-
1
-
-
44449085539
-
Paul Ehrlich's magic bullet concept: 100 Years of progress
-
DOI 10.1038/nrc2394, PII NRC2394
-
Strebhardt K, Ullrich A. Paul Ehrlich's magic bullet concept: 100 years of progress. Nat. Rev. Cancer 8(6), 473-480 (2008). (Pubitemid 351752547)
-
(2008)
Nature Reviews Cancer
, vol.8
, Issue.6
, pp. 473-480
-
-
Strebhardt, K.1
Ullrich, A.2
-
2
-
-
0016756272
-
Continuous cultures of fused cells secreting antibody of predefined specificity
-
Kohler G, Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256(5517), 495-497 (1975).
-
(1975)
Nature
, vol.256
, Issue.5517
, pp. 495-497
-
-
Kohler, G.1
Milstein, C.2
-
3
-
-
0345337254
-
Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: Half of patients respond to a four-dose treatment program
-
McLaughlin P, Grillo-Lopez AJ, Link BK et al. Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: Half of patients respond to a four-dose treatment program. J. Clin. Oncol. 16(8), 2825-2833 (1998). nn Pivotal trial of rituximab that led to its US FDA approval. (Pubitemid 28363048)
-
(1998)
Journal of Clinical Oncology
, vol.16
, Issue.8
, pp. 2825-2833
-
-
McLaughlin, P.1
Grillo-Lopez, A.J.2
Link, B.K.3
Levy, R.4
Czuczman, M.S.5
Williams, M.E.6
Heyman, M.R.7
Bence-Bruckler, I.8
White, C.A.9
Cabanillas, F.10
Jain, V.11
Ho, A.D.12
Lister, J.13
Wey, K.14
Shen, D.15
Dallaire, B.K.16
-
4
-
-
0034468618
-
CD20: A gene in search of a function
-
Riley JK, Sliwkowski MX. CD20: A gene in search of a function. Semin. Oncol. 27(6 Suppl. 12), 17-24 (2000). (Pubitemid 32164592)
-
(2000)
Seminars in Oncology
, vol.27
, Issue.6 SUPPL. 12
, pp. 17-24
-
-
Riley, J.K.1
Sliwkowski, M.X.2
-
5
-
-
77950331000
-
CD20 as a target for therapeutic type I and II monoclonal antibodies
-
Beers SA, Chan CH, French RR, Cragg MS, Glennie MJ. CD20 as a target for therapeutic type I and II monoclonal antibodies. Semin. Hematol. 47(2), 107-114 (2010).
-
(2010)
Semin. Hematol.
, vol.47
, Issue.2
, pp. 107-114
-
-
Beers, S.A.1
Chan, C.H.2
French, R.R.3
Cragg, M.S.4
Glennie, M.J.5
-
6
-
-
16544389341
-
The biology of CD20 and its potential as a target for mAb therapy
-
Cragg MS, Walshe CA, Ivanov AO, Glennie MJ. The biology of CD20 and its potential as a target for mAb therapy. Curr. Dir. Autoimmun. 8, 140-174 (2005).
-
(2005)
Curr. Dir. Autoimmun.
, vol.8
, pp. 140-174
-
-
Cragg, M.S.1
Walshe, C.A.2
Ivanov, A.O.3
Glennie, M.J.4
-
7
-
-
0031962079
-
Rapid redistribution of CD20 to a low density detergent-insoluble membrane compartment
-
DOI 10.1074/jbc.273.1.344
-
Deans JP, Robbins SM, Polyak MJ, Savage JA. Rapid redistribution of CD20 to a low density detergent-insoluble membrane compartment. J. Biol. Chem. 273(1), 344-348 (1998). (Pubitemid 28042215)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.1
, pp. 344-348
-
-
Deans, J.P.1
Robbins, S.M.2
Polyak, M.J.3
Savage, J.A.4
-
8
-
-
78651376557
-
New anti-CD20 monoclonal antibodies for the treatment of B-cell lymphoid malignancies
-
Robak T, Robak E. New anti-CD20 monoclonal antibodies for the treatment of B-cell lymphoid malignancies. Biodrugs 25(1), 13-25 (2011).
-
(2011)
Biodrugs
, vol.25
, Issue.1
, pp. 13-25
-
-
Robak, T.1
Robak, E.2
-
9
-
-
0141704595
-
CD20-induced lymphoma cell death is independent of both caspases and its redistribution into triton X-100 insoluble membrane rafts
-
Chan HT, Hughes D, French RR et al. CD20-induced lymphoma cell death is independent of both caspases and its redistribution into triton X-100 insoluble membrane rafts. Cancer Res. 63(17), 5480-5489 (2003). (Pubitemid 37139867)
-
(2003)
Cancer Research
, vol.63
, Issue.17
, pp. 5480-5489
-
-
Chan, H.T.C.1
Hughes, D.2
French, R.R.3
Tutt, A.L.4
Walshe, C.A.5
Teeling, J.L.6
Glennie, M.J.7
Cragg, M.S.8
-
10
-
-
48549100414
-
Immunotherapeutic mechanisms of anti-CD20 monoclonal antibodies
-
Taylor RP, Lindorfer MA. Immunotherapeutic mechanisms of anti-CD20 monoclonal antibodies. Curr. Opin. Immunol. 20(4), 444-449 (2008).
-
(2008)
Curr. Opin. Immunol.
, vol.20
, Issue.4
, pp. 444-449
-
-
Taylor, R.P.1
Lindorfer, M.A.2
-
11
-
-
0034660092
-
Biologic response of B lymphoma cells to anti-CD20 monoclonal antibody rituximab in vitro: CD55 and CD59 regulate complement-mediated cell lysis
-
Golay J, Zaffaroni L, Vaccari T et al. Biologic response of B lymphoma cells to anti-CD20 monoclonal antibody rituximab in vitro: CD55 and CD59 regulate complement-mediated cell lysis. Blood 95(12), 3900-3908 (2000). (Pubitemid 30412866)
-
(2000)
Blood
, vol.95
, Issue.12
, pp. 3900-3908
-
-
Golay, J.1
Zaffaroni, L.2
Vaccari, T.3
Lazzari, M.4
Borleri, G.-M.5
Bernasconi, S.6
Tedesco, F.7
Rambaldi, A.8
Introna, M.9
-
12
-
-
33747880652
-
Ex vivo-activated human macrophages kill chronic lymphocytic leukemia cells in the presence of rituximab: Mechanism of antibody-dependent cellular cytotoxicity and impact of human serum
-
DOI 10.1097/01.cji.0000203081.43235.d7, PII 0000237120060700000005
-
Lefebvre ML, Krause SW, Salcedo M, Nardin A. Ex vivo-activated human macrophages kill chronic lymphocytic leukemia cells in the presence of rituximab: Mechanism of antibody-dependent cellular cytotoxicity and impact of human serum. J. Immunother. 29(4), 388-397 (2006). (Pubitemid 44288951)
-
(2006)
Journal of Immunotherapy
, vol.29
, Issue.4
, pp. 388-397
-
-
Lefebvre, M.-L.1
Krause, S.W.2
Salcedo, M.3
Nardin, A.4
-
13
-
-
0036464611
-
The mechanism of tumor cell clearance by rituximab in vivo in patients with B-cell chronic lymphocytic leukemia: Evidence of caspase activation and apoptosis induction
-
DOI 10.1182/blood.V99.3.1038
-
Byrd JC, Kitada S, Flinn IW et al. The mechanism of tumor cell clearance by rituximab in vivo in patients with B-cell chronic lymphocytic leukemia: Evidence of caspase activation and apoptosis induction. Blood 99(3), 1038-1043 (2002). (Pubitemid 34525569)
-
(2002)
Blood
, vol.99
, Issue.3
, pp. 1038-1043
-
-
Byrd, J.C.1
Kitada, S.2
Flinn, I.W.3
Aron, J.L.4
Pearson, M.5
Lucas, D.6
Reed, J.C.7
-
14
-
-
0034467186
-
Chemotherapy sensitization by rituximab: Experimental and clinical evidence
-
Wilson WH. Chemotherapy sensitization by rituximab: Experimental and clinical evidence. Semin. Oncol. 27(6 Suppl. 12), 30-36 (2000). (Pubitemid 32164594)
-
(2000)
Seminars in Oncology
, vol.27
, Issue.6 SUPPL. 12
, pp. 30-36
-
-
Wilson, W.H.1
-
15
-
-
0033855660
-
Rituximab anti-CD20 monoclonal antibody therapy in non-Hodgkin's lymphoma: Safety and efficacy of re-treatment
-
Davis TA, Grillo-Lopez AJ, White CA et al. Rituximab anti-CD20 monoclonal antibody therapy in non-Hodgkin's lymphoma: Safety and efficacy of re-treatment. J. Clin. Oncol. 18(17), 3135-3143 (2000).
-
(2000)
J. Clin. Oncol.
, vol.18
, Issue.17
, pp. 3135-3143
-
-
Davis, T.A.1
Grillo-Lopez, A.J.2
White, C.A.3
-
16
-
-
68449093749
-
Molecular mechanisms of resistance to rituximab and pharmacologic strategies for its circumvention
-
Stolz C, Schuler M. Molecular mechanisms of resistance to rituximab and pharmacologic strategies for its circumvention. Leuk. Lymphoma 50(6), 873-885 (2009).
-
(2009)
Leuk. Lymphoma
, vol.50
, Issue.6
, pp. 873-885
-
-
Stolz, C.1
Schuler, M.2
-
18
-
-
0036464719
-
Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcγrIIIa gene
-
DOI 10.1182/blood.V99.3.754
-
Cartron G, Dacheux L, Salles G et al. Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcgRIIIa gene. Blood 99(3), 754-758 (2002). (Pubitemid 34525533)
-
(2002)
Blood
, vol.99
, Issue.3
, pp. 754-758
-
-
Cartron, G.1
Dacheux, L.2
Salles, G.3
Solal-Celigny, P.4
Bardos, P.5
Colombat, P.6
Watier, H.7
-
19
-
-
1942502328
-
Characterization of a new humanized anti-CD20 monoclonal antibody, IMMU-106, and its use in combination with the humanized anti-CD22 antibody, epratuzumab, for the therapy of non-Hodgkin's lymphoma
-
DOI 10.1158/1078-0432.CCR-03-0493
-
Stein R, Qu Z, Chen S et al. Characterization of a new humanized anti-CD20 monoclonal antibody, IMMU-106, and its use in combination with the humanized anti-CD22 antibody, epratuzumab, for the therapy of non-Hodgkin's lymphoma. Clin. Cancer Res. 10(8), 2868-2878 (2004). (Pubitemid 38509167)
-
(2004)
Clinical Cancer Research
, vol.10
, Issue.8
, pp. 2868-2878
-
-
Stein, R.1
Qu, Z.2
Chen, S.3
Rosario, A.4
Shi, V.5
Hayes, M.6
Horak, I.D.7
Hansen, H.J.8
Goldenberg, D.M.9
-
20
-
-
60849089338
-
Properties and structure-function relationships of veltuzumab (hA20), a humanized anti-CD20 monoclonal antibody
-
Goldenberg DM, Rossi EA, Stein R et al. Properties and structure-function relationships of veltuzumab (hA20), a humanized anti-CD20 monoclonal antibody. Blood 113(5), 1062-1070 (2009).
-
(2009)
Blood
, vol.113
, Issue.5
, pp. 1062-1070
-
-
Goldenberg, D.M.1
Rossi, E.A.2
Stein, R.3
-
21
-
-
63849169216
-
Veltuzumab, an anti-CD20 mAb for the treatment of non-Hodgkin's lymphoma, chronic lymphocytic leukemia and immune thrombocytopenic purpura
-
Milani C, Castillo J. Veltuzumab, an anti-CD20 mAb for the treatment of non-Hodgkin's lymphoma, chronic lymphocytic leukemia and immune thrombocytopenic purpura. Curr. Opin. Mol. Ther. 11(2), 200-207 (2009).
-
(2009)
Curr. Opin. Mol. Ther.
, vol.11
, Issue.2
, pp. 200-207
-
-
Milani, C.1
Castillo, J.2
-
22
-
-
79953883456
-
Subcutaneous injections of low-dose veltuzumab (humanized anti-CD20 antibody) are safe and active in patients with indolent non-Hodgkin lymphoma
-
Negrea OG, Elstrom R, Allen SL et al. Subcutaneous injections of low-dose veltuzumab (humanized anti-CD20 antibody) are safe and active in patients with indolent non-Hodgkin lymphoma. Haematologica 96(4), 567-573 (2011).
-
(2011)
Haematologica
, vol.96
, Issue.4
, pp. 567-573
-
-
Negrea, O.G.1
Elstrom, R.2
Allen, S.L.3
-
23
-
-
70249106098
-
Humanized anti-CD20 antibody, veltuzumab, in refractory/recurrent non-Hodgkin's lymphoma: Phase I/II results
-
Morschhauser F, Leonard JP, Fayad L et al. Humanized anti-CD20 antibody, veltuzumab, in refractory/recurrent non-Hodgkin's lymphoma: Phase I/II results. J. Clin. Oncol. 27(20), 3346-3353 (2009).
-
(2009)
J. Clin. Oncol.
, vol.27
, Issue.20
, pp. 3346-3353
-
-
Morschhauser, F.1
Leonard, J.P.2
Fayad, L.3
-
24
-
-
67349188801
-
Structure of the Fab fragment of therapeutic antibody Ofatumumab provides insights into the recognition mechanism with CD20
-
Du J, Yang H, Guo Y, Ding J. Structure of the Fab fragment of therapeutic antibody Ofatumumab provides insights into the recognition mechanism with CD20. Mol. Immunol. 46(11-12), 2419-2423 (2009).
-
(2009)
Mol. Immunol.
, vol.46
, Issue.11-12
, pp. 2419-2423
-
-
Du, J.1
Yang, H.2
Guo, Y.3
Ding, J.4
-
25
-
-
4444343395
-
Characterization of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin lymphomas
-
DOI 10.1182/blood-2004-01-0039
-
Teeling JL, French RR, Cragg MS et al. Characterization of new human CD20 monoclonal antibodies with potent cytolytic activity against non-Hodgkin lymphomas. Blood 104(6), 1793-1800 (2004). (Pubitemid 39202289)
-
(2004)
Blood
, vol.104
, Issue.6
, pp. 1793-1800
-
-
Teeling, J.L.1
French, R.R.2
Cragg, M.S.3
Van Den Brakel, J.4
Pluyter, M.5
Huang, H.6
Chan, C.7
Parren, P.W.H.I.8
Hack, C.E.9
Dechant, M.10
Valerius, T.11
Van De Winkel, J.G.J.12
Glennie, M.J.13
-
26
-
-
33745324686
-
The biological activity of human CD20 monoclonal antibodies is linked to unique epitopes on CD20
-
Teeling JL, Mackus WJ, Wiegman LJ et al. The biological activity of human CD20 monoclonal antibodies is linked to unique epitopes on CD20. J. Immunol. 177(1), 362-371 (2006). (Pubitemid 43939148)
-
(2006)
Journal of Immunology
, vol.177
, Issue.1
, pp. 362-371
-
-
Teeling, J.L.1
Mackus, W.J.M.2
Wiegman, L.J.J.M.3
Van Den Brakel, J.H.N.4
Beers, S.A.5
French, R.R.6
Van Meerten, T.7
Ebeling, S.8
Vink, T.9
Slootstra, J.W.10
Parren, P.W.H.I.11
Glennie, M.J.12
Van De Winkel, J.G.J.13
-
27
-
-
38349138517
-
Estimation of dose requirements for sustained in vivo activity of a therapeutic human anti-CD20 antibody
-
Bleeker WK, Munk ME, Mackus WJ et al. Estimation of dose requirements for sustained in vivo activity of a therapeutic human anti-CD20 antibody. Br. J. Haematol. 140(3), 303-312 (2008).
-
(2008)
Br. J. Haematol.
, vol.140
, Issue.3
, pp. 303-312
-
-
Bleeker, W.K.1
Munk, M.E.2
Mackus, W.J.3
-
28
-
-
47049124865
-
First clinical use of ofatumumab, a novel fully human anti-CD20 monoclonal antibody in relapsed or refractory follicular lymphoma: Results of a Phase 1/2 trial
-
Hagenbeek A, Gadeberg O, Johnson P et al. First clinical use of ofatumumab, a novel fully human anti-CD20 monoclonal antibody in relapsed or refractory follicular lymphoma: Results of a Phase 1/2 trial. Blood 111(12), 5486-5495 (2008).
-
(2008)
Blood
, vol.111
, Issue.12
, pp. 5486-5495
-
-
Hagenbeek, A.1
Gadeberg, O.2
Johnson, P.3
-
29
-
-
38949185742
-
Safety and efficacy of ofatumumab, a fully human monoclonal anti-CD20 antibody, in patients with relapsed or refractory B-cell chronic lymphocytic leukemia: A phase 1-2 study
-
DOI 10.1182/blood-2007-09-111781
-
Coiffier B, Lepretre S, Pedersen LM et al. Safety and efficacy of ofatumumab, a fully human monoclonal anti-CD20 antibody, in patients with relapsed or refractory B-cell chronic lymphocytic leukemia: A Phase 1-2 study. Blood 111(3), 1094-1100 (2008). (Pubitemid 351213387)
-
(2008)
Blood
, vol.111
, Issue.3
, pp. 1094-1100
-
-
Coiffier, B.1
Lepretre, S.2
Pedersen, L.M.3
Gadeberg, O.4
Fredriksen, H.5
Van Oers, M.H.J.6
Wooldridge, J.7
Kloczko, J.8
Holowiecki, J.9
Hellmann, A.10
Walewski, J.11
Flensburg, M.12
Petersen, J.13
Robak, T.14
-
30
-
-
77953517111
-
Pharmacokinetics and pharmacokinetic/pharmacodynamic associations of ofatumumab, a human monoclonal CD20 antibody, in patients with relapsed or refractory chronic lymphocytic leukaemia: A Phase 1-2 study
-
Coiffier B, Losic N, Ronn BB et al. Pharmacokinetics and pharmacokinetic/pharmacodynamic associations of ofatumumab, a human monoclonal CD20 antibody, in patients with relapsed or refractory chronic lymphocytic leukaemia: A Phase 1-2 study. Br. J. Haematol. 150(1), 58-71 (2010).
-
(2010)
Br. J. Haematol.
, vol.150
, Issue.1
, pp. 58-71
-
-
Coiffier, B.1
Losic, N.2
Ronn, B.B.3
-
31
-
-
77950502126
-
Ofatumumab as single-agent CD20 immunotherapy in fludarabine-refractory chronic lymphocytic leukemia
-
nn Demonstrates activity of a novel second-generation anti-CD20 monoclonal antibody (ofatumumab), which led to the FDA approval of its use in chronic lymphocytic leukemia.
-
Wierda WG, Kipps TJ, Mayer J et al. Ofatumumab as single-agent CD20 immunotherapy in fludarabine-refractory chronic lymphocytic leukemia. J. Clin. Oncol. 28(10), 1749-1755 (2010). nn Demonstrates activity of a novel second-generation anti-CD20 monoclonal antibody (ofatumumab), which led to the FDA approval of its use in chronic lymphocytic leukemia.
-
(2010)
J. Clin. Oncol.
, vol.28
, Issue.10
, pp. 1749-1755
-
-
Wierda, W.G.1
Kipps, T.J.2
Mayer, J.3
-
32
-
-
67650345281
-
Ocrelizumab: A step forward in the evolution of B-cell therapy
-
Kausar F, Mustafa K, Sweis G et al. Ocrelizumab: A step forward in the evolution of B-cell therapy. Expert Opin. Biol. Ther. 9(7), 889-895 (2009).
-
(2009)
Expert Opin. Biol. Ther.
, vol.9
, Issue.7
, pp. 889-895
-
-
Kausar, F.1
Mustafa, K.2
Sweis, G.3
-
33
-
-
77955175014
-
Results of a Phase I/II study of ocrelizumab, a fully humanized anti-CD20 mAb, in patients with relapsed/refractory follicular lymphoma
-
Morschhauser F, Marlton P, Vitolo U et al. Results of a Phase I/II study of ocrelizumab, a fully humanized anti-CD20 mAb, in patients with relapsed/refractory follicular lymphoma. Ann. Oncol. 21(9), 1870-1876 (2010).
-
(2010)
Ann. Oncol.
, vol.21
, Issue.9
, pp. 1870-1876
-
-
Morschhauser, F.1
Marlton, P.2
Vitolo, U.3
-
34
-
-
77951561987
-
Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell-mediated B-cell cytotoxicity
-
Mossner E, Brunker P, Moser S et al. Increasing the efficacy of CD20 antibody therapy through the engineering of a new type II anti-CD20 antibody with enhanced direct and immune effector cell-mediated B-cell cytotoxicity. Blood 115(22), 4393-4402 (2010).
-
(2010)
Blood
, vol.115
, Issue.22
, pp. 4393-4402
-
-
Mossner, E.1
Brunker, P.2
Moser, S.3
-
35
-
-
34548386910
-
Novel 3rd generation humanized type II CD20 antibody with glycoengineered Fc and modified elbow hinge for enhanced ADCC and superior apoptosis induction
-
Abstract 229
-
Umana P, Moessner E, Bruenker P et al. Novel 3rd generation humanized type II CD20 antibody with glycoengineered Fc and modified elbow hinge for enhanced ADCC and superior apoptosis induction. Blood 108(11), Abstract 229 (2006).
-
(2006)
Blood
, vol.108
, Issue.11
-
-
Umana, P.1
Moessner, E.2
Bruenker, P.3
-
36
-
-
79955979273
-
Novel type II anti-CD20 monoclonal antibody (GA101) evokes homotypic adhesion and actin-dependent, lysosome-mediated cell death in B-cell malignancies
-
nn Exciting information regarding type II anti-CD20 monoclonal antibodies that are currently in clinical trials.
-
Alduaij W, Ivanov A, Honeychurch J et al. Novel type II anti-CD20 monoclonal antibody (GA101) evokes homotypic adhesion and actin-dependent, lysosome-mediated cell death in B-cell malignancies. Blood 117(17), 4519-4529 (2011). nn Exciting information regarding type II anti-CD20 monoclonal antibodies that are currently in clinical trials.
-
(2011)
Blood
, vol.117
, Issue.17
, pp. 4519-4529
-
-
Alduaij, W.1
Ivanov, A.2
Honeychurch, J.3
-
37
-
-
78751564397
-
Preclinical studies on the mechanism of action and the anti-lymphoma activity of the novel anti-CD20 antibody GA101
-
Dalle S, Reslan L, Besseyre De Horts T et al. Preclinical studies on the mechanism of action and the anti-lymphoma activity of the novel anti-CD20 antibody GA101. Mol. Cancer Ther. 10(1), 178-185 (2011).
-
(2011)
Mol. Cancer Ther.
, vol.10
, Issue.1
, pp. 178-185
-
-
Dalle, S.1
Reslan, L.2
Besseyre De Horts, T.3
-
38
-
-
78651354250
-
Comparison of the in vitro effects of the anti-CD20 antibodies rituximab and GA101 on chronic lymphocytic leukaemia cells
-
Patz M, Isaeva P, Forcob N et al. Comparison of the in vitro effects of the anti-CD20 antibodies rituximab and GA101 on chronic lymphocytic leukaemia cells. Br. J. Haematol. 152(3), 295-306 (2011).
-
(2011)
Br. J. Haematol.
, vol.152
, Issue.3
, pp. 295-306
-
-
Patz, M.1
Isaeva, P.2
Forcob, N.3
-
39
-
-
77950309251
-
Crystal structure analysis reveals that the novel type II anti-CD20 antibody GA101 interacts with a similar epitope as rituximab and ocrelizumab but in a fundamentally different way
-
Abstract 3726
-
Niederfellner G, Lammens A, Schwaiger M, et al. Crystal structure analysis reveals that the novel type II anti-CD20 antibody GA101 interacts with a similar epitope as rituximab and ocrelizumab but in a fundamentally different way. Blood 114(22), Abstract 3726 (2009).
-
(2009)
Blood
, vol.114
, Issue.22
-
-
Niederfellner, G.1
Lammens, A.2
Schwaiger, M.3
-
40
-
-
76949097312
-
Phase I study of RO5072759 (GA101) in patients with relapsed/refractory CD20+ non-Hodgkin lymphoma (NHL)
-
Abstract 1704
-
Salles G, Morschhauser F, Lamy T et al. Phase I study of RO5072759 (GA101) in patients with relapsed/refractory CD20+ non-Hodgkin lymphoma (NHL). Blood 114(22), Abstract 1704 (2009).
-
(2009)
Blood
, vol.114
, pp. 22
-
-
Salles, G.1
Morschhauser, F.2
Lamy, T.3
-
41
-
-
76949107685
-
Phase I study of RO5072759 (GA101) in relapsed/refractory chronic lymphocytic leukemia
-
Abstract 884
-
Morschhauser F, Cartron G, Lamy T. Phase I study of RO5072759 (GA101) in relapsed/refractory chronic lymphocytic leukemia. Blood 114, Abstract 884 (2009).
-
(2009)
Blood
, vol.114
-
-
Morschhauser, F.1
Cartron, G.2
Lamy, T.3
-
42
-
-
0032147065
-
CD22 negatively and positively regulates signal transduction through the B lymphocyte antigen receptor
-
DOI 10.1006/smim.1998.0121
-
Sato S, Tuscano JM, Inaoki M, Tedder TF. CD22 negatively and positively regulates signal transduction through the B lymphocyte antigen receptor. Semin. Immunol. 10(4), 287-297 (1998). (Pubitemid 28375304)
-
(1998)
Seminars in Immunology
, vol.10
, Issue.4
, pp. 287-297
-
-
Sato, S.1
Tuscano, J.M.2
Inaoki, M.3
Tedder, T.F.4
-
43
-
-
0026375173
-
Phase I immunotoxin trial in patients with B-cell lymphoma
-
Vitetta ES, Stone M, Amlot P et al. Phase I immunotoxin trial in patients with B-cell lymphoma. Cancer Res. 51(15), 4052-4058 (1991).
-
(1991)
Cancer Res.
, vol.51
, Issue.15
, pp. 4052-4058
-
-
Vitetta, E.S.1
Stone, M.2
Amlot, P.3
-
44
-
-
0030467610
-
CD22 regulates thymus-independent responses and the lifespan of B cells
-
Otipoby KL, Andersson KB, Draves KE et al. CD22 regulates thymus-independent responses and the lifespan of B cells. Nature 384(6610), 634-637 (1996).
-
(1996)
Nature
, vol.384
, Issue.6610
, pp. 634-637
-
-
Otipoby, K.L.1
Andersson, K.B.2
Draves, K.E.3
-
45
-
-
0042413843
-
Phase I/II trial of epratuzumab (humanized anti-CD22 antibody) in indolent non-Hodgkin's lymphoma
-
DOI 10.1200/JCO.2003.01.082
-
Leonard JP, Coleman M, Ketas JC et al. Phase I/II trial of epratuzumab (humanized anti-CD22 antibody) in indolent non-Hodgkin's lymphoma. J. Clin. Oncol. 21(16), 3051-3059 (2003). (Pubitemid 46606284)
-
(2003)
Journal of Clinical Oncology
, vol.21
, Issue.16
, pp. 3051-3059
-
-
Leonard, J.P.1
Coleman, M.2
Ketas, J.C.3
Chadburn, A.4
Ely, S.5
Furman, R.R.6
Wegener, W.A.7
Hansen, H.J.8
Ziccardi, H.9
Eschenberg, M.10
Gayko, U.11
Cesano, A.12
Goldenberg, D.M.13
-
46
-
-
4143123338
-
Epratuzumab, a humanized anti-CD22 antibody, in aggressive non-Hodgkin's lymphoma: Phase I/II clinical trial results
-
DOI 10.1158/1078-0432.CCR-04-0294
-
Leonard JP, Coleman M, Ketas JC et al. Epratuzumab, a humanized anti-CD22 antibody, in aggressive non-Hodgkin's lymphoma: Phase I/II clinical trial results. Clin. Cancer Res. 10(16), 5327-5334 (2004). (Pubitemid 39100467)
-
(2004)
Clinical Cancer Research
, vol.10
, Issue.16
, pp. 5327-5334
-
-
Leonard, J.P.1
Coleman, M.2
Ketas, J.C.3
Chadburn, A.4
Furman, R.5
Schuster, M.W.6
Feldman, E.J.7
Ashe, M.8
Schuster, S.J.9
Wegener, W.A.10
Hansen, H.J.11
Ziccardi, H.12
Eschenberg, M.13
Gayko, U.14
Fields, S.Z.15
Cesano, A.16
Goldenberg, D.M.17
-
47
-
-
33748471355
-
Multicenter phase II trial of immunotherapy with the humanized anti-CD22 antibody, epratuzumab, in combination with rituximab, in refractory or recurrent non-Hodgkin's lymphoma
-
DOI 10.1200/JCO.2006.05.6291
-
Strauss SJ, Morschhauser F, Rech J et al. Multicenter Phase II trial of immunotherapy with the humanized anti-CD22 antibody, epratuzumab, in combination with rituximab, in refractory or recurrent non-Hodgkin's lymphoma. J. Clin. Oncol. 24(24), 3880-3886 (2006). (Pubitemid 46630735)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.24
, pp. 3880-3886
-
-
Strauss, S.J.1
Morschhauser, F.2
Rech, J.3
Repp, R.4
Solal-Celigny, P.5
Zinzani, P.L.6
Engert, A.7
Coiffier, B.8
Hoelzer, D.F.9
Wegener, W.A.10
Teoh, N.K.W.11
Goldenberg, D.M.12
Lister, T.A.13
-
48
-
-
33845597766
-
A pilot study of epratuzumab and rituximab in combination with cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy in patients with previously untreated, diffuse large B-cell lymphoma
-
DOI 10.1002/cncr.22342
-
Micallef IN, Kahl BS, Maurer MJ et al. A pilot study of epratuzumab and rituximab in combination with cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy in patients with previously untreated, diffuse large B-cell lymphoma. Cancer 107(12), 2826-2832 (2006). (Pubitemid 44937036)
-
(2006)
Cancer
, vol.107
, Issue.12
, pp. 2826-2832
-
-
Micallef, I.N.M.1
Kahl, B.S.2
Maurer, M.J.3
Dogan, A.4
Ansell, S.M.5
Colgan, J.P.6
Geyer, S.7
Inwards, D.J.8
White, W.L.9
Habermann, T.M.10
-
49
-
-
70350656449
-
Final results of NCCTG N0489: Epratuzumab and rituximab in combination with cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy (ER-CHOP) in patients with previously untreated diffuse large B-cell lymphoma
-
Abstract 8508
-
Micallef IN, Maurer MJ, Nikcevich DA et al. Final results of NCCTG N0489: Epratuzumab and rituximab in combination with cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy (ER-CHOP) in patients with previously untreated diffuse large B-cell lymphoma. J. Clin. Oncol. 27(15), Abstract 8508 (2009).
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 15
-
-
Micallef, I.N.1
Maurer, M.J.2
Nikcevich, D.A.3
-
50
-
-
0037083345
-
Rationales, evidence, and design considerations for fractionated radioimmunotherapy
-
Denardo GL, Schlom J, Buchsbaum DJ et al. Rationales, evidence, and design considerations for fractionated radioimmunotherapy. Cancer 94(4 Suppl.), 1332-1348 (2002). (Pubitemid 34150897)
-
(2002)
Cancer
, vol.94
, Issue.4 SUPPL.
, pp. 1332-1348
-
-
DeNardo, G.L.1
Schlom, J.2
Buchsbaum, D.J.3
Meredith, R.F.4
O'Donoghue, J.A.5
Sgouros, G.6
Humm, J.L.7
DeNardo, S.J.8
-
51
-
-
8544267259
-
Advantage of residualizing radiolabels for an internalizing antibody against the B-cell lymphoma antigen, CD22
-
DOI 10.1007/s002620050371
-
Sharkey RM, Behr TM, Mattes MJ et al. Advantage of residualizing radiolabels for an internalizing antibody against the B-cell lymphoma antigen, CD22. Cancer Immunol. Immunother. 44(3), 179-188 (1997). (Pubitemid 27278391)
-
(1997)
Cancer Immunology Immunotherapy
, vol.44
, Issue.3
, pp. 179-188
-
-
Sharkey, R.M.1
Behr, T.M.2
Mattes, M.J.3
Stein, R.4
Griffiths, G.L.5
Shih, L.B.6
Hansen, H.J.7
Blumenthal, R.D.8
Dunn, R.M.9
Juweid, M.E.10
Goldenberg, D.M.11
-
52
-
-
0037207880
-
90Y-DOTA-hLL2: An agent for radioimmunotherapy of non-Hodgkin's lymphoma
-
Griffiths GL, Govindan SV, Sharkey RM, Fisher DR, Goldenberg DM. 90Y-DOTA-hLL2: An agent for radioimmunotherapy of non-Hodgkin's lymphoma. J. Nucl. Med. 44(1), 77-84 (2003). (Pubitemid 36077716)
-
(2003)
Journal of Nuclear Medicine
, vol.44
, Issue.1
, pp. 77-84
-
-
Griffiths, G.L.1
Govindan, S.V.2
Sharkey, R.M.3
Fisher, D.R.4
Goldenberg, D.M.5
-
53
-
-
22344437047
-
90Y-radiollabeled, humanized anti-CD22 monoclonal antibody, epratuzumab
-
DOI 10.1158/1078-0432.CCR-05-0172
-
Linden O, Hindorf C, Cavallin-Stahl E et al. Dose-fractionated radioimmunotherapy in non-Hodgkin's lymphoma using DOTA-conjugated, 90Y-radiolabeled, humanized anti-CD22 monoclonal antibody, epratuzumab. Clin. Cancer Res. 11(14), 5215-5222 (2005). (Pubitemid 41003709)
-
(2005)
Clinical Cancer Research
, vol.11
, Issue.14
, pp. 5215-5222
-
-
Linden, O.1
Hindorf, C.2
Cavallin-Stahl, E.3
Wegener, W.A.4
Goldenberg, D.M.5
Horne, H.6
Ohlsson, T.7
Stenberg, L.8
Strand, S.-E.9
Tennvall, J.10
-
54
-
-
77957272703
-
High rates of durable responses with anti-CD22 fractionated radioimmunotherapy: Results of a multicenter, Phase I/II study in non-Hodgkin's lymphoma
-
nn Demonstrates the significant clinical activity of an anti-CD22 radiolabeled antibody. The radiolabeled anti-CD22 antibody is internalized once it is bound to its target (i.e., to CD22
-
Morschhauser F, Kraeber-Bodere F, Wegener WA et al. High rates of durable responses with anti-CD22 fractionated radioimmunotherapy: Results of a multicenter, Phase I/II study in non-Hodgkin's lymphoma. J. Clin. Oncol. 28(23), 3709-3716 (2010). nn Demonstrates the significant clinical activity of an anti-CD22 radiolabeled antibody. The radiolabeled anti-CD22 antibody is internalized once it is bound to its target (i.e., to CD22).
-
(2010)
J. Clin. Oncol.
, vol.28
, Issue.23
, pp. 3709-3716
-
-
Morschhauser, F.1
Kraeber-Bodere, F.2
Wegener, W.A.3
-
55
-
-
10744229449
-
Antibody-targeted chemotherapy with CMC-544: A CD22-targeted immunoconjugate of calicheamicin for the treatment of B-lymphoid malignancies
-
DOI 10.1182/blood-2003-07-2466
-
Dijoseph JF, Armellino DC, Boghaert ER et al. Antibody-targeted chemotherapy with CMC-544: A CD22-targeted immunoconjugate of calicheamicin for the treatment of B-lymphoid malignancies. Blood 103(5), 1807-1814 (2004). (Pubitemid 38268977)
-
(2004)
Blood
, vol.103
, Issue.5
, pp. 1807-1814
-
-
DiJoseph, J.F.1
Armellino, D.C.2
Boghaert, E.R.3
Khandke, K.4
Dougher, M.M.5
Sridharan, L.6
Kunz, A.7
Hamann, P.R.8
Gorovits, B.9
Udata, C.10
Moran, J.K.11
Popplewell, A.G.12
Stephens, S.13
Frost, P.14
Damle, N.K.15
-
56
-
-
4544320025
-
Potent and specific antitumor efficacy of CMC-544, a CD22-targeted immunoconjugate of calicheamicin, against systemically disseminated B-cell lymphoma
-
DOI 10.1158/1078-0432.CCR-04-1134
-
Dijoseph JF, Goad ME, Dougher MM et al. Potent and specific antitumor efficacy of CMC-544, a CD22-targeted immunoconjugate of calicheamicin, against systemically disseminated B-cell lymphoma. Clin. Cancer Res. 10(24), 8620-8629 (2004). (Pubitemid 40053430)
-
(2004)
Clinical Cancer Research
, vol.10
, Issue.24
, pp. 8620-8629
-
-
DiJoseph, J.F.1
Goad, M.E.2
Dougher, M.M.3
Boghaert, E.R.4
Kunz, A.5
Hamann, P.R.6
Damle, N.K.7
-
57
-
-
77951648118
-
Safety, pharmacokinetics, and preliminary clinical activity of inotuzumab ozogamicin, a novel immunoconjugate for the treatment of B-cell non-Hodgkin's lymphoma: Results of a Phase I study
-
Advani A, Coiffier B, Czuczman MS et al. Safety, pharmacokinetics, and preliminary clinical activity of inotuzumab ozogamicin, a novel immunoconjugate for the treatment of B-cell non-Hodgkin's lymphoma: Results of a Phase I study. J. Clin. Oncol. 28(12), 2085-2093 (2010).
-
(2010)
J. Clin. Oncol.
, vol.28
, Issue.12
, pp. 2085-2093
-
-
Advani, A.1
Coiffier, B.2
Czuczman, M.S.3
-
58
-
-
77953682059
-
Anti-CD22 immunoconjugate inotuzumab ozogamicin (CMC-544) + rituximab: Clinical activity including survival in patients with recurrent/refractory follicular or 'aggressive' lymphoma
-
Abstract 584
-
Dang NH, Smith MR, Offner F et al. Anti-CD22 immunoconjugate inotuzumab ozogamicin (CMC-544) + rituximab: Clinical activity including survival in patients with recurrent/refractory follicular or 'aggressive' lymphoma. Blood 114(22), Abstract 584 (2009).
-
(2009)
Blood
, vol.114
, pp. 22
-
-
Dang, N.H.1
Smith, M.R.2
Offner, F.3
-
59
-
-
0035954624
-
Efficacy of the anti-CD22 recombinant immunotoxin BL22 in chemotherapy-resistant hairy-cell leukemia
-
DOI 10.1056/NEJM200107263450402
-
Kreitman RJ, Wilson WH, Bergeron K et al. Efficacy of the anti-CD22 recombinant immunotoxin BL22 in chemotherapy-resistant hairy-cell leukemia. N. Engl. J. Med. 345(4), 241-247 (2001). (Pubitemid 32695063)
-
(2001)
New England Journal of Medicine
, vol.345
, Issue.4
, pp. 241-247
-
-
Kreitman, R.J.1
Wilson, W.H.2
Bergeron, K.3
Raggio, M.4
Stetler-Stevenson, M.5
Fitzgerald, D.J.6
Pastan, I.7
-
60
-
-
67649933809
-
Phase II trial of recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) in patients with hairy cell leukemia
-
Kreitman RJ, Stetler-Stevenson M, Margulies I et al. Phase II trial of recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) in patients with hairy cell leukemia. J. Clin. Oncol. 27(18), 2983-2990 (2009).
-
(2009)
J. Clin. Oncol.
, vol.27
, Issue.18
, pp. 2983-2990
-
-
Kreitman, R.J.1
Stetler-Stevenson, M.2
Margulies, I.3
-
61
-
-
80051710392
-
Long term results of BL22 (CAT-3888) in multiply relapsed hairy cell leukemia
-
Abstract 3442
-
Kreitman RJ, Wilson WH, Stetler-Stevenson M, Noel P, Fitzgerald DJ, Pastan I. Long term results of BL22 (CAT-3888) in multiply relapsed hairy cell leukemia. Blood 114, Abstract 3442 (2009).
-
(2009)
Blood
, vol.114
-
-
Kreitman, R.J.1
Wilson, W.H.2
Stetler-Stevenson, M.3
Noel, P.4
Fitzgerald, D.J.5
Pastan, I.6
-
62
-
-
61349115036
-
CAT-8015: A second-generation pseudomonas exotoxin A-based immunotherapy targeting CD22-expressing hematologic malignancies
-
Alderson RF, Kreitman RJ, Chen T et al. CAT-8015: A second-generation pseudomonas exotoxin A-based immunotherapy targeting CD22-expressing hematologic malignancies. Clin. Cancer Res. 15(3), 832-839 (2009).
-
(2009)
Clin. Cancer Res.
, vol.15
, Issue.3
, pp. 832-839
-
-
Alderson, R.F.1
Kreitman, R.J.2
Chen, T.3
-
63
-
-
80051743261
-
A Phase 1 study of moxetumomab pasudotox, an anti-CD22 recombinant immunotoxin, in relapsed/refractory hairy cell leukemia (HCL): Updated results
-
Abstract 2516
-
Kreitman RJ, Tallman MS, Coutre S et al. A Phase 1 study of moxetumomab pasudotox, an anti-CD22 recombinant immunotoxin, in relapsed/refractory hairy cell leukemia (HCL): Updated results. Blood 116, Abstract 2516 (2010).
-
(2010)
Blood
, pp. 116
-
-
Kreitman, R.J.1
Tallman, M.S.2
Coutre, S.3
-
64
-
-
0025758477
-
Recombinant 25-kDa CD23 and interleukin 1 a promote the survival of germinal center B cells: Evidence for bifurcation in the development of centrocytes rescued from apoptosis
-
Liu YJ, Cairns JA, Holder MJ et al. Recombinant 25-kDa CD23 and interleukin 1 a promote the survival of germinal center B cells: Evidence for bifurcation in the development of centrocytes rescued from apoptosis. Eur. J. Immunol. 21(5), 1107-1114 (1991).
-
(1991)
Eur. J. Immunol.
, vol.21
, Issue.5
, pp. 1107-1114
-
-
Liu, Y.J.1
Cairns, J.A.2
Holder, M.J.3
-
65
-
-
0033652964
-
Quantitative expression of CD23 and its ligand CD21 in chronic lymphocytic leukemia
-
Lopez-Matas M, Rodriguez-Justo M, Morilla R, Catovsky D, Matutes E. Quantitative expression of CD23 and its ligand CD21 in chronic lymphocytic leukemia. Haematologica 85(11), 1140-1145 (2000).
-
(2000)
Haematologica
, vol.85
, Issue.11
, pp. 1140-1145
-
-
Lopez-Matas, M.1
Rodriguez-Justo, M.2
Morilla, R.3
Catovsky, D.4
Matutes, E.5
-
66
-
-
14744294919
-
Primatization' of recombinant antibodies for immunotherapy of human diseases: A macaque/human chimeric antibody against human CD4
-
Newman R, Alberts J, Anderson D et al. 'Primatization' of recombinant antibodies for immunotherapy of human diseases: A macaque/human chimeric antibody against human CD4. Biotechnology (NY) 10(11), 1455-1460 (1992).
-
(1992)
Biotechnology (NY)
, vol.10
, Issue.11
, pp. 1455-1460
-
-
Newman, R.1
Alberts, J.2
Anderson, D.3
-
67
-
-
38949180269
-
+ lymphoma cell lines
-
DOI 10.1182/blood-2007-03-082024
-
Pathan NI, Chu P, Hariharan K, Cheney C, Molina A, Byrd J. Mediation of apoptosis by and antitumor activity of lumiliximab in chronic lymphocytic leukemia cells and CD23+ lymphoma cell lines. Blood 111(3), 1594-1602 (2008). (Pubitemid 351213450)
-
(2008)
Blood
, vol.111
, Issue.3
, pp. 1594-1602
-
-
Pathan, N.I.1
Chu, P.2
Hariharan, K.3
Cheney, C.4
Molina, A.5
Byrd, J.6
-
68
-
-
34547691135
-
Phase 1 study of lumiliximab with detailed pharmacokinetic and pharmacodynamic measurements in patients with relapsed or refractory chronic lymphocytic leukemia
-
DOI 10.1158/1078-0432.CCR-06-1463
-
Byrd JC, O'Brien S, Flinn IW et al. Phase 1 study of lumiliximab with detailed pharmacokinetic and pharmacodynamic measurements in patients with relapsed or refractory chronic lymphocytic leukemia. Clin. Cancer Res. 13(15 Pt 1), 4448-4455 (2007). (Pubitemid 47219713)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.15
, pp. 4448-4455
-
-
Byrd, J.C.1
O'Brien, S.2
Flinn, I.W.3
Kipps, T.J.4
Weiss, M.5
Rai, K.6
Lin, T.S.7
Woodworth, J.8
Wynne, D.9
Reid, J.10
Molina, A.11
Leigh, B.12
Harris, S.13
-
69
-
-
77449133613
-
Phase 1/2 study of lumiliximab combined with fludarabine, cyclophosphamide, and rituximab in patients with relapsed or refractory chronic lymphocytic leukemia
-
Byrd JC, Kipps TJ, Flinn IW et al. Phase 1/2 study of lumiliximab combined with fludarabine, cyclophosphamide, and rituximab in patients with relapsed or refractory chronic lymphocytic leukemia. Blood 115(3), 489-495 (2010).
-
(2010)
Blood
, vol.115
, Issue.3
, pp. 489-495
-
-
Byrd, J.C.1
Kipps, T.J.2
Flinn, I.W.3
-
70
-
-
23044501404
-
Chemoimmunotherapy with fludarabine, cyclophosphamide, and rituximab for relapsed and refractory chronic lymphocytic leukemia
-
DOI 10.1200/JCO.2005.12.516
-
Wierda W, O'Brien S, Wen S et al. Chemoimmunotherapy with fludarabine, cyclophosphamide, and rituximab for relapsed and refractory chronic lymphocytic leukemia. J. Clin. Oncol. 23(18), 4070-4078 (2005). nn This regimen has very high and durable response rates in relapsed/refractory chronic lymphocytic leukemia, but also in treatment-naive patients. (Pubitemid 46211312)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.18
, pp. 4070-4078
-
-
Wierda, W.1
O'Brien, S.2
Wen, S.3
Faderl, S.4
Garcia-Manero, G.5
Thomas, D.6
Do, K.-A.7
Cortes, J.8
Koller, C.9
Beran, M.10
Ferrajoli, A.11
Giles, F.12
Lerner, S.13
Albitar, M.14
Kantarjian, H.15
Keating, M.16
-
71
-
-
0029133256
-
Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28
-
Peach RJ, Bajorath J, Naemura J et al. Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28. J. Biol. Chem. 270(36), 21181-21187 (1995).
-
(1995)
J. Biol. Chem.
, vol.270
, Issue.36
, pp. 21181-21187
-
-
Peach, R.J.1
Bajorath, J.2
Naemura, J.3
-
72
-
-
0030701589
-
In vivo expression of B7-1 and B7-2 by follicular lymphoma cells can prevent induction of T-cell anergy but is insufficient to induce significant T-cell proliferation
-
Dorfman DM, Schultze JL, Shahsafaei A et al. In vivo expression of B7-1 and B7-2 by follicular lymphoma cells can prevent induction of T-cell anergy but is insufficient to induce significant T-cell proliferation. Blood 90(11), 4297-4306 (1997). (Pubitemid 27508435)
-
(1997)
Blood
, vol.90
, Issue.11
, pp. 4297-4306
-
-
Dorfman, D.M.1
Schultze, J.L.2
Shahsafaei, A.3
Michalak, S.4
Gribben, J.G.5
Freeman, G.J.6
Pinkus, G.S.7
Nadler, L.M.8
-
73
-
-
0037040863
-
Distinct role of CD80 and CD86 in the regulation of the activation of B cell and B cell lymphoma
-
DOI 10.1074/jbc.M105902200
-
Suvas S, Singh V, Sahdev S, Vohra H, Agrewala JN. Distinct role of CD80 and CD86 in the regulation of the activation of B cell and B cell lymphoma. J. Biol. Chem. 277(10), 7766-7775 (2002). (Pubitemid 34968223)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.10
, pp. 7766-7775
-
-
Suvas, S.1
Singh, V.2
Sahdev, S.3
Vohra, H.4
Agrewala, J.N.5
-
74
-
-
79960971073
-
Therapeutic activity of IDEC-114 (anti-CD80) and rituximab (Rituxan®) in B-cell lymphoma
-
Abstract 2549
-
Hariharan K, Anderson D, Leigh B et al. Therapeutic activity of IDEC-114 (anti-CD80) and rituximab (Rituxan®) in B-cell lymphoma. Blood 98(608A), Abstract 2549 (2001).
-
(2001)
Blood
, vol.98
, Issue.608 A
-
-
Hariharan, K.1
Anderson, D.2
Leigh, B.3
-
75
-
-
22344436992
-
Phase I/II study of galiximab, an anti-CD80 antibody, for relapsed or refractory follicular lymphoma
-
DOI 10.1200/JCO.2005.09.018
-
Czuczman MS, Thall A, Witzig TE et al. Phase I/II study of galiximab, an anti-CD80 antibody, for relapsed or refractory follicular lymphoma. J. Clin. Oncol. 23(19), 4390-4398 (2005). (Pubitemid 46207013)
-
(2005)
Journal of Clinical Oncology
, vol.23
, Issue.19
, pp. 4390-4398
-
-
Czuczman, M.S.1
Thall, A.2
Witzig, T.E.3
Vose, J.M.4
Younes, A.5
Emmanouilides, C.6
Miller, T.P.7
Moore, J.O.8
Leonard, J.P.9
Gordon, L.I.10
Sweetenham, J.11
Alkuzweny, B.12
Finucane, D.M.13
Leigh, B.R.14
-
76
-
-
34547844167
-
A phase I/II study of galiximab (an anti-CD80 monoclonal antibody) in combination with rituximab for relapsed or refractory, follicular lymphoma
-
DOI 10.1093/annonc/mdm114
-
Leonard JP, Friedberg JW, Younes A et al. A Phase I/II study of galiximab (an anti-CD80 monoclonal antibody) in combination with rituximab for relapsed or refractory, follicular lymphoma. Ann. Oncol. 18(7), 1216-1223 (2007). (Pubitemid 47244369)
-
(2007)
Annals of Oncology
, vol.18
, Issue.7
, pp. 1216-1223
-
-
Leonard, J.P.1
Friedberg, J.W.2
Younes, A.3
Fisher, D.4
Gordon, L.I.5
Moore, J.6
Czuczman, M.7
Miller, T.8
Stiff, P.9
Cheson, B.D.10
Forero-Torres, A.11
Chieffo, N.12
McKinney, B.13
Finucane, D.14
Molina, A.15
-
77
-
-
70350663275
-
Durable responses in patients treated with galiximab (anti-CD80) in combination with rituximab for relapsed or refractory follicular lymphoma: Long-term follow-up of a Phase II clinical trial
-
Abstract 1004
-
Friedberg JW, Younes A, Fisher DC et al. Durable responses in patients treated with galiximab (anti-CD80) in combination with rituximab for relapsed or refractory follicular lymphoma: Long-term follow-up of a Phase II clinical trial. Blood 112(11), Abstract 1004 (2008).
-
(2008)
Blood
, vol.112
, pp. 11
-
-
Friedberg, J.W.1
Younes, A.2
Fisher, D.C.3
-
78
-
-
77951047055
-
FLIPI score is applicable and predictive of response to upfront immunotherapy in CALGB 50402: Phase II trial of extended induction galiximab ([G] anti-CD80 monoclonal antibody) plus rituximab [R]
-
Abstract 1003
-
Czuczman MS, Leonard JP, Johnson JL et al. FLIPI score is applicable and predictive of response to upfront immunotherapy in CALGB 50402: Phase II trial of extended induction galiximab ([G] anti-CD80 monoclonal antibody) plus rituximab [R]. Blood 112(11), Abstract 1003 (2008).
-
(2008)
Blood
, vol.112
, pp. 11
-
-
Czuczman, M.S.1
Leonard, J.P.2
Johnson, J.L.3
-
79
-
-
79955814669
-
A Phase 2, double-blind, placebo-controlled trial of rituximab + galiximab vs rituximab + placebo in advanced follicular non-Hodgkin's lymphoma (NHL)
-
Abstract 428
-
Bence-Bruckler I, Macdonald D, Stiff PJ et al. A Phase 2, double-blind, placebo-controlled trial of rituximab + galiximab vs rituximab + placebo in advanced follicular non-Hodgkin's lymphoma (NHL). Blood 116(21), Abstract 428 (2010).
-
(2010)
Blood
, vol.116
, Issue.21
-
-
Bence-Bruckler, I.1
Macdonald, D.2
Stiff, P.J.3
-
80
-
-
0025630628
-
Temporal association of CD40 antigen expression with discrete stages of human B-cell ontogeny and the efficacy of anti-CD40 immunotoxins against clonogenic B-lineage acute lymphoblastic leukemia as well as B-lineage non-Hodgkin's lymphoma cells
-
Uckun FM, Gajl-Peczalska K, Myers DE, Jaszcz W, Haissig S, Ledbetter JA. Temporal association of CD40 antigen expression with discrete stages of human B-cell ontogeny and the efficacy of anti-CD40 immunotoxins against clonogenic B-lineage acute lymphoblastic leukemia as well as B-lineage non-Hodgkin's lymphoma cells. Blood 76(12), 2449-2456 (1990).
-
(1990)
Blood
, vol.76
, Issue.12
, pp. 2449-2456
-
-
Uckun, F.M.1
Gajl-Peczalska, K.2
Myers, D.E.3
Jaszcz, W.4
Haissig, S.5
Ledbetter, J.A.6
-
81
-
-
0030937548
-
CD40/CD40 ligand interactions in normal, reactive and malignant lympho-hematopoietic tissues
-
Gruss HJ, Herrmann F, Gattei V, Gloghini A, Pinto A, Carbone A. CD40/CD40 ligand interactions in normal, reactive and malignant lympho-hematopoietic tissues. Leuk. Lymphoma 24(5-6), 393-422 (1997). (Pubitemid 27182198)
-
(1997)
Leukemia and Lymphoma
, vol.24
, Issue.5-6
, pp. 393-422
-
-
Gruss, H.-J.1
Herrmann, F.2
Gattei, V.3
Gloghini, A.4
Pinto, A.5
Carbone, A.6
-
82
-
-
0028059817
-
Expression and function of CD40 on Hodgkin and Reed-Sternberg cells and the possible relevance for Hodgkin's disease
-
Gruss HJ, Hirschstein D, Wright B et al. Expression and function of CD40 on Hodgkin and Reed-Sternberg cells and the possible relevance for Hodgkin's disease. Blood 84(7), 2305-2314 (1994). (Pubitemid 24296393)
-
(1994)
Blood
, vol.84
, Issue.7
, pp. 2305-2314
-
-
Gruss, H.-J.1
Hirschstein, D.2
Wright, B.3
Ulrich, D.4
Caligiuri, M.A.5
Barcos, M.6
Strockbine, L.7
Armitage, R.J.8
Dower, S.K.9
-
83
-
-
24944581157
-
Preclinical antilymphoma activity of a humanized anti-CD40 monoclonal antibody, SGN-40
-
DOI 10.1158/0008-5472.CAN-05-0095
-
Law CL, Gordon KA, Collier J et al. Preclinical antilymphoma activity of a humanized anti-CD40 monoclonal antibody, SGN-40. Cancer Res. 65(18), 8331-8338 (2005). (Pubitemid 41330598)
-
(2005)
Cancer Research
, vol.65
, Issue.18
, pp. 8331-8338
-
-
Law, C.-L.1
Gordon, K.A.2
Collier, J.3
Klussman, K.4
McEarchern, J.A.5
Cerveny, C.G.6
Mixan, B.J.7
Lee, W.P.8
Lin, Z.9
Valdez, P.10
Wahl, A.F.11
Grewal, I.S.12
-
84
-
-
79958093024
-
Proapoptotic signaling activity of the anti-CD40 monoclonal antibody dacetuzumab circumvents multiple oncogenic transformation events and chemosensitizes NHL cells
-
Lewis TS, McCormick RS, Stone IJ et al. Proapoptotic signaling activity of the anti-CD40 monoclonal antibody dacetuzumab circumvents multiple oncogenic transformation events and chemosensitizes NHL cells. Leukemia 25(6), 1007-1016 (2011).
-
(2011)
Leukemia
, vol.25
, Issue.6
, pp. 1007-1016
-
-
Lewis, T.S.1
McCormick, R.S.2
Stone, I.J.3
-
85
-
-
70349334508
-
Phase I study of the humanized anti-CD40 monoclonal antibody dacetuzumab in refractory or recurrent non-Hodgkin's lymphoma
-
Advani R, Forero-Torres A, Furman RR et al. Phase I study of the humanized anti-CD40 monoclonal antibody dacetuzumab in refractory or recurrent non-Hodgkin's lymphoma. J. Clin. Oncol. 27(26), 4371-4377 (2009).
-
(2009)
J. Clin. Oncol.
, vol.27
, Issue.26
, pp. 4371-4377
-
-
Advani, R.1
Forero-Torres, A.2
Furman, R.R.3
-
86
-
-
66749176390
-
A Phase 2 clinical trial of SGN-40 monotherapy in relapsed diffuse large B-cell lymphoma
-
Abstract 1000
-
Advani R, Vos SD, Ansell SM et al. A Phase 2 clinical trial of SGN-40 monotherapy in relapsed diffuse large B-cell lymphoma. Blood 112(11), Abstract 1000 (2008).
-
(2008)
Blood
, vol.112
, pp. 11
-
-
Advani, R.1
Vos, S.D.2
Ansell, S.M.3
-
87
-
-
80051710011
-
A Phase 1b clinical trial of dacetuzumab in combination with rituximab and gemcitabine: Multiple responses observed in patients with relapsed diffuse large B-cell lymphoma
-
Abstract 586
-
Forero-Torres A, Bartlett NL, Nasta SD et al. A Phase 1b clinical trial of dacetuzumab in combination with rituximab and gemcitabine: Multiple responses observed in patients with relapsed diffuse large B-cell lymphoma. Blood 114(22), Abstract 586 (2009).
-
(2009)
Blood
, vol.114
, pp. 22
-
-
Forero-Torres, A.1
Bartlett, N.L.2
Nasta, S.D.3
-
88
-
-
80051772478
-
Dacetuzumab (SGN-40), lenalidomide, and weekly dexamethasone in relapsed or refractory multiple myeloma: Multiple responses observed in a Phase 1b study
-
Abstract 2870
-
Agura E, Niesvizky R, Matous J et al. Dacetuzumab (SGN-40), lenalidomide, and weekly dexamethasone in relapsed or refractory multiple myeloma: Multiple responses observed in a Phase 1b study. Blood 114(22), Abstract 2870 (2009).
-
(2009)
Blood
, vol.114
, pp. 22
-
-
Agura, E.1
Niesvizky, R.2
Matous, J.3
-
89
-
-
50949133383
-
The antileukemia activity of a human anti-CD40 antagonist antibody, HCD122, on human chronic lymphocytic leukemia cells
-
Luqman M, Klabunde S, Lin K et al. The antileukemia activity of a human anti-CD40 antagonist antibody, HCD122, on human chronic lymphocytic leukemia cells. Blood 112(3), 711-720 (2008).
-
(2008)
Blood
, vol.112
, Issue.3
, pp. 711-720
-
-
Luqman, M.1
Klabunde, S.2
Lin, K.3
-
90
-
-
0028829967
-
CD30 (Ki-1) molecule: A new cytokine receptor of the tumor necrosis factor receptor superfamily as a tool for diagnosis and immunotherapy
-
Falini B, Pileri S, Pizzolo G et al. CD30 (Ki-1) molecule: A new cytokine receptor of the tumor necrosis factor receptor superfamily as a tool for diagnosis and immunotherapy. Blood 85(1), 1-14 (1995).
-
(1995)
Blood
, vol.85
, Issue.1
, pp. 1-14
-
-
Falini, B.1
Pileri, S.2
Pizzolo, G.3
-
91
-
-
0026601968
-
Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin's disease
-
Durkop H, Latza U, Hummel M, Eitelbach F, Seed B, Stein H. Molecular cloning and expression of a new member of the nerve growth factor receptor family that is characteristic for Hodgkin's disease. Cell 68(3), 421-427 (1992).
-
(1992)
Cell
, vol.68
, Issue.3
, pp. 421-427
-
-
Durkop, H.1
Latza, U.2
Hummel, M.3
Eitelbach, F.4
Seed, B.5
Stein, H.6
-
92
-
-
0842321788
-
Extremely rapid and intense induction of apoptosis in human eosinophils by anti-CD30 antibody treatment in vitro
-
Matsumoto K, Terakawa M, Miura K, Fukuda S, Nakajima T, Saito H. Extremely rapid and intense induction of apoptosis in human eosinophils by anti-CD30 antibody treatment in vitro. J. Immunol. 172(4), 2186-2193 (2004). (Pubitemid 38182365)
-
(2004)
Journal of Immunology
, vol.172
, Issue.4
, pp. 2186-2193
-
-
Matsumoto, K.1
Terakawa, M.2
Miura, K.3
Fukuda, S.4
Nakajima, T.5
Saito, H.6
-
93
-
-
41349086204
-
+ hematologic malignancies
-
DOI 10.1182/blood-2007-07-099317
-
Bartlett NL, Younes A, Carabasi MH et al. A Phase 1 multidose study of SGN-30 immunotherapy in patients with refractory or recurrent CD30+ hematologic malignancies. Blood 111(4), 1848-1854 (2008). (Pubitemid 351451492)
-
(2008)
Blood
, vol.111
, Issue.4
, pp. 1848-1854
-
-
Bartlett, N.L.1
Younes, A.2
Carabasi, M.H.3
Forero, A.4
Rosenblatt, J.D.5
Leonard, J.P.6
Bernstein, S.H.7
Bociek, R.G.8
Lorenz, J.M.9
Hart, B.W.10
Barton, J.11
-
94
-
-
67649908324
-
A Phase II study of SGN-30 (anti-CD30 mAb) in Hodgkin lymphoma or systemic anaplastic large cell lymphoma
-
Forero-Torres A, Leonard JP, Younes A et al. A Phase II study of SGN-30 (anti-CD30 mAb) in Hodgkin lymphoma or systemic anaplastic large cell lymphoma. Br. J. Haematol. 146(2), 171-179 (2009).
-
(2009)
Br. J. Haematol.
, vol.146
, Issue.2
, pp. 171-179
-
-
Forero-Torres, A.1
Leonard, J.P.2
Younes, A.3
-
95
-
-
78049515807
-
Brentuximab vedotin (SGN-35) for relapsed CD30-positive lymphomas
-
nn Presents a very exciting drug immunoconjugate that targets CD30 and will be evaluated by the FDA later in 2011. Represents an important antitumor agent for Hodgkin lymphoma and anaplastic non-Hodgkin lymphoma.
-
Younes A, Bartlett NL, Leonard JP et al. Brentuximab vedotin (SGN-35) for relapsed CD30-positive lymphomas. N. Engl. J. Med. 363(19), 1812-1821 (2010). nn Presents a very exciting drug immunoconjugate that targets CD30 and will be evaluated by the FDA later in 2011. Represents an important antitumor agent for Hodgkin lymphoma and anaplastic non-Hodgkin lymphoma.
-
(2010)
N. Engl. J. Med.
, vol.363
, Issue.19
, pp. 1812-1821
-
-
Younes, A.1
Bartlett, N.L.2
Leonard, J.P.3
-
96
-
-
78951477856
-
Results of a pivotal Phase 2 study of brentuximab vedotin (SGN-35) in patients with relapsed or refractory Hodgkin lymphoma
-
Abstract 283
-
Chen R, Gopal A, Smith S et al. Results of a pivotal Phase 2 study of brentuximab vedotin (SGN-35) in patients with relapsed or refractory Hodgkin lymphoma. Blood 116, Abstract 283 (2010).
-
(2010)
Blood
, pp. 116
-
-
Chen, R.1
Gopal, A.2
Smith, S.3
-
97
-
-
78951471865
-
Complete remissions with brentuximab vedotin (SGN-35) in patients with relapsed or refractory systemic anaplastic large cell lymphoma
-
Abstract 961
-
Shustov A, Advani R, Brice P et al. Complete remissions with brentuximab vedotin (SGN-35) in patients with relapsed or refractory systemic anaplastic large cell lymphoma. Blood 116(21), Abstract 961 (2010).
-
(2010)
Blood
, vol.116
, Issue.21
-
-
Shustov, A.1
Advani, R.2
Brice, P.3
-
98
-
-
34447573999
-
Phase I/II study of an anti-CD30 monoclonal antibody (MDX-060) in Hodgkin's lymphoma and anaplastic large-cell lymphoma
-
DOI 10.1200/JCO.2006.07.8972
-
Ansell SM, Horwitz SM, Engert A et al. Phase I/II study of an anti-CD30 monoclonal antibody (MDX-060) in Hodgkin's lymphoma and anaplastic large-cell lymphoma. J. Clin. Oncol. 25(19), 2764-2769 (2007). (Pubitemid 47123185)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.19
, pp. 2764-2769
-
-
Ansell, S.M.1
Horwitz, S.M.2
Engert, A.3
Khan, K.D.4
Lin, T.5
Strair, R.6
Keler, T.7
Graziano, R.8
Blanset, D.9
Yellin, M.10
Fischkoff, S.11
Assad, A.12
Borchmann, P.13
-
99
-
-
76749151760
-
Phase I study of an anti-CD30 Fc engineered humanized monoclonal antibody in Hodgkin lymphoma (HL) or anaplastic large cell lymphoma (ALCL) patients: Safety, pharmacokinetics (PK), immunogenicity, and efficacy
-
Abstract 8531
-
Blum KA, Smith MR, Fung HC et al. Phase I study of an anti-CD30 Fc engineered humanized monoclonal antibody in Hodgkin lymphoma (HL) or anaplastic large cell lymphoma (ALCL) patients: Safety, pharmacokinetics (PK), immunogenicity, and efficacy. J. Clin. Oncol. 27(15 Suppl.), Abstract 8531 (2009).
-
(2009)
J. Clin. Oncol.
, vol.27
, Issue.15 SUPPL.
-
-
Blum, K.A.1
Smith, M.R.2
Fung, H.C.3
-
100
-
-
77949670310
-
Death receptor agonists as a targeted therapy for cancer
-
Wiezorek J, Holland P, Graves J. Death receptor agonists as a targeted therapy for cancer. Clin. Cancer Res. 16(6), 1701-1708 (2010).
-
(2010)
Clin. Cancer Res.
, vol.16
, Issue.6
, pp. 1701-1708
-
-
Wiezorek, J.1
Holland, P.2
Graves, J.3
-
101
-
-
0035892123
-
Expression of tumor necrosis factor-related apoptosis-inducing ligand, Apo2L, and its receptors in myelodysplastic syndrome: Effects on in vitro hemopoiesis
-
Zang DY, Goodwin RG, Loken MR, Bryant E, Deeg HJ. Expression of tumor necrosis factor-related apoptosis-inducing ligand, Apo2L, and its receptors in myelodysplastic syndrome: Effects on in vitro hemopoiesis. Blood 98(10), 3058-3065 (2001).
-
(2001)
Blood
, vol.98
, Issue.10
, pp. 3058-3065
-
-
Zang, D.Y.1
Goodwin, R.G.2
Loken, M.R.3
Bryant, E.4
Deeg, H.J.5
-
102
-
-
14944367957
-
Increased sensitivity to TRAIL-induced apoptosis occurs during the adenoma to carcinoma transition of colorectal carcinogenesis
-
DOI 10.1038/sj.bjc.6602387
-
Hague A, Hicks DJ, Hasan F et al. Increased sensitivity to TRAIL-induced apoptosis occurs during the adenoma to carcinoma transition of colorectal carcinogenesis. Br. J. Cancer 92(4), 736-742 (2005). (Pubitemid 40460611)
-
(2005)
British Journal of Cancer
, vol.92
, Issue.4
, pp. 736-742
-
-
Hague, A.1
Hicks, D.J.2
Hasan, F.3
Smartt, H.4
Cohen, G.M.5
Paraskeva, C.6
MacFarlane, M.7
-
103
-
-
52749085743
-
Targeted manipulation of apoptosis in cancer treatment
-
Call JA, Eckhardt SG, Camidge DR. Targeted manipulation of apoptosis in cancer treatment. Lancet Oncol. 9(10), 1002-1011 (2008).
-
(2008)
Lancet Oncol.
, vol.9
, Issue.10
, pp. 1002-1011
-
-
Call, J.A.1
Eckhardt, S.G.2
Camidge, D.R.3
-
104
-
-
21044441651
-
HGS-ETR1, a fully human TRAIL-receptor 1 monoclonal antibody, induces cell death in multiple tumour types in vitro and in vivo
-
DOI 10.1038/sj.bjc.6602487
-
Pukac L, Kanakaraj P, Humphreys R et al. HGS-ETR1, a fully human TRAIL-receptor 1 monoclonal antibody, induces cell death in multiple tumour types in vitro and in vivo. Br. J. Cancer 92(8), 1430-1441 (2005). (Pubitemid 40705010)
-
(2005)
British Journal of Cancer
, vol.92
, Issue.8
, pp. 1430-1441
-
-
Pukae, L.1
Kanakaraj, P.2
Humphreys, R.3
Alderson, R.4
Bloom, M.5
Sung, C.6
Riccobene, T.7
Johnson, R.8
Fiscella, M.9
Mahoney, A.10
Carrell, J.11
Boyd, E.12
Yao, X.T.13
Zhang, L.14
Zhong, L.15
Von Kerczek, A.16
Shepard, L.17
Vaughan, T.18
Edwards, B.19
Dobson, C.20
Salcedo, T.21
Albert, V.22
more..
-
105
-
-
34547653954
-
Augmented antitumor activity against B-cell lymphoma by a combination of monoclonal antibodies targeting TRAIL-R1 and CD20
-
DOI 10.1158/1078-0432.CCR-07-0680
-
Maddipatla S, Hernandez-Ilizaliturri FJ, Knight J, Czuczman MS. Augmented antitumor activity against B-cell lymphoma by a combination of monoclonal antibodies targeting TRAIL-R1 and CD20. Clin. Cancer Res. 13(15 Pt 1), 4556-4564 (2007). (Pubitemid 47219726)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.15
, pp. 4556-4564
-
-
Maddipatla, S.1
Hernandez-Ilizaliturri, F.J.2
Knight, J.3
Czuczman, M.S.4
-
106
-
-
37049008917
-
Cooperation of the proapoptotic receptor agonist rhApo2L/TRAIL with the CD20 antibody rituximab against non-Hodgkin lymphoma xenografts
-
DOI 10.1182/blood-2007-02-076075
-
Daniel D, Yang B, Lawrence DA et al. Cooperation of the proapoptotic receptor agonist rhApo2L/TRAIL with the CD20 antibody rituximab against non-Hodgkin lymphoma xenografts. Blood 110(12), 4037-4046 (2007). (Pubitemid 350248460)
-
(2007)
Blood
, vol.110
, Issue.12
, pp. 4037-4046
-
-
Daniel, D.1
Yang, B.2
Lawrence, D.A.3
Totpal, K.4
Balter, I.5
Lee, W.P.6
Gogineni, A.7
Cole, M.J.8
Yee, S.F.9
Ross, S.10
Ashkenazi, A.11
-
107
-
-
34248187996
-
Phase I pharmacokinetic and biologic correlative study of mapatumumab, a fully human monoclonal antibody with agonist activity to tumor necrosis factor-related apoptosis-inducing ligand receptor-1
-
DOI 10.1200/JCO.2006.08.8898
-
Tolcher AW, Mita M, Meropol NJ et al. Phase I pharmacokinetic and biologic correlative study of mapatumumab, a fully human monoclonal antibody with agonist activity to tumor necrosis factor-related apoptosis-inducing ligand receptor-1. J. Clin. Oncol. 25(11), 1390-1395 (2007). (Pubitemid 46706887)
-
(2007)
Journal of Clinical Oncology
, vol.25
, Issue.11
, pp. 1390-1395
-
-
Tolcher, A.W.1
Mita, M.2
Meropol, N.J.3
Von Mehren, M.4
Patnaik, A.5
Padavic, K.6
Hill, M.7
Mays, T.8
McCoy, T.9
Fox, N.L.10
Halpern, W.11
Corey, A.12
Cohen, R.B.13
-
108
-
-
45649084324
-
Phase 2 study of mapatumumab, a fully human agonistic monoclonal antibody which targets and activates the TRAIL receptor-1, in patients with advanced non-small cell lung cancer
-
Greco FA, Bonomi P, Crawford J et al. Phase 2 study of mapatumumab, a fully human agonistic monoclonal antibody which targets and activates the TRAIL receptor-1, in patients with advanced non-small cell lung cancer. Lung Cancer 61(1), 82-90 (2008).
-
(2008)
Lung Cancer
, vol.61
, Issue.1
, pp. 82-90
-
-
Greco, F.A.1
Bonomi, P.2
Crawford, J.3
-
109
-
-
50349092260
-
A Phase 1 study of mapatumumab (fully human monoclonal antibody to TRAIL-R1) in patients with advanced solid malignancies
-
Hotte SJ, Hirte HW, Chen EX et al. A Phase 1 study of mapatumumab (fully human monoclonal antibody to TRAIL-R1) in patients with advanced solid malignancies. Clin. Cancer Res. 14(11), 3450-3455 (2008).
-
(2008)
Clin. Cancer Res.
, vol.14
, Issue.11
, pp. 3450-3455
-
-
Hotte, S.J.1
Hirte, H.W.2
Chen, E.X.3
-
110
-
-
69949110775
-
Mapatumumab, a fully human agonistic monoclonal antibody that targets TRAIL-R1, in combination with gemcitabine and cisplatin: A Phase I study
-
Mom CH, Verweij J, Oldenhuis CN et al. Mapatumumab, a fully human agonistic monoclonal antibody that targets TRAIL-R1, in combination with gemcitabine and cisplatin: A Phase I study. Clin. Cancer Res. 15(17), 5584-5590 (2009).
-
(2009)
Clin. Cancer Res.
, vol.15
, Issue.17
, pp. 5584-5590
-
-
Mom, C.H.1
Verweij, J.2
Oldenhuis, C.N.3
-
111
-
-
76349085626
-
Phase II trial of mapatumumab, a fully human agonistic monoclonal antibody that targets and activates the tumour necrosis factor apoptosis-inducing ligand receptor-1 (TRAIL-R1), in patients with refractory colorectal cancer
-
Trarbach T, Moehler M, Heinemann V et al. Phase II trial of mapatumumab, a fully human agonistic monoclonal antibody that targets and activates the tumour necrosis factor apoptosis-inducing ligand receptor-1 (TRAIL-R1), in patients with refractory colorectal cancer. Br. J. Cancer 102(3), 506-512 (2010).
-
(2010)
Br. J. Cancer
, vol.102
, Issue.3
, pp. 506-512
-
-
Trarbach, T.1
Moehler, M.2
Heinemann, V.3
-
112
-
-
78650021203
-
A Phase 1b/2 trial of mapatumumab in patients with relapsed/refractory non-Hodgkin's lymphoma
-
Younes A, Vose JM, Zelenetz AD et al. A Phase 1b/2 trial of mapatumumab in patients with relapsed/refractory non-Hodgkin's lymphoma. Br. J. Cancer 103(12), 1783-1787 (2010).
-
(2010)
Br. J. Cancer
, vol.103
, Issue.12
, pp. 1783-1787
-
-
Younes, A.1
Vose, J.M.2
Zelenetz, A.D.3
-
113
-
-
33846860644
-
CD8+ T-cell content in diagnostic lymph nodes measured by flow cytometry is a predictor of survival in follicular lymphoma
-
DOI 10.1158/1078-0432.CCR-06-1734
-
Wahlin BE, Sander B, Christensson B, Kimby E. CD8+ T-cell content in diagnostic lymph nodes measured by flow cytometry is a predictor of survival in follicular lymphoma. Clin. Cancer Res. 13(2 Pt 1), 388-397 (2007). (Pubitemid 46225341)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.2
, pp. 388-397
-
-
Wahlin, B.E.1
Sander, B.2
Christensson, B.3
Kimby, E.4
-
114
-
-
68449086890
-
Immunotherapy of lymphoma and leukemia with T-cell engaging BiTE antibody blinatumomab
-
Nagorsen D, Bargou R, Ruttinger D, Kufer P, Baeuerle PA, Zugmaier G. Immunotherapy of lymphoma and leukemia with T-cell engaging BiTE antibody blinatumomab. Leuk. Lymphoma 50(6), 886-891 (2009).
-
(2009)
Leuk. Lymphoma
, vol.50
, Issue.6
, pp. 886-891
-
-
Nagorsen, D.1
Bargou, R.2
Ruttinger, D.3
Kufer, P.4
Baeuerle, P.A.5
Zugmaier, G.6
-
115
-
-
37349123501
-
Strictly target cell-dependent activation of T cells by bispecific single-chain antibody constructs of the BiTE class
-
DOI 10.1097/CJI.0b013e318156750c, PII 0000237120071100000002
-
Brischwein K, Parr L, Pflanz S et al. Strictly target cell-dependent activation of T cells by bispecific single-chain antibody constructs of the BiTE class. J. Immunother. 30(8), 798-807 (2007). (Pubitemid 350295358)
-
(2007)
Journal of Immunotherapy
, vol.30
, Issue.8
, pp. 798-807
-
-
Brischwein, K.1
Parr, L.2
Pflanz, S.3
Volkland, J.4
Lumsden, J.5
Klinger, M.6
Locher, M.7
Hammond, S.A.8
Kiener, P.9
Kufer, P.10
Schlereth, B.11
Baeuerle, P.A.12
-
116
-
-
58849085569
-
BiTE: Teaching antibodies to engage T-cells for cancer therapy
-
Baeuerle PA, Kufer P, Bargou R. BiTE: Teaching antibodies to engage T-cells for cancer therapy. Curr. Opin. Mol. Ther. 11(1), 22-30 (2009).
-
(2009)
Curr. Opin. Mol. Ther.
, vol.11
, Issue.1
, pp. 22-30
-
-
Baeuerle, P.A.1
Kufer, P.2
Bargou, R.3
-
117
-
-
0037446782
-
T cell costimulus-independent and very efficacious inhibition of tumor growth in mice bearing subcutaneous or leukemic human B cell lymphoma xenografts by a CD19-/CD3-bispecific single-chain antibody construct
-
Dreier T, Baeuerle PA, Fichtner I et al. T cell costimulus-independent and very efficacious inhibition of tumor growth in mice bearing subcutaneous or leukemic human B cell lymphoma xenografts by a CD19-/CD3-bispecific single-chain antibody construct. J. Immunol. 170(8), 4397-4402 (2003). (Pubitemid 36428210)
-
(2003)
Journal of Immunology
, vol.170
, Issue.8
, pp. 4397-4402
-
-
Dreier, T.1
Baeuerle, P.A.2
Fichtner, I.3
Grun, M.4
Schlereth, B.5
Lorenczewski, G.6
Kufer, P.7
Lutterbuse, R.8
Riethmuller, G.9
Gjorstrup, P.10
Bargou, R.C.11
-
118
-
-
49649120397
-
Tumor regression in cancer patients by very low doses of a T cell-engaging antibody
-
Bargou R, Leo E, Zugmaier G et al. Tumor regression in cancer patients by very low doses of a T cell-engaging antibody. Science 321(5891), 974-977 (2008).
-
(2008)
Science
, vol.321
, Issue.5891
, pp. 974-977
-
-
Bargou, R.1
Leo, E.2
Zugmaier, G.3
-
119
-
-
58549109813
-
Combination of rituximab with blinatumomab (MT103/MEDI-538), a T cell-engaging CD19-/CD3-bispecific antibody, for highly efficient lysis of human B lymphoma cells
-
D'Argouges S, Wissing S, Brandl C et al. Combination of rituximab with blinatumomab (MT103/MEDI-538), a T cell-engaging CD19-/CD3-bispecific antibody, for highly efficient lysis of human B lymphoma cells. Leuk. Res. 33(3), 465-473 (2009).
-
(2009)
Leuk. Res.
, vol.33
, Issue.3
, pp. 465-473
-
-
D'Argouges, S.1
Wissing, S.2
Brandl, C.3
-
120
-
-
33751347582
-
Biopharmaceutical drug discovery using novel protein scaffolds
-
DOI 10.1016/j.copbio.2006.10.003, PII S0958166906001479
-
Gill DS, Damle NK. Biopharmaceutical drug discovery using novel protein scaffolds. Curr. Opin. Biotechnol. 17(6), 653-658 (2006). (Pubitemid 44802987)
-
(2006)
Current Opinion in Biotechnology
, vol.17
, Issue.6
, pp. 653-658
-
-
Gill, D.S.1
Damle, N.K.2
-
121
-
-
65249090847
-
CD20-directed small modular immunopharmaceutical, TRU-015, depletes normal and malignant B cells
-
Hayden-Ledbetter MS, Cerveny CG, Espling E et al. CD20-directed small modular immunopharmaceutical, TRU-015, depletes normal and malignant B cells. Clin. Cancer Res. 15(8), 2739-2746 (2009).
-
(2009)
Clin. Cancer Res.
, vol.15
, Issue.8
, pp. 2739-2746
-
-
Hayden-Ledbetter, M.S.1
Cerveny, C.G.2
Espling, E.3
-
122
-
-
77649221390
-
Investigational immunotherapeutics for B-cell malignancies
-
Quintas-Cardama A, Wierda W, O'Brien S. Investigational immunotherapeutics for B-cell malignancies. J. Clin. Oncol. 28(5), 884-892 (2010).
-
(2010)
J. Clin. Oncol.
, vol.28
, Issue.5
, pp. 884-892
-
-
Quintas-Cardama, A.1
Wierda, W.2
O'Brien, S.3
-
123
-
-
56149114691
-
Pharmacokinetic and pharmacodynamic properties of TRU-015, a CD20-directed small modular immunopharmaceutical protein therapeutic, in patients with rheumatoid arthritis: A Phase I, open-label, dose-escalation clinical study
-
Burge DJ, Bookbinder SA, Kivitz AJ, Fleischmann RM, Shu C, Bannink J. Pharmacokinetic and pharmacodynamic properties of TRU-015, a CD20-directed small modular immunopharmaceutical protein therapeutic, in patients with rheumatoid arthritis: A Phase I, open-label, dose-escalation clinical study. Clin. Ther. 30(10), 1806-1816 (2008).
-
(2008)
Clin. Ther.
, vol.30
, Issue.10
, pp. 1806-1816
-
-
Burge, D.J.1
Bookbinder, S.A.2
Kivitz, A.J.3
Fleischmann, R.M.4
Shu, C.5
Bannink, J.6
-
124
-
-
71249091846
-
TRU-016, a humanized anti-CD37 IgG fusion protein for the potential treatment of B-cell malignancies
-
Robak T, Robak P, Smolewski P. TRU-016, a humanized anti-CD37 IgG fusion protein for the potential treatment of B-cell malignancies. Curr. Opin. Investig. Drugs 10(12), 1383-1390 (2009).
-
(2009)
Curr. Opin. Investig. Drugs
, vol.10
, Issue.12
, pp. 1383-1390
-
-
Robak, T.1
Robak, P.2
Smolewski, P.3
-
125
-
-
77949421075
-
Evaluation of the effect of TRU-016, an anti-CD37 directed SMIP in combination with other therapeutic drugs in models of non-Hodgkin's lymphoma
-
Abstract 8571
-
Baum PR, Cerveny C, Gordon B. Evaluation of the effect of TRU-016, an anti-CD37 directed SMIP in combination with other therapeutic drugs in models of non-Hodgkin's lymphoma. J. Clin. Oncol. 27(15 Suppl.), Abstract 8571 (2009).
-
(2009)
J. Clin. Oncol.
, vol.27
, Issue.15 SUPPL.
-
-
Baum, P.R.1
Cerveny, C.2
Gordon, B.3
-
126
-
-
80051766856
-
TRU-016, an anti-CD37 SMIPTM biologic, in combination with other therapeutic drugs in models of non-Hodgkin's lymphoma
-
Absract 3931
-
Algate PA, Wiens J, Nilsson C et al. TRU-016, an anti-CD37 SMIPTM biologic, in combination with other therapeutic drugs in models of non-Hodgkin's lymphoma. Blood 116(3931), Absract 3931 (2010).
-
(2010)
Blood
, vol.116
, Issue.3931
-
-
Algate, P.A.1
Wiens, J.2
Nilsson, C.3
-
127
-
-
80051744286
-
Phase 1 dose escalation study of TRU-016, an anti-CD37 SMIP™ protein in relapsed and refractory CLL
-
Abstract 56
-
Furman RR, Andritsos L, Flinn IW et al. Phase 1 dose escalation study of TRU-016, an anti-CD37 SMIP™ protein in relapsed and refractory CLL. Blood 116(21), Abstract 56 (2010).
-
(2010)
Blood
, vol.116
, Issue.21
-
-
Furman, R.R.1
Andritsos, L.2
Flinn, I.W.3
|