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Volumn 40, Issue 3-4, 2008, Pages 136-140

Experimental melanin-induced uveitis: Experimental model of human acute anterior uveitis

Author keywords

Experimental melanin induced uveitis; Human acute anterior uveitis

Indexed keywords

AMINOGUANIDINE; CD4 ANTIBODY; CELL ADHESION MOLECULE; CHEMOKINE; COMPLEMENT; CYTOKINE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 ANTIBODY; INTERCELLULAR ADHESION MOLECULE 1 ANTIBODY; INTERLEUKIN 10; MELANIN; NITRIC OXIDE; TRICYCLO[4.3.0.1]DECAN 9 YL XANTHOGENATE;

EID: 42449134976     PISSN: 00303747     EISSN: None     Source Type: Journal    
DOI: 10.1159/000119864     Document Type: Review
Times cited : (14)

References (42)
  • 1
    • 0025734916 scopus 로고
    • Experimental autoimmune anterior uveitis (EAAU), a new form of experimental uveitis. I. Induction by a detergent-insoluble, intrinsic protein fraction of the retinal pigment epithelium
    • Broekhuyse RM, Kuhlmann ED, Winkens HJ, Van Vugt AH: Experimental autoimmune anterior uveitis (EAAU), a new form of experimental uveitis. I. Induction by a detergent-insoluble, intrinsic protein fraction of the retinal pigment epithelium. Exp Eye Res 1991;52:465-474.
    • (1991) Exp Eye Res , vol.52 , pp. 465-474
    • Broekhuyse, R.M.1    Kuhlmann, E.D.2    Winkens, H.J.3    Van Vugt, A.H.4
  • 2
    • 0026806793 scopus 로고
    • Experimental autoimmune anterior uveitis (EAAU). II. Dose-dependent induction and adoptive transfer using a melaninbound antigen of the retinal pigment epithelium
    • Broekhuyse RM, Kuhlmann ED, Winkens HJ: Experimental autoimmune anterior uveitis (EAAU). II. Dose-dependent induction and adoptive transfer using a melaninbound antigen of the retinal pigment epithelium. Exp Eye Res 1992;55:401-411.
    • (1992) Exp Eye Res , vol.55 , pp. 401-411
    • Broekhuyse, R.M.1    Kuhlmann, E.D.2    Winkens, H.J.3
  • 3
    • 0027167846 scopus 로고
    • Experimental autoimmune anterior uveitis (EAAU). III. Induction by immunization with purified uveal and skin melanins
    • Broekhuyse RM, Kuhlmann ED, Winkens HJ: Experimental autoimmune anterior uveitis (EAAU). III. Induction by immunization with purified uveal and skin melanins. Exp Eye Res 1993;56:575-583.
    • (1993) Exp Eye Res , vol.56 , pp. 575-583
    • Broekhuyse, R.M.1    Kuhlmann, E.D.2    Winkens, H.J.3
  • 5
    • 0028956306 scopus 로고
    • Experimental autoimmune anterior uveitis: Induction with melanin-associated antigen from the iris and ciliary body
    • Bora NS, Kim MC, Kabeer NH, et al: Experimental autoimmune anterior uveitis: Induction with melanin-associated antigen from the iris and ciliary body. Invest Ophthalmol Vis Sci 1995;36:1056-1066.
    • (1995) Invest Ophthalmol Vis Sci , vol.36 , pp. 1056-1066
    • Bora, N.S.1    Kim, M.C.2    Kabeer, N.H.3
  • 6
    • 2442691583 scopus 로고    scopus 로고
    • Type I collagen is the autoantigen in experimental autoimmune anterior uveitis
    • Bora NS, Sohn JH, Kang SG, et al: Type I collagen is the autoantigen in experimental autoimmune anterior uveitis. J Immunol 2004;172:7086-7094.
    • (2004) J Immunol , vol.172 , pp. 7086-7094
    • Bora, N.S.1    Sohn, J.H.2    Kang, S.G.3
  • 8
    • 0032891207 scopus 로고    scopus 로고
    • Experimental melanin-induced uveitis in the Fischer 344 rat is inhibited by anti-CD4 monoclonal antibody, but not by mannose-6-phosphate
    • Smith JR, Hart PH, Parish CR, Standfield SD, Coster DJ, Williams KA: Experimental melanin-induced uveitis in the Fischer 344 rat is inhibited by anti-CD4 monoclonal antibody, but not by mannose-6-phosphate. Clin Exp Immunol 1999;115:64-71.
    • (1999) Clin Exp Immunol , vol.115 , pp. 64-71
    • Smith, J.R.1    Hart, P.H.2    Parish, C.R.3    Standfield, S.D.4    Coster, D.J.5    Williams, K.A.6
  • 9
  • 10
    • 0026554541 scopus 로고
    • Acute anterior uveitis and spondyloarthropathies
    • Rosenbaum JT: Acute anterior uveitis and spondyloarthropathies. Rheum Dis Clin North Am 1992;18:143-151.
    • (1992) Rheum Dis Clin North Am , vol.18 , pp. 143-151
    • Rosenbaum, J.T.1
  • 12
    • 42449156437 scopus 로고    scopus 로고
    • Chan CC, Dastgheib K, Hikita N, Walton RC, Nussenblatt RB, Broekhuyse RM: Experimental melanin-protein induced uveitis ('EMIU', formerly 'EAAU'): immunopathology, susceptibility and therapy; in Nussenblatt RB, Whitcup SM, Caspi RR, Gery I (eds): Advances in Ocular Immunology. Amsterdam, Elsevier Science, 1994, pp 91-94.
    • Chan CC, Dastgheib K, Hikita N, Walton RC, Nussenblatt RB, Broekhuyse RM: Experimental melanin-protein induced uveitis ('EMIU', formerly 'EAAU'): immunopathology, susceptibility and therapy; in Nussenblatt RB, Whitcup SM, Caspi RR, Gery I (eds): Advances in Ocular Immunology. Amsterdam, Elsevier Science, 1994, pp 91-94.
  • 13
    • 0029872877 scopus 로고    scopus 로고
    • Intraperitoneally injected melanin is highly uveitogenic
    • Broekhuyse RM, Winkens HJ, Kuhlmann ED: Intraperitoneally injected melanin is highly uveitogenic. Exp Eye Res 1996;62:199-200.
    • (1996) Exp Eye Res , vol.62 , pp. 199-200
    • Broekhuyse, R.M.1    Winkens, H.J.2    Kuhlmann, E.D.3
  • 14
    • 0030431706 scopus 로고    scopus 로고
    • Experimental melanin-protein induced uveitis (EMIU) is the sole type of uveitis evoked by a diversity of ocular melanin preparations and melanin-derived soluble polypeptides
    • Broekhuyse RM, Kuhlmann ED, Winkens HJ: Experimental melanin-protein induced uveitis (EMIU) is the sole type of uveitis evoked by a diversity of ocular melanin preparations and melanin-derived soluble polypeptides. Jpn J Ophthalmol 1996;40:459-468.
    • (1996) Jpn J Ophthalmol , vol.40 , pp. 459-468
    • Broekhuyse, R.M.1    Kuhlmann, E.D.2    Winkens, H.J.3
  • 15
    • 0030930846 scopus 로고    scopus 로고
    • Induction of experimental autoimmune anterior uveitis by a self-antigen: Melanin complex without adjuvant
    • Bora NS, Woon MD, Tandhasetti MT, Cirrito TP, Kaplan HJ: Induction of experimental autoimmune anterior uveitis by a self-antigen: melanin complex without adjuvant. Invest Ophthalmol Vis Sci 1997;38:2171-2175.
    • (1997) Invest Ophthalmol Vis Sci , vol.38 , pp. 2171-2175
    • Bora, N.S.1    Woon, M.D.2    Tandhasetti, M.T.3    Cirrito, T.P.4    Kaplan, H.J.5
  • 16
    • 0034465999 scopus 로고    scopus 로고
    • Anti-rat ICAM-1 antibody does not influence the course of experimental melanin-induced uveitis
    • Smith JR, O'Rourke LM, Becker MD, et al: Anti-rat ICAM-1 antibody does not influence the course of experimental melanin-induced uveitis. Curr Eye Res 2000;21:906-912.
    • (2000) Curr Eye Res , vol.21 , pp. 906-912
    • Smith, J.R.1    O'Rourke, L.M.2    Becker, M.D.3
  • 17
    • 0029091958 scopus 로고
    • Immunohistochemical studies on melanin associated antigen (MAA) induced experimental autoimmune anterior uveitis (EAAU)
    • Kim MC, Kabeer NH, Tandhasetti MT, Kaplan HJ, Bora NS: Immunohistochemical studies on melanin associated antigen (MAA) induced experimental autoimmune anterior uveitis (EAAU). Curr Eye Res 1995;14:703-710.
    • (1995) Curr Eye Res , vol.14 , pp. 703-710
    • Kim, M.C.1    Kabeer, N.H.2    Tandhasetti, M.T.3    Kaplan, H.J.4    Bora, N.S.5
  • 18
    • 0034780040 scopus 로고    scopus 로고
    • Macrophage depletion prevents leukocyte adhesion and disease induction in experimental melanin-protein induced uveitis
    • Baatz H, Puchta J, Reszka R, Pleyer U: Macrophage depletion prevents leukocyte adhesion and disease induction in experimental melanin-protein induced uveitis. Exp Eye Res 2001;73:101-109.
    • (2001) Exp Eye Res , vol.73 , pp. 101-109
    • Baatz, H.1    Puchta, J.2    Reszka, R.3    Pleyer, U.4
  • 19
    • 0011813763 scopus 로고
    • Expression of transforming growth factor β1 (TGFβ1) in experimental melanin protein induced uveitis and experimental autoimmune uveitis
    • Nussenblatt RB, Whitcup SM, Caspi RR eds, Amsterdam, Elsevier Science
    • Li Q, Dastgheib K, Luyo D, Egwuagu C, Nussenblatt RB, Chan CC: Expression of transforming growth factor β1 (TGFβ1) in experimental melanin protein induced uveitis and experimental autoimmune uveitis; in Nussenblatt RB, Whitcup SM, Caspi RR (eds): Advances in Ocular Immunology. Amsterdam, Elsevier Science, 1994, pp 99-102.
    • (1994) Advances in Ocular Immunology , pp. 99-102
    • Li, Q.1    Dastgheib, K.2    Luyo, D.3    Egwuagu, C.4    Nussenblatt, R.B.5    Chan, C.C.6
  • 20
    • 0032836832 scopus 로고    scopus 로고
    • Cytokines and apoptotic molecules in experimental melanin-protein induced uveitis (EMIU) and experimental autoimmune uveoretinitis (EAU)
    • Li Q, Sun B, Matteson DM, O'Brien TP, Chan CC: Cytokines and apoptotic molecules in experimental melanin-protein induced uveitis (EMIU) and experimental autoimmune uveoretinitis (EAU). Autoimmunity 1999;30:171-182.
    • (1999) Autoimmunity , vol.30 , pp. 171-182
    • Li, Q.1    Sun, B.2    Matteson, D.M.3    O'Brien, T.P.4    Chan, C.C.5
  • 21
    • 0031712882 scopus 로고    scopus 로고
    • Kinetics of cytokine production in experimental autoimmune anterior uveitis (EAAU)
    • Woon MD, Kaplan HJ, Bora NS: Kinetics of cytokine production in experimental autoimmune anterior uveitis (EAAU). Curr Eye Res 1998;17:955-961.
    • (1998) Curr Eye Res , vol.17 , pp. 955-961
    • Woon, M.D.1    Kaplan, H.J.2    Bora, N.S.3
  • 22
    • 0035672691 scopus 로고    scopus 로고
    • The expression of multiple cytokines and inducible nitric oxide synthase in experimental melanin-protein-0induced uveitis
    • Kim HS, Yoon SK, Joo CK: The expression of multiple cytokines and inducible nitric oxide synthase in experimental melanin-protein-0induced uveitis. Ophthalmic Res 2001;33:329-335.
    • (2001) Ophthalmic Res , vol.33 , pp. 329-335
    • Kim, H.S.1    Yoon, S.K.2    Joo, C.K.3
  • 23
  • 24
    • 0036897465 scopus 로고    scopus 로고
    • Anti-tumor necrosis factor-alpha therapy with infliximab as an alternative to corticosteroids in the treatment of human leukocyte antigen B27-associated acute anterior uveitis
    • El-Shabrawi Y, Hermann J: Anti-tumor necrosis factor-alpha therapy with infliximab as an alternative to corticosteroids in the treatment of human leukocyte antigen B27-associated acute anterior uveitis. Ophthalmology 2002;109:2342-2346.
    • (2002) Ophthalmology , vol.109 , pp. 2342-2346
    • El-Shabrawi, Y.1    Hermann, J.2
  • 26
    • 1942423159 scopus 로고    scopus 로고
    • Expression of chemokine and receptors in Lewis rats with experimental autoimmune anterior uveitis
    • Fang IM, Yang CH, Lin CP, Yang CM, Chen MS: Expression of chemokine and receptors in Lewis rats with experimental autoimmune anterior uveitis. Exp Eye Res 2004;78:1043-1055.
    • (2004) Exp Eye Res , vol.78 , pp. 1043-1055
    • Fang, I.M.1    Yang, C.H.2    Lin, C.P.3    Yang, C.M.4    Chen, M.S.5
  • 27
    • 26244443835 scopus 로고    scopus 로고
    • Expression of CX3C chemokine, fractalkine, and its receptor CX3CR1 in experimental autoimmune anterior uveitis
    • Fang IM, Lin CP, Yang CM, Chen MS, Yang CH: Expression of CX3C chemokine, fractalkine, and its receptor CX3CR1 in experimental autoimmune anterior uveitis. Mol Vis 2005;11:443-451.
    • (2005) Mol Vis , vol.11 , pp. 443-451
    • Fang, I.M.1    Lin, C.P.2    Yang, C.M.3    Chen, M.S.4    Yang, C.H.5
  • 28
    • 0030659426 scopus 로고    scopus 로고
    • Chemokines in acute anterior uveitis
    • Verma MJ, Lloyd A, Rager H, et al: Chemokines in acute anterior uveitis. Curr Eye Res 1997;16:1202-1208.
    • (1997) Curr Eye Res , vol.16 , pp. 1202-1208
    • Verma, M.J.1    Lloyd, A.2    Rager, H.3
  • 30
    • 0036627236 scopus 로고    scopus 로고
    • Aqueous humor nitric oxide levels in patients with Behçet disease
    • Yilmaz G, Sizmaz S, Yilmaz ED, Duman S, Aydin P: Aqueous humor nitric oxide levels in patients with Behçet disease. Retina 2002;22:330-335.
    • (2002) Retina , vol.22 , pp. 330-335
    • Yilmaz, G.1    Sizmaz, S.2    Yilmaz, E.D.3    Duman, S.4    Aydin, P.5
  • 31
    • 0032819795 scopus 로고    scopus 로고
    • Fas-Fas ligand-mediated apoptosis within aqueous during idiopathic acute anterior uveitis
    • Dick AD, Siepmann K, Dees C, et al: Fas-Fas ligand-mediated apoptosis within aqueous during idiopathic acute anterior uveitis. Invest Ophthalmol Vis Sci 1999;40:2258-2267.
    • (1999) Invest Ophthalmol Vis Sci , vol.40 , pp. 2258-2267
    • Dick, A.D.1    Siepmann, K.2    Dees, C.3
  • 32
    • 6344247561 scopus 로고    scopus 로고
    • Inhibition of T cell apoptosis in the aqueous humor of patients with uveitis by IL-6/soluble IL-6 receptor trans-signaling
    • Curnow SJ, Scheel-Toellner D, Jenkinson W, et al: Inhibition of T cell apoptosis in the aqueous humor of patients with uveitis by IL-6/soluble IL-6 receptor trans-signaling. J Immunol 2004;173:5290-5297.
    • (2004) J Immunol , vol.173 , pp. 5290-5297
    • Curnow, S.J.1    Scheel-Toellner, D.2    Jenkinson, W.3
  • 33
    • 0032716706 scopus 로고    scopus 로고
    • Apoptosis of CD4+ T cells occurs in experimental autoimmune anterior uveitis (EAAU)
    • Yu HG, Chung H, Lee WJ: Apoptosis of CD4+ T cells occurs in experimental autoimmune anterior uveitis (EAAU). Clin Exp Immunol 1999;118:357-363.
    • (1999) Clin Exp Immunol , vol.118 , pp. 357-363
    • Yu, H.G.1    Chung, H.2    Lee, W.J.3
  • 34
    • 0033659939 scopus 로고    scopus 로고
    • Complement regulatory activity of normal human intraocular fluid is mediated by MCP, DAF, and CD59
    • Sohn JH, Kaplan HJ, Suk HJ, Bora PS, Bora NS: Complement regulatory activity of normal human intraocular fluid is mediated by MCP, DAF, and CD59. Invest Ophthalmol Vis Sci 2000;41:4195-4202.
    • (2000) Invest Ophthalmol Vis Sci , vol.41 , pp. 4195-4202
    • Sohn, J.H.1    Kaplan, H.J.2    Suk, H.J.3    Bora, P.S.4    Bora, N.S.5
  • 35
    • 0033775686 scopus 로고    scopus 로고
    • Chronic low level complement activation within the eye is controlled by intraocular complement regulatory proteins
    • Sohn JH, Kaplan HJ, Suk HJ, Bora PS, Bora NS: Chronic low level complement activation within the eye is controlled by intraocular complement regulatory proteins. Invest Ophthalmol Vis Sci 2000;41:3492-3502.
    • (2000) Invest Ophthalmol Vis Sci , vol.41 , pp. 3492-3502
    • Sohn, J.H.1    Kaplan, H.J.2    Suk, H.J.3    Bora, P.S.4    Bora, N.S.5
  • 36
    • 33645404385 scopus 로고    scopus 로고
    • The complement system plays a critical role in the development of experimental autoimmune anterior uveitis
    • Jha P, Sohn JH, Xu Q, et al: The complement system plays a critical role in the development of experimental autoimmune anterior uveitis. Invest Ophthalmol Vis Sci 2006;47:1030-1038.
    • (2006) Invest Ophthalmol Vis Sci , vol.47 , pp. 1030-1038
    • Jha, P.1    Sohn, J.H.2    Xu, Q.3
  • 37
    • 33744906052 scopus 로고    scopus 로고
    • Suppression of complement regulatory proteins (CRPs) exacerbates experimental autoimmune anterior uveitis (EAAU)
    • Jha P, Sohn JH, Xu Q, et al: Suppression of complement regulatory proteins (CRPs) exacerbates experimental autoimmune anterior uveitis (EAAU). J Immunol 2006;176:7221-7231.
    • (2006) J Immunol , vol.176 , pp. 7221-7231
    • Jha, P.1    Sohn, J.H.2    Xu, Q.3
  • 38
    • 0034897702 scopus 로고    scopus 로고
    • Requirement of B7-mediated costimulation in the induction of experimental autoimmune anterior uveitis
    • Shao H, Woon MD, Nakamura S, et al: Requirement of B7-mediated costimulation in the induction of experimental autoimmune anterior uveitis. Invest Ophthalmol Vis Sci 2001;42:2016-2021.
    • (2001) Invest Ophthalmol Vis Sci , vol.42 , pp. 2016-2021
    • Shao, H.1    Woon, M.D.2    Nakamura, S.3
  • 39
    • 30544453442 scopus 로고    scopus 로고
    • Inhibition of experimental autoimmune anterior uveitis by adenovirus-mediated transfer of the interleukin-10 gene
    • Fang IM, Lin CP, Yang CH, et al: Inhibition of experimental autoimmune anterior uveitis by adenovirus-mediated transfer of the interleukin-10 gene. J Ocul Pharmacol Ther 2005;21:420-428.
    • (2005) J Ocul Pharmacol Ther , vol.21 , pp. 420-428
    • Fang, I.M.1    Lin, C.P.2    Yang, C.H.3
  • 40
    • 0028278578 scopus 로고
    • Suppression of experimental uveitis with monoclonal antibodies to ICAM-1 and LFA-1
    • Uchio E, Kijima M, Tanaka S, Ohno S: Suppression of experimental uveitis with monoclonal antibodies to ICAM-1 and LFA-1. Invest Ophthalmol Vis Sci 1994;35:2626-2631.
    • (1994) Invest Ophthalmol Vis Sci , vol.35 , pp. 2626-2631
    • Uchio, E.1    Kijima, M.2    Tanaka, S.3    Ohno, S.4
  • 41
    • 0344069486 scopus 로고    scopus 로고
    • Inhibition of experimental melanin protein-induced uveitis (EMIU) by targeting nitric oxide via phosphatidylcholine-specific phospholipase C
    • Matteson DM, Shen DF, Chan CC: Inhibition of experimental melanin protein-induced uveitis (EMIU) by targeting nitric oxide via phosphatidylcholine-specific phospholipase C. J Autoimmun 1999;13:197-204.
    • (1999) J Autoimmun , vol.13 , pp. 197-204
    • Matteson, D.M.1    Shen, D.F.2    Chan, C.C.3
  • 42
    • 25144442376 scopus 로고    scopus 로고
    • Anti-inflammatory effects of specific cyclooxygenase 2,5-lipoxygenase, and inducible nitric oxide synthase inhibitors on experimental autoimmune anterior uveitis (EAAU)
    • Bora NS, Sohn JH, Bora PS, Kaplan HJ, Kulkarni P: Anti-inflammatory effects of specific cyclooxygenase 2,5-lipoxygenase, and inducible nitric oxide synthase inhibitors on experimental autoimmune anterior uveitis (EAAU). Ocul Immunol Inflamm 2005;13:183-189.
    • (2005) Ocul Immunol Inflamm , vol.13 , pp. 183-189
    • Bora, N.S.1    Sohn, J.H.2    Bora, P.S.3    Kaplan, H.J.4    Kulkarni, P.5


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