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Volumn 2, Issue 2, 2011, Pages 33-40

Osteopontin and multiple sclerosis: An update

Author keywords

cytokine; experimental autoimmune encephalomyelitis; genetic polymorphism; immune regulation; multiple sclerosis; osteopontin

Indexed keywords

BETA INTERFERON; GAMMA INTERFERON; INTERLEUKIN 12; OSTEOPONTIN;

EID: 80051684782     PISSN: None     EISSN: 17591961     Source Type: Journal    
DOI: 10.1111/j.1759-1961.2011.00019.x     Document Type: Review
Times cited : (12)

References (68)
  • 1
    • 79952232716 scopus 로고    scopus 로고
    • What drives disease in multiple sclerosis: Inflammation or neurodegeneration?
    • Lassmann F,. What drives disease in multiple sclerosis: inflammation or neurodegeneration? Clin Exp Neuroimmunol. 2010; 1: 2-11.
    • (2010) Clin Exp Neuroimmunol , vol.1 , pp. 2-11
    • Lassmann, F.1
  • 3
    • 57049166456 scopus 로고    scopus 로고
    • Osteopontin: Role in immune regulation and stress responses
    • Wang KX, Denhardt DT,. Osteopontin: role in immune regulation and stress responses. Cytokine Growth Factor Rev. 2008; 19: 333-45.
    • (2008) Cytokine Growth Factor Rev , vol.19 , pp. 333-345
    • Wang, K.X.1    Denhardt, D.T.2
  • 5
    • 32644467590 scopus 로고    scopus 로고
    • Osteopontin: Role in cell signaling and cancer progression
    • DOI 10.1016/j.tcb.2005.12.005, PII S0962892405003132
    • Rangaswami H, Bulbule A, Kundu GC,. Osteopontin: role in cell signaling and cancer progression. Trends Cell Biol. 2006; 16: 79-87. (Pubitemid 43247403)
    • (2006) Trends in Cell Biology , vol.16 , Issue.2 , pp. 79-87
    • Rangaswami, H.1    Bulbule, A.2    Kundu, G.C.3
  • 7
    • 0028982713 scopus 로고
    • 3 integrin are coordinately expressed in regenerating endothelium in vivo and stimulate Arg-Gly-Asp-dependent endothelial migration in vitro
    • 3 integrin are coordinately expressed in regenerating endothelium in vivo and stimulate Arg-Gly-Asp-dependent endothelial migration in vitro. Circ Res. 1995; 77: 665-72.
    • (1995) Circ Res , vol.77 , pp. 665-672
    • Liaw, L.1    Lindner, V.2    Schwartz, S.M.3    Chambers, A.F.4    Giachelli, C.M.5
  • 8
    • 0028981367 scopus 로고
    • The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin
    • Schnapp LM, Hatch N, Ramos DM, Klimanskaya IV, Sheppard D, Pytela R,. The human integrin alpha 8 beta 1 functions as a receptor for tenascin, fibronectin, and vitronectin. J Biol Chem. 1995; 270: 23196-202.
    • (1995) J Biol Chem , vol.270 , pp. 23196-23202
    • Schnapp, L.M.1    Hatch, N.2    Ramos, D.M.3    Klimanskaya, I.V.4    Sheppard, D.5    Pytela, R.6
  • 11
    • 0035839024 scopus 로고    scopus 로고
    • 4 integrins
    • DOI 10.1016/S0014-5793(01)02690-4, PII S0014579301026904
    • Green PM, Ludbrook SB, Miller DD, Horgan CM, Barry ST,. Structural elements of the osteopontin SVVYGLR motif important for the interaction with a4 integrins. FEBS Lett. 2001; 503: 75-9. (Pubitemid 32769959)
    • (2001) FEBS Letters , vol.503 , Issue.1 , pp. 75-79
    • Green, P.M.1    Ludbrook, S.B.2    Miller, D.D.3    Horgan, C.M.T.4    Barry, S.T.5
  • 12
    • 35648934023 scopus 로고    scopus 로고
    • Control of osteopontin signaling and function by post-translational phosphorylation and protein folding
    • DOI 10.1002/jcb.21558
    • Kazanecki CC, Uzwiak DJ, Denhardt DT,. Control of osteopontin signaling and function by post-translational phosphorylation and protein folding. J Cell Biochem. 2007; 102: 912-24. (Pubitemid 350036931)
    • (2007) Journal of Cellular Biochemistry , vol.102 , Issue.4 , pp. 912-924
    • Kazanecki, C.C.1    Uzwiak, D.J.2    Denhardt, D.T.3
  • 13
    • 0043245084 scopus 로고    scopus 로고
    • Osteopontin: A bridge between bone and the immune system
    • DOI 10.1172/JCI200319190
    • Gravallese EM,. Osteopontin: a bridge between bone and the immune system. J Clin Invest. 2003; 112: 147-9. (Pubitemid 38056349)
    • (2003) Journal of Clinical Investigation , vol.112 , Issue.2 , pp. 147-149
    • Gravallese, E.M.1
  • 16
    • 58849083626 scopus 로고    scopus 로고
    • Regulation of T-helper-cell lineage development by osteopontin: The inside story
    • Cantor H, Shinohara ML,. Regulation of T-helper-cell lineage development by osteopontin: the inside story. Nat Rev Immunol. 2009; 9: 137-41.
    • (2009) Nat Rev Immunol , vol.9 , pp. 137-141
    • Cantor, H.1    Shinohara, M.L.2
  • 17
    • 33645963170 scopus 로고    scopus 로고
    • Osteopontin expression is essential for interferon-a production by plasmacytoid dendritic cells
    • Shinohara ML, Lu L, Bu J, Werneck MB, Kobayashi KS, Glimcher LH, et al., Osteopontin expression is essential for interferon-a production by plasmacytoid dendritic cells. Nat Immunol. 2006; 7: 498-506.
    • (2006) Nat Immunol , vol.7 , pp. 498-506
    • Shinohara, M.L.1    Lu, L.2    Bu, J.3    Werneck, M.B.4    Kobayashi, K.S.5    Glimcher, L.H.6
  • 19
    • 47149105615 scopus 로고    scopus 로고
    • Osteopontin is extensively expressed by macrophages following CNS demyelination but has a redundant role in remyelination
    • Zhao C, Fancy SP, ffrench-Constant C, Franklin RJ,. Osteopontin is extensively expressed by macrophages following CNS demyelination but has a redundant role in remyelination. Neurobiol Dis. 2008; 31: 209-17.
    • (2008) Neurobiol Dis , vol.31 , pp. 209-217
    • Zhao, C.1    Fancy, S.P.2    Ffrench-Constant, C.3    Franklin, R.J.4
  • 20
    • 33645764948 scopus 로고    scopus 로고
    • Protein co-expression with axonal injury in multiple sclerosis plaques
    • Diaz-Sanchez M, Williams K, DeLuca GC, Esiri MM,. Protein co-expression with axonal injury in multiple sclerosis plaques. Acta Neuropathol. 2006; 111: 289-99.
    • (2006) Acta Neuropathol , vol.111 , pp. 289-299
    • Diaz-Sanchez, M.1    Williams, K.2    Deluca, G.C.3    Esiri, M.M.4
  • 22
    • 0035021027 scopus 로고    scopus 로고
    • Osteopontin as a means to cope with environmental insults: Regulation of inflammation, tissue remodeling, and cell survival
    • Denhardt DT, Noda M, O'Regan AW, Pavlin D, Berman JS,. Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival. J Clin Invest. 2001; 107: 1055-61. (Pubitemid 32422899)
    • (2001) Journal of Clinical Investigation , vol.107 , Issue.9 , pp. 1055-1061
    • Denhardt, D.T.1    Noda, M.2    O'Regan, A.W.3    Pavlin, D.4    Berman, J.S.5
  • 23
    • 71849086031 scopus 로고    scopus 로고
    • + T cells in experimental autoimmune encephalomyelitis and in multiple sclerosis
    • + T cells in experimental autoimmune encephalomyelitis and in multiple sclerosis. J Immunol. 2008; 181: 7480-8.
    • (2008) J Immunol , vol.181 , pp. 7480-7488
    • Murugaiyan, G.1    Mittal, A.2    Weiner, H.L.3
  • 24
    • 0034455957 scopus 로고    scopus 로고
    • Osteopontin: A key cytokine in cell-mediated and granulomatous inflammation
    • DOI 10.1046/j.1365-2613.2000.00163.x
    • O'Regan A, Berman JS,. Osteopontin: a key cytokine in cell-mediated and granulomatous inflammation. Int J Exp Pathol. 2000; 81: 373-90. (Pubitemid 32291179)
    • (2000) International Journal of Experimental Pathology , vol.81 , Issue.6 , pp. 373-390
    • O'Regan, A.1    Berman, J.S.2
  • 25
    • 0033780805 scopus 로고    scopus 로고
    • Osteopontin augments CD3-mediated interferon-gamma and CD40 ligand expression by T cells, which results in IL-12 production from peripheral blood mononuclear cells
    • O'Regan AW, Hayden JM, Berman JS,. Osteopontin augments CD3-mediated interferon-gamma and CD40 ligand expression by T cells, which results in IL-12 production from peripheral blood mononuclear cells. J Leukoc Biol. 2000; 68: 495-502.
    • (2000) J Leukoc Biol , vol.68 , pp. 495-502
    • O'Regan, A.W.1    Hayden, J.M.2    Berman, J.S.3
  • 26
    • 0036499086 scopus 로고    scopus 로고
    • Cutting edge: Attenuated experimental autoimmune encephalomyelitis in ETA-1/osteopontin-deficient mice
    • Jansson M, Panoutsakopoulou V, Baker J, Klein L, Cantor H,. Cutting edge: attenuated experimental autoimmune encephalomyelitis in eta-1/osteopontin- deficient mice. J Immunol. 2002; 168: 2096-9. (Pubitemid 34171807)
    • (2002) Journal of Immunology , vol.168 , Issue.5 , pp. 2096-2099
    • Jansson, M.1    Panoutsakopoulou, V.2    Baker, J.3    Klein, L.4    Cantor, H.5
  • 27
    • 43549094992 scopus 로고    scopus 로고
    • Increased osteopontin levels in the cerebrospinal fluid of patients with multiple sclerosis
    • DOI 10.1001/archneur.65.5.633
    • Braitch M, Nunan R, Niepel G, Edwards LJ, Constantinescu CS,. Increased osteopontin levels in the cerebrospinal fluid of patients with multiple sclerosis. Arch Neurol. 2008; 65: 633-5. (Pubitemid 351679658)
    • (2008) Archives of Neurology , vol.65 , Issue.5 , pp. 633-635
    • Braitch, M.1    Nunan, R.2    Niepel, G.3    Edwards, L.J.4    Constantinescu, C.S.5
  • 29
    • 0141924167 scopus 로고    scopus 로고
    • The roles of soluble osteopontin using osteopontin-transgenic mice in vivo: Proliferation of CD4+ T lymphocytes and the enhancement of cell-mediated immune responses
    • DOI 10.1159/000072956
    • Higuchi Y, Tamura Y, Uchida T, Matsuura K, Hijiya N, Yamamoto S,. The roles of soluble osteopontin using osteopontin-transgenic mice in vivo: proliferation of CD4+ T lymphocytes and the enhancement of cell-mediated immune responses. Pathobiology. 2004; 71: 1-11. (Pubitemid 37256021)
    • (2004) Pathobiology , vol.71 , Issue.1 , pp. 1-11
    • Higuchi, Y.1    Tamura, Y.2    Uchida, T.3    Matsuura, K.4    Hijiya, N.5    Yamamoto, S.6
  • 30
    • 0030064334 scopus 로고    scopus 로고
    • Receptor-ligand interaction between CD44 and osteopontin (Eta-1)
    • Weber GF, Ashkar S, Glimcher MJ, Cantor H,. Receptor-ligand interaction between CD44 and osteopontin (Eta-1). Science. 1996; 271: 509-12. (Pubitemid 26044470)
    • (1996) Science , vol.271 , Issue.5248 , pp. 509-512
    • Weber, G.F.1    Ashkar, S.2    Glimcher, M.J.3    Cantor, H.4
  • 31
    • 66149083273 scopus 로고    scopus 로고
    • Receptor crosstalk: Reprogramming B cell receptor signalling to an alternate pathway results in expression and secretion of the autoimmunity-associated cytokine, osteopontin
    • Rothstein TL, Guo B,. Receptor crosstalk: reprogramming B cell receptor signalling to an alternate pathway results in expression and secretion of the autoimmunity-associated cytokine, osteopontin. J Intern Med. 2009; 265: 632-43.
    • (2009) J Intern Med , vol.265 , pp. 632-643
    • Rothstein, T.L.1    Guo, B.2
  • 32
    • 58249097206 scopus 로고    scopus 로고
    • B cell receptor crosstalk: B cells express osteopontin through the combined action of the alternate and classical BCR signaling pathways
    • Guo B, Tumang JR, Rothstein TL,. B cell receptor crosstalk: B cells express osteopontin through the combined action of the alternate and classical BCR signaling pathways. Mol Immunol. 2009; 46: 587-91.
    • (2009) Mol Immunol , vol.46 , pp. 587-591
    • Guo, B.1    Tumang, J.R.2    Rothstein, T.L.3
  • 33
    • 25444516852 scopus 로고    scopus 로고
    • Potential roles of follicular dendritic cell-associated osteopontin in lymphoid follicle pathology and repair and in B cell regulation in HIV-1 and SIV infection
    • DOI 10.1086/444430
    • Li Q, Lifson JD, Duan L, Schacker TW, Reilly C, Carlis J, et al., Potential roles of follicular dendritic cell-associated osteopontin in lymphoid follicle pathology and repair and in B cell regulation in HIV-1 and SIV infection. J Infect Dis. 2005; 192: 1269-76. (Pubitemid 41368429)
    • (2005) Journal of Infectious Diseases , vol.192 , Issue.7 , pp. 1269-1276
    • Li, Q.1    Lifson, J.D.2    Duan, L.3    Schacker, T.W.4    Reilly, C.5    Carlis, J.6    Estes, J.D.7    Haase, A.T.8
  • 34
    • 1642316557 scopus 로고    scopus 로고
    • Osteopontin Modulates CD44-Dependent Chemotaxis of Peritoneal Macrophages Through G-Protein-Coupled Receptors: Evidence of a Role for an Intracellular Form of Osteopontin
    • DOI 10.1002/jcp.10394
    • Zhu B, Suzuki K, Goldberg HA, Rittling SR, Denhardt DT, McCulloch CA, et al., Osteopontin modulates CD44-dependent chemotaxis of peritoneal macrophages through G-protein-coupled receptors: evidence of a role for an intracellular form of osteopontin. J Cell Physiol. 2004; 198: 155-67. (Pubitemid 38120976)
    • (2004) Journal of Cellular Physiology , vol.198 , Issue.1 , pp. 155-167
    • Zhu, B.1    Suzuki, K.2    Goldberg, H.A.3    Rittling, S.R.4    Denhardt, D.T.5    McCulloch, C.A.G.6    Sodek, J.7
  • 35
    • 0031906847 scopus 로고    scopus 로고
    • Evidence for a role of osteopontin in macrophage infiltration in response to pathological stimuli in vivo
    • Giachelli CM, Lombardi D, Johnson RJ, Murry CE, Almeida M,. Evidence for a role of osteopontin in macrophage infiltration in response to pathological stimuli in vivo. Am J Pathol. 1998; 152: 353-8. (Pubitemid 28106380)
    • (1998) American Journal of Pathology , vol.152 , Issue.2 , pp. 353-358
    • Giachelli, C.M.1    Lombardi, D.2    Johnson, R.J.3    Murry, C.E.4    Almeida, M.5
  • 37
    • 0029790518 scopus 로고    scopus 로고
    • Osteopontin inhibits nitric oxide production and cytotoxicity by activated RAW264.7 macrophages
    • Rollo EE, Laskin DL, Denhardt DT,. Osteopontin inhibits nitric oxide production and cytotoxicity by activated RAW264.7 macrophages. J Leukoc Biol. 1996; 60: 397-404. (Pubitemid 26325622)
    • (1996) Journal of Leukocyte Biology , vol.60 , Issue.3 , pp. 397-404
    • Rollo, E.E.1    Laskin, D.L.2    Denhardt, D.T.3
  • 38
    • 67649383126 scopus 로고    scopus 로고
    • Th17 cells in MS and experimental autoimmune encephalomyelitis
    • Hofstetter H, Gold R, Hartung HP,. Th17 Cells in MS and Experimental Autoimmune Encephalomyelitis. Int MS J. 2009; 16: 12-8.
    • (2009) Int MS J , vol.16 , pp. 12-18
    • Hofstetter, H.1    Gold, R.2    Hartung, H.P.3
  • 39
    • 70349257850 scopus 로고    scopus 로고
    • Regulatory effects of IFN-beta on production of osteopontin and IL-17 by CD4+ T Cells in MS
    • Chen M, Chen G, Nie H, Zhang X, Niu X, Zang YC, et al., Regulatory effects of IFN-beta on production of osteopontin and IL-17 by CD4+ T Cells in MS. Eur J Immunol. 2009; 39: 2525-36.
    • (2009) Eur J Immunol , vol.39 , pp. 2525-2536
    • Chen, M.1    Chen, G.2    Nie, H.3    Zhang, X.4    Niu, X.5    Zang, Y.C.6
  • 40
    • 44449146212 scopus 로고    scopus 로고
    • Engagement of the type i interferon receptor on dendritic cells inhibits T helper 17 cell development: Central role of intracellular osteopontin
    • Shinohara ML, Kim JH, Garcia VA, Cantor H,. Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: central role of intracellular osteopontin. Immunity. 2008; 29: 68-78.
    • (2008) Immunity , vol.29 , pp. 68-78
    • Shinohara, M.L.1    Kim, J.H.2    Garcia, V.A.3    Cantor, H.4
  • 41
    • 77954939162 scopus 로고    scopus 로고
    • Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-g limits IL-17-mediated autoimmune inflammation
    • Murugaiyan G, Mittal A, Weiner HL,. Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-g limits IL-17-mediated autoimmune inflammation. Proc Natl Acad Sci U S A. 2010; 107: 11495-500.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 11495-11500
    • Murugaiyan, G.1    Mittal, A.2    Weiner, H.L.3
  • 42
    • 33846998653 scopus 로고    scopus 로고
    • Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells
    • DOI 10.1038/ni1415, PII NI1415
    • Hur EM, Youssef S, Haws ME, Zhang SY, Sobel RA, Steinman L,. Osteopontin-induced relapse and progression of autoimmune brain disease through enhanced survival of activated T cells. Nat Immunol. 2007; 8: 74-83. (Pubitemid 46242361)
    • (2007) Nature Immunology , vol.8 , Issue.1 , pp. 74-83
    • Hur, E.M.1    Youssef, S.2    Haws, M.E.3    Zhang, S.Y.4    Sobel, R.A.5    Steinman, L.6
  • 43
    • 7044264360 scopus 로고    scopus 로고
    • Role of osteopontin in adhesion, migration, cell survival and bone remodeling
    • Standal T, Borset M, Sundan A,. Role of osteopontin in adhesion, migration, cell survival and bone remodeling. Exp Oncol. 2004; 26: 179-84.
    • (2004) Exp Oncol , vol.26 , pp. 179-184
    • Standal, T.1    Borset, M.2    Sundan, A.3
  • 45
    • 2442509934 scopus 로고    scopus 로고
    • Expression of osteopontin and its ligand, CD44, in the spinal cords of Lewis rats with experimental autoimmune encephalomyelitis
    • DOI 10.1016/j.jneuroim.2004.02.014, PII S016557280400075X
    • Kim MD, Cho HJ, Shin T,. Expression of osteopontin and its ligand, CD44, in the spinal cords of Lewis rats with experimental autoimmune encephalomyelitis. J Neuroimmunol. 2004; 151: 78-84. (Pubitemid 38624402)
    • (2004) Journal of Neuroimmunology , vol.151 , Issue.1-2 , pp. 78-84
    • Kim, M.D.1    Cho, H.J.2    Shin, T.3
  • 46
    • 0037459657 scopus 로고    scopus 로고
    • Comment on "the influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease"
    • Blom T, Franzén A, HeinegÃrd D, Holmdahl R,. Comment on "The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease". Science. 2003; 299: 1845.
    • (2003) Science , vol.299 , pp. 1845
    • Blom, T.1    Franzén, A.2    Heinegãrd, D.3    Holmdahl, R.4
  • 47
    • 77956543890 scopus 로고    scopus 로고
    • Cleavage of osteopontin by matrix metalloproteinase-12 modulates experimental autoimmune encephalomyelitis disease in C57BL/6 mice
    • GoncalvesDaSilva A, Liaw L, Yong VW,. Cleavage of osteopontin by matrix metalloproteinase-12 modulates experimental autoimmune encephalomyelitis disease in C57BL/6 mice. Am J Pathol. 2010; 177: 1448-58.
    • (2010) Am J Pathol , vol.177 , pp. 1448-1458
    • Goncalvesdasilva, A.1    Liaw, L.2    Yong, V.W.3
  • 48
    • 0142218037 scopus 로고    scopus 로고
    • Induction and temporal changes of osteopontin mRNA and protein in the brain following systemic lipopolysaccharide injection
    • Choi JS, Park HJ, Cha JH, Chung JW, Chun MH, Lee MY,. Induction and temporal changes of osteopontin mRNA and protein in the brain following systemic lipopolysaccharide injection. J Neuroimmunol. 2003; 141: 65-73.
    • (2003) J Neuroimmunol , vol.141 , pp. 65-73
    • Choi, J.S.1    Park, H.J.2    Cha, J.H.3    Chung, J.W.4    Chun, M.H.5    Lee, M.Y.6
  • 49
    • 20444483807 scopus 로고    scopus 로고
    • An examination of MS candidate genes identified as differentially regulated in multiple sclerosis plaque tissue, using absolute and comparative real-time Q-PCR analysis
    • DOI 10.1016/j.brainresprot.2005.04.003, PII S1385299X05000462
    • Tajouri L, Mellick AS, Tourtellotte A, Nagra RM, Griffiths LR,. An examination of MS candidate genes identified as differentially regulated in multiple sclerosis plaque tissue, using absolute and comparative real-time Q-PCR analysis. Brain Res Brain Res Protoc. 2005; 15: 79-91. (Pubitemid 40828888)
    • (2005) Brain Research Protocols , vol.15 , Issue.2 , pp. 79-91
    • Tajouri, L.1    Mellick, A.S.2    Tourtellotte, A.3    Nagra, R.M.4    Griffiths, L.R.5
  • 50
    • 37349018717 scopus 로고    scopus 로고
    • Downregulation of macrophage inhibitory molecules in multiple sclerosis lesions
    • DOI 10.1002/ana.21220
    • Koning N, Bö L, Hoek RM, Huitinga I,. Downregulation of macrophage inhibitory molecules in multiple sclerosis lesions. Ann Neurol. 2007; 62: 504-14. (Pubitemid 350308775)
    • (2007) Annals of Neurology , vol.62 , Issue.5 , pp. 504-514
    • Koning, N.1    Bo, L.2    Hoek, R.M.3    Huitinga, I.4
  • 51
    • 20044394594 scopus 로고    scopus 로고
    • Up-regulation of osteopontin and αB-crystallin in the normal-appearing white matter of multiple sclerosis: An immunohistochemical study utilizing tissue microarrays
    • DOI 10.1111/j.1365-2990.2004.00638.x
    • Sinclair C, Mirakhur M, Kirk J, Farrell M, McQuaid S,. Up-regulation of osteopontin and aB-crystallin in the normal-appearing white matter of multiple sclerosis: an immunohistochemical study utilizing tissue microarrays. Neuropathol Appl Neurobiol. 2005; 31: 292-303. (Pubitemid 40769528)
    • (2005) Neuropathology and Applied Neurobiology , vol.31 , Issue.3 , pp. 292-303
    • Sinclair, C.1    Mirakhur, M.2    Kirkt, J.3    Farrell, M.4    McQuaid, S.5
  • 53
    • 0037766217 scopus 로고    scopus 로고
    • Elevated osteopontin levels in active relapsing-remitting multiple sclerosis
    • DOI 10.1002/ana.10606
    • Vogt MH, Lopatinskaya L, Smits M, Polman CH, Nagelkerken L,. Elevated osteopontin levels in active relapsing-remitting multiple sclerosis. Ann Neurol. 2003; 53: 819-22. (Pubitemid 36622524)
    • (2003) Annals of Neurology , vol.53 , Issue.6 , pp. 819-822
    • Vogt, M.H.J.1    Lopatinskaya, L.2    Smits, M.3    Polman, C.H.4    Nagelkerken, L.5
  • 55
    • 77954671743 scopus 로고    scopus 로고
    • Increased osteopontin plasma levels in multiple sclerosis patients correlate with bone-specific markers
    • Vogt MH, ten Kate J, Drent RJ, Polman CH, Hupperts R,. Increased osteopontin plasma levels in multiple sclerosis patients correlate with bone-specific markers. Mult Scler. 2010; 16: 443-9.
    • (2010) Mult Scler , vol.16 , pp. 443-449
    • Vogt, M.H.1    Ten Kate, J.2    Drent, R.J.3    Polman, C.H.4    Hupperts, R.5
  • 56
    • 39049136065 scopus 로고    scopus 로고
    • Specificity and correlation with disease activity of cerebrospinal fluid osteopontin levels in patients with multiple sclerosis
    • DOI 10.1001/archneurol.2007.33
    • Chowdhury SA, Lin J, Sadiq SA,. Specificity and correlation with disease activity of cerebrospinal fluid osteopontin levels in patients with multiple sclerosis. Arch Neurol. 2008; 65: 232-5. (Pubitemid 351240786)
    • (2008) Archives of Neurology , vol.65 , Issue.2 , pp. 232-235
    • Chowdhury, S.A.1    Lin, J.2    Sadiq, S.A.3
  • 58
    • 62849098757 scopus 로고    scopus 로고
    • The effects of natalizumab on inflammatory mediators in multiple sclerosis: Prospects for treatment-sensitive biomarkers
    • Khademi M, Bornsen L, Rafatnia F, Andersson M, Brundin L, Piehl F, et al., The effects of natalizumab on inflammatory mediators in multiple sclerosis: prospects for treatment-sensitive biomarkers. Eur J Neurol. 2009; 16: 528-36.
    • (2009) Eur J Neurol , vol.16 , pp. 528-536
    • Khademi, M.1    Bornsen, L.2    Rafatnia, F.3    Andersson, M.4    Brundin, L.5    Piehl, F.6
  • 59
    • 34548853712 scopus 로고    scopus 로고
    • Recent advances in genetic analysis of multiple sclerosis: Genetic associations and therapeutic implications
    • DOI 10.1586/14737175.7.9.1175
    • Niino M, Fukazawa T, Kikuchi S, Sasaki H,. Recent advances in genetic analysis of multiple sclerosis: genetic associations and therapeutic implications. Expert Rev Neurother. 2007; 7: 1175-88. (Pubitemid 47451024)
    • (2007) Expert Review of Neurotherapeutics , vol.7 , Issue.9 , pp. 1175-1188
    • Niino, M.1    Fukazawa, T.2    Kikuchi, S.3    Sasaki, H.4
  • 60
    • 0037333211 scopus 로고    scopus 로고
    • Genetic polymorphisms of osteopontin in association with multiple sclerosis in Japanese patients
    • DOI 10.1016/S0165-5728(03)00004-3
    • Niino M, Kikuchi S, Fukazawa T, Yabe I, Tashiro K,. Genetic polymorphisms of osteopontin in association with multiple sclerosis in Japanese patients. J Neuroimmunol. 2003; 136: 125-9. (Pubitemid 36298851)
    • (2003) Journal of Neuroimmunology , vol.136 , Issue.1-2 , pp. 125-129
    • Niino, M.1    Kikuchi, S.2    Fukazawa, T.3    Yabe, I.4    Tashiro, K.5
  • 63
    • 34247112257 scopus 로고    scopus 로고
    • The 795CT polymorphism in osteopontin gene is not associated with multiple sclerosis in Spanish population
    • DOI 10.1177/1352458506070944
    • Mas A, Martínez A, de lasHeras V, Bartolomé M, de la Concha EG, Arroyo R, et al., The 795CT polymorphism in osteopontin gene is not associated with multiple sclerosis in a Spanish population. Mult Scler. 2007; 13: 250-2. (Pubitemid 46592779)
    • (2007) Multiple Sclerosis , vol.13 , Issue.2 , pp. 250-252
    • Mas, A.1    Martinez, A.2    De Las Heras, V.3    Bartolome, M.4    De La Concha, E.G.5    Arroyo, R.6    Urcelay, E.7
  • 67
    • 70349232886 scopus 로고    scopus 로고
    • Shifting therapeutic attention in MS to osteopontin, type 1 and type 2 IFN
    • Steinman L,. Shifting therapeutic attention in MS to osteopontin, type 1 and type 2 IFN. Eur J Immunol. 2009; 39: 2358-60.
    • (2009) Eur J Immunol , vol.39 , pp. 2358-2360
    • Steinman, L.1
  • 68
    • 67349213676 scopus 로고    scopus 로고
    • A molecular trio in relapse and remission in multiple sclerosis
    • Steinman L,. A molecular trio in relapse and remission in multiple sclerosis. Nat Rev Immunol. 2009; 9: 440-7.
    • (2009) Nat Rev Immunol , vol.9 , pp. 440-447
    • Steinman, L.1


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