Rapid HATU-mediated solution phase siRNA conjugation

Bioconjugate Chemistry

Volumn 22, Issue 8, 2011, Pages 1723-1728

  Aaronson, Jeffrey G ^a   Klein, Lee J ^a   Momose, Aaron A ^a   O'Brien, Ann M ^a   Shaw, Anthony W ^a   Tucker, Thomas J ^a   Yuan, Yu ^a   Tellers, David M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED ESTER; CONDITION; COUPLING REAGENTS; LIPOPHILICITY; SOLUTION PHASE;

ORGANIC COMPOUNDS;

AMINE; CARBOXYLIC ACID; ESTER DERIVATIVE; O (7 AZABENZOTRIAZOL 1 YL) N,N,N',N' TETRAMETHYLURONIUM HEXAFLUOROPHOSPHATE; OLIGONUCLEOTIDE; PHOSPHATE; REAGENT; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

AMIDATION; ARTICLE; CHEMICAL REACTION; CONJUGATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIPOPHILICITY; SOLID PHASE SYNTHESIS;

EID: 80051740510     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc2001227     Document Type: Article

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