Antioxidant and antigenotoxic effects of rosemary (Rosmarinus officinalis L.) extracts in Salmonella typhimurium TA98 and HepG2 cells

Environmental Toxicology and Pharmacology

Volumn 32, Issue 2, 2011, Pages 296-305

  Žegura, Bojana ^a   Dobnik, David ^a   Niderl, Maša Hojnik ^b   Filipič, Metka ^a  

^a NATIONAL INSTITUTE OF BIOLOGY   (Slovenia)

^b VITIVA dd   (Slovenia)

Author keywords

Antigenotoxicity; Antioxidants; Bacterial reverse mutation assay; Comet assay; HepG2 cells; Rosmarinus officinalis L

Indexed keywords

2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; 2 AMINO 3 METHYLIMIDAZO[4,5 F]QUINOLINE; 4 NITROQUINOLINE 1 OXIDE; AQUAROX; BENZO[A]PYRENE; ROSMARINUS OFFICINALIS EXTRACT; TERT BUTYL HYDROPEROXIDE; UNCLASSIFIED DRUG; VIVOX;

ANTIGENOTOXIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CELL STRAIN HEPG2; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; DRUG ACTIVITY; DRUG CYTOTOXICITY; GENOTOXICITY; MUTAGENICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SALMONELLA TYPHIMURIUM;

BACTERIA (MICROORGANISMS); ROSMARINUS OFFICINALIS; SALMONELLA TYPHIMURIUM;

EID: 80051598109     PISSN: 13826689     EISSN: 18727077     Source Type: Journal    
DOI: 10.1016/j.etap.2011.06.002     Document Type: Article

References (51)

1. al-Sereiti M.R., Abu-Amer K.M., Sen P. Pharmacology of rosemary (Rosmarinus officinalis Linn.) and its therapeutic potentials. Indian J. Exp. Biol. 1999, 37:124-130.
2. Amagase H., Sakamoto K., Segal E.R., Milner J.A. Dietary rosemary suppresses 7,12-dimethylbenz(a)anthracene binding to rat mammary cell DNA. J. Nutr. 1996, 126:1475-1480.
3. Ames B.N. Dietary carcinogens and anticarcinogens oxygen radicals and degenerative diseases. Science 1983, 221:1256-1264.
4. Anderson R.F., Amarasinghe C., Fisher L.J., Mak W.B., Packer J.E. Reduction in free-radical-induced DNA strand breaks and base damage through fast chemical repair by flavonoids. Free Radic. Res. 2000, 33:91-103.
5. Aruoma O.I., Halliwell B., Aeschbach R., Loligers J. Antioxidant and pro-oxidant properties of active rosemary constituents: carnosol and carnosic acid. Xenobiotica 1992, 22:257-268.
6. Aruoma O.I., Spencer J.P.E., Rossi R., Aeschbach R., Khan A., Mahmood N., Munoz A., Murcia A., Butler J., Halliwell B. An evaluation of the antioxidant and antiviral action of extracts of rosemary and provençal herbs. Food Chem. Toxicol. 1996, 34:449-456.
7. Baardseth P. Effect of selected antioxidants on the stability of dehydrated mashed potatoes. Food Addit. Contam. 1989, 6:201-207.
8. Blosi M.S. Antioxidant determinations by the use of a stable free radical. Nature 1958, 181:1199-1200.
9. Cervellati R., Renzulli C., Guerra M.C., Speroni E. Evaluation of antioxidant activity of some natural polyphenolic compounds using the Briggs-Rauscher reaction method. J. Agric. Food Chem. 2002, 50:7504-7509.
10. Debersac P., Heydel J.M., Amiot M.J., Goudonnet H., Artur Y., Suschetet M., Siess M.H. Induction of cytochrome P450 and/or detoxication enzymes by various extracts of rosemary: description of specific patterns. Food Chem. Toxicol. 2001, 39:907-918.
11. Debersac P., Vernevaut M.F., Amiot M.J., Suschetet M., Siess M.H. Effects of a water-soluble extract of rosemary and its purified component rosmarinic acid on xenobiotic-metabolizing enzymes in rat liver. Food Chem. Toxicol. 2001, 39:109-117.
12. Erkan N., Ayranci G., Ayranci E. Antioxidant activities of rosemary (Rosmarinus officinalis L.) extract, blackseed (Nigella sativa L.) essential oil, carnosic acid, rosmarinic acid and sesamol. Food Chem. 2008, 110:76-82.
13. Ferguson L.R. Role of plant polyphenols in genomic stability. Mutat. Res. 2001, 475:89-111.
14. Ferguson L.R., Philpott M., Karunasinghe N. Dietary cancer and prevention using antimutagens. Toxicology 2004, 198:147-159.
15. Furtado M.A., de Almeida L.C.F., Furtado R.A., Cunha W.R., Tavares D.C. Antimutagenicity of rosmarinic acid in Swiss mice evaluated by the micronucleus assay. Mutat. Res./Genet. Toxicol. Environ. Mutagen. 2008, 657:150-154.
16. Haraguchi H., Saito T., Okamura N., Yagi A. Inhibition of lipid peroxidation and superoxide generation by diterpenoids from Rosmarinus officinalis. Planta Med. 1995, 61:333-336.
17. Hernández-Hernández E., Ponce-Alquicira E., Jaramillo-Flores M.E., Guerrero Legarreta I. Antioxidant effect rosemary (Rosmarinus officinalis L.) and oregano (Origanum vulgare L.) extracts on TBARS and colour of model raw pork batters. Meat Sci. 2009, 81:410-417.
18. Horváthová E., Slamenová D., Navarová J. Administration of rosemary essential oil enhances resistance of rat hepatocytes against DNA-damaging oxidative agents. Food Chem. 2010, 123:151-156.
19. Huang M.T., Ho C.T., Wang Z.Y., Ferraro T., Lou Y.R., Stauber K., Ma W., Georgiadis C., Laskin J.D., Conney A.H. Inhibition of skin tumorigenesis by rosemary and its constituents carnosol and ursolic acid. Cancer Res. 1994, 54:701-708.
20. Huang S.-C., Ho C.-T., Lin-Shiau S.-Y., Lin J.-K. Carnosol inhibits the invasion of B16/F10 mouse melanoma cells by suppressing metalloproteinase-9 through down-regulating nuclear factor-kappaB and c-Jun. Biochem. Pharmacol. 2005, 69:221-232.
21. Huang S.-s., Zheng R.-l. Rosmarinic acid inhibits angiogenesis and its mechanism of action in vitro. Cancer Lett. 2006, 239:271-280.
22. Ikken Y., Morales P., Martinez A., Marin M.L., Haza A.I., Cambero M.I. Antimutagenic effect of fruit and vegetable ethanolic extracts against N-nitrosamines evaluated by the Ames test. J. Agric. Food Chem. 1999, 47:3257-3264.
23. Izumi M., Satoh T., Inukai Y., Tutumi Y., Nakayama N., Kosaka K., Itoh K. Carnosic acid and carnosol as neuroprotective electrophilic compounds. Neurosci. Res. 2007, 58:S208-S1208.
24. Knasmüller S., Mersch-Sundermann V., Kevekordes S., Darroudi F., Huber W.W., Hoelzl C., Bichler J., Majer B.J. Use of human-derived liver cell lines for the detection of environmental and dietary genotoxicants; current state of knowledge. Toxicology 2004, 198:315-328.
25. Li G.-S., Jiang W.-L., Tian J.-W., Qu G.-W., Zhu H.-B., Fu F.-H. In vitro and in vivo antifibrotic effects of rosmarinic acid on experimental liver fibrosis. Phytomedicine 2010, 17(3-4):282-288.
26. Lima C.F., Fernandes-Ferreira M., Pereira-Wilson C. Phenolic compounds protect HepG2 cells from oxidative damage: relevance of glutathione levels. Life Sci. 2006, 79:2056-2068.
27. Mackenzie P.I., Rodbourn L., Iyanagi T. Glucuronidation of carcinogen metabolites by complementary DNA-expressed uridine 5′-diphosphate glucuronosyltransferases. Cancer Res. 1993, 53:1529-1533.
28. Maron D.M., Ames B.N. Revised methods for the Salmonella mutagenicity test. Mutat. Res. 1983, 113:173-215.
29. Mersch-Sundermann V., Knasmüller S., Wu X.-j., Darroudi F., Kassie F. Use of a human-derived liver cell line for the detection of cytoprotective, antigenotoxic and cogenotoxic agents. Toxicology 2004, 198:329-340.
30. Minnunni M., Wolleb U., Mueller O., Pfeifer A., Aeschbacher H.U. Natural antioxidants as inhibitors of oxygen species induced mutagenicity. Mutat. Res./Fundam. Mol. Mech. Mutagen. 1992, 269:193-200.
31. Mitic-Culafic D., Zegura B., Nikolic B., Vukovic-Gacic B., Knezevic-Vukcevic J., Filipic M. Protective effect of linalool, myrcene and eucalyptol against t-butyl hydroperoxide induced genotoxicity in bacteria and cultured human cells. Food Chem. Toxicol. 2009, 47:260-266.
32. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 1983, 65:55-63.
33. Offord E.A., Macé K., Avanti O., Pfeifer A.M.A. Mechanisms involved in the chemoprotective effects of rosemary extract studied in human liver and bronchial cells. Cancer Lett. 1997, 114:275-281.
34. Offord E.A., Mace K., Ruffieux C., Malnoe A., Pfeifer A.M. Rosemary components inhibit benzo[a]pyrene-induced genotoxicity in human bronchial cells. Carcinogenesis 1995, 16:2057-2062.
35. Oluwatuyi M., Kaatz G.W., Gibbons S. Antibacterial and resistance modifying activity of Rosmarinus officinalis. Phytochemistry 2004, 65:3249-3254.
36. Osakabe N., Yasuda A., Natsume M., Sanbongi C., Kato Y., Osawa T., Yoshikawa T. Rosmarinic acid, a major polyphenolic component of Perilla frutescens, reduces lipopolysaccharide (LPS)-induced liver injury in d-galactosamine (d-GalN)-sensitized mice. Free Radic. Biol. Med. 2002, 33:798-806.
37. Peng C.H., Su J.D., Chyau C.C., Sung T.Y., Ho S.S., Peng C.C., Peng R.Y. Supercritical fluid extracts of rosemary leaves exhibit potent anti-inflammation and anti-tumor effects. Biosci. Biotechnol. Biochem. 2007, 71:2223-2232.
38. Plazar J., Zegura B., Lah T.T., Filipic M. Protective effects of xanthohumol against the genotoxicity of benzo(a)pyrene (BaP), 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and tert-butyl hydroperoxide (t-BOOH) in HepG2 human hepatoma cells. Mutat. Res./Genet. Toxicol. Environ. Mutagen. 2007, 632:1-8.
39. Renzulli C., Galvano F., Pierdomenico L., Speroni E., Guerra M.C. Effects of rosmarinic acid against aflatoxin B1 and ochratoxin-A-induced cell damage in a human hepatoma cell line (Hep G2). J. Appl. Toxicol. 2004, 24:289-296.
40. Rice-Evans C.A., Miller N.J., Paganga G. Structure-antioxidant activity relationships of flavonoids and phenolic acids. Free Radic. Biol. Med. 1996, 20:933-956.
41. Scarpati M.L., Oriente G. Isolamento e costituzione dell'acido rosmarinico (dal rosmarinus off.). Riserca Sci. 1958, 28:2329-2333.
42. Singh N.P., McCoy M.T., Tice R.R., Schneider E.L. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res. 1988, 175:184-191.
43. Singletary K., MacDonald C., Wallig M. Inhibition by rosemary and carnosol of 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesis and in vivo DMBA-DNA adduct formation. Cancer Lett. 1996, 104:43-48.
44. Singletary K.W. Rosemary extract and carnosol stimulate rat liver glutathione-S-transferase and quinone reductase activities. Cancer Lett. 1996, 100:139-144.
45. Singletary K.W., Nelshoppen J.M. Inhibition of 7,12-dimethylbenz[a]anthracene(DMBA)-induced mammary tumorigenesis and of in vivo formation of mammary DMBA-DNA adducts by rosemary extract. Cancer Lett. 1991, 60:169-175.
46. 2 or visible light-excited Methylene Blue. Cancer Lett. 2002, 177:145-153.
47. Spencer J.P.E., Abd El Mohsen M.M., Rice-Evans C. Cellular uptake and metabolism of flavonoids and their metabolites: implications for their bioactivity. Arch. Biochem. Biophys. 2004, 423:148-161.
48. Takeda H., Tsuji M., Inazu M., Egashira T., Matsumiya T. Rosmarinic acid and caffeic acid produce antidepressive-like effect in the forced swimming test in mice. Eur. J. Pharmacol. 2002, 449:261-267.
49. Vattem D.A., Jang H.-D., Levin R., Shetty K. Synergism of cranberry phenolics with ellagic acid and rosmarinic acid for antimutagenic and DNA protection functions. J. Food Biochem. 2006, 30:98-116.
50. Winter H.K., Ehrlich V.A., Grusch M., Lackner A., Schulte-Hermann R., Grasl-Kraupp B., Mikulits W., Knasmüller S. Use of four new human-derived liver-cell lines for the detection of genotoxic compounds in the single-cell gel electrophoresis (SCGE) assay. Mutat. Res./Genet. Toxicol. Environ. Mutagen. 2008, 657:133-139.
51. Zegura B., Sedmak B., Filipic M. Microcystin-LR induces oxidative DNA damage in human hepatoma cell line HepG2. Toxicon 2003, 41:41-48.