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Volumn 16, Issue 15-16, 2011, Pages 715-721

MTOR as a multifunctional therapeutic target in HIV infection

Author keywords

[No Author keywords available]

Indexed keywords

APLAVIROC; ENFUVIRTIDE; EVEROLIMUS; GROWTH FACTOR; GROWTH FACTOR RECEPTOR; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN KINASE B; PROTEIN P110; PROTEIN P85; RAPAMYCIN; RAS PROTEIN; RIDAFOROLIMUS; S6 KINASE; TEMSIROLIMUS; VICRIVIROC;

EID: 80051665056     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2011.05.008     Document Type: Review
Times cited : (89)

References (60)
  • 1
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • DOI 10.1016/j.cell.2006.01.016, PII S0092867406001085
    • S. Wullschleger TOR signaling in growth and metabolism Cell 124 2006 471 484 (Pubitemid 43199434)
    • (2006) Cell , vol.124 , Issue.3 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 2
    • 78650510609 scopus 로고    scopus 로고
    • MTOR: From growth signal integration to cancer, diabetes and ageing
    • R. Zoncu mTOR: from growth signal integration to cancer, diabetes and ageing Nat. Rev. Mol. Cell Biol. 12 2011 21 35
    • (2011) Nat. Rev. Mol. Cell Biol. , vol.12 , pp. 21-35
    • Zoncu, R.1
  • 3
    • 78649348967 scopus 로고    scopus 로고
    • Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress
    • S. Sengupta Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress Mol. Cell 2010 310 322
    • (2010) Mol. Cell , pp. 310-322
    • Sengupta, S.1
  • 4
    • 77955483125 scopus 로고    scopus 로고
    • Activation of a metabolic gene regulatory network downstream of mTOR complex 1
    • K. Düvel Activation of a metabolic gene regulatory network downstream of mTOR complex 1 Mol. Cell 39 2010 171 183
    • (2010) Mol. Cell , vol.39 , pp. 171-183
    • Düvel, K.1
  • 5
    • 3342895823 scopus 로고    scopus 로고
    • Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
    • D.D. Sarbassov Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton Curr. Biol. 14 2004 1296 1302
    • (2004) Curr. Biol. , vol.14 , pp. 1296-1302
    • Sarbassov, D.D.1
  • 6
    • 0016724057 scopus 로고
    • Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle
    • C. Vézina Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle J. Antibiot. (Tokyo) 28 1975 721 726
    • (1975) J. Antibiot. (Tokyo) , vol.28 , pp. 721-726
    • Vézina, C.1
  • 7
    • 34548700597 scopus 로고    scopus 로고
    • Rapamycin: Something old, something new, sometimes borrowed and now renewed
    • DOI 10.1038/sj.clpt.6100317, PII 6100317
    • C.M. Hartford, and M.J. Ratain Rapamycin: something old, something new, sometimes borrowed and now renewed Clin. Pharmacol. Ther. 82 2007 381 388 (Pubitemid 47414349)
    • (2007) Clinical Pharmacology and Therapeutics , vol.82 , Issue.4 , pp. 381-388
    • Hartford, C.M.1    Ratain, M.J.2
  • 8
    • 75749127850 scopus 로고    scopus 로고
    • Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease
    • C. Malagelada Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease J. Neurosci. 30 2010 1166 1175
    • (2010) J. Neurosci. , vol.30 , pp. 1166-1175
    • Malagelada, C.1
  • 9
    • 79651475390 scopus 로고    scopus 로고
    • Rapamycin for treating Tuberous sclerosis and Autism spectrum disorders
    • D. Ehninger, and A.J. Silva Rapamycin for treating Tuberous sclerosis and Autism spectrum disorders Trends Mol. Med. 17 2011 78 87
    • (2011) Trends Mol. Med. , vol.17 , pp. 78-87
    • Ehninger, D.1    Silva, A.J.2
  • 10
    • 33750072949 scopus 로고    scopus 로고
    • MTOR and cancer therapy
    • DOI 10.1038/sj.onc.1209886, PII 1209886
    • J.B. Easton, and P.J. Houghton mTOR and cancer therapy Oncogene 25 2006 6436 6446 (Pubitemid 44582287)
    • (2006) Oncogene , vol.25 , Issue.48 , pp. 6436-6446
    • Easton, J.B.1    Houghton, P.J.2
  • 12
    • 78349247944 scopus 로고    scopus 로고
    • Potential use of rapamycin in HIV infection
    • M. Donia Potential use of rapamycin in HIV infection Br. J. Clin. Pharmacol. 70 2010 784 793
    • (2010) Br. J. Clin. Pharmacol. , vol.70 , pp. 784-793
    • Donia, M.1
  • 13
    • 57449093795 scopus 로고    scopus 로고
    • Inhibition of human immunodeficiency virus (HIV-1) infection in human peripheral blood leucocytes-SCID reconstituted mice by rapamycin
    • F. Nicoletti Inhibition of human immunodeficiency virus (HIV-1) infection in human peripheral blood leucocytes-SCID reconstituted mice by rapamycin Clin. Exp. Immunol. 155 2009 28 34
    • (2009) Clin. Exp. Immunol. , vol.155 , pp. 28-34
    • Nicoletti, F.1
  • 14
    • 77949908335 scopus 로고    scopus 로고
    • First report on a series of HIV patients undergoing rapamycin monotherapy after liver transplantation
    • F. Di Benedetto First report on a series of HIV patients undergoing rapamycin monotherapy after liver transplantation Transplantation 89 2010 733 738
    • (2010) Transplantation , vol.89 , pp. 733-738
    • Di Benedetto, F.1
  • 15
    • 65349135496 scopus 로고    scopus 로고
    • HIV and SIV infection: The role of cellular restriction and immune responses in viral replication and pathogenesis
    • K.C. Williams, and T.H. Burdo HIV and SIV infection: the role of cellular restriction and immune responses in viral replication and pathogenesis APMIS 117 2009 400 412
    • (2009) APMIS , vol.117 , pp. 400-412
    • Williams, K.C.1    Burdo, T.H.2
  • 16
    • 74549178998 scopus 로고    scopus 로고
    • Chemokine coreceptor signaling in HIV-1 infection and pathogenesis
    • Y. Wu, and A. Yoder Chemokine coreceptor signaling in HIV-1 infection and pathogenesis PLoS Pathog. 5 2009 e1000520
    • (2009) PLoS Pathog. , vol.5 , pp. 1000520
    • Wu, Y.1    Yoder, A.2
  • 17
    • 53949120216 scopus 로고    scopus 로고
    • HIV immunopathogenesis and strategies for intervention
    • M. Cadogan, and A.G. Dalgleish HIV immunopathogenesis and strategies for intervention Lancet Infect. Dis. 8 2008 675 684
    • (2008) Lancet Infect. Dis. , vol.8 , pp. 675-684
    • Cadogan, M.1    Dalgleish, A.G.2
  • 18
    • 77953679372 scopus 로고    scopus 로고
    • Innate immune recognition and activation during HIV infection
    • T.H. Mogensen Innate immune recognition and activation during HIV infection Retrovirology 7 2010 54
    • (2010) Retrovirology , vol.7 , pp. 54
    • Mogensen, T.H.1
  • 19
    • 33644822414 scopus 로고    scopus 로고
    • Pathogenesis of HIV infection: What the virus spares is as important as what it destroys
    • DOI 10.1038/nm1380, PII N1380
    • Z. Grossman Pathogenesis of HIV infection: what the virus spares is as important as what it destroys Nat. Med. 12 2006 289 295 (Pubitemid 43355074)
    • (2006) Nature Medicine , vol.12 , Issue.3 , pp. 289-295
    • Grossman, Z.1    Meier-Schellersheim, M.2    Paul, W.E.3    Picker, L.J.4
  • 20
    • 48949097660 scopus 로고    scopus 로고
    • Antiretroviral treatment of adult HIV infection: Recommendations of the International AIDS Society-USA panel
    • S.M. Hammer Antiretroviral treatment of adult HIV infection: recommendations of the International AIDS Society-USA panel JAMA 300 2008 555 570
    • (2008) JAMA , vol.300 , pp. 555-570
    • Hammer, S.M.1
  • 22
    • 50949090165 scopus 로고    scopus 로고
    • + recovery with antiretroviral therapy prolongs immune depletion and increases risk for AIDS and non-AIDS diseases
    • + recovery with antiretroviral therapy prolongs immune depletion and increases risk for AIDS and non-AIDS diseases J. Acquir. Immune Defic. Syndr. 48 2008 541 546
    • (2008) J. Acquir. Immune Defic. Syndr. , vol.48 , pp. 541-546
    • Baker, J.V.1
  • 23
    • 33847119474 scopus 로고    scopus 로고
    • Risk of non-AIDS-related mortality may exceed risk of AIDS-related mortality among individuals enrolling into care with CD4+ counts greater than 200 cells/mm3
    • DOI 10.1097/01.qai.0000247229.68246.c5, PII 0012633420070201000009
    • + counts greater than 200 cells/mm3 J. Acquir. Immune Defic. Syndr. 44 2007 179 187 (Pubitemid 46292221)
    • (2007) Journal of Acquired Immune Deficiency Syndromes , vol.44 , Issue.2 , pp. 179-187
    • Lau, B.1    Gange, S.J.2    Moore, R.D.3
  • 24
    • 22744435902 scopus 로고    scopus 로고
    • Mechanisms of apoptosis induction by the HIV-1 envelope
    • J.L. Perfettini Mechanisms of apoptosis induction by the HIV-1 envelope Cell Death Differ. 12 Suppl. 1 2005 916 923
    • (2005) Cell Death Differ. , vol.12 , Issue.SUPPL. 1 , pp. 916-923
    • Perfettini, J.L.1
  • 27
    • 41349095737 scopus 로고    scopus 로고
    • Human immunodeficiency virus type-1 infection inhibits autophagy
    • DOI 10.1097/QAD.0b013e3282f4a836, PII 0000203020080330000003
    • D. Zhou, and S.A. Spector Human immunodeficiency virus type-1 infection inhibits autophagy AIDS 22 2008 695 699 (Pubitemid 351450637)
    • (2008) AIDS , vol.22 , Issue.6 , pp. 695-699
    • Zhou, D.1    Spector, S.A.2
  • 28
    • 48249154992 scopus 로고    scopus 로고
    • Autophagy: An overlooked mechanism of HIV-1 pathogenesis and neuroAIDS?
    • S.A. Spector, and D. Zhou Autophagy: an overlooked mechanism of HIV-1 pathogenesis and neuroAIDS? Autophagy 4 2008 704 706
    • (2008) Autophagy , vol.4 , pp. 704-706
    • Spector, S.A.1    Zhou, D.2
  • 29
    • 0037322692 scopus 로고    scopus 로고
    • Defective phagocytosis by human monocyte/macrophages following HIV-1 infection: Underlying mechanisms and modulation by adjunctive cytokine therapy
    • DOI 10.1016/S1386-6532(02)00123-3, PII S1386653202001233
    • K. Kedzierska Defective phagocytosis by human monocyte/macrophages following HIV-1 infection: underlying mechanisms and modulation by adjunctive cytokine therapy J. Clin. Virol. 26 2003 247 263 (Pubitemid 36206609)
    • (2003) Journal of Clinical Virology , vol.26 , Issue.2 , pp. 247-263
    • Kedzierska, K.1    Azzam, R.2    Ellery, P.3    Mak, J.4    Jaworowski, A.5    Crowe, S.M.6
  • 30
    • 77955375856 scopus 로고    scopus 로고
    • HIV-1 inhibits autophagy in bystander macrophage/monocytic cells through Src-Akt and STAT3
    • J. Van Grol HIV-1 inhibits autophagy in bystander macrophage/monocytic cells through Src-Akt and STAT3 PLoS ONE 5 2010 e11733
    • (2010) PLoS ONE , vol.5 , pp. 11733
    • Van Grol, J.1
  • 31
    • 62049084947 scopus 로고    scopus 로고
    • Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic cells
    • C. Jagannath Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic cells Nat. Med. 15 2009 267 276
    • (2009) Nat. Med. , vol.15 , pp. 267-276
    • Jagannath, C.1
  • 32
    • 77953272740 scopus 로고    scopus 로고
    • Human immunodeficiency virus-1 inhibition of immunoamphisomes in dendritic cells impairs early innate and adaptive immune responses
    • F.P. Blanchet Human immunodeficiency virus-1 inhibition of immunoamphisomes in dendritic cells impairs early innate and adaptive immune responses Immunity 32 2010 654 669
    • (2010) Immunity , vol.32 , pp. 654-669
    • Blanchet, F.P.1
  • 33
    • 77952940200 scopus 로고    scopus 로고
    • Human immunodeficiency virus-associated neurocognitive disorders: Mind the gap
    • J.C. McArthur Human immunodeficiency virus-associated neurocognitive disorders: mind the gap Ann. Neurol. 67 2010 699 714
    • (2010) Ann. Neurol. , vol.67 , pp. 699-714
    • McArthur, J.C.1
  • 34
    • 77952938752 scopus 로고    scopus 로고
    • Cognitive dysfunction in HIV patients despite long-standing suppression of viremia
    • S. Simioni Cognitive dysfunction in HIV patients despite long-standing suppression of viremia AIDS 24 2010 1243 1250
    • (2010) AIDS , vol.24 , pp. 1243-1250
    • Simioni, S.1
  • 35
    • 0029984877 scopus 로고    scopus 로고
    • Neuropathology of human immunodeficiency virus infection at different disease stages
    • DOI 10.1016/S0046-8177(96)90391-3
    • K. Kibayashi Neuropathology of human immunodeficiency virus infection at different disease stages Hum. Pathol. 27 1996 637 642 (Pubitemid 26240313)
    • (1996) Human Pathology , vol.27 , Issue.7 , pp. 637-642
    • Kibayashi, K.1    Mastri, A.R.2    Hirsch, C.S.3
  • 36
    • 53549096775 scopus 로고    scopus 로고
    • Decreased neuronal autophagy in HIV dementia: A mechanism of indirect neurotoxicity
    • M. Alirezaei Decreased neuronal autophagy in HIV dementia: a mechanism of indirect neurotoxicity Autophagy 4 2008 963 966
    • (2008) Autophagy , vol.4 , pp. 963-966
    • Alirezaei, M.1
  • 37
    • 51449119611 scopus 로고    scopus 로고
    • Disruption of neuronal autophagy by infected microglia results in neurodegeneration
    • M. Alirezaei Disruption of neuronal autophagy by infected microglia results in neurodegeneration PLoS ONE 3 2008 e2906
    • (2008) PLoS ONE , vol.3 , pp. 2906
    • Alirezaei, M.1
  • 39
    • 71249145352 scopus 로고    scopus 로고
    • Diagnosis and natural history of HIV-associated nephropathy
    • M.G. Atta Diagnosis and natural history of HIV-associated nephropathy Adv. Chronic Kidney Dis. 17 2010 52 58
    • (2010) Adv. Chronic Kidney Dis. , vol.17 , pp. 52-58
    • Atta, M.G.1
  • 40
    • 71249146525 scopus 로고    scopus 로고
    • The pathogenesis of HIV-associated nephropathy
    • L. Kaufman The pathogenesis of HIV-associated nephropathy Adv. Chronic Kidney Dis. 17 2010 36 43
    • (2010) Adv. Chronic Kidney Dis. , vol.17 , pp. 36-43
    • Kaufman, L.1
  • 41
    • 55649092856 scopus 로고    scopus 로고
    • HIV-associated nephropathy: Clinical presentation, pathology, and epidemiology in the era of antiretroviral therapy
    • C.M. Wyatt HIV-associated nephropathy: clinical presentation, pathology, and epidemiology in the era of antiretroviral therapy Semin. Nephrol. 28 2008 513 522
    • (2008) Semin. Nephrol. , vol.28 , pp. 513-522
    • Wyatt, C.M.1
  • 42
    • 77957267854 scopus 로고    scopus 로고
    • HIV-associated nephropathy: Role of mammalian target of rapamycin pathway
    • D. Kumar HIV-associated nephropathy: role of mammalian target of rapamycin pathway Am. J. Pathol. 177 2010 813 821
    • (2010) Am. J. Pathol. , vol.177 , pp. 813-821
    • Kumar, D.1
  • 43
    • 29244479193 scopus 로고    scopus 로고
    • AIDS and associated malignancies
    • DOI 10.1038/sj.cr.7290372
    • C. Wood, and W. Harrington Jr. AIDS and associated malignancies Cell Res. 15 2005 947 952 (Pubitemid 41826264)
    • (2005) Cell Research , vol.15 , Issue.11-12 , pp. 947-952
    • Wood, C.1    Harrington Jr., W.2
  • 44
    • 69849114151 scopus 로고    scopus 로고
    • Cancer risk in HIV-infected persons: Influence of CD4(+) count
    • G.M. Clifford, and S. Franceschi Cancer risk in HIV-infected persons: influence of CD4(+) count Fut. Oncol. 5 2009 669 678
    • (2009) Fut. Oncol. , vol.5 , pp. 669-678
    • Clifford, G.M.1    Franceschi, S.2
  • 45
    • 34548591679 scopus 로고    scopus 로고
    • HIV infection and cancer in the era of highly active antiretroviral therapy
    • G. Barbaro, and G. Barbarini HIV infection and cancer in the era of highly active antiretroviral therapy Oncol. Rep. 17 2007 1121 1126
    • (2007) Oncol. Rep. , vol.17 , pp. 1121-1126
    • Barbaro, G.1    Barbarini, G.2
  • 46
    • 70649103959 scopus 로고    scopus 로고
    • Clinical Epidemiology Group of the FHDH-ANRS CO4 cohort. Effect of immunodeficiency, HIV viral load, and antiretroviral therapy on the risk of individual malignancies (FHDH-ANRS CO4): A prospective cohort study
    • M. Guiguet Clinical Epidemiology Group of the FHDH-ANRS CO4 cohort. Effect of immunodeficiency, HIV viral load, and antiretroviral therapy on the risk of individual malignancies (FHDH-ANRS CO4): a prospective cohort study Lancet Oncol. 10 2009 1152 1159
    • (2009) Lancet Oncol. , vol.10 , pp. 1152-1159
    • Guiguet, M.1
  • 47
    • 77349101588 scopus 로고    scopus 로고
    • AIDS-related malignancies: Revisited
    • W. Cáceres AIDS-related malignancies: revisited P. R. Health Sci. J. 29 2010 70 75
    • (2010) P. R. Health Sci. J. , vol.29 , pp. 70-75
    • Cáceres, W.1
  • 48
    • 67849084535 scopus 로고    scopus 로고
    • Do antiretrovirals reduce the risk of non-AIDS-defining malignancies?
    • M.J. Silverberg, and D.I. Abrams Do antiretrovirals reduce the risk of non-AIDS-defining malignancies? Curr. Opin. HIV AIDS 4 2009 42 51
    • (2009) Curr. Opin. HIV AIDS , vol.4 , pp. 42-51
    • Silverberg, M.J.1    Abrams, D.I.2
  • 49
    • 78650389019 scopus 로고    scopus 로고
    • Rapamycin inhibits anal carcinogenesis in two preclinical animal models
    • M.K. Stelzer Rapamycin inhibits anal carcinogenesis in two preclinical animal models Cancer Prev. Res. (Phila.) 3 2010 1542 1551
    • (2010) Cancer Prev. Res. (Phila.) , vol.3 , pp. 1542-1551
    • Stelzer, M.K.1
  • 50
    • 73949094320 scopus 로고    scopus 로고
    • AIDS-related Kaposi's sarcoma: State of the art and therapeutic strategies
    • F. Martellotta AIDS-related Kaposi's sarcoma: state of the art and therapeutic strategies Curr. HIV Res. 7 2009 634 638
    • (2009) Curr. HIV Res. , vol.7 , pp. 634-638
    • Martellotta, F.1
  • 51
    • 33847779638 scopus 로고    scopus 로고
    • Akt/TSC/mTOR activation by the KSHV G protein-coupled receptor: Emerging insights into the molecular oncogenesis and treatment of Kaposi's sarcoma
    • S. Montaner Akt/TSC/mTOR activation by the KSHV G protein-coupled receptor: emerging insights into the molecular oncogenesis and treatment of Kaposi's sarcoma Cell Cycle 6 2007 438 443 (Pubitemid 46393447)
    • (2007) Cell Cycle , vol.6 , Issue.4 , pp. 438-443
    • Montaner, S.1
  • 53
    • 0036282619 scopus 로고    scopus 로고
    • AIDS-related non-Hodgkin's lymphomas: From pathology and molecular pathogenesis to treatment
    • DOI 10.1053/hupa.2002.124723
    • A. Carbone AIDS-related non-Hodgkin's lymphomas: from pathology and molecular pathogenesis to treatment Pathology 33 2002 392 404 (Pubitemid 34627589)
    • (2002) Human Pathology , vol.33 , Issue.4 , pp. 392-404
    • Carbone, A.1
  • 54
    • 26944435227 scopus 로고    scopus 로고
    • Therapy insight: AIDS-related malignancies - The influence of antiviral therapy on pathogenesis and management
    • DOI 10.1038/ncponc0253, PII N0253
    • R. Yarchoan Therapy insight: AIDS-related malignancies - the influence of antiviral therapy on pathogenesis and management Nat. Clin. Pract. Oncol. 2 2005 406 415 (Pubitemid 43115009)
    • (2005) Nature Clinical Practice Oncology , vol.2 , Issue.8 , pp. 406-415
    • Yarchoan, R.1    Tosato, G.2    Little, R.F.3
  • 55
    • 68449090866 scopus 로고    scopus 로고
    • Activation of mTORC1 signaling pathway in AIDS-related lymphomas
    • M. El-Salem Activation of mTORC1 signaling pathway in AIDS-related lymphomas Am. J. Pathol. 175 2009 817 824
    • (2009) Am. J. Pathol. , vol.175 , pp. 817-824
    • El-Salem, M.1
  • 57
    • 0038054547 scopus 로고    scopus 로고
    • Immunosuppressive tor kinase inhibitor everolimus (RAD) suppresses growth of cells derived from posttransplant lymphoproliferative disorder at allograft-protecting doses
    • DOI 10.1097/01.TP.0000063934.89714.19
    • M. Majewski Immunosuppressive signal transduction inhibitor RAD suppresses growth of cells derived from post-transplant lymphoproliferative disorder at allograft protecting doses Transplantation 75 2003 1710 1717 (Pubitemid 36629155)
    • (2003) Transplantation , vol.75 , Issue.10 , pp. 1710-1717
    • Majewski, M.1    Korecka, M.2    Joergensen, J.3    Fields, L.4    Kossev, P.5    Schuler, W.6    Shaw, L.7    Wasik, M.A.8
  • 58
    • 42649109348 scopus 로고    scopus 로고
    • Inhibition of mTOR by sirolimus induces remission of post-transplant lymphoproliferative disorders
    • DOI 10.1111/j.1432-2277.2008.00655.x
    • M. Boratynska, and D. Smolska Inhibition of mTOR by sirolimus induces remission of post-transplant lymphoproliferative disorders Transpl. Int. 21 2008 605 608 (Pubitemid 351600070)
    • (2008) Transplant International , vol.21 , Issue.6 , pp. 605-608
    • Boratynska, M.1    Smolska, D.2
  • 59
    • 77953932867 scopus 로고    scopus 로고
    • Dual inhibition of PI3K and mTOR inhibits autocrine and paracrine proliferative loops in PI3K/Akt/mTOR-addicted lymphomas
    • A.P. Bhatt Dual inhibition of PI3K and mTOR inhibits autocrine and paracrine proliferative loops in PI3K/Akt/mTOR-addicted lymphomas Blood 115 2010 4455 4463
    • (2010) Blood , vol.115 , pp. 4455-4463
    • Bhatt, A.P.1
  • 60
    • 68949102180 scopus 로고    scopus 로고
    • Phase III study to evaluate temsirolimus compared with investigator's choice therapy for the treatment of relapsed or refractory mantle cell lymphoma
    • G. Hess Phase III study to evaluate temsirolimus compared with investigator's choice therapy for the treatment of relapsed or refractory mantle cell lymphoma J. Clin. Oncol. 27 2009 3822 3829
    • (2009) J. Clin. Oncol. , vol.27 , pp. 3822-3829
    • Hess, G.1


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