The relative biological effectiveness of densely ionizing heavy-ion radiation for inducing ocular cataracts in wild type versus mice heterozygous for the ATM gene

Radiation and Environmental Biophysics

Volumn 45, Issue 2, 2006, Pages 99-104

  Hall, Eric J ^a   Worgul, Basil V ^a   Smilenov, Lubomir ^a   Elliston, Carl D ^a   Brenner, David J ^a  

^a Department of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GALACTIC COSMIC RAY RADIATION; HAPLOINSUFFICIENT ANIMALS; HIGH-ENERGY HEAVY IONS; RELATIVE BIOLOGICAL EFFECTIVENESS (RBE);

COSMIC RAYS; DOSIMETRY; GALAXIES; IONS; X RAYS;

RADIATION HAZARDS;

ATM PROTEIN; HEAVY ION; IRON;

ANIMAL EXPERIMENT; ARTICLE; CATARACT; LINEAR ENERGY TRANSFER; MOUSE; NONHUMAN; NUCLEON; RELATIVE BIOLOGIC EFFECTIVENESS; WILD TYPE; X RAY;

ANIMALS; CATARACT; CELL CYCLE PROTEINS; DNA-BINDING PROTEINS; HEAVY IONS; HETEROZYGOTE; IRON; LINEAR ENERGY TRANSFER; MICE; MICE, KNOCKOUT; PROTEIN-SERINE-THREONINE KINASES; RADIATION DOSAGE; RADIATION INJURIES, EXPERIMENTAL; RELATIVE BIOLOGICAL EFFECTIVENESS; TIME FACTORS; TUMOR SUPPRESSOR PROTEINS; X-RAYS;

ANIMALIA;

EID: 33745841544     PISSN: 0301634X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00411-006-0052-5     Document Type: Article

References (29)

1. Cucinotta FA, Manuel FK, Jones J, Iszard G, Murrey J, Djojonegro B, Wear M (2001) Space radiation and cataracts in astronauts. Radiat Res 156:460-466
2. Rafnsson V, Olafsdottir E, Hrafnkelsson J, Sasaki H, Arnarsson A, Jonasson F (2005) Cosmic radiation increases the risk of nuclear cataract in airline pilots: a population-based case-control study. Arch Ophthalmol 123:1102-1105
3. Worgul BV, Merriam GR Jr, Medvedovsky C (1989) Cortical cataract development - an expression of primary damage to the lens epithelium. Lens Eye Toxic Res 6:559-571
4. Worgul BV (1986) Cataract analysis and the assessment of radiation risk in space. Adv Space Res 6:285-293
5. Brenner DJ, Medvedovsky C, Huang Y, Merriam GR Jr, Worgul BV (1991) Accelerated heavy particles and the lens. VI. RBE studies at low doses. Radiat Res 128:73-81
6. Worgul BV, Medvedovsky C, Huang Y, Marino SA, Randers-Pehrson G, Brenner DJ (1996) Quantitative assessment of the cataractogenic potential of very low doses of neutrons. Radiat Res 145:343-349
7. Hall EJ, Brenner DJ, Worgul B, Smilenov L (2005) Genetic susceptibility to radiation. Adv Space Res 35:249-253
8. Taylor AM, Harnden DG, Arlett CF, Harcourt SA, Lehmann AR, Stevens S, Bridges BA (1975) Ataxia telangiectasia: a human mutation with abnormal radiation sensitivity. Nature 258:427-429
9. Taylor AM, Byrd PJ (2005) Molecular pathology of ataxia telangiectasia. J Clin Pathol 58:1009-1015
10. Swift M, Morrell D, Cromartie E, Chamberlin AR, Skolnick MH, Bishop DT (1986) The incidence and gene frequency of ataxia-telangiectasia in the United States. Am J Hum Genet 39:573-583
11. FitzGerald MG, Bean JM, Hegde SR, Unsal H, MacDonald DJ, Harkin DP, Finkelstein DM, Isselbacher KJ, Haber DA (1997) Heterozygous ATM mutations do not contribute to early onset of breast cancer. Nat Genet 15:307-310
12. Thompson D, Duedal S, Kirner J, McGuffog L, Last J, Reiman A, Byrd P, Taylor M, Easton DF (2005) Cancer risks and mortality in heterozygous ATM mutation carriers. J Natl Cancer Inst 97:813-822
13. Angele S, Hall J (2000) The ATM gene and breast cancer: is it really a risk factor? Mutat Res 462:167-178
14. Swift M, Morrell D, Massey RB, Chase CL (1991) Incidence of cancer in 161 families affected by ataxia-telangiectasia. N Engl J Med 325:1831-1836
15. Lavin MF, Birrell G, Chen P, Kozlov S, Scott S, Gueven N (2005) ATM signaling and genomic stability in response to DNA damage. Mutat Res 569:123-132
16. Iliakis G, Wang Y, Guan J, Wang H (2003) DNA damage checkpoint control in cells exposed to ionizing radiation. Oncogene 22:5834-5847
17. Pandita TK, Hittelman WN (1994) Increased initial levels of chromosome damage and heterogeneous chromosome repair in ataxia telangiectasia heterozygote cells. Mutat Res 310:1-13
18. Hall EJ, Schiff PB, Hanks GE, Brenner DJ, Russo J, Chen J, Sawant SG, Pandita TK (1998) A preliminary report: frequency of A-T heterozygotes among prostate cancer patients with severe late responses to radiation therapy. Can J Sci Am 4:385-389
19. Cesaretti JA, Stock RG, Lehrer S, Atencio DA, Bernstein JL, Stone NN, Wallenstein S, Green S, Loeb K, Kollmeier M, Smith M, Rosenstein BS (2005) ATM sequence variants are predictive of adverse radiotherapy response among patients treated for prostate cancer. Int J Radiat Oncol Biol Phys 61:196-202
20. Worgul BV, Smilenov L, Brenner DJ, Junk A, Zhou W, Hall EJ (2002) Atm heterozygous mice are more sensitive to radiation-induced cataracts than are their wild-type counterparts. Proc Natl Acad Sci USA 99:9836-9839
21. Worgul BV, Smilenov L, Brenner DJ, Vazquez M, Hall EJ (2005) Mice heterozygous for the ATM gene are more sensitive to both X-ray and heavy ion exposure than are wildtypes. Adv Space Res 35:254-259
22. Zeitlin C, Heilbronn L, Miller J, Rademacher SE, Borak T, Carter TR, Frankel KA, Schimmerling W, Stronach CE (1997) Heavy fragment production cross section from 1.05 GeV/nucleon 56Fe in C, Al, Cu, Pb, and CH2 targets. Phys Rev C Nucl Phys 56:388-397
23. Merriam GR Jr, Focht EF (1962) A clinical and experimental study of the effect of single and divided doses of radiation on cataract production. Trans Am Ophthalmol Soc 60:35-52
24. Brenner DJ, Medvedovsky C, Huang Y, Worgul BV (1993) Accelerated heavy particles and the lens. VIII. Comparisons between the effects of acute low doses of iron ions (190 keV/ micron) and argon ions (88 keV/micron). Radiat Res 133:198-203
25. Kaplan EL, Meier P (1957) Non-parametric estimation from incomplete observations. J Am Stat Assoc 53:457-481
26. Greenwood M (1926) The natural duration of cancer. Rep Pub Health Med Subj 53:1-26
27. Akima H (1978) A method of bivariate interpolation and smooth surface fitting for irregularly distributed data points. ACM Trans Math Softw 4:148-159
28. 56Fe particles: a comparison with mitotic effects. Radiat Res 125:298-305
29. Lett JT, Cox AB, Lee AC (1985) Some perspectives on cataractogenesis from heavy charged particles. Radiat Res Suppl 8:S201-S207