Mechanisms of increased risk of tumorigenesis in Atm and Brca1 double heterozygosity

Radiation Oncology

Volumn 6, Issue 1, 2011, Pages

  Wang, Jufang ^a   Su, Fengtao ^a   Smilenov, Lubomir B ^b   Zhou, Libin ^a   Hu, Wentao ^a,c   Ding, Nan ^a,c   Zhou, Guangming ^a  

^a INSTITUTE OF MODERN PHYSICS   (China)

^b New York Presbyterian Morgan Stanley Children's Hospital   (United States)

^c UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Cell cycle checkpoint; DNA damage; Genomic instability; Haploinsufficiency; Heterozygosity; Tumorigenesis

Indexed keywords

ATM PROTEIN; BRCA1 PROTEIN; BRCA1 PROTEIN, HUMAN; CELL CYCLE PROTEIN; DNA BINDING PROTEIN; H2AFX PROTEIN, HUMAN; HISTONE; PROTEIN SERINE THREONINE KINASE; TUMOR SUPPRESSOR PROTEIN;

ANIMAL CELL; ARTICLE; ATM GENE; CANCER RISK; CANCER SUSCEPTIBILITY; CARCINOGENESIS; CELL CYCLE; CELL FATE; CELL TRANSFORMATION; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DOUBLE HETEROZYGOSITY; GENE; GENOMIC INSTABILITY; HAPLOINSUFFICIENCY; HETEROZYGOSITY; IONIZING RADIATION; MICRONUCLEUS; NONHUMAN; ONCOGENE; PATHOGENESIS; PROTEIN EXPRESSION; TUMOR; WILD TYPE; CELL SURVIVAL; COMET ASSAY; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; HETEROZYGOTE; HUMAN; METABOLISM; MICRONUCLEUS TEST; NEOPLASM; PHOTON; RADIATION DOSE; RISK;

BRCA1 PROTEIN; CELL CYCLE; CELL CYCLE PROTEINS; CELL SURVIVAL; CELL TRANSFORMATION, NEOPLASTIC; COMET ASSAY; DNA DAMAGE; DNA REPAIR; DNA-BINDING PROTEINS; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HETEROZYGOTE; HISTONES; HUMANS; MICRONUCLEUS TESTS; NEOPLASMS; PHOTONS; PROTEIN-SERINE-THREONINE KINASES; RADIATION TOLERANCE; RADIATION, IONIZING; RISK; TUMOR SUPPRESSOR PROTEINS;

EID: 80051660476     PISSN: None     EISSN: 1748717X     Source Type: Journal    
DOI: 10.1186/1748-717X-6-96     Document Type: Article

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