메뉴 건너뛰기




Volumn 63, Issue 6, 2011, Pages 569-574

Anti-apoptotic and anti-inflammatory effects of Silybum marianum in treatment of experimental steatohepatitis

Author keywords

JNK; Nonalcoholic steatohepatitis; Silybum marianum; TGF ; TNF

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CASPASE 3; CHOLINE; GLUTATHIONE; MALONALDEHYDE; MESSENGER RNA; METHIONINE; MITOGEN ACTIVATED PROTEIN KINASE; PROCASPASE 3; SILYBUM MARIANUM EXTRACT; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

EID: 80051678335     PISSN: 09402993     EISSN: 16181433     Source Type: Journal    
DOI: 10.1016/j.etp.2010.04.009     Document Type: Article
Times cited : (58)

References (37)
  • 1
    • 77953539052 scopus 로고    scopus 로고
    • Inhibition of JNK along with activation of ERK1/2 MAPK pathways improve steatohepatitis among the rats. Clin Nutr, doi:10.1016/j.clnu.2009.08.014
    • Aghazadeh S, Yazdanparast R. Inhibition of JNK along with activation of ERK1/2 MAPK pathways improve steatohepatitis among the rats. Clin Nutr (2009), doi:10.1016/j.clnu.2009.08.014.
    • (2009)
    • Aghazadeh, S.1    Yazdanparast, R.2
  • 2
    • 0037129380 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Angulo P. Nonalcoholic fatty liver disease. N Engl J Med 2002, 346:1221-1231.
    • (2002) N Engl J Med , vol.346 , pp. 1221-1231
    • Angulo, P.1
  • 3
    • 0034767501 scopus 로고    scopus 로고
    • Transforming growth factor beta and the liver
    • Bissell D.M., Roulot D., George J. Transforming growth factor beta and the liver. Hepatology 2001, 34:859-867.
    • (2001) Hepatology , vol.34 , pp. 859-867
    • Bissell, D.M.1    Roulot, D.2    George, J.3
  • 5
    • 1242336980 scopus 로고    scopus 로고
    • Apoptosis: the nexus of liver injury and fibrosis
    • Canbay A., Friedman S., Gores G.J. Apoptosis: the nexus of liver injury and fibrosis. Hepatology 2004, 39:273-278.
    • (2004) Hepatology , vol.39 , pp. 273-278
    • Canbay, A.1    Friedman, S.2    Gores, G.J.3
  • 6
    • 33846322877 scopus 로고    scopus 로고
    • The role of cytokines in non-alcoholic steatohepatitis. A systematic review
    • Copaci I., Micu L., Voiculescu M. The role of cytokines in non-alcoholic steatohepatitis. A systematic review. J Gastrointestin Liver Dis 2006, 15:363-373.
    • (2006) J Gastrointestin Liver Dis , vol.15 , pp. 363-373
    • Copaci, I.1    Micu, L.2    Voiculescu, M.3
  • 7
    • 0038580372 scopus 로고    scopus 로고
    • Oxidant-induced hepatocyte injury from menadione is regulated by ERK and AP-1 signaling
    • Czaja M.J., Liu H., Wang Y. Oxidant-induced hepatocyte injury from menadione is regulated by ERK and AP-1 signaling. Hepatology 2003, 37:1405-1413.
    • (2003) Hepatology , vol.37 , pp. 1405-1413
    • Czaja, M.J.1    Liu, H.2    Wang, Y.3
  • 8
    • 0031947715 scopus 로고    scopus 로고
    • Steatohepatitis: a tale of two " hits"
    • Day C.P., James O.F. Steatohepatitis: a tale of two " hits" Gastroenterology 1998, 114:842-845.
    • (1998) Gastroenterology , vol.114 , pp. 842-845
    • Day, C.P.1    James, O.F.2
  • 9
    • 0006198863 scopus 로고    scopus 로고
    • Biomarkers of free radical damage applications in experimental animals and in humans
    • de Zwart L.L., Meerman J.H., Commandeur J.N., Vermeulen N.P. Biomarkers of free radical damage applications in experimental animals and in humans. Free Radic Biol Med 1999, 26:202-226.
    • (1999) Free Radic Biol Med , vol.26 , pp. 202-226
    • de Zwart, L.L.1    Meerman, J.H.2    Commandeur, J.N.3    Vermeulen, N.P.4
  • 10
    • 0025142672 scopus 로고
    • Malondialdehyde determination as index of lipid peroxidation
    • Draper H.H., Hadley M. Malondialdehyde determination as index of lipid peroxidation. Meth Enzymol 1990, 186:421-431.
    • (1990) Meth Enzymol , vol.186 , pp. 421-431
    • Draper, H.H.1    Hadley, M.2
  • 11
    • 0042165989 scopus 로고    scopus 로고
    • Hepatocyte apoptosis and Fas expression are prominent features of human nonalcoholic steatohepatitis
    • Feldstein A.E., Canbay A., Angulo P., Taniai M., Burgart L.J., Lindor K.D., et al. Hepatocyte apoptosis and Fas expression are prominent features of human nonalcoholic steatohepatitis. Gastroenterology 2003, 125:437-443.
    • (2003) Gastroenterology , vol.125 , pp. 437-443
    • Feldstein, A.E.1    Canbay, A.2    Angulo, P.3    Taniai, M.4    Burgart, L.J.5    Lindor, K.D.6
  • 12
    • 0035183475 scopus 로고    scopus 로고
    • Gene expression of tumor necrosis factor alpha and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients
    • Fernández-Escalante J.C., Pons-Romero F. Gene expression of tumor necrosis factor alpha and TNF-receptors, p55 and p75, in nonalcoholic steatohepatitis patients. Hepatology 2001, 34:1158-1163.
    • (2001) Hepatology , vol.34 , pp. 1158-1163
    • Fernández-Escalante, J.C.1    Pons-Romero, F.2
  • 13
    • 68249113551 scopus 로고    scopus 로고
    • Rat activin-βE mRNA expression during development and in acute and chronic liver injury
    • Gold E.J., Monaghan M.A., Fleming J.S. Rat activin-βE mRNA expression during development and in acute and chronic liver injury. J Mol Genet Med 2006, 2:93-100.
    • (2006) J Mol Genet Med , vol.2 , pp. 93-100
    • Gold, E.J.1    Monaghan, M.A.2    Fleming, J.S.3
  • 14
    • 0033851609 scopus 로고    scopus 로고
    • Starvation impairs antioxidant defense in fatty livers of rats fed a choline-deficient diet
    • Grattagliano I., Vendemiale G., Caraceni P., Domenicali M., Nardo B., Cavallari A., et al. Starvation impairs antioxidant defense in fatty livers of rats fed a choline-deficient diet. J Nutr 2000, 130:2131-2136.
    • (2000) J Nutr , vol.130 , pp. 2131-2136
    • Grattagliano, I.1    Vendemiale, G.2    Caraceni, P.3    Domenicali, M.4    Nardo, B.5    Cavallari, A.6
  • 15
    • 0036841764 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis: what we know in the new millennium
    • Harrison S.A., Kadakia S., Lang K.A., Schenker S. Nonalcoholic steatohepatitis: what we know in the new millennium. Am J Gastroenterol 2002, 97:2714-2724.
    • (2002) Am J Gastroenterol , vol.97 , pp. 2714-2724
    • Harrison, S.A.1    Kadakia, S.2    Lang, K.A.3    Schenker, S.4
  • 17
    • 0016151122 scopus 로고
    • Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite
    • Jollow D.J., Mitchell J.R., Zampaglione N., Gillette J.R. Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite. Pharmacology 1974, 11:151-169.
    • (1974) Pharmacology , vol.11 , pp. 151-169
    • Jollow, D.J.1    Mitchell, J.R.2    Zampaglione, N.3    Gillette, J.R.4
  • 18
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • Kleiner D.E., Brunt E.M., Van Natta M., Behling C., Contos M.J., Cummings O.W., et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005, 41:1313-1321.
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • Kleiner, D.E.1    Brunt, E.M.2    Van Natta, M.3    Behling, C.4    Contos, M.J.5    Cummings, O.W.6
  • 19
    • 33744971866 scopus 로고    scopus 로고
    • Silybin and silymarin: new effects and applications
    • Kren V., Walterová D. Silybin and silymarin: new effects and applications. Biomed Pap 2005, 149:29-41.
    • (2005) Biomed Pap , vol.149 , pp. 29-41
    • Kren, V.1    Walterová, D.2
  • 20
    • 2342591361 scopus 로고    scopus 로고
    • Pivotal role of superoxide anion and beneficial effect of antioxidant molecules in murine steatohepatitis
    • Laurent A., Nicco C., Tran Van Nhieu J., Borderie D., Chéreau C., Conti F., et al. Pivotal role of superoxide anion and beneficial effect of antioxidant molecules in murine steatohepatitis. Hepatology 2004, 39:1277-1285.
    • (2004) Hepatology , vol.39 , pp. 1277-1285
    • Laurent, A.1    Nicco, C.2    Tran Van Nhieu, J.3    Borderie, D.4    Chéreau, C.5    Conti, F.6
  • 22
    • 47349109305 scopus 로고    scopus 로고
    • Molecular mechanism of hepatic stellate cell activation and antifibrotic therapeutic strategies
    • Li J.T., Liao Z.X., Ping J., Xu D., Wang H. Molecular mechanism of hepatic stellate cell activation and antifibrotic therapeutic strategies. J Gastroenterol 2008, 43:419-428.
    • (2008) J Gastroenterol , vol.43 , pp. 419-428
    • Li, J.T.1    Liao, Z.X.2    Ping, J.3    Xu, D.4    Wang, H.5
  • 23
    • 0036260697 scopus 로고    scopus 로고
    • Cellular response to oxidative stress: signaling for suicide and survival
    • Martindale J.L., Holbrook N.J. Cellular response to oxidative stress: signaling for suicide and survival. J Cell Physiol 2002, 192:1-15.
    • (2002) J Cell Physiol , vol.192 , pp. 1-15
    • Martindale, J.L.1    Holbrook, N.J.2
  • 24
    • 0035984393 scopus 로고    scopus 로고
    • AT1 receptor blockade reduces cardiac calcineurin activity in hypertensive rats
    • Nagata K., Somura F., Obata K., Odashima M., Izawa H., Ichihara S., et al. AT1 receptor blockade reduces cardiac calcineurin activity in hypertensive rats. Hypertension 2002, 40:168-174.
    • (2002) Hypertension , vol.40 , pp. 168-174
    • Nagata, K.1    Somura, F.2    Obata, K.3    Odashima, M.4    Izawa, H.5    Ichihara, S.6
  • 25
    • 0036652185 scopus 로고    scopus 로고
    • Oxidative stress in the pathogenesis of nonalcoholic fatty liver disease, in rats fed with a choline-deficient diet
    • Oliveira C.P., Gayotto L.C., Tatai C., Della Bina B.I., Janiszewski M., Lima E.S., et al. Oxidative stress in the pathogenesis of nonalcoholic fatty liver disease, in rats fed with a choline-deficient diet. J Cell Mol Med 2002, 6:399-406.
    • (2002) J Cell Mol Med , vol.6 , pp. 399-406
    • Oliveira, C.P.1    Gayotto, L.C.2    Tatai, C.3    Della Bina, B.I.4    Janiszewski, M.5    Lima, E.S.6
  • 26
    • 33846519345 scopus 로고    scopus 로고
    • Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine
    • Pradhan S.C., Girish C. Hepatoprotective herbal drug, silymarin from experimental pharmacology to clinical medicine. Indian J Med Res 2006, 124:491-504.
    • (2006) Indian J Med Res , vol.124 , pp. 491-504
    • Pradhan, S.C.1    Girish, C.2
  • 27
    • 33646828371 scopus 로고    scopus 로고
    • Suppression of N-nitrosodiethylamine induced hepatocarcinogenesis by silymarin in rats
    • Ramakrishnan G., Raghavendran H.R., Vinodhkumar R., Devaki T. Suppression of N-nitrosodiethylamine induced hepatocarcinogenesis by silymarin in rats. Chem Biol Interact 2006, 161:104-114.
    • (2006) Chem Biol Interact , vol.161 , pp. 104-114
    • Ramakrishnan, G.1    Raghavendran, H.R.2    Vinodhkumar, R.3    Devaki, T.4
  • 28
    • 25444489549 scopus 로고    scopus 로고
    • Gene expression profiles in the rat streptococcal cell wall-induced arthritis model identified using microarray analysis
    • Rioja I., Clayton C.L., Graham S.J., Life P.F., Dickson M.C. Gene expression profiles in the rat streptococcal cell wall-induced arthritis model identified using microarray analysis. Arthritis Res Ther 2005, 7:R101-117.
    • (2005) Arthritis Res Ther , vol.7
    • Rioja, I.1    Clayton, C.L.2    Graham, S.J.3    Life, P.F.4    Dickson, M.C.5
  • 30
    • 0028061674 scopus 로고
    • Signal transduction by tumor necrosis factor mediated by JNK protein kinases
    • Sluss H.K., Barrett T., Dérijard B., Davis R.J. Signal transduction by tumor necrosis factor mediated by JNK protein kinases. Mol Cell Biol 1994, 14:8376-8384.
    • (1994) Mol Cell Biol , vol.14 , pp. 8376-8384
    • Sluss, H.K.1    Barrett, T.2    Dérijard, B.3    Davis, R.J.4
  • 31
    • 0034676629 scopus 로고    scopus 로고
    • Cytokines in alcoholic and nonalcoholic steatohepatitis
    • Tilg H., Diehl A.M. Cytokines in alcoholic and nonalcoholic steatohepatitis. N Engl J Med 2000, 343:1467-1476.
    • (2000) N Engl J Med , vol.343 , pp. 1467-1476
    • Tilg, H.1    Diehl, A.M.2
  • 32
    • 0034933130 scopus 로고    scopus 로고
    • MST1-JNK promotes apoptosis via caspase-dependent and independent pathways
    • Ura S., Masuyama N., Graves J.D., Gotoh Y. MST1-JNK promotes apoptosis via caspase-dependent and independent pathways. Genes Cells 2001, 6:519-530.
    • (2001) Genes Cells , vol.6 , pp. 519-530
    • Ura, S.1    Masuyama, N.2    Graves, J.D.3    Gotoh, Y.4
  • 33
    • 34347395156 scopus 로고    scopus 로고
    • Protective effects of soy isoflavones and activity levels of plasma paraoxonase and arylesterase in the experimental nonalcoholic steatohepatitis model
    • Ustundag B., Bahcecioglu I.H., Sahin K., Duzgun S., Koca S., Gulcu F., et al. Protective effects of soy isoflavones and activity levels of plasma paraoxonase and arylesterase in the experimental nonalcoholic steatohepatitis model. Dig Dis Sci 2007, 52:2006-2014.
    • (2007) Dig Dis Sci , vol.52 , pp. 2006-2014
    • Ustundag, B.1    Bahcecioglu, I.H.2    Sahin, K.3    Duzgun, S.4    Koca, S.5    Gulcu, F.6
  • 34
    • 0028136553 scopus 로고
    • Biochemical bases of the pharmacological action of the flavonoid silymarin and of its structural isomer silibinin
    • Valenzuela A., Garrido A. Biochemical bases of the pharmacological action of the flavonoid silymarin and of its structural isomer silibinin. Biol Res 1994, 27:105-112.
    • (1994) Biol Res , vol.27 , pp. 105-112
    • Valenzuela, A.1    Garrido, A.2
  • 35
    • 33847754623 scopus 로고    scopus 로고
    • The JNK signal transduction pathway
    • Weston C.R., Davis R.J. The JNK signal transduction pathway. Curr Opin Cell Biol 2007, 19:142-149.
    • (2007) Curr Opin Cell Biol , vol.19 , pp. 142-149
    • Weston, C.R.1    Davis, R.J.2
  • 36
    • 33745904468 scopus 로고    scopus 로고
    • In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease
    • Wieckowska A., Zein N.N., Yerian L.M., Lopez A.R., McCullough A.J., Feldstein A.E. In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease. Hepatology 2006, 44:27-33.
    • (2006) Hepatology , vol.44 , pp. 27-33
    • Wieckowska, A.1    Zein, N.N.2    Yerian, L.M.3    Lopez, A.R.4    McCullough, A.J.5    Feldstein, A.E.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.