieminen T, Kähönen M, Islam S, Raitakari OT, Hutri-Kähönen N, Marniemi J, Juonala M, Rontu R, Viikari J, Lehtimäki T, Circ J 2007 71 741 5 10.1253/circj.71.741 17457002 (Pubitemid 46683367)
37. APOA5 gene polymorphism modulates levels of triglyceride, HDL cholesterol and FERHDL but is not a risk factor for coronary artery disease. Lee KWJ, Ayyobi AF, Frohlich JJ, Hill JS, Atherosclerosis 2004 176 165 72 10.1016/j.atherosclerosis.2004.04.024 15306190 (Pubitemid 39089097)
38. Newly identified apolipoprotein AV gene predisposes to high plasma triglycerides in familial combined hyperlipidemia. Ribalta J, Figuera L, Fernandez-Ballart J, Vilella E, Castro Cabezas M, Masana L, Joven J, Clin Chem 2002 48 1597 600 12194944 (Pubitemid 34925802)
39. Effects of demographic, dietary and other lifestyle factors on the prevalence of hyperlipidemia in Guangxi Hei Yi Zhuang and Han populations. Ruixing Y, Yuming C, Shangling P, Fengping H, Tangwei L, Dezhai Y, Jinzhen W, Limei Y, Weixiong L, Rongshan L, Jiandong H, Eur J Cardiovasc Prev Rehabil 2006 13 977 84 10.1097/01.hjr.0000239476.79428.25 17143131 (Pubitemid 44901161)
40. Apolipoprotein C-III gene polymorphism and several environmental factors with serum lipid levels in the Guangxi Hei Yi Zhuang and Han populations. Yiyang L, Ruixing Y, Meng L, Kela L, Xingjiang L, Lin Z, Wanying L, Shangling P, Dezhai Y, Weixiong L, J Investig Med 2010 58 777 85 20517165
41. Prevalence, awareness, treatment, control and risk factors of hypertension in the Guangxi Hei Yi Zhuang and Han populations. Ruixing Y, Limei Y, Yuming C, Dezhai Y, Weixiong L, Muyan L, Fengping H, Jinzhen W, Guangqing Y, Zhenbiao N, Hypertens Res 2006 29 423 32 10.1291/hypres.29.423 16940705 (Pubitemid 44102810)
42. Dietary and plasma lipid, lipoprotein, and apolipoprotein profiles among elderly Hispanics and non-Hispanics and their association with diabetes. Bermudez OI, Velez-Carrasco W, Schaefer EJ, Tucker KL, Am J Clin Nutr 2002 76 1214 21 12450885 (Pubitemid 35416554)
43. Black-white differences in cholesterol levels of serum high-density lipoprotein subclasses among children: the Bogalusa Heart Study. Srinivasan SR, Freedman DS, Webber LS, Berenson GS, Circulation 1987 76 272 9 10.1161/01.CIR.76.2.272 3608116 (Pubitemid 17124743)
44. Endogenous postmenopausal hormones and serum lipids: the atherosclerosis risk in communities study. Mudali S, Dobs AS, Ding J, Cauley JA, Szklo M, Golden SH, atherosclerosis risk in communities study, J Clin Endocrinol Metab 2005 90 1202 9 15546905 (Pubitemid 40279255)
45. Acute effects of estradiol and progesterone on insulin, lipids and lipoproteins in postmenopausal women: a pilot study. Cheung AP, Maturitas 2000 35 45 50 10.1016/S0378-5122(00)00091-8 10802399 (Pubitemid 30236280)
46. Interaction of alcohol and the G to A substitution at the promoter region of the apolipoprotein AI gene in determining plasma apolipoprotein AI levels in Yi and Han Chinese. Zhao Q, She M, Shen P, Zhang H, Zhou M, Chin Med J (Engl) 2000 113 471 4
47. Polymorphisms in the apolipoprotein (apo) AI-CIII-AIV gene cluster: detection of genetic variation determining plasma apo AI, apo CIII and apoA IV concentrations. Paul-Hayase H, Rosseneu M, Robinson D, Van Bervliet JP, Deslypere JP, Humphries SE, Hum Genet 1992 88 439 46 10.1007/BF00215679 1740321
48. Interaction between a polymorphism of the apoA-I promoter region and smoking determines plasma levels of HDL and apoA-I. Sigurdsson G Jr, Gudnason V, Sigurdsson G, Humphries SE, Arterioscler Thromb 1992 12 1017 22 10.1161/01.ATV.12.9.1017 1525115
49. Interaction between obesity and genetic polymorphisms in the apolipoprotein CIII gene and lipoprotein lipase gene on the risk of hypertriglyceridemia in Chinese. Ko YL, Ko YS, Wu SM, Teng MS, Chen FR, Hsu TS, Chiang CW, Lee YS, Hum Genet 1997 100 327 33 10.1007/s004390050511 9272150 (Pubitemid 27386835)
50. Association between coronary heart disease and the apolipoprotein A-I/C-III/A-IV complex in a Japanese population. Bai H, Saku K, Liu R, Imamura M, Arakawa K, Hum Genet 1995 95 102 4 7814010
51. Apolipoprotein C3 SstI polymorphism and triglyceride levels in Asian Indians. Chhabra S, Narang R, Krishnan LR, Vasisht S, Agarwal DP, Srivastava LM, Manchanda SC, Das N, BMC Genet 2002 3 9 12052247
52. Association of the Sst-I polymorphism at the APOC3 gene locus with variations in lipid levels, lipoprotein subclass profiles and coronary heart disease risk: the Framingham offspring study. Russo GT, Meigs JB, Cupples LA, Demissie S, Otvos JD, Wilson PW, Lahoz C, Cucinotta D, Couture P, Mallory T, Schaefer EJ, Ordovas JM, Atherosclerosis 2001 158 173 81 10.1016/S0021-9150(01) 00409-9 11500189 (Pubitemid 32735482)
53. ApoA5 -1131TC polymorphism is associated with triglyceride levels in Chinese men. Baum L, Tomlinson B, Thomas GN, Clin Genet 2003 63 377 9 10.1034/j.1399-0004.2003.00063.x 12752569 (Pubitemid 36944080)
54. Association between DNA variant sites in the apolipoprotein A5 gene and coronary heart disease in Chinese. Liu H, Zhang S, Lin J, Li H, Huang A, Xiao C, Li X, Su Z, Wang C, Nebert DW, Zhou B, Zheng K, Shi J, Li G, Huang D, Metabolism 2005 54 568 72 10.1016/j.metabol.2004.11.009 15877284 (Pubitemid 40585644)
55. The ApoA5 locus is a strong determinant of plasma triglyceride concentrations across ethnic groups in Singapore. Lai CQ, Tai ES, Tan CE, Cutter J, Chew SK, Zhu YP, Adiconis X, Ordovas JM, J Lipid Res 2003 44 2365 73 10.1194/jlr.M300251-JLR200 12951359 (Pubitemid 38082495)
56. Association found between the promoter region polymorphism in the apolipoprotein A-V gene and the serum triglyceride level in Japanese schoolchildren. Endo K, Yanagi H, Araki J, Hirano C, Yamakawa-Kobayashi K, Tomura S, Hum Genet 2002 111 570 2 10.1007/s00439-002-0825-0 12436249 (Pubitemid 36075090)
57. The genetic effect of the apoprotein AV gene on the serum triglyceride level in Japanese. Nabika T, Nasreen S, Kobayashi S, Masuda J, Atherosclerosis 2002 165 201 4 10.1016/S0021-9150(02)00252-6 12417270 (Pubitemid 35333346)
58. Two independent apolipoprotein A5 haplotypes influence human plasma triglyceride levels. Pennacchio LA, Olivier M, Hubacek JA, Krauss RM, Rubin EM, Cohen JC, Hum Mol Genet 2001 11 3031 8
59. Genetic analysis of a polymorphism in the human apoA-V gene: effect on plasma lipids. Aouizerat BE, Kulkarni M, Heilbron D, Drown D, Raskin S, Pullinger CR, Malloy MJ, Kane JP, J Lipid Res 2003 44 1167 73 10.1194/jlr.M200480-JLR200 12671030 (Pubitemid 37279634)
60. Association of SNP3 polymorphism in the apolipoprotein A-V gene with plasma triglyceride level in Tunisian type 2 diabetes. Chaaba R, Attia N, Hammami S, Smaoui M, Mahjoub S, Hammami M, Masmoudi AS, Lipids Health Dis 2005 4 1 10.1186/1476-511X-4-1 15636639 (Pubitemid 40300845)
61. A genetic variant c.553GT in the apolipoprotein A5 gene is associated with an increased risk of coronary artery disease and altered triglyceride levels in a Chinese population. Tang Y, Sun P, Guo D, Ferro A, Ji Y, Chen Q, Fan L, Atherosclerosis 2006 185 433 7 10.1016/j.atherosclerosis.2005.06.026 16046221
62. A novel genetic variant in the apolipoprotein A5 gene is associated with hypertriglyceridemia. Kao JT, Wen HC, Chien KL, Hsu HC, Lin SW, Hum Mol Genet 2003 12 2533 9 10.1093/hmg/ddg255 12915450 (Pubitemid 37220417)
63. Genetic variations of apolipoprotein A5 gene is associated with the risk of coronary artery disease among Chinese in Taiwan. Hsu LA, Ko YL, Chang CJ, Hu CF, Wu S, Teng MS, Wang CL, Ho WJ, Ko YS, Hsu TS, Lee YS, Atherosclerosis 2006 185 143 9 10.1016/j.atherosclerosis.2005.05.031 16054149 (Pubitemid 43117561)
64. New variants in the apolipoprotein AV gene in individuals with extreme triglyceride levels. Hubácek JA, Adámková V, Ceska R, Poledne R, Horínek A, Vráblík M, Physiol Res 2004 53 225 8 15046561 (Pubitemid 38525128)
65. Impact of apolipoprotein A5 variants on statin treatment efficacy. Hubacek JA, Adamkova V, Prusikova M, Snejdrlova M, Hirschfeldova K, Lanska V, Ceska R, Vrablik M, Pharmacogenomics 2009 10 945 50 10.2217/pgs.09.17 19530961
66. Polymorphism in the promoter region of the apolipoprotein AI gene associated with differences in apolipoprotein AI levels: the European Atherosclerosis research study. Talmud PJ, Ye S, Humphries SE, Genet Epidemiol 1994 11 265 80 10.1002/gepi.1370110305 8088507 (Pubitemid 24184735)
67. G to A substitution in the promoter region of the apolipoprotein AI gene is associated with elevated serum apolipoprotein AI and high density lipoprotein cholesterol concentrations. Jeenah M, Kessling A, Miller N, Humphries SE, Mol Biol Med 1990 7 233 41 1977072 (Pubitemid 20283936)
68. Interaction between a polymorphism of the apoA-I promoter region and smoking determines plasma levels of HDL and apoA-I. Sigurdsson G Jr, Gudnason V, Sigurdsson G, Humphries SE, Arterioscler Thromb 1992 12 1017 22 10.1161/01.ATV.12.9.1017 1525115
69. Role of genetic variation at the apoAI-CIII-AIV gene cluster in determining plasma apoA-I levels in boys and girls. Xu CF, Angelico F, Del Ben M, and Humphries SE, Genet Epidermiol 1993 10 113 22 10.1002/gepi.1370100204 (Pubitemid 23180566)
70. Human apolipoprotein A-I gene promoter polymorphism: association with hyperalphalipoproteinemia. Pagani F, Sidoli A, Giudici GA, Barenghi L, Vergani C, Baralle FE, J Lipid Res 1990 31 1371 7 1980685 (Pubitemid 20261901)
71. RFLP studies in different ethnic groups. Humphries S, Talmud P, Monsalve V, McKeigue P, Atherosclerosis 1989 75 249 50 10.1016/0021-9150(89)90183-4 2565722