메뉴 건너뛰기




Volumn 6, Issue 5, 2011, Pages 411-418

Generalized immune activation and innate immune responses in simian immunodeficiency virus infection

Author keywords

African green monkey; chronic immune activation; HIV; IFNa; innate immunity; interferon stimulated genes; plasmacytoid dendritic cells; review; simian immunodeficiency virus; sooty mangabey type I interferon

Indexed keywords

INTERFERON;

EID: 80051786980     PISSN: 1746630X     EISSN: 17466318     Source Type: Journal    
DOI: 10.1097/COH.0b013e3283499cf6     Document Type: Review
Times cited : (55)

References (58)
  • 1
    • 67650711146 scopus 로고    scopus 로고
    • Lessons learned from the natural hosts of HIV-related viruses
    • Paiardini M, Pandrea I, Apetrei C, et al. Lessons learned from the natural hosts of HIV-related viruses. Annu Rev Med 2009; 60:485-495.
    • (2009) Annu Rev Med , vol.60 , pp. 485-495
    • Paiardini, M.1    Pandrea, I.2    Apetrei, C.3
  • 2
    • 77953901782 scopus 로고    scopus 로고
    • Nonprogressive and progressive primate immunodeficiency lentivirus infections
    • Brenchley JM, Silvestri G, Douek DC. Nonprogressive and progressive primate immunodeficiency lentivirus infections. Immunity 2010; 32:737-742.
    • (2010) Immunity , vol.32 , pp. 737-742
    • Brenchley, J.M.1    Silvestri, G.2    Douek, D.C.3
  • 3
    • 67749145263 scopus 로고    scopus 로고
    • Increased mortality and AIDS-like immunopathology in wild chimpanzees infected with SIVcpz
    • Keele BF, Jones JH, Terio KA, et al. Increased mortality and AIDS-like immunopathology in wild chimpanzees infected with SIVcpz. Nature 2009; 460:515-519.
    • (2009) Nature , vol.460 , pp. 515-519
    • Keele, B.F.1    Jones, J.H.2    Terio, K.A.3
  • 4
    • 0023694580 scopus 로고
    • AIDS as immune system activation: A model for pathogenesis
    • Ascher MS, Sheppard HW. AIDS as immune system activation: a model for pathogenesis. Clin Exp Immunol 1988; 73:165-167.
    • (1988) Clin Exp Immunol , vol.73 , pp. 165-167
    • Ascher, M.S.1    Sheppard, H.W.2
  • 5
    • 0027373516 scopus 로고
    • From HIV infection to AIDS: Are the manifestations of effective immune resistance misinterpreted?
    • DOI 10.1006/clin.1993.1160
    • Grossman Z, Bentwich Z, Herberman RB. From HIV infection to AIDS: are the manifestations of effective immune resistance misinterpreted? Clin Immunol Immunopathol 1993; 69:123-135. (Pubitemid 23319378)
    • (1993) Clinical Immunology and Immunopathology , vol.69 , Issue.2 , pp. 123-135
    • Grossman, Z.1    Bentwich, Z.2    Herberman, R.B.3
  • 6
    • 0030915369 scopus 로고    scopus 로고
    • T-cell homeostasis in HIV infection is neither failing nor blind: Modified cell counts reflect an adaptive response of the host
    • Grossman Z, Herberman RB. T-cell homeostasis in HIV infection is neither failing nor blind: modified cell counts reflect an adaptive response of the host. Nat Med 1997; 3:486-490. (Pubitemid 27198637)
    • (1997) Nature Medicine , vol.3 , Issue.5 , pp. 486-490
    • Grossman, Z.1    Herberman, R.B.2
  • 8
    • 0037343278 scopus 로고    scopus 로고
    • Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia
    • DOI 10.1016/S1074-7613(03)00060-8
    • Silvestri G, Sodora DL, Koup RA, et al. Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia. Immunity 2003; 18:441-452. (Pubitemid 36351522)
    • (2003) Immunity , vol.18 , Issue.3 , pp. 441-452
    • Silvestri, G.1    Sodora, D.L.2    Koup, R.A.3    Paiardini, M.4    O'Neil, S.P.5    McClure, H.M.6    Staprans, S.I.7    Feinberg, M.B.8
  • 9
    • 39849096860 scopus 로고    scopus 로고
    • Immune activation and AIDS pathogenesis
    • DOI 10.1097/QAD.0b013e3282f2dbe7, PII 0000203020080219000001
    • Sodora DL, Silvestri G. Immune activation and AIDS pathogenesis. AIDS 2008; 22:439-446. (Pubitemid 351317285)
    • (2008) AIDS , vol.22 , Issue.4 , pp. 439-446
    • Sodora, D.L.1    Silvestri, G.2
  • 10
    • 68349157582 scopus 로고    scopus 로고
    • Toward an AIDS vaccine: Lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts
    • Sodora DL, Allan JS, Apetrei C, et al. Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts. Nat Med 2009; 15:861-865.
    • (2009) Nat Med , vol.15 , pp. 861-865
    • Sodora, D.L.1    Allan, J.S.2    Apetrei, C.3
  • 11
    • 63449124466 scopus 로고    scopus 로고
    • Emerging concepts in the immunopathogenesis of AIDS
    • Douek DC, Roederer M, Koup RA. Emerging concepts in the immunopathogenesis of AIDS. Annu Rev Med 2009; 60:471-484.
    • (2009) Annu Rev Med , vol.60 , pp. 471-484
    • Douek, D.C.1    Roederer, M.2    Koup, R.A.3
  • 12
    • 17644372733 scopus 로고    scopus 로고
    • IPC: Professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors
    • Liu YJ. IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Annu Rev Immunol 2005; 23:275-306.
    • (2005) Annu Rev Immunol , vol.23 , pp. 275-306
    • Liu, Y.J.1
  • 15
    • 0035179882 scopus 로고    scopus 로고
    • Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells
    • DOI 10.1002/1521-4141(200111)31:11<3388::AID-IMMU3388>3.0.CO;2-Q
    • Jarrossay D, Napolitani G, Colonna M, et al. Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells. Eur J Immunol 2001; 31:3388-3393. (Pubitemid 33100532)
    • (2001) European Journal of Immunology , vol.31 , Issue.11 , pp. 3388-3393
    • Jarrossay, D.1    Napolitani, G.2    Colonna, M.3    Sallusto, F.4    Lanzavecchia, A.5
  • 18
    • 0035881860 scopus 로고    scopus 로고
    • Cutting edge: Selective usage of chemokine receptors by plasmacytoid dendritic cells
    • Penna G, Sozzani S, Adorini L. Cutting edge: selective usage of chemokine receptors by plasmacytoid dendritic cells. J Immunol 2001; 167:1862-1866. (Pubitemid 32747488)
    • (2001) Journal of Immunology , vol.167 , Issue.4 , pp. 1862-1866
    • Penna, G.1    Sozzani, S.2    Adorini, L.3
  • 19
    • 0036931501 scopus 로고    scopus 로고
    • Natural type 1 interferon producing cells in HIV infection
    • DOI 10.1016/S0198-8859(02)00760-7, PII S0198885902007607
    • Soumelis V, Scott I, Liu YJ, et al. Natural type 1 interferon producing cells in HIV infection. Hum Immunol 2002; 63:1206-1212. (Pubitemid 36025996)
    • (2002) Human Immunology , vol.63 , Issue.12 , pp. 1206-1212
    • Soumelis, V.1    Scott, I.2    Liu, Y.-J.3    Levy, J.4
  • 20
    • 34547665291 scopus 로고    scopus 로고
    • Disparate effects of acute and chronic infection with SIVmac239 or SHIV-89.6P on macaque plasmacytoid dendritic cells
    • DOI 10.1016/j.virol.2007.03.055, PII S0042682207002371
    • Reeves RK, Fultz PN. Disparate effects of acute and chronic infection with SIVmac239 or SHIV-89.6P on macaque plasmacytoid dendritic cells. Virology 2007; 365:356-368. (Pubitemid 47223317)
    • (2007) Virology , vol.365 , Issue.2 , pp. 356-368
    • Reeves, R.K.1    Fultz, P.N.2
  • 21
    • 34249774578 scopus 로고    scopus 로고
    • Parallel loss of myeloid and plasmacytoid dendritic cells from blood and lymphoid tissue in simian AIDS
    • Brown KN, Trichel A, Barratt-Boyes SM. Parallel loss of myeloid and plasmacytoid dendritic cells from blood and lymphoid tissue in simian AIDS. J Immunol 2007; 178:6958-6967. (Pubitemid 46847422)
    • (2007) Journal of Immunology , vol.178 , Issue.11 , pp. 6958-6967
    • Brown, K.N.1    Trichel, A.2    Barratt-Boyes, S.M.3
  • 23
    • 58149380860 scopus 로고    scopus 로고
    • Primary infection with simian immunodeficiency virus: Plasmacytoid dendritic cell homing to lymph nodes, type i interferon, and immune suppression
    • Malleret B, Maneglier B, Karlsson I, et al. Primary infection with simian immunodeficiency virus: plasmacytoid dendritic cell homing to lymph nodes, type I interferon, and immune suppression. Blood 2008; 112: 4598-4608.
    • (2008) Blood , vol.112 , pp. 4598-4608
    • Malleret, B.1    Maneglier, B.2    Karlsson, I.3
  • 24
    • 67249117245 scopus 로고    scopus 로고
    • Rapid influx and death of plasmacytoid dendritic cells in lymph nodes mediate depletion in acute simian immunodeficiency virus infection
    • Brown KN, Wijewardana V, Liu X, et al. Rapid influx and death of plasmacytoid dendritic cells in lymph nodes mediate depletion in acute simian immunodeficiency virus infection. PLoS Pathog 2009; 5:e1000413.
    • (2009) PLoS Pathog , vol.5
    • Brown, K.N.1    Wijewardana, V.2    Liu, X.3
  • 25
    • 53549103852 scopus 로고    scopus 로고
    • Divergent TLR7 and TLR9 signaling and type i interferon production distinguish pathogenic and nonpathogenic AIDS virus infections
    • Mandl JN, Barry AP, Vanderford TH, et al. Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections. Nat Med 2008; 14:1077-1087.
    • (2008) Nat Med , vol.14 , pp. 1077-1087
    • Mandl, J.N.1    Barry, A.P.2    Vanderford, T.H.3
  • 26
    • 0036316023 scopus 로고    scopus 로고
    • The relationship between simian immunodeficiency virus RNA levels and the mRNA levels of alpha/beta interferons (IFN-α/β) and IFN-α/β-inducible Mx in lymphoid tissues of rhesus macaques during acute and chronic infection
    • DOI 10.1128/JVI.76.16.8433-8445.2002
    • Abel K, Alegria-Hartman MJ, Rothaeusler K, et al. The relationship between simian immunodeficiency virus RNA levels and the mRNA levels of alpha/beta interferons (IFN-alpha/beta) and IFN-alpha/beta-inducible Mx in lymphoid tissues of rhesus macaques during acute and chronic infection. J Virol 2002; 76:8433-8445. (Pubitemid 34809095)
    • (2002) Journal of Virology , vol.76 , Issue.16 , pp. 8433-8445
    • Abel, K.1    Alegria-Hartman, M.J.2    Rothaeusler, K.3    Marthas, M.4    Miller, C.J.5
  • 30
    • 70449713657 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells express TRAIL and induce CD4+ T-cell apoptosis in HIV-1 viremic patients
    • Stary G, Klein I, Kohlhofer S, et al. Plasmacytoid dendritic cells express TRAIL and induce CD4+ T-cell apoptosis in HIV-1 viremic patients. Blood 2009; 114:3854-3863.
    • (2009) Blood , vol.114 , pp. 3854-3863
    • Stary, G.1    Klein, I.2    Kohlhofer, S.3
  • 31
    • 55849140547 scopus 로고    scopus 로고
    • HIV-activated human plasmacytoid DCs induce Tregs through an indoleamine 2, 3-dioxygenase-dependent mechanism
    • Manches O, Munn D, Fallahi A, et al. HIV-activated human plasmacytoid DCs induce Tregs through an indoleamine 2, 3-dioxygenase-dependent mechanism. J Clin Invest 2008; 118:3431-3439.
    • (2008) J Clin Invest , vol.118 , pp. 3431-3439
    • Manches, O.1    Munn, D.2    Fallahi, A.3
  • 32
    • 80051798291 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells are recruited to the colorectum and contribute to immune activation during pathogenic SIV infection in rhesus macaques
    • [Epub ahead of print] doi: 10.1182/blood-2011-02-339515
    • Kwa S, Kannanganat S, Nigam P, et al. Plasmacytoid dendritic cells are recruited to the colorectum and contribute to immune activation during pathogenic SIV infection in rhesus macaques. Blood 2011; [Epub ahead of print] doi: 10.1182/blood-2011-02-339515.
    • (2011) Blood
    • Kwa, S.1    Kannanganat, S.2    Nigam, P.3
  • 34
    • 79251555316 scopus 로고    scopus 로고
    • Blocking of alpha4beta7 gut-homing integrin during acute infection leads to decreased plasma and gastrointestinal tissue viral loads in simian immunodeficiency virus-infected rhesus macaques
    • Ansari AA, Reimann KA, Mayne AE, et al. Blocking of alpha4beta7 gut-homing integrin during acute infection leads to decreased plasma and gastrointestinal tissue viral loads in simian immunodeficiency virus-infected rhesus macaques. J Immunol 2011; 186:1044-1059.
    • (2011) J Immunol , vol.186 , pp. 1044-1059
    • Ansari, A.A.1    Reimann, K.A.2    Mayne, A.E.3
  • 35
    • 77955144402 scopus 로고    scopus 로고
    • In acute pathogenic SIV infection plasmacytoid dendritic cells are depleted from blood and lymph nodes despite mobilization
    • Barratt-Boyes SM, Wijewardana V, Brown KN. In acute pathogenic SIV infection plasmacytoid dendritic cells are depleted from blood and lymph nodes despite mobilization. J Med Primatol 2010; 39:235-242.
    • (2010) J Med Primatol , vol.39 , pp. 235-242
    • Barratt-Boyes, S.M.1    Wijewardana, V.2    Brown, K.N.3
  • 36
    • 78650623074 scopus 로고    scopus 로고
    • SIV infection in natural hosts: Resolution of immune activation during the acute-to-chronic transition phase
    • Mir KD, Gasper MA, Sundaravaradan V, et al. SIV infection in natural hosts: resolution of immune activation during the acute-to-chronic transition phase. Microbes Infect 2011; 13:14-24.
    • (2011) Microbes Infect , vol.13 , pp. 14-24
    • Mir, K.D.1    Gasper, M.A.2    Sundaravaradan, V.3
  • 37
    • 68349131723 scopus 로고    scopus 로고
    • Sex differences in the Toll-like receptormediated response of plasmacytoid dendritic cells to HIV-1
    • Meier A, Chang JJ, Chan ES, et al. Sex differences in the Toll-like receptormediated response of plasmacytoid dendritic cells to HIV-1. Nat Med 2009; 15:955-959.
    • (2009) Nat Med , vol.15 , pp. 955-959
    • Meier, A.1    Chang, J.J.2    Chan, E.S.3
  • 38
    • 78149442321 scopus 로고    scopus 로고
    • Evidence of dysregulation of dendritic cells in primary HIV infection
    • Sabado RL, O'Brien M, Subedi A, et al. Evidence of dysregulation of dendritic cells in primary HIV infection. Blood 2010; 116:3839-3852.
    • (2010) Blood , vol.116 , pp. 3839-3852
    • Sabado, R.L.1    O'Brien, M.2    Subedi, A.3
  • 39
    • 79952234401 scopus 로고    scopus 로고
    • Spatiotemporal trafficking of HIV in human plasmacytoid dendritic cells defines a persistently IFN-alpha-producing and partially matured phenotype
    • O'Brien M, Manches O, Sabado RL, et al. Spatiotemporal trafficking of HIV in human plasmacytoid dendritic cells defines a persistently IFN-alpha-producing and partially matured phenotype. J Clin Invest 2011; 121:1088-1101.
    • (2011) J Clin Invest , vol.121 , pp. 1088-1101
    • O'Brien, M.1    Manches, O.2    Sabado, R.L.3
  • 40
    • 79952132247 scopus 로고    scopus 로고
    • DCs and NK cells: Critical effectors in the immune response to HIV-1
    • Altfeld M, Fadda L, Frleta D, et al. DCs and NK cells: critical effectors in the immune response to HIV-1. Nat Rev Immunol 2011; 11:176-186.
    • (2011) Nat Rev Immunol , vol.11 , pp. 176-186
    • Altfeld, M.1    Fadda, L.2    Frleta, D.3
  • 41
    • 78149444740 scopus 로고    scopus 로고
    • HIV and DC: Hate at first sight
    • Boasso A. HIV and DC: hate at first sight. Blood 2010; 116:3687-3689.
    • (2010) Blood , vol.116 , pp. 3687-3689
    • Boasso, A.1
  • 42
    • 72849132344 scopus 로고    scopus 로고
    • Global genomic analysis reveals rapid control of a robust innate response in SIV-infected sooty mangabeys
    • Bosinger SE, Li Q, Gordon SN, et al. Global genomic analysis reveals rapid control of a robust innate response in SIV-infected sooty mangabeys. J Clin Invest 2009; 119:3556-3572.
    • (2009) J Clin Invest , vol.119 , pp. 3556-3572
    • Bosinger, S.E.1    Li, Q.2    Gordon, S.N.3
  • 43
    • 72849136282 scopus 로고    scopus 로고
    • Nonpathogenic SIV infection of African green monkeys induces a strong but rapidly controlled type i IFN response
    • Jacquelin B, Mayau V, Targat B, et al. Nonpathogenic SIV infection of African green monkeys induces a strong but rapidly controlled type I IFN response. J Clin Invest 2009; 119:3544-3555.
    • (2009) J Clin Invest , vol.119 , pp. 3544-3555
    • Jacquelin, B.1    Mayau, V.2    Targat, B.3
  • 44
    • 61449229744 scopus 로고    scopus 로고
    • Transcriptional profiling in pathogenic and nonpathogenic SIV infections reveals significant distinctions in kinetics and tissue compartmentalization
    • Lederer S, Favre D, Walters KA, et al. Transcriptional profiling in pathogenic and nonpathogenic SIV infections reveals significant distinctions in kinetics and tissue compartmentalization. PLoS Pathog 2009; 5:e1000296.
    • (2009) PLoS Pathog , vol.5
    • Lederer, S.1    Favre, D.2    Walters, K.A.3
  • 45
    • 61449115882 scopus 로고    scopus 로고
    • Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection
    • Favre D, Lederer S, Kanwar B, et al. Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection. PLoS Pathog 2009; 5:e1000295.
    • (2009) PLoS Pathog , vol.5
    • Favre, D.1    Lederer, S.2    Kanwar, B.3
  • 46
    • 77954498359 scopus 로고    scopus 로고
    • Downregulation of robust acute type i interferon responses distinguishes nonpathogenic simian immunodeficiency virus (SIV) infection of natural hosts from pathogenic SIV infection of rhesus macaques
    • Harris LD, Tabb B, Sodora DL, et al. Downregulation of robust acute type I interferon responses distinguishes nonpathogenic simian immunodeficiency virus (SIV) infection of natural hosts from pathogenic SIV infection of rhesus macaques. J Virol 2010; 84:7886-7891.
    • (2010) J Virol , vol.84 , pp. 7886-7891
    • Harris, L.D.1    Tabb, B.2    Sodora, D.L.3
  • 47
    • 75449089285 scopus 로고    scopus 로고
    • Nonpathogenesis of simian immunodeficiency virus infection is associated with reduced inflammation and recruitment of plasmacytoid dendritic cells to lymph nodes, not to lack of an interferon type i response, during the acute phase
    • Campillo-Gimenez L, Laforge M, Fay M, et al. Nonpathogenesis of simian immunodeficiency virus infection is associated with reduced inflammation and recruitment of plasmacytoid dendritic cells to lymph nodes, not to lack of an interferon type I response, during the acute phase. J Virol 2010; 84:1838-1846.
    • (2010) J Virol , vol.84 , pp. 1838-1846
    • Campillo-Gimenez, L.1    Laforge, M.2    Fay, M.3
  • 48
    • 72849144270 scopus 로고    scopus 로고
    • Resolution of immune activation defines nonpathogenic SIV infection
    • Manches O, Bhardwaj N. Resolution of immune activation defines nonpathogenic SIV infection. J Clin Invest 2009; 119:3512-3515.
    • (2009) J Clin Invest , vol.119 , pp. 3512-3515
    • Manches, O.1    Bhardwaj, N.2
  • 49
    • 38849134878 scopus 로고    scopus 로고
    • + T-cell activation and depletion in human immunodeficiency virus type 1 infection: Type I interferon-mediated disruption of T-cell dynamics
    • DOI 10.1128/JVI.02228-07
    • Sedaghat AR, German J, Teslovich TM, et al. Chronic CD4+ T-cell activation and depletion in human immunodeficiency virus type 1 infection: type I interferon-mediated disruption of T-cell dynamics. J Virol 2008; 82:1870-1883. (Pubitemid 351206935)
    • (2008) Journal of Virology , vol.82 , Issue.4 , pp. 1870-1883
    • Sedaghat, A.R.1    German, J.2    Teslovich, T.M.3    Cofrancesco Jr., J.4    Jie, C.C.5    Talbot Jr., C.C.6    Siliciano, R.F.7
  • 51
    • 79957912712 scopus 로고    scopus 로고
    • Comparative transcriptomics of extreme phenotypes of human HIV-1 infection and SIV infection in sooty mangabey and rhesus macaque
    • Rotger M, Dalmau J, Rauch A, et al. Comparative transcriptomics of extreme phenotypes of human HIV-1 infection and SIV infection in sooty mangabey and rhesus macaque. J Clin Invest 2011; 121:2391-2400.
    • (2011) J Clin Invest , vol.121 , pp. 2391-2400
    • Rotger, M.1    Dalmau, J.2    Rauch, A.3
  • 52
    • 36048989674 scopus 로고    scopus 로고
    • Virally induced CD4+ T cell depletion is not sufficient to induce AIDS in a natural host
    • Milush JM, Reeves JD, Gordon SN, et al. Virally induced CD4+ T cell depletion is not sufficient to induce AIDS in a natural host. J Immunol 2007; 179:3047-3056.
    • (2007) J Immunol , vol.179 , pp. 3047-3056
    • Milush, J.M.1    Reeves, J.D.2    Gordon, S.N.3
  • 53
    • 79952236823 scopus 로고    scopus 로고
    • Lack of clinical AIDS in SIVinfected sooty mangabeys with significant CD4+T cell loss is associated with double-negative T cells
    • Milush JM, Mir KD, Sundaravaradan V, et al. Lack of clinical AIDS in SIVinfected sooty mangabeys with significant CD4+T cell loss is associated with double-negative T cells. J Clin Invest 2011; 121:1102-1110.
    • (2011) J Clin Invest , vol.121 , pp. 1102-1110
    • Milush, J.M.1    Mir, K.D.2    Sundaravaradan, V.3
  • 54
    • 77951990027 scopus 로고    scopus 로고
    • A five-year longitudinal analysis of sooty mangabeys naturally infected with simian immunodeficiency virus reveals a slow but progressive decline in CD4+ T-cell count whose magnitude is not predicted by viral load or immune activation
    • Taaffe J, Chahroudi A, Engram J, et al. A five-year longitudinal analysis of sooty mangabeys naturally infected with simian immunodeficiency virus reveals a slow but progressive decline in CD4+ T-cell count whose magnitude is not predicted by viral load or immune activation. J Virol 2010; 84:5476-5484.
    • (2010) J Virol , vol.84 , pp. 5476-5484
    • Taaffe, J.1    Chahroudi, A.2    Engram, J.3
  • 55
    • 0141458813 scopus 로고    scopus 로고
    • +-T-cell profiles during the asymptomatic phase of simian immunodeficiency virus SIVmac251 infection in rhesus macaques
    • DOI 10.1128/JVI.77.18.10047-10059.2003
    • +-T-cell profiles during the asymptomatic phase of simian immunodeficiency virus SIVmac251 infection in rhesus macaques. J Virol 2003; 77:10047-10059. (Pubitemid 37122086)
    • (2003) Journal of Virology , vol.77 , Issue.18 , pp. 10047-10059
    • Monceaux, V.1    Ho Tsong Fang, R.2    Cumont, M.C.3    Hurtrel, B.4    Estaquier, J.5
  • 56
    • 35448976736 scopus 로고    scopus 로고
    • Severe depletion of mucosal CD4+ T cells in AIDS-free simian immunodeficiency virus-infected sooty mangabeys
    • Gordon SN, Klatt NR, Bosinger SE, et al. Severe depletion of mucosal CD4+ T cells in AIDS-free simian immunodeficiency virus-infected sooty mangabeys. J Immunol 2007; 179:3026-3034.
    • (2007) J Immunol , vol.179 , pp. 3026-3034
    • Gordon, S.N.1    Klatt, N.R.2    Bosinger, S.E.3
  • 57
    • 77956497003 scopus 로고    scopus 로고
    • A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells
    • Manel N, Hogstad B, Wang Y, et al. A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells. Nature 2010; 467:214-217.
    • (2010) Nature , vol.467 , pp. 214-217
    • Manel, N.1    Hogstad, B.2    Wang, Y.3
  • 58
    • 79960131812 scopus 로고    scopus 로고
    • Low levels of SIV infection in sooty mangabey central-memory CD4+ T-cells is associated with limited CCR5 expression
    • in press
    • Paiardini M, Cervasi B, Reyes-Aviles E, et al. Low levels of SIV infection in sooty mangabey central-memory CD4+ T-cells is associated with limited CCR5 expression. Nat Med 2011 (in press).
    • (2011) Nat Med
    • Paiardini, M.1    Cervasi, B.2    Reyes-Aviles, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.