Linkage Disequilibrium of the Apo AI-CIII-AIV Gene Cluster and Their Relationship to Plasma Triglyceride, Apolipoprotein AI and CIII Levels in Koreans

Molecules and Cells

Volumn 8, Issue 1, 1998, Pages 12-18

  Song, Junghan ^a   Park, Joo Won ^b   Park, Hyosoon ^c   Kim, Jin Q ^a  

^a Seoul National University   (South Korea)

^b Dankook University   (South Korea)

^c Sungkyunkwan University School of Medicine   (South Korea)

Author keywords

Apo AI CIII AIV gene cluster; Ethnic group; Linkage disequilibrium; RFLP

Indexed keywords

APOLIPOPROTEIN A; APOLIPOPROTEIN A-IV; APOLIPOPROTEIN A1; APOLIPOPROTEIN A4; APOLIPOPROTEIN C; APOLIPOPROTEIN C3; TRIACYLGLYCEROL;

ADOLESCENT; ADULT; AGED; ALLELE; ARTICLE; ASIAN; BLOOD; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENETICS; GENOTYPE; HAPLOTYPE; HUMAN; KOREA; MALE; MIDDLE AGED; MULTIGENE FAMILY; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

ADOLESCENT; ADULT; AGED; ALLELES; APOLIPOPROTEIN A-I; APOLIPOPROTEIN C-III; APOLIPOPROTEINS A; APOLIPOPROTEINS C; ASIAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENOTYPE; HAPLOTYPES; HUMANS; KOREA; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; MULTIGENE FAMILY; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; TRIGLYCERIDES;

EID: 0032574004     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Antonarakis, S. E., Oettgen, P., Chakravarti, A., Halloran, S. L., Hudson, R. R., Feisee, L., and Karathanasis, S. K. (1988) DNA polymorphic haplotypes of the human apolipoprotein APOA1-APOC3-APOA4 gene cluster. Hum. Genet. 80, 265-273.
2. Barre, D. E., Guerra, R., Verstraete, R., Wang, Z., Grundy, S. M., and Cohen, J. C. (1994) Genetic analysis of a polymorphism in the human apolipoprotein A-I gene promoter: Effect on plasma HDL-cholesterol levels. J. Lipid. Res. 35, 1292-1296.
3. Botstein, D., White, R.L., Skolnick, M., and Davis, R.W. (1980) Construction of a genetic linkage map in man using restriction fragment length polymorphism. Am. J. Hum. Genet. 32, 314-331.
4. Hong, S. H., Park, W. H., Lee, C. C., Song, J. H., and Kim, J. Q. (1997) Association between genetic variations of apo AI-CIII-AIV cluster gene and hypertriglyceridemic subjects. Clin Chem 43, 13-17.
5. Humphries, S. E., (1988) DNA polymorphisms of the apolipoprotein genes - their use in the investigation of the genetic component of hyperlipidaemia and atherosclerosis. Atherosclerosis 72, 89-108.
6. Jeenah, M., Kessling A., Miller N., and Humphries, S.E. (1990) G to A substitution in the promoter region of the apolipoprotein AI gene is associated with elevated serum apolipoprotein AI and high density lipoprotein cholesterol concentrations. Mol. Biol. Med. 7, 233-241.
7. Karathanasis, S. K. (1985) Apolipoprotein multigene family: Tandem organization of human apolipoprotein AI, CIII and AIV genes. Proc. Natl. Acad. Sci. USA 82, 6374-6378.
8. Kessling, A. M., Rajput-Wiliams, J., Bainton, D., Scott, J., Miller, N. E., Baker, I., and Humphries, S. E. (1988a) DNA polymorphisms of the apolipoprotein AII and AI-CIII-AIV genes: A study in men selected for differences in high-density-lipoprotein cholesterol concentration. Am. J. Hum. Genet. 42, 458-467.
9. Kessling, A. M., Temple, A., Taylor, A., Hutson, J., Hidalgo, A., and Humphries, S. E. (1988b) A PvuII polymorphism in the 5′ flanking region of the apo AIV gene: detection of genetic variation determining apo AI and HDL-cholesterol concentration. Hum. Genet. 78, 237-239.
10. Lee, Y. C., Synn, H. A., Lee, K. Y. Park, Y. H., and Rhee, C. S. (1992) A study on concentrations of serum lipids and food & daily habit of healthy Korean adults. Kor. J. Lipidol. 2, 41-51.
11. Marasco, O., Melina, F., Mele, E., Quaresima, B., Zingone, A., Focarelli, E., Picciotti, E., Martelli, M. L., Fotino, L., Vigna, M. F., Baudi, F., Dominiganni, A., Angotti, E., Pujia, A., Perrotti, N., Colonna, A., Mattioli, P. L., Porcellini, A., Costanzo, F., and Avvedimento, V. E. (1993) Linkage disequilibrium of three polymorphic RFLP markers in the apolipoprotein AI-CIII gene cluster on chromosome 11. Hum. Genet. 91, 169-174.
12. Minnich, A., DeLangavant, G., Lavigne, J., Roederer, G., Lussier-Cacan, S., and Davignon, J. (1995) G → A substitution at position -75 of the apolipoprotein A-I gene promoter: Evidence against a direct effect on HDL cholesterol levels. Arterioscler. Thmmb. Vasc. Biol. 15, 1740-1745.
13. Ordovas, J. M., Civeira, F. Genest, J. Jr., Craig, S., Robbinss, A. H., Meade, T., Pocovi, M., Frossard, P. M., Masharani, U., Wilson, P. W. F. Salem, D. N., Ward, R. H., and Schaefer, E. J. (1991) Restriction fragment length polymorphisms of the apolipoprotein AI, CIII, AIV gene locus. Relationships with lipids, apolipoproteins and premature coronary artery disease. Atherosclerosis 87, 75-86.
14. Pagani, F., Sidoli, A., Giudici, G. A., Barenghi, L., Vergani, C., and Baralle, F. E. (1990) Human apolipoprotein A-I gene promoter polymorphism: association with hyperalphalipo-proteinemia. J. Lipid. Res. 31, 1371-1377.
15. Park Y. S., Kim, H. K., Park, K. S., Kim, S. Y. Park, Y. B., Cho, B. Y. Lee, H. K., Koh, C-S., Min, H. K., Kim, J. Q., Kim, Y. I., Shin, Y. S., and Paik, H. Y. (1993) Community-based epidemiologic study on serum lipid profiles and their interaction with other atherosclerotic cardiovascular risk factors in Yonchon county. Kor. J. Lipidol. 3, 191-203.
16. Paul, H., Galton, D., and Stocks, J. (1987) DNA polymorphic patterns and haplotype arrangements of the apo A-I, apo C-III, apo A-IV gene cluster in different ethnic groups. Hum. Genet. 75, 264-268.
17. Paul-Hayase, H., Rosseneu, M., Robinson, D., Bervliet, J. P. V., Deslypere, J. P., and Humphries, S. E. (1992) Polymorphisms in the apolipoprotein (apo) AI-CIII-AIV gene cluster: detection of genetic variation determining plasma apo AI, apo CIII and apo AIV concentrations. Hum. Genet. 88, 439-446.
18. Rees, A., Stocks, J., Paul, H., Ohuchi, Y., and Galton, D. (1986) Haplotypes identified by DNA polymorphisms at the apolipoprotein A-I and C-III loci and hypertriglyceridemia. A study in a Japanese population. Hum. Genet. 72, 168-171.
19. Rees, A., Stocks, J., Shoulders, C. C., Galton, D. J., and Baralle, F. E. (1983) DNA polymorphism adjacent to human apoprotein A-I gene: relation to hypertriglyceridemia. Lancet I, 444-446.
20. Shoulders, C. C., Harry, P. J., Lagrost, L., White, S. E., Shah, N. F., North, J. D., Gilligan, M., Gambert, P., and Ball, M. J. (1991) Variation at the apo AI/CIII/AIV gene complex is associated with elevated plasma levels of apo CIII. Atherosclerosis 87, 239-247.
21. Smith, J. D., Brinton, E. A., and Breslow, J. L. (1992) Polymorphism in the human apolipoprotein A-I gene promoter region. Association of the minor allele with decreased production rate in vivo and promoter activity in vitro. J. Clin. Invest. 89, 1796-1800.
22. Sun, S. H., Chen, C. C., Lin, S. J., Hong, C. Y., Chaing, B. N., and Sun, G. Y. (1987) An initial screening of serum lipids and fatty acid profiles of hypertensive and normotensive subjecls. Life Science 40, 527-534.
23. Surguchov, A. P., Page, G. P., Smith, L., Patsch, W., and Boerwinkle, E. (1996) Polymorphic markers in apolipoprotein C-III gene flanking regions and hypertriglyceridemia. Arterioscler. Thromb. Vasc. Biol. 16, 941-947.
24. Terwilliger, J. and Oil, J. (1994) Handbook for Human Genetic Linkage. Johns Hopkins Universily Press.
25. Thompson, E. A., Deeb, S., Walker, D., and Motulsky, A.G. (1988) The detection of linkage disequilibrium between closely linked markers: RFLPs at the AI-CIII apolipoprotein genes. Am. J. Hum. Genet. 42, 113-124.
26. Xu, C-F., Nanjee, M. N., Savill, J., Talmud, P., Angelico, F., Del Ben, M., Antonini, R., Muzzarella, B., Miller, N., and Humphries, S. E. (1990) Variation at the apolipoprotein (apo) AI-CIII-AIV gene cluster and apo B gene loci is associated with lipoprotein and apolipoprotein levels in Italian children. Am. J. Hum. Genet. 47, 429-439.
27. Zeng, Q., Dammerman, M., Takada, Y., Matsunaga, A., Breslow, J. L., and Sasaki, J. (1995) An apolipoprotein CIII marker associated with hypertriglyceridemia in Caucasians also confers increased risk in a west Japanese population. Hum. Genet. 95, 361-375.