Lack of association between genetic variations of apo A-I - C-III - A- IV gene cluster and myocardial infarction in a sample of European male: ECTIM study

Atherosclerosis

Volumn 145, Issue 1, 1999, Pages 187-195

  Kee, F ^a   Amouyel, P ^b,c   Fumeron, F ^d   Arveiler, D ^e   Cambou, J P ^f   Evans, A ^a   Cambien, F ^g   Fruchart, J C ^b,h   Ducimetiere P ⁱ   Dallongeville, J ^b  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b INSTITUT PASTEUR DE LILLE   (France)

^c LILLE UNIVERSITY HOSPITAL   (France)

^d Faculté Bichat   (France)

^e UNIVERSITÉ DE STRASBOURG   (France)

^f UNIVERSITÉ DE TOULOUSE   (France)

^g INSERM   (France)

^h UNIV LILLE   (France)

ⁱ HÔPITAL BROUSSAIS   (France)

Author keywords

Apolipoprotein A l; Apolipoprotein A IV; Apolipoprotein C III; Lipids; Lipoproteins; Myocardial infarction

Indexed keywords

APOLIPOPROTEIN A1; APOLIPOPROTEIN A4; APOLIPOPROTEIN C3; LIPOPROTEIN; TRIACYLGLYCEROL;

AGE; ALLELE; ARTICLE; CONTROLLED STUDY; DYSLIPIDEMIA; EUROPE; GENE CLUSTER; GENE LOCUS; GENETIC POLYMORPHISM; GENETIC VARIABILITY; HAPLOTYPE; HEART INFARCTION; HUMAN; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; SEX DIFFERENCE; SMOKING HABIT; SURVIVAL RATE; TRIACYLGLYCEROL BLOOD LEVEL;

ADULT; AGE FACTORS; ALLELES; APOLIPOPROTEIN A-I; APOLIPOPROTEIN C-III; APOLIPOPROTEINS A; APOLIPOPROTEINS C; FRANCE; GENE FREQUENCY; HUMANS; IRELAND; LIPIDS; LIPOPROTEINS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; POLYMORPHISM, GENETIC; SMOKING;

EID: 0033009208     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(99)00066-0     Document Type: Article

References (56)

1. Karathanasis S.K. Apolipoprotein multigene family: tandem organization of human apolipoprotein AI, CIII, and AIV genes. Proc Natl Acad Sci USA. 82:1985;6374-6378.
2. Mahley R.W., Innerarity T.L., Rall S.C.J., Weisgraber K.H. Plasma lipoproteins: apolipoprotein structure and function. J Lipid Res. 25:1984;1277-1294.
3. Green P.H., Glickman R.M., Saudek C.D., Blum C.B., Tall A.R. Human intestinal lipoproteins. Studies in chyluric subjects. J Clin Invest. 64:1979;233-242.
4. Wile D.B., Barbir M., Gallagher J., Myant N.B., Ritchie C.D., Thompson G.R., Humphries S.E. Apolipoprotein A-I gene polymorphisms: frequency in patients with coronary artery disease and healthy controls and association with serum apo A-I and HDL-cholesterol concentration. Atherosclerosis. 78:1989;9-18.
5. Aalto-Setälä K., Kontula K., Sane T., Nieminen M., Nikkila E. DNA polymorphisms of apolipoprotein A-I/C-III and insulin genes in familial hypertriglyceridemia and coronary heart disease. Atherosclerosis. 66:1987;145-152.
6. Ordovas J.M., Schaefer E.J., Salem D., Ward R.H., Glueck C.J., Vergani C., Wilson P.W., Karathanasis S.K. Apolipoprotein A-I gene polymorphism associated with premature coronary artery disease and familial hypoalphalipoproteinemia. New Engl J Med. 314:1986;671-677.
7. Ferns G.A., Stocks J., Ritchie C., Galton D.J. Genetic polymorphisms of apolipoprotein C-III and insulin in survivors of myocardial infarction. Lancet. 2:1985;300-303.
8. Rees A., Stocks J., Williams L.G., Caplin J.L., Jowett N.I., Camm A.J., Galton D.J. DNA polymorphisms in the apolipoprotein C-III and insulin genes and atherosclerosis. Atherosclerosis. 58:1985;269-275.
9. Dammerman M., Sandkuijl L.A., Halaas J.L., Chung W., Breslow J.L. An apolipoprotein CIII haplotype protective against hypertriglyceridemia is specified by promoter and 3′ untranslated region polymorphisms. Proc Natl Acad Sci USA. 90:1993;4562-4566.
10. Xu C.F., Talmud P., Schuster H., Houlston R., Miller G., Humphries S. Association between genetic variation at the APO AI-CIII-AIV gene cluster and familial combined hyperlipidaemia. Clin Genet. 46:1994;385-397.
11. Ribalta J., La Ville A.E., Vallve J.C., Humphries S., Turner P.R., Masana L. A variation in the apolipoprotein C-III gene is associated with an increased number of circulating VLDL and IDL particles in familial combined hyperlipidemia. J Lipid Res. 38:1997;1061-1069.
12. Dallinga-Thie G.M., Bu X.D., van Linde-Sibenius T., Rotter J.I., Lusis A.J., de Bruin T.W. Apolipoprotein A-I/C-III/A-IV gene cluster in familial combined hyperlipidemia: effects on LDL-cholesterol and apolipoproteins B and C- III. J Lipid Res. 37:1996;136-147.
13. Dallinga-Thie G.M., van Linde-Sibenius T., Rotter J.I., Cantor R.M., Bu X., Lusis A.J., de Bruin T.W. Complex genetic contribution of the Apo AI-CIII-AIV gene cluster to familial combined hyperlipidemia. Identification of different susceptibility haplotypes. J Clin Invest. 99:1997;953-961.
14. Ordovas J.M., Civeira F., Genest J.J., Craig S., Robbins A.H., Meade T., Pocovi M., Frossard P.M., Masharani U., Wilson P.W. Restriction fragment length polymorphisms of the apolipoprotein A-I, C-III, A-IV gene locus. Relationships with lipids, apolipoproteins, and premature coronary artery disease. Atherosclerosis. 87:1991;75-86.
15. Talmud P.J., Humphries S.E. Apolipoprotein C-III gene variation and dyslipidaemia. Curr Opin Lipidol. 8:1997;154-158.
16. Kandoussi A., Cachera C., Parsy D., Bard J.M., Fruchart J.C. Quantitative determination of different apolipoprotein B containing lipoproteins by an enzyme linked immunosorbent assay: apo B with apo C-III and apo B with apo E. J Immunoassay. 12:1991;305-323.
17. Leroy A., Dallongeville J., Fruchart J.C. Apolipoprotein A-I-containing lipoproteins and atherosclerosis. Curr Opin Lipidol. 6:1995;281-285.
18. Chivot L., Mainard F., Bigot E., Bard J.M., Auget J.L., Madec Y., Fruchart J.C. Logistic discriminant analysis of lipids and apolipoproteins in a population of coronary bypass patients and the significance of apolipoproteins C-III and E. Atherosclerosis. 82:1990;205-211.
19. Parra H.J., Arveiler D., Evans A.E., Cambou J.P., Amouyel P., Bingham A., McMaster D., Schaffer P., Douste-Blazy P., Luc G. A case-control study of lipoprotein particles in two populations at contrasting risk for coronary heart disease. The ECTIM Study. Arterioscler Thromb. 12:1992;701-707.
20. Leroy A., Vu-dac N., Koffigan M., Clavey V., Fruchart J.C. Characterization of a monoclonal antibody that binds to apolipoprotein E and to lipoprotein of human plasma containing apo E. Applications to ELISA quantification of plasma apo E. J Immunoassay. 9:1988;309-334.
21. Parsy D., Clavey V., Fievet C., Kora I., Duriez P., Fruchart J.C. Quantification of apolipoprotein C-III in serum by a non-competitive immunoenzymometric assay. Clin Chem. 31:1985;1632-1635.
22. Parra H.J., Mezdour H., Ghalim N., Bard J.M., Fruchart J.C. Differential electroimmunoassay of human LpA-I lipoprotein particles on ready-to-use plates. Clin Chem. 36:1990;1431-1435. see comments.
23. Kessling A.M., Horsthemke B., Humphries S.E. A study of DNA polymorphisms around the human apolipoprotein AI gene in hyperlipidaemic and normal individuals. Clin Genet. 28:1985;296-306.
24. Karathanasis S.K., Oettgen P., Haddad I.A., Antonarakis S.E. Structure, evolution, and polymorphisms of the human apolipoprotein A4 gene (APOA4). Proc Natl Acad Sci USA. 83:1986;8457-8461.
25. Hixson J.E., Vernier D.T., Powers P.K. Detection of SstI restriction site polymorphism in human APOC3 by the polymerase chain reaction. Nucleic Acids Res. 19:1991;196.
26. MacLean C.J., Morton N.E. Estimation of myriad haplotype frequencies. Genet Epidemiol. 2:1985;263-272.
27. Cox N.J., Bell G.I., Xiang K.S. Linkage disequilibrium in the human insulin/insulin-like growth factor II region of human chromosome II. Am J Hum Genet. 43:1988;495-501.
28. Benlian P., Boileau C., Loux N., Pastier D., Masliah J., Coulon M., Nigou M., Ragab A., Guimard J., Ruidavets J.B. Extended haplotypes and linkage disequilibrium between 11 markers at the APOA1-C3-A4 gene cluster on chromosome 11. Am J Hum Genet. 48:1991;903-910.
29. Shoulders C.C., Grantham T.T., North J.D., Gaspardone A., Tomai F., de Fazio A., Versaci F., Gioffre P.A., Cox N.J. Hypertriglyceridemia and the apolipoprotein CIII gene locus: lack of association with the variant insulin response element in Italian school children. Hum Genet. 98:1996;557-566.
30. Wick U., Witt E., Engel W. Restriction fragment length polymorphisms at the apoprotein genes AI, CIII and B-100 and in the 5′ flanking region of the insulin gene as possible markers of coronary heart disease. Clin Genet. 47:1995;184-190.
31. Porkka K.V., Taimela S., Kontula K., Lehtimaki T., Aalto-Setala K., Akerblom H.K., Viikari J.S. Variability gene effects of DNA polymorphisms at the apo B, apo A I/C III and apo E loci on serum lipids: the Cardiovascular Risk in Young Finns Study. Clin Genet. 45:1994;113-121.
32. Tiret L., de Knijff P., Menzel H.J., Ehnholm C., Nicaud V., Havekes L.M. ApoE polymorphism and predisposition to coronary heart disease in youths of different European populations. The EARS Study. European Atherosclerosis Research Study. Arterioscler Thromb. 14:1994;1617-1624.
33. Luc G., Bard J.M., Arveiler D., Evans A., Cambou J.P., Bingham A., Amouyel P., Schaffer P., Ruidavets J.B., Cambien F. Impact of apolipoprotein E polymorphism on lipoproteins and risk of myocardial infarction. The ECTIM Study. Arterioscler Thromb. 14:1994;1412-1419.
34. Peacock R.E., Hamsten A., Johansson J., Nilsson-Ehle P., Humphries S.E. Associations of genotypes at the apolipoprotein AI-CIII-AIV, apolipoprotein B and lipoprotein lipase gene loci with coronary atherosclerosis and high density lipoprotein subclasses. Clin Genet. 46:1994;273-282.
35. Tybjaerg-Hansen A., Nordestgaard B.G., Gerdes L.U., Faergeman O., Humphries S.E. Genetic markers in the apo AI-CIII-AIV gene cluster for combined hyperlipidemia, hypertriglyceridemia, and predisposition to atherosclerosis. Atherosclerosis. 100:1993;157-169.
36. Anderson R.A., Benda T.J., Wallace R.B., Eliason S.L., Lee J., Burns T.L. Prevalence and associations of apolipoprotein A-I linked DNA polymorphisms: results from a population study. Genet Epidemiol. 3:1986;385-397.
37. Bai H., Saku K., Liu R., Imamura M., Arakawa K. Association between coronary heart disease and the apolipoprotein A-I/C-III/A-IV complex in a Japanese population. Hum Genet. 95:1995;102-104.
38. Morris S.W., Price W.H. DNA sequence polymorphisms in the apolipoprotein A-I/C-III gene cluster. Lancet. 2:1985;1127-1128. Letter.
39. Rees A., Stocks J., Sharpe C.R., Vella M.A., Shoulders C.C., Katz J., Jowett N.I., Baralle F.E., Galton D.J. Deoxyribonucleic acid polymorphism in the apolipoprotein A-1-C-III gene cluster. Association with hypertriglyceridemia. J Clin Invest. 76:1985;1090-1095.
40. Paul H., Galton D., Stocks J. DNA polymorphic patterns and haplotype arrangements of the apo A-1, apo C-III, apo A-IV gene cluster in different ethnic groups. Hum Genet. 75:1987;264-268.
41. Antonarakis S.E., Oettgen P., Chakravarti A., Halloran S.L., Hudson R.R., Feisee L., Karathanasis S.K. DNA polymorphism haplotypes of the human apolipoprotein APOA1-APOC3-APOA4 gene cluster. Hum Genet. 80:1988;265-273.
42. Paul-Hayase H., Rosseneu M., Robinson D., Van Bervliet J.P., Deslypere J.P., Humphries S.E. Polymorphisms in the apolipoprotein (apo) AI-CIII-AIV gene cluster: detection of genetic variation determining plasma apo AI, apo CIII and apo AIV concentrations. Hum Genet. 88:1992;439-446.
43. Myklebost O., Rogne S., Hjermann I., Olaisen B., Prydz H. Association analysis of lipid levels and apolipoprotein restriction fragment length polymorphisms. Hum Genet. 86:1990;209-214.
44. Peacock R.E., Temple A., Gudnason V., Rosseneu M., Humphries S.E. Variation at the lipoprotein lipase and apolipoprotein AI-CIII gene loci are associated with fasting lipid and lipoprotein traits in a population sample from Iceland: interaction between genotype, gender, and smoking status. Genet Epidemiol. 14:1997;265-282.
45. Patsch W., Sharrett A.R., Chen I.Y., Lin-Lee Y.C., Brown S.A., Gotto A.M.J., Boerwinkle E. Associations of allelic differences at the A-I/C-III/A-IV gene cluster with carotid artery intima-media thickness and plasma lipid transport in hypercholesterolemic-hypertriglyceridemic humans. Arterioscler Thromb. 14:1994;874-883.
46. Xu C.F., Angelico F., Del Ben M., Humphries S. Role of genetic variation at the apo AI-CIII-AIV gene cluster in determining plasma apo AI levels in boys and girls. Genet Epidemiol. 10:1993;113-122.
47. Oppert J.M., Fumeron F., Moreel J.F., Apfelbaum M. Association of a DNA polymorphism of the apolipoprotein A-I/C-III/A-IV gene cluster with hypertriglyceridemia in obese people. Int J Obes Relat Metab Disord. 16:1992;891-896.
48. Sigurdsson G.J., Gudnason V., Sigurdsson G., Humphries S.E. Interaction between a polymorphism of the apo A-I promoter region and smoking determines plasma levels of HDL and apo A-I. Arterioscler Thromb. 12:1992;1017-1022.
49. Kessling A., Ouellette S., Bouffard O., Chamberland A., Betard C., Selinger E., Xhignesse M., Lussier-Cacan S., Davignon J. Patterns of association between genetic variability in apolipoprotein (apo) B, apo AI-CIII-AIV, and cholesterol ester transfer protein gene regions and quantitative variation in lipid and lipoprotein traits: influence of gender and exogenous hormones. Am J Hum Genet. 50:1992;92-106.
50. Anderson R.A., Burns T.L., Lee J., Swenson D., Bristow J.L. Restriction fragment length polymorphisms associated with abnormal lipid levels in an adolescent population. Atherosclerosis. 77:1989;227-237.
51. Tas S. Strong association of a single nucleotide substitution in the 3′-untranslated region of the apolipoprotein-CIII gene with common hypertriglyceridemia in Arabs. Clin Chem. 35:1989;256-259.
52. Monsalve M.V., Young R., Wiseman S.A., Dhamu S., Powell J.T., Greenhalgh R.M., Humphries S.E. Study of DNA polymorphisms of the apolipoprotein AI-CIII-AIV gene cluster in patients with peripheral arterial disease. Clin Sci. 76:1989;221-228.
53. Kessling A.M., Rajput-Wiliams J., Bainton D., Scott J., Miller N.E., Baker I., Humphries S.E. DNA polymorphisms of the apolipoprotein AII and AI-CIII-AIV genes: a study in men selected for differences in high-density-lipoprotein cholesterol concentration. Am J Hum Genet. 42:1988;458-467.
54. Hegele R.A., Connelly P.W., Hanley A.J., Sun F., Harris S.B., Zinman B. Common genomic variants associated with variation in plasma lipoproteins in young aboriginal Canadians. Arterioscler Thromb Vasc Biol. 17:1997;1060-1066.
55. Tas S. Genetic predisposition to coronary heart disease and gene for apolipoprotein-CIII. Lancet. 337:1991;113-114. Letter.
56. Dallongeville J., Lussier-Cacan S., Davignon J. Modulation of plasma triglyceride levels by apoE phenotype: a meta-analysis. J Lipid Res. 33:1992;447-454.