Low-density lipoprotein triglycerides associated with low-grade systemic inflammation, adhesion molecules, and angiographic coronary artery disease: The Ludwigshafen Risk and Cardiovascular Health Study

Circulation

Volumn 110, Issue 19, 2004, Pages 3068-3074

  März, Winfried ^a   Scharnagl, Hubert ^a   Winkler, Karl ^b   Tiran, Andreas ^a   Nauck, Markus ^b   Boehm, Bernhard O ^c   Winkelmann, Bernhard R ^d  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

^b UNIVERSITY OF FREIBURG   (Germany)

^c UNIVERSITY HOSPITAL ULM   (Germany)

^d UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Cholesterol; Inflammation; Lipoproteins; Triglycerides

Indexed keywords

C REACTIVE PROTEIN; CELL ADHESION MOLECULE; CHOLESTEROL ESTER; FIBRINOGEN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; SERUM AMYLOID A; TRIACYLGLYCEROL; VASCULAR CELL ADHESION MOLECULE 1;

ADULT; AGED; ANGIOCARDIOGRAPHY; ARTICLE; BLOOD VESSEL INJURY; CARDIOVASCULAR RISK; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DISEASE ASSOCIATION; DISEASE MARKER; FEMALE; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INFLAMMATION; LIPOPROTEIN METABOLISM; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL;

AGED; APOLIPOPROTEINS B; C-REACTIVE PROTEIN; CHOLESTEROL ESTERS; COHORT STUDIES; CORONARY DISEASE; CROSS-SECTIONAL STUDIES; DIABETES COMPLICATIONS; FEMALE; GERMANY; HUMANS; INFLAMMATION; INTERCELLULAR ADHESION MOLECULE-1; INTERLEUKIN-6; LIPOPROTEINS; LIPOPROTEINS, HDL; LIPOPROTEINS, IDL; LIPOPROTEINS, LDL; LIPOPROTEINS, VLDL; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; RISK FACTORS; SERUM AMYLOID A PROTEIN; VASCULAR CELL ADHESION MOLECULE-1;

EID: 8444246524     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000146898.06923.80     Document Type: Article

References (28)

1. Libby P. Inflammation in atherosclerosis. Nature. 2002;420:868-874.
2. Ridker PM. Clinical application of C-reactive protein for cardiovascular disease detection and prevention. Circulation. 2003;107:363-369.
3. Koenig W, Sund M, Frohlich M, et al. C-reactive protein, a sensitive marker of inflammation, predicts future risk of coronary heart disease in initially healthy middle-aged men: results from the MONICA (Monitoring Trends and Determinants in Cardiovascular Disease) Augsburg Cohort Study, 1984 to 1992. Circulation. 1999;99:237-242.
4. Ridker PM, Buring JE, Cook NR, et al. C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14 719 initially healthy American women. Circulation. 2003;107: 391-397.
5. Ridker PM, Rifai N, Rose L, et al. Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events. N Engl J Med. 2002;347:1557-1565.
6. Winkelmann BR, März W, Boehm BO, et al. Rationale and design of the LURIC study: a resource for functional genomics, pharmacogenomics and long-term prognosis of cardiovascular disease. Pharmacogenomics. 2001;2:S1-S73.
7. Austen WG, Edwards JE, Frye RL, et al. A reporting system on patients evaluated for coronary artery disease: report of the ad hoc committee for grading of coronary artery disease. Circulation. 1975;50(suppl 5):7-40.
8. American Diabetes Association. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care. 1997; 20:1183-1197.
9. Wanner C, Hörl WH, Luley C, et al. Effects of HMG-CoA reductase inhibitors in hypercholesterolemic patients on hemodialysis. Kidney Int. 1991;31:754-760.
10. Baumstark MW, Kreutz W, Berg A, et al. Structure of human low-density lipoprotein subfractions, determined by x-ray small-angle scattering. Biochim Biophys Acta. 1990;1037:48-57.
11. Winkler K, Wetzka B, Hoffmann MM, et al. Low density lipoprotein (LDL) subfractions during pregnancy: accumulation of buoyant LDL with advancing gestation. J Clin Endocrinol Metab. 2000;85:4543-4550.
12. Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation. 2002;106:3143-3421.
13. Goldberg IJ. Lipoprotein lipase and lipolysis: central roles in lipoprotein metabolism and atherogenesis. J Lipid Res. 1996;37:693-707.
14. Feingold KR, Marshall M, Gulli R, et al. Effect of endotoxin and cytokines on lipoprotein lipase activity in mice. Arterioscler Thromb. 1994; 14:1866-1872.
15. Grunfeld C, Feingold KR. Regulation of lipid metabolism by cytokines during host defense. Nutrition. 1996;12:S24-S26.
16. Feingold KR, Memon RA, Moser AH, et al. Endotoxin and interleukin-1 decrease hepatic lipase mRNA levels. Atherosclerosis. 1999;142: 379-387.
17. Doi H, Kugiyama K, Oka H, et al. Remnant lipoproteins induce proatherothrombogenic molecules in endothelial cells through a redox-sensitive mechanism. Circulation. 2000;102:670-676.
18. Huo Y, Ley K. Adhesion molecules and atherogenesis. Acta Physiol Scand. 2001;173:35-43.
19. Packard CJ. Understanding coronary heart disease as a consequence of defective regulation of apolipoprotein B metabolism. Curr Opin Lipidol. 1999;10:237-244.
20. Gardner CD, Fortmann SP, Krauss RM. Association of small low-density lipoprotein particles with the incidence of coronary artery disease in men and women. JAMA. 1996;276:875-881.
21. Lamarche B, Tchernof A, Moorjani S, et al. Small, dense low-density lipoprotein particles as a predictor of the risk of ischemic heart disease in men: prospective results from the Quebec Cardiovascular Study. Circulation. 1997;95:69-75.
22. Stampfer MJ, Krauss RM, Ma J, et al. A prospective study of triglyceride level, low-density lipoprotein particle diameter, and risk of myocardial infarction. JAMA. 1996;276:882-888.
23. Vakkilainen J, Mäkimattila S, Seppälä-Lindroos A, et al. Endothelial dysfunction in men with small LDL particles. Circulation. 2000;102: 716-721.
24. Campos H, Moye LA, Glasser SP, et al. Low-density lipoprotein size, pravastatin treatment, and coronary events. JAMA. 2001;286:1468-1474.
25. Winkler K, Nauck M, Siekmeier R, et al. Determination of triglycerides in lipoproteins separated by agarose gel electrophoresis. J Lipid Res. 1995;36:1839-1847.
26. Shen MMS, Krauss RM, Lindgren FT, et al. Heterogeneity of serum low density lipoproteins in normal human subjects. J Lipid Res. 1981;22: 236-244.
27. Wolf-Maier K, Cooper RS, Banegas JR, et al. Hypertension prevalence and blood pressure levels in 6 European countries, Canada, and the United States. JAMA. 2003;289:2363-2369.
28. Prevalence of diabetes and impaired fasting glucose in adults - United States, 1999-2000. MMWR Morb Mortal Wkly Rep. 2003;52:833-837.