Autophagy: An overlooked mechanism of HIV-1 pathogenesis and neuroAIDS?

Autophagy

Volumn 4, Issue 5, 2008, Pages 704-706

  Spector, Stephen A ^a,b   Zhou, Dejiang ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

AIDS; Autophagy; Beclin 1; HIV pathogenesis; HIV 1; HIV associated dementia; HIV related cognitive impairment; Neuroaids

Indexed keywords

BECLIN 1; GLYCOPROTEIN GP 120; MESSENGER RNA;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; AUTOPHAGY; CD4+ T LYMPHOCYTE; COGNITIVE DEFECT; DEMENTIA; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NONHUMAN; PATHOGENESIS; PHAGOSOME; PROTEIN EXPRESSION; PROTEIN SECRETION; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 48249154992     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.6105     Document Type: Article

References (17)

1. Maiuri MC, Zalckvar E, Kimchi A and Kroemer G. Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol 2007; 8:741-52.
2. Espert L, Denizot M, Grimaldi M, et al. Autophagy is involved in T cell death after binding of HIV-1 envelope proteins to CXCR4. J Clin Invest 2006; 116:2161-72.
3. + T lymphocyte destruction by HIV-1. Autophagy 2007; 3:32-4.
4. Zhou D, Spector SA. Human immunodeficiency virus type-1 infection inhibits autophagy. Aids 2008; 22:695-9.
5. Levine B. Eating oneself and uninvited guests: autophagy-related pathways in cellular defense. Cell 2005; 120:159-62.
6. Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008; 132:27-42.
7. Mizushima N, Levine B, Cuervo AM and Klionsky DJ. Autophagy fights disease through cellular self-digestion. Nature 2008; 451:1069-75.
8. Munz C. Viral evasion of autophagy. Cell Host & Microbe 2007; 1:9-11.
9. Jackson WT, Giddings TH Jr, Taylor MP, et al. Subversion of cellular autophagosomal machinery by RNA viruses. PLoS Biol 2005; 3:156.
10. Orvedahl A, Alexander D, Talloczy Z, et al. HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein. Cell Host & Microbe 2007; 1:23-35.
11. Heaton RK, Grant I, Butters N, et al. The HNRC 500 - neuropsychology of HIV infection at different disease stages. HIV Neurobehavioral Research Center. J Int Neuropsychol Soc 1995; 1:231-51.
12. He C, Klionsky DJ. Autophagy and neurodegeneration. ACS Chem Biol 2006; 1:211-3.
13. Jellinger KA, Stadelmann C. Mechanisms of cell death in neurodegenerative disorders. J Neural Transm Suppl 2000; 59:95-114.
14. Jellinger KA, Stadelmann C. Problems of cell death in neurodegeneration and Alzheimer's Disease. J Alzheimers Dis 2001; 3:31-40.
15. Ravikumar B, Acevedo Arozena A, Imarisio S, et al. Dynein mutations impair autophagic clearance of aggregate-prone proteins. Nat Genet 2005; 37:771-6.
16. Rubinsztein DC, Huntington JA. Paradoxical aggregation versus oligomerisation properties of mutant and wild-type huntingtin fragments. Exp Neurol 2006; 199:243-4.
17. Kaul M, Lipton SA. Chemokines and activated macrophages in HIV gp120-induced neuronal apoptosis. Proc Natl Acad Sci USA 1999; 96:8212-6.