The Pathogenesis of HIV-Associated Nephropathy

Advances in Chronic Kidney Disease

Volumn 17, Issue 1, 2010, Pages 36-43

  Kaufman, Lewis ^a   Collins, Susan E ^a   Klotman, Paul E ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Glomerulosclerosis; HIV associated nephropathy; MYH9; Podocyte

Indexed keywords

MYOSIN;

FOCAL GLOMERULOSCLEROSIS; GENE EXPRESSION; HEREDITY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS ASSOCIATED NEPHROPATHY; KIDNEY DISEASE; KIDNEY EPITHELIUM; KIDNEY FAILURE; NONHUMAN; PATHOGENESIS; PODOCYTE; PRIORITY JOURNAL; PROTEINURIA; REVIEW; TUBULAR DYSFUNCTION;

AIDS-ASSOCIATED NEPHROPATHY; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; HUMANS; KIDNEY FAILURE, CHRONIC; PODOCYTES;

EID: 71249146525     PISSN: 15485595     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.ackd.2009.08.012     Document Type: Review

References (47)

1. Rao T.K., Friedman E.A., and Nicastri A.D. The types of renal disease in the acquired immunodeficiency syndrome. N Engl J Med 316 (1987) 1062-1068
2. D'Agati V., Suh J.I., Carbone L., et al. Pathology of HIV-associated nephropathy: A detailed morphologic and comparative study. Kidney Int 35 (1989) 1358-1370
3. Pierson T., McArthur J., and Siliciano R.F. Reservoirs for HIV-1: Mechanisms for viral persistence in the presence of antiviral immune responses and antiretroviral therapy. Annu Rev Immunol 18 (2000) 665-708
4. Speth C., Dierich M.P., and Sopper S. HIV-infection of the central nervous system: the tightrope walk of innate immunity. Mol Immunol 42 (2005) 213-228
5. Chun T.W., Davey Jr. R.T., Ostrowski M., et al. Relationship between pre-existing viral reservoirs and the re-emergence of plasma viremia after discontinuation of highly active anti-retroviral therapy. Nat Med 6 (2000) 757-761
6. Bruggeman L.A., Dikman S., Meng C., et al. Nephropathy in human immunodeficiency virus-1 transgenic mice is due to renal transgene expression. J Clin Invest 100 (1997) 84-92
7. Bruggeman L.A., Ross M.D., Tanji N., et al. Renal epithelium is a previously unrecognized site of HIV-1 infection. J Am Soc Nephrol 11 (2000) 2079-2087
8. Winston J.A., Bruggeman L.A., Ross M.D., et al. Nephropathy and establishment of a renal reservoir of HIV type 1 during primary infection. N Engl J Med 344 (2001) 1979-1984
9. Marras D., Bruggeman L.A., Gao F., et al. Replication and compartmentalization of HIV-1 in kidney epithelium of patients with HIV-associated nephropathy. Nat Med 8 (2002) 522-526
10. Cantor E.S., Kimmel P.L., and Bosch J.P. Effect of race on expression of acquired immunodeficiency syndrome-associated nephropathy. Arch Intern Med 151 (1991) 125-128
11. Kopp J.B., Klotman M.E., Adler S.H., et al. Progressive glomerulosclerosis and enhanced renal accumulation of basement membrane components in mice transgenic for human immunodeficiency virus type 1 genes. Proc Natl Acad Sci USA 89 (1992) 1577-1581
12. Gharavi A.G., Ahmad T., Wong R.D., et al. Mapping a locus for susceptibility to HIV-1-associated nephropathy to mouse chromosome 3. Proc Natl Acad Sci USA 101 (2004) 2488-2493
13. Zhong J., Zuo Y., Ma J., et al. Expression of HIV-1 genes in podocytes alone can lead to the full spectrum of HIV-1-associated nephropathy. Kidney Int 68 (2005) 1048-1060
14. Chan K.T., Papeta N., Martino J., et al. Accelerated development of collapsing glomerulopathy in mice congenic for the HIVAN1 locus. Kidney Int 75 (2009) 366-372
15. Papeta N., Chan K.T., Prakash S., et al. Susceptibility loci for murine HIV-associated nephropathy encode trans-regulators of podocyte gene expression. J Clin Invest 119 (2009) 1178-1188
16. Kopp J.B., Smith M.W., Nelson G.W., et al. MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis. Nat Genet 40 (2008) 1175-1184
17. Kao W.H., Klag M.J., Meoni L.A., et al. MYH9 is associated with nondiabetic end-stage renal disease in African Americans. Nat Genet 40 (2008) 1185-1192
18. Heath K.E., Campos-Barros A., Toren A., et al. Nonmuscle myosin heavy chain IIA mutations define a spectrum of autosomal dominant macrothrombocytopenias: May-Hegglin anomaly and Fechtner, Sebastian, Epstein, and Alport-like syndromes. Am J Hum Genet 69 (2001) 1033-1045
19. Kelley M.J., Jawien W., Ortel T.L., et al. Mutation of MYH9, encoding non-muscle myosin heavy chain A, in May-Hegglin anomaly. Nat Genet 26 (2000) 106-108
20. Seri M., Cusano R., Gangarossa S., et al. Mutations in MYH9 result in the May-Hegglin anomaly, and Fechtner and Sebastian syndromes. The May-Hegglin/Fechtner Syndrome Consortium. Nat Genet 26 (2000) 103-105
21. Mhatre A.N., Li Y., Bhatia N., et al. Generation and characterization of mice with Myh9 deficiency. Neuromolecular Med 9 (2007) 205-215
22. Barisoni L., Kriz W., Mundel P., et al. The dysregulated podocyte phenotype: A novel concept in the pathogenesis of collapsing idiopathic focal segmental glomerulosclerosis and HIV-associated nephropathy. J Am Soc Nephrol 10 (1999) 51-61
23. Barisoni L., and Kopp J.B. Modulation of podocyte phenotype in collapsing glomerulopathies. Microsc Res Tech 57 (2002) 254-262
24. Dijkman H.B., Weening J.J., Smeets B., et al. Proliferating cells in HIV and pamidronate-associated collapsing focal segmental glomerulosclerosis are parietal epithelial cells. Kidney Int 70 (2006) 338-344
25. Suzuki T., Matsusaka T., Nakayama M., et al. Genetic podocyte lineage reveals progressive podocytopenia with parietal cell hyperplasia in a murine model of cellular/collapsing focal segmental glomerulosclerosis. Am J Pathol 174 (2009) 1675-1682
26. Barisoni L., Mokrzycki M., Sablay L., et al. Podocyte cell cycle regulation and proliferation in collapsing glomerulopathies. Kidney Int 58 (2000) 137-143
27. Barisoni L., Bruggeman L.A., Mundel P., et al. HIV-1 induces renal epithelial dedifferentiation in a transgenic model of HIV-associated nephropathy. Kidney Int 58 (2000) 173-181
28. Schwartz E.J., Cara A., Snoeck H., et al. Human immunodeficiency virus-1 induces loss of contact inhibition in podocytes. J Am Soc Nephrol 12 (2001) 1677-1684
29. Husain M., Gusella G.L., Klotman M.E., et al. HIV-1 nef induces proliferation and anchorage-independent growth in podocytes. J Am Soc Nephrol 13 (2002) 1806-1815
30. Sunamoto M., Husain M., He J.C., et al. Critical role for Nef in HIV-1-induced podocyte dedifferentiation. Kidney Int 64 (2003) 1695-1701
31. Husain M., D'Agati V.D., He J.C., et al. HIV-1 Nef induces dedifferentiation of podocytes in vivo: A characteristic feature of HIVAN. AIDS 19 (2005) 1975-1980
32. Zuo Y., Matsusaka T., Zhong J., et al. HIV-1 genes vpr and nef synergistically damage podocytes, leading to glomerulosclerosis. J Am Soc Nephrol 17 (2006) 2832-2843
33. Fackler O.T., and Baur A.S. Live and let die: Nef functions beyond HIV replication. Immunity 16 (2002) 493-497
34. He J.C., Husain M., Sunamoto M., et al. Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathways. J Clin Invest 114 (2004) 643-651
35. He J.C., Lu T.C., Fleet M., et al. Retinoic acid inhibits HIV-1-induced podocyte proliferation through the cAMP pathway. J Am Soc Nephrol 18 (2007) 93-102
36. Lu T.C., Wang Z., Feng X., et al. Retinoic acid utilizes CREB and USF1 in a transcriptional feed-forward loop in order to stimulate MKP1 expression in human immunodeficiency virus-infected podocytes. Mol Cell Biol 28 (2008) 5785-5794
37. Ross M.J., Martinka S., D'Agati V.D., et al. NF-kappaB regulates Fas-mediated apoptosis in HIV-associated nephropathy. J Am Soc Nephrol 16 (2005) 2403-2411
38. Martinka S., and Bruggeman L.A. Persistent NF-kappaB activation in renal epithelial cells in a mouse model of HIV-associated nephropathy. Am J Physiol Renal Physiol 290 (2006) F657-F665
39. Husain M., Meggs L.G., Vashishtha H., et al. Inhibtion of P66SHCA longevity gene rescues podocytes from HIV-1-induced oxidative stress and apoptosis. J Biol Chem 284 (2009) 16648-16658
40. Kaufman L., Hayashi K., Ross M.J., et al. Sidekick-1 is upregulated in glomeruli in HIV-associated nephropathy. J Am Soc Nephrol 15 (2004) 1721-1730
41. Kaufman L., Yang G., Hayashi K., et al. The homophilic adhesion molecule sidekick-1 contributes to augmented podocyte aggregation in HIV-associated nephropathy. FASEB J 21 (2007) 1367-1375
42. Ross M.D., Bruggeman L.A., Hanss B., et al. Podocan, a novel small leucine-rich repeat protein expressed in the sclerotic glomerular lesion of experimental HIV-associated nephropathy. J Biol Chem 278 (2003) 33248-33255
43. Eustace J.A., Nuermberger E., Choi M., et al. Cohort study of the treatment of severe HIV-associated nephropathy with corticosteroids. Kidney Int 58 (2000) 1253-1260
44. Smith M.C., Austen J.L., Carey J.T., et al. Prednisone improves renal function and proteinuria in human immunodeficiency virus-associated nephropathy. Am J Med 101 (1996) 41-48
45. Ross M.J., Fan C., Ross M.D., et al. HIV-1 infection initiates an inflammatory cascade in human renal tubular epithelial cells. J Acquir Immune Defic Syndr 42 (2006) 1-11
46. Kimmel P.L., Cohen D.J., Abraham A.A., et al. Upregulation of MHC class II, interferon-alpha and interferon-gamma receptor protein expression in HIV-associated nephropathy. Nephrol Dial Transplant 18 (2003) 285-292
47. Ross M.J., Wosnitzer M.S., Ross M.D., et al. Role of ubiquitin-like protein FAT10 in epithelial apoptosis in renal disease. J Am Soc Nephrol 17 (2006) 996-1004