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Volumn 10, Issue 16, 2011, Pages 2714-2723

Hdm2- and proteasome-dependent turnover limits p21 accumulation during S phase

Author keywords

Cell cycle phase dependent; hdm2; p21; Protein turnover; skp2

Indexed keywords

CYCLIN DEPENDENT KINASE 2 INHIBITOR; LIGASE; P21 ACTIVATED KINASE; PROTEASOME; PROTEIN MDM2; PROTEIN P53;

EID: 80051780218     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.10.16.16725     Document Type: Article
Times cited : (13)

References (37)
  • 1
    • 3943107573 scopus 로고    scopus 로고
    • Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
    • PMID: 15189136; DOI: 10.1146/ annurev.biochem.73.011303.073723
    • Sancar A., Lindsey-Boltz L.A., Unsal-Kacmaz K., Linn S Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints Annu Rev Biochem 2004; 73:39-85; PMID: 15189136; DOI: 10.1146/ annurev.biochem.73.011303. 073723.
    • (2004) Annu Rev Biochem , vol.73 , pp. 39-85
    • Sancar, A.1    Lindsey-Boltz, L.A.2    Unsal-Kacmaz, K.3    Linn, S.4
  • 2
    • 0037329056 scopus 로고    scopus 로고
    • The p53-Mdm2 module and the ubiquitin system
    • PMID: 12507556; DOI: 10.1016/S1044-(02)00099-8
    • Michael D., Oren M The p53-Mdm2 module and the ubiquitin system Semin Cancer Biol 2003; 13:49-58; PMID: 12507556; DOI: 10.1016/S1044-(02)00099-8.
    • (2003) Semin Cancer Biol , vol.13 , pp. 49-58
    • Michael, D.1    Oren, M.2
  • 3
    • 0029097759 scopus 로고
    • Radiation-induced cell cycle arrest compromised by p21 deficiency
    • PMID: 7566157; DOI: 10.1038/377552a0
    • Brugarolas J., Chandrasekaran C., Gordon J.I., Beach D., Jacks T., Hannon GJ Radiation-induced cell cycle arrest compromised by p21 deficiency Nature 1995; 377:552- 7; PMID: 7566157; DOI: 10.1038/377552a0.
    • (1995) Nature , vol.377 , pp. 552-557
    • Brugarolas, J.1    Chandrasekaran, C.2    Gordon, J.I.3    Beach, D.4    Jacks, T.5    Hannon, G.J.6
  • 5
    • 0028978183 scopus 로고
    • Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
    • PMID: 7664346; DOI: 10.1016/0092- 8674(95)90039-X
    • 1 checkpoint control. Cell 1995; 82:675-84; PMID: 7664346; DOI: 10.1016/0092- 8674(95)90039-X.
    • (1995) Cell , vol.82 , pp. 675-684
    • Deng, C.1    Zhang, P.2    Harper, J.W.3    Elledge, S.J.4    Leder, P.5
  • 6
    • 25844453939 scopus 로고    scopus 로고
    • Testicular germ cell tumours: The paradigm of chemo-sensitive solid tumours
    • PMID: 16099193; DOI: 10.1016/j.biocel.2005.06.014
    • di Pietro A., Vries E.G., Gietema J.A., Spierings D.C., de Jong S Testicular germ cell tumours: the paradigm of chemo-sensitive solid tumours Int J Biochem Cell Biol 2005; 37:2437-56; PMID: 16099193; DOI: 10.1016/j.biocel. 2005.06.014.
    • (2005) Int J Biochem Cell Biol , vol.37 , pp. 2437-2456
    • Di Pietro, A.1    Vries, E.G.2    Gietema, J.A.3    Spierings, D.C.4    De Jong, S.5
  • 7
    • 18144382254 scopus 로고    scopus 로고
    • Ablation of either p21 or Bax prevents p53-dependent apoptosis induced by green tea polyphenol epigallocatechin- 3-gallate
    • PMID: 15764647
    • Hastak K., Agarwal M.K., Mukhtar H., Agarwal M.L. Ablation of either p21 or Bax prevents p53-dependent apoptosis induced by green tea polyphenol epigallocatechin- 3-gallate. FASEB J 2005; 19:789-791; PMID: 15764647.
    • (2005) FASEB J , vol.19 , pp. 789-791
    • Hastak, K.1    Agarwal, M.K.2    Mukhtar, H.3    Agarwal, M.L.4
  • 8
    • 0028849274 scopus 로고
    • p21 is necessary for the p53-mediated G1 arrest in human cancer cells
    • PMID: 7585571
    • Waldman T., Kinzler K.W., Vogelstein B. p21 is necessary for the p53-mediated G1 arrest in human cancer cells. Cancer Res 1995; 55:5187-5190; PMID: 7585571.
    • (1995) Cancer Res , vol.55 , pp. 5187-5190
    • Waldman, T.1    Kinzler, K.W.2    Vogelstein, B.3
  • 9
    • 5044220936 scopus 로고    scopus 로고
    • Checking on DNA damage in S phase
    • PMID: 15459660; DOI: 10.1038/nrm1493
    • Bartek J., Lukas C., Lukas J Checking on DNA damage in S phase Nat Rev Mol Cell Biol 2004; 5:792-804; PMID: 15459660; DOI: 10.1038/nrm1493.
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 792-804
    • Bartek, J.1    Lukas, C.2    Lukas, J.3
  • 10
    • 0036510055 scopus 로고    scopus 로고
    • The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways
    • PMID: 11850621; DOI: 10.1038/ng845.
    • Falck J., Petrini J.H., Williams B.R., Lukas J., Bartek J The DNA damage-dependent intra-S phase checkpoint is regulated by parallel pathways Nat Genet 2002; 30:290-4; PMID: 11850621; DOI: 10.1038/ng845.
    • (2002) Nat Genet , vol.30 , pp. 290-294
    • Falck, J.1    Petrini, J.H.2    Williams, B.R.3    Lukas, J.4    Bartek, J.5
  • 11
    • 0034576494 scopus 로고    scopus 로고
    • The many substrates and functions of ATM
    • PMID: 11252893; DOI: 10.1038/35043058
    • Kastan M.B., Lim DS The many substrates and functions of ATM Nat Rev Mol Cell Biol 2000; 1:179-86; PMID: 11252893; DOI: 10.1038/35043058.
    • (2000) Nat Rev Mol Cell Biol , vol.1 , pp. 179-186
    • Kastan, M.B.1    Lim, D.S.2
  • 12
    • 4544280871 scopus 로고    scopus 로고
    • Interaction of FANCD2 and NBS1 in the DNA damage response
    • PMID: 12447395; DOI: 10.1038/ ncb879
    • Nakanishi K., Taniguchi T., Ranganathan V., New H.V., Moreau L.A., Stotsky M., et al. Interaction of FANCD2 and NBS1 in the DNA damage response. Nat Cell Biol 2002; 4:913-20; PMID: 12447395; DOI: 10.1038/ ncb879.
    • (2002) Nat Cell Biol , vol.4 , pp. 913-920
    • Nakanishi, K.1    Taniguchi, T.2    Ranganathan, V.3    New, H.V.4    Moreau, L.A.5    Stotsky, M.6
  • 13
    • 1242294418 scopus 로고    scopus 로고
    • Decreased p21 levels are required for efficient restart of DNA synthesis after S phase block
    • PMID: 14597617; DOI: 10.1074/jbc. M310373200
    • Gottifredi V., McKinney K., Poyurovsky M.V., Prives C Decreased p21 levels are required for efficient restart of DNA synthesis after S phase block J Biol Chem 2004; 279:5802-10; PMID: 14597617; DOI: 10.1074/jbc. M310373200.
    • (2004) J Biol Chem , vol.279 , pp. 5802-5810
    • Gottifredi, V.1    McKinney, K.2    Poyurovsky, M.V.3    Prives, C.4
  • 14
    • 33646156444 scopus 로고    scopus 로고
    • P21Cip1/WAF1 downregulation is required for efficient PCNA ubiquitination after UV irradiation
    • PMID: 16407842; DOI: 10.1038/ sj.onc.1209315
    • Cip1/WAF1 downregulation is required for efficient PCNA ubiquitination after UV irradiation. Oncogene 2006; 25:2829-38; PMID: 16407842; DOI: 10.1038/ sj.onc.1209315.
    • (2006) Oncogene , vol.25 , pp. 2829-2838
    • Soria, G.1    Podhajcer, O.2    Prives, C.3    Gottifredi, V.4
  • 15
    • 0141429168 scopus 로고    scopus 로고
    • UV irradiation triggers ubiquitin-dependent degradation of p21(WAF1) to promote DNA repair
    • PMID: 13678583; DOI: 10.1016/j.cell.2003.08.001
    • Bendjennat M., Boulaire J., Jascur T., Brickner H., Barbier V., Sarasin A., et al. UV irradiation triggers ubiquitin-dependent degradation of p21(WAF1) to promote DNA repair. Cell 2003; 114:599-610; PMID: 13678583; DOI: 10.1016/j.cell.2003.08.001.
    • (2003) Cell , vol.114 , pp. 599-610
    • Bendjennat, M.1    Boulaire, J.2    Jascur, T.3    Brickner, H.4    Barbier, V.5    Sarasin, A.6
  • 16
    • 0033226985 scopus 로고    scopus 로고
    • Differences in induction of p53, p21WAF1 and apoptosis in relation to cell cycle phase of MCF-7 cells treated with camptothecin
    • PMID: 10536167
    • WAF1 and apoptosis in relation to cell cycle phase of MCF-7 cells treated with camptothecin. Int J Oncol 1999; 15:861-871; PMID: 10536167.
    • (1999) Int J Oncol , vol.15 , pp. 861-871
    • Deptala, A.1    Li, X.2    Bedner, E.3    Cheng, W.4    Traganos, F.5    Darzynkiewicz, Z.6
  • 17
    • 11144224782 scopus 로고    scopus 로고
    • Phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis
    • PMID: 15471885; DOI: 10.1074/jbc.M410233200
    • Thompson T., Tovar C., Yang H., Carvajal D., Vu B.T., Xu Q., et al. Phosphorylation of p53 on key serines is dispensable for transcriptional activation and apoptosis. J Biol Chem 2004; 279:53015-22; PMID: 15471885; DOI: 10.1074/jbc.M410233200.
    • (2004) J Biol Chem , vol.279 , pp. 53015-53022
    • Thompson, T.1    Tovar, C.2    Yang, H.3    Carvajal, D.4    Vu, B.T.5    Xu, Q.6
  • 18
    • 0037325853 scopus 로고    scopus 로고
    • Deregulated degradation of the cdk inhibitor p27 and malignant transformation
    • PMID: 12507555; DOI: 10.1016/S1044-579X(02)00098-6
    • Bloom J., Pagano M Deregulated degradation of the cdk inhibitor p27 and malignant transformation Semin Cancer Biol 2003; 13:41-7; PMID: 12507555; DOI: 10.1016/S1044-579X(02)00098-6.
    • (2003) Semin Cancer Biol , vol.13 , pp. 41-47
    • Bloom, J.1    Pagano, M.2
  • 19
    • 2442515980 scopus 로고    scopus 로고
    • Control of DNA synthesis and mitosis by the Skp2-p27-Cdk1/2 axis
    • PMID: 15149588; DOI: 10.1016/S1097- 2765(04)00268-0
    • Pagano M Control of DNA synthesis and mitosis by the Skp2-p27-Cdk1/2 axis Mol Cell 2004; 14:414-6; PMID: 15149588; DOI: 10.1016/S1097- 2765(04)00268-0.
    • (2004) Mol Cell , vol.14 , pp. 414-416
    • Pagano, M.1
  • 20
    • 1542724587 scopus 로고    scopus 로고
    • Cytometry of the cell cycle: Cycling through history
    • PMID: 14994216; DOI: 10.1002/cyto.a.20003
    • Darzynkiewicz Z., Crissman H., Jacobberger JW Cytometry of the cell cycle: cycling through history Cytometry A 2004; 58:21-32; PMID: 14994216; DOI: 10.1002/cyto.a.20003.
    • (2004) Cytometry A , vol.58 , pp. 21-32
    • Darzynkiewicz, Z.1    Crissman, H.2    Jacobberger, J.W.3
  • 21
    • 85047680162 scopus 로고    scopus 로고
    • p53 accumulates but is functionally impaired when DNA synthesis is blocked
    • PMID: 11158590; DOI: 10.1073/pnas.021282898
    • Gottifredi V., Shieh S., Taya Y., Prives C p53 accumulates but is functionally impaired when DNA synthesis is blocked Proc Natl Acad Sci USA 2001; 98:1036-41; PMID: 11158590; DOI: 10.1073/pnas.021282898.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 1036-1041
    • Gottifredi, V.1    Shieh, S.2    Taya, Y.3    Prives, C.4
  • 22
    • 0030722533 scopus 로고    scopus 로고
    • Intracellular localization of p53 tumor suppressor protein in gammairradiated cells is cell cycle regulated and determined by the nucleus
    • PMID: 9393737
    • Komarova E.A., Zelnick C.R., Chin D., Zeremski M., Gleiberman A.S., Bacus S.S., et al. Intracellular localization of p53 tumor suppressor protein in gammairradiated cells is cell cycle regulated and determined by the nucleus. Cancer Res 1997; 57:5217-5220; PMID: 9393737.
    • (1997) Cancer Res , vol.57 , pp. 5217-5220
    • Komarova, E.A.1    Zelnick, C.R.2    Chin, D.3    Zeremski, M.4    Gleiberman, A.S.5    Bacus, S.S.6
  • 23
    • 12344249855 scopus 로고    scopus 로고
    • Regulation of p21(WAF1/ CIP1) stability by WISp39, a Hsp90 binding TPR protein
    • PMID: 15664193; DOI: 10.1016/j.molcel.2004.11.049
    • Jascur T., Brickner H., Salles-Passador I., Barbier V., El Khissiin A., Smith B., et al. Regulation of p21(WAF1/ CIP1) stability by WISp39, a Hsp90 binding TPR protein. Mol Cell 2005; 17:237-49; PMID: 15664193; DOI: 10.1016/j.molcel.2004.11.049.
    • (2005) Mol Cell , vol.17 , pp. 237-249
    • Jascur, T.1    Brickner, H.2    Salles-Passador, I.3    Barbier, V.4    El Khissiin, A.5    Smith, B.6
  • 25
    • 27644451320 scopus 로고    scopus 로고
    • Ubiquitination of p21Cip1/WAF1 by SCFSkp2: Substrate requirement and ubiquitination site selection
    • PMID: 16262255; DOI: 10.1021/bi051071j
    • Skp2: substrate requirement and ubiquitination site selection. Biochemistry 2005; 44:14553- 64; PMID: 16262255; DOI: 10.1021/bi051071j.
    • (2005) Biochemistry , vol.44 , pp. 14553-14564
    • Wang, W.1    Nacusi, L.2    Sheaff, R.J.3    Liu, X.4
  • 26
    • 0032530151 scopus 로고    scopus 로고
    • Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins
    • PMID: 9736735; DOI: 10.1073/pnas.95.19.11324
    • Yu Z.K., Gervais J.L., Zhang H Human CUL-1 associates with the SKP1/SKP2 complex and regulates p21(CIP1/WAF1) and cyclin D proteins Proc Natl Acad Sci USA 1998; 95:11324-9; PMID: 9736735; DOI: 10.1073/pnas.95.19.11324.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 11324-11329
    • Yu, Z.K.1    Gervais, J.L.2    Zhang, H.3
  • 27
    • 0346243936 scopus 로고    scopus 로고
    • MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation
    • PMID: 14633995; DOI: 10.1093/emboj/cdg600
    • waf1/cip1 proteasomal turnover independently of ubiquitylation. EMBO J 2003; 22:6365-77; PMID: 14633995; DOI: 10.1093/emboj/cdg600.
    • (2003) EMBO J , vol.22 , pp. 6365-6377
    • Jin, Y.1    Lee, H.2    Zeng, S.X.3    Dai, M.S.4    Lu, H.5
  • 28
    • 1942437554 scopus 로고    scopus 로고
    • MDM2 is a negative regulator of p21WAF1/CIP1, independent of p53
    • PMID: 14761977; DOI: 10.1074/jbc.M312264200
    • WAF1/CIP1, independent of p53. J Biol Chem 2004; 279:16000-6; PMID: 14761977; DOI: 10.1074/jbc.M312264200.
    • (2004) J Biol Chem , vol.279 , pp. 16000-16006
    • Zhang, Z.1    Wang, H.2    Li, M.3    Agrawal, S.4    Chen, X.5    Zhang, R.6
  • 29
    • 2342650733 scopus 로고    scopus 로고
    • Skp2-mediated degradation of p27 regulates progression into mitosis
    • PMID: 15130491; DOI: 10.1016/S1534-5807(04)00131-5
    • Nakayama K., Nagahama H., Minamishima Y.A., Miyake S., Ishida N., Hatakeyama S., et al. Skp2-mediated degradation of p27 regulates progression into mitosis. Dev Cell 2004; 6:661-72; PMID: 15130491; DOI: 10.1016/S1534- 5807(04)00131-5.
    • (2004) Dev Cell , vol.6 , pp. 661-672
    • Nakayama, K.1    Nagahama, H.2    Minamishima, Y.A.3    Miyake, S.4    Ishida, N.5    Hatakeyama, S.6
  • 30
    • 0034595292 scopus 로고    scopus 로고
    • Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication
    • PMID: 10790373; DOI: 10.1093/emboj/19.9.2069
    • Nakayama K., Nagahama H., Minamishima Y.A., Matsumoto M., Nakamichi I., Kitagawa K., et al. Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication. EMBO J 2000; 19:2069-81; PMID: 10790373; DOI: 10.1093/emboj/19.9.2069.
    • (2000) EMBO J , vol.19 , pp. 2069-2081
    • Nakayama, K.1    Nagahama, H.2    Minamishima, Y.A.3    Matsumoto, M.4    Nakamichi, I.5    Kitagawa, K.6
  • 32
    • 0035092687 scopus 로고    scopus 로고
    • The cell cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27
    • PMID: 11231585; DOI: 10.1038/35060126
    • Ganoth D., Bornstein G., Ko T.K., Larsen B., Tyers M., Pagano M., et al. The cell cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27. Nat Cell Biol 2001; 3:321-4; PMID: 11231585; DOI: 10.1038/35060126.
    • (2001) Nat Cell Biol , vol.3 , pp. 321-324
    • Ganoth, D.1    Bornstein, G.2    Ko, T.K.3    Larsen, B.4    Tyers, M.5    Pagano, M.6
  • 34
    • 25844441096 scopus 로고    scopus 로고
    • Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase
    • PMID: 16209941; DOI: 10.1016/j.molcel.2005.09.003
    • Hao B., Zheng N., Schulman B.A., Wu G., Miller J.J., Pagano M., et al. Structural basis of the Cks1-dependent recognition of p27(Kip1) by the SCF(Skp2) ubiquitin ligase. Mol Cell 2005; 20:9-19; PMID: 16209941; DOI: 10.1016/j.molcel.2005.09.003.
    • (2005) Mol Cell , vol.20 , pp. 9-19
    • Hao, B.1    Zheng, N.2    Schulman, B.A.3    Wu, G.4    Miller, J.J.5    Pagano, M.6
  • 35
    • 77955747085 scopus 로고    scopus 로고
    • The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway
    • (Albany NY) PMID: 20606252
    • Korotchkina L.G., Leontieva O.V., Bukreeva E.I., Demidenko Z.N., Gudkov A.V., Blagosklonny M.V. The choice between p53-induced senescence and quiescence is determined in part by the mTOR pathway. Aging (Albany NY) 2010; 2:344-352; PMID: 20606252.
    • (2010) Aging , vol.2 , pp. 344-352
    • Korotchkina, L.G.1    Leontieva, O.V.2    Bukreeva, E.I.3    Demidenko, Z.N.4    Gudkov, A.V.5    Blagosklonny, M.V.6
  • 36
    • 77953087439 scopus 로고    scopus 로고
    • Paradoxical suppression of cellular senescence by p53
    • PMID: 20457898; DOI: 10.1073/ pnas.1002298107
    • Demidenko Z.N., Korotchkina L.G., Gudkov A.V., Blagosklonny MV Paradoxical suppression of cellular senescence by p53 Proc Natl Acad Sci USA 2010; 107:9660-4; PMID: 20457898; DOI: 10.1073/ pnas.1002298107.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 9660-9664
    • Demidenko, Z.N.1    Korotchkina, L.G.2    Gudkov, A.V.3    Blagosklonny, M.V.4
  • 37
    • 0032905150 scopus 로고    scopus 로고
    • Cell-free degradation of p27(kip1), a G1 cyclin-dependent kinase inhibitor, is dependent on CDK2 activity and the proteasome
    • PMID: 9891053
    • 1 cyclin-dependent kinase inhibitor, is dependent on CDK2 activity and the proteasome. Mol Cell Biol 1999; 19:1190-1201; PMID: 9891053.
    • (1999) Mol Cell Biol , vol.19 , pp. 1190-1201
    • Nguyen, H.1    Gitig, D.M.2    Koff, A.3


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