Enhanced antitumor effects by chemical modified IGb3 analogues

Molecular Cancer Therapeutics

Volumn 10, Issue 8, 2011, Pages 1375-1384

  Zhou, Zhixia ^a   Zhang, Cai ^a   Xia, Chengfeng ^b   Chen, Wenlan ^c   Zhu, Huawei ^a   Shang, Pingping ^a   Ma, Fang ^a   Wang, Peng George ^c   Zhang, Jian ^a   Xu, Wenfang ^a   Tian, Zhigang ^a,d  

^a SHANDONG UNIVERSITY   (China)

^b KUNMING INSTITUTE OF BOTANY   (China)

^c OHIO STATE UNIVERSITY   (United States)

^d UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

4''' DH ISOGLOBOTRIHEXOSYLCERAMIDE; ANTINEOPLASTIC AGENT; BETA ACTIN; CD1D ANTIGEN; DENDRITIC CELL VACCINE; GALACTOSE; GAMMA INTERFERON; GLYCOLIPID; HYDROXYL GROUP; INTERLEUKIN 4; ISOGLOBOTRIHEXOSYLCERAMIDE; STAT1 PROTEIN; STAT6 PROTEIN; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; BONE MARROW CELL; CANCER INHIBITION; CHEMICAL MODIFICATION; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; IMMUNE RESPONSE; INTERFERON PRODUCTION; LUNG METASTASIS; MELANOMA; METASTASIS INHIBITION; MOLECULAR STABILITY; MOUSE; NATURAL KILLER T CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; TH1 CELL; TH2 CELL;

ANIMALS; ANTIGENS, CD1D; ANTINEOPLASTIC AGENTS; BINDING SITES; DENDRITIC CELLS; GLOBOSIDES; KILLER CELLS, NATURAL; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; MODELS, MOLECULAR; NEOPLASM METASTASIS; PROTEIN BINDING; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; STAT1 TRANSCRIPTION FACTOR; T-BOX DOMAIN PROTEINS; TRIHEXOSYLCERAMIDES;

EID: 80051579344     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-11-0030     Document Type: Article

References (35)

1. Brigl M, van den Elzen P, Chen X, Meyers JH, Wu D, Wong CH, et al. Conserved and heterogeneous lipid antigen specificities of CD1drestricted NKT cell receptors. J Immunol 2006;176:3625-34. (Pubitemid 43364010)
2. Bendelac A, Rivera MN, Park SH, Roark JH. Mouse CD1-specific NK1 T cells: development, specificity, and function. Annu Rev Immunol 1997;15:535-62. (Pubitemid 27169416)
3. Godfrey DI, Hammond KJ, Poulton LD, Smyth MJ, Baxter AG. NKT cells: facts, functions and fallacies. Immunol Today 2000;21:573-58.
4. Berger A. Th1 and Th2 responses: what are they? BMJ 2000;321:424.
5. Godfrey DI, Kronenberg M. Going both ways: immune regulation via CD1d-dependent NKT cells. J Clin Invest 2004;114:1379-88. (Pubitemid 40385565)
6. Tupin E, Nicoletti A, Elhage R, Rudling M, Ljunggren HG, Hansson GK, et al. CD1d-dependent activation of NKT cells aggravates atherosclerosis. J Exp Med 2004;199:417-22. (Pubitemid 38252053)
7. Ko SY, Ko HJ, Chang WS, Park SH, Kweon MN, Kang CY. alpha- Galactosylceramide can act as a nasal vaccine adjuvant inducing protective immune responses against viral infection and tumor. J Immunol 2005;175:3309-17.
8. Smyth MJ, Wallace ME, Nutt SL, Yagita H, Godfrey DI, Hayakawa Y. Sequential activation of NKT cells and NK cells provides effective innate immunotherapy of cancer. J Exp Med 2005;201:1973-85. (Pubitemid 41002933)
9. Singh AK, Wilson MT, Hong S, Olivares-Villagómez D, Du C, Stanic AK, et al. Natural killer T cell activation protects mice against experimental autoimmune encephalomyelitis. J Exp Med 2001;194:1801-11. (Pubitemid 34028659)
10. Zajonc DM, Savage PB, Bendelac A, Wilson IA, Teyton L. Crystal structures of mouse CD1d-iGb3 complex and its cognate Vα14 T cell receptor suggest a model for dual recognition of foreign and self glycolipids. J Mol Biol 2008;377:1104-16.
11. Wei DG, Curran SA, Savage PB, Teyton L, Bendelac A. Mechanisms imposing the Vb bias of Vα14 natural killer T cells and consequences for microbial glycolipid recognition. J Exp Med 2006;203:1197-207. (Pubitemid 43736590)
12. Zhou D. The immunological function of iGb3. Curr Protein Pept Sci 2006;7:325-33.
13. Miyamoto K, Miyake S, Yamamura T. A synthetic glycolipid prevents autoimmune encephalomyelitis by inducing TH2 bias of natural killer T cells. Nature 2001;413:531-4. (Pubitemid 32938752)
14. Schmieg J, Yang G, Franck RW, Tsuji M. Superior protection against malaria and melanoma metastases by a C-glycoside analogue of the natural killer T cell ligand-galactosylceramide. J Exp Med 2003;198:1631-41. (Pubitemid 37494156)
15. Shang P, Zhang C, Xia C, Chen W, Han Q, Wang PG, et al. Chemical modification of iGb3 increases IFN-gamma production by hepatic NKT cells. Int Immunopharmacol 2008;8:645-53.
16. Sidobre S, Hammond KJ, Bénazet-Sidobre L, Maltsev SD, Richardson SK, Ndonye RM, et al. Glycosphingolipid antigen recognition The T cell antigen receptor expressed by Vα14i NKT cells has a unique mode of glycosphingolipid antigen recognition. Proc Natl Acad Sci U S A 2004;17:12254-9. (Pubitemid 39145430)
17. Xia C, Yao Q, Schuemann J, Rossy E, Chen W, Zhu L, et al. Synthesis and biological evaluation of α-galactosylceramide (KRN7000) and isoglobotrihexosylceramide (iGb3). Bioorg Med Chem Lett 2006;16:2195-9. (Pubitemid 43351077)
18. Xia C, Schümann J, Emmanuel R, Zhang Y, Chen W, Zhang W, et al. Modification of the ceramide moiety of isoglobotrihexosylceramide on its agonist activity in stimulation of invariant natural killer T cells. J Med Chem 2007;50:3489-96. (Pubitemid 47195458)
19. Inaba K, Inaba M, Romani N, Aya H, Deguchi M, Ikehara S, et al. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J Exp Med 1992;176:1693-702.
20. Toura I, Kawano T, Akutsu Y, Nakayama T, Ochiai T, Taniguchi M. Cutting edge: inhibition of experimental tumor metastasis by dendritic cells pulsed with alpha-galactosylceramide. J Immunol 1999;163:2387-91. (Pubitemid 29399156)
21. Fujii S, Shimizu K, Hemmi H, Fukui M, Bonito AJ, Chen G, et al. Glycolipid alpha-C-galactosylceramide is a distinct inducer of dendritic cell function during innate and adaptive immune responses of mice. Proc Natl Acad Sci U S A 2006;103:11252-7. (Pubitemid 44156505)
22. Rengarajan J, Szabo SJ, Glimcher LH. Transcriptional regulation of Th1/Th2 polarization. Immunol Today 2000;21:479-83.
23. Murphy KM, Ouyang W, Farrar JD, Yang J, Ranganath S, Asnagli H, et al. Signaling and transcription in T helper development. Annual Rev Immunol 2000;18:451-94. (Pubitemid 30365388)
24. McCarthy C, Shepherd D, Fleire S, Stronge VS, Koch M, Illarionov PA, et al. The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation. J Exp Med 2007;204:1131-44. (Pubitemid 46798156)
25. Gadola SD, Koch M, Marles-Wright J, Lissin NM, Shepherd D, Matulis G, et al. Structure and binding kinetics of three different human CD1dalpha- galactosylceramide-specific T cell receptors. J Exp Med 2006;203:699-710.
26. Kamada N, Iijima H, Kimura K, Harada M, Shimizu E, Motohashi Si, et al. Crucial amino acid residues of mouse CD1d for glycolipid ligand presentation to V(alpha)14 NKT cells. Int Immunol 2001;13:853-61. (Pubitemid 32685198)
27. Li Y, Thapa P, Hawke D, Kondo Y, Furukawa K, Furukawa K, et al. Immunologic glycosphingolipidomics and NKT cell development in mouse thymus. J Proteome Res 2009;8:2740-51.
28. Dias BR, Rodrigues EG, Nimrichter L, Nakayasu ES, Almeida IC, Travassos LR. Identification of iGb3 and iGb4 in melanoma B16F10-Nex2 cells and the iNKT cell-mediated antitumor effect of dendritic cells primed with iGb3. Mol Cancer 2009;7:116.
29. Afkarian M, Sedy JR, Yang J, Jacobson NG, Cereb N, Yang SY, et al. T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells. Nat Immunol 2002;3:549-57. (Pubitemid 34662307)
30. Szabo SJ, Sullivan BM, Stemmann C, Satoskar AR, Sleckman BP, Glimcher LH. Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science 2002;295:338-42. (Pubitemid 34074366)
31. Ho I, Pai SY. GATA-3 - not just for Th2 cells anymore. Cell Mol Immunol 2007;4:15-29.
32. Wang ZY, Kusam S, Munugalavadla V, Kapur R, Brutkiewicz RR, Dent AL. Regulation of Th2 cytokine expression in NKT cells: unconventional use of Stat6, GATA-3, and NFAT2. J Immunol 2006;176:880-8. (Pubitemid 43099685)
33. Kim PJ, Pai SY, Brigl M, Besra GS, Gumperz J, Ho IC. GATA-3 regulates the development and function of invariant NKT cells. J Immunol 2006;177:6650-9. (Pubitemid 44715028)
34. Townsend MJ, Weinmann AS, Matsuda JL, Salomon R, Farnham PJ, Biron CA, et al. T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells. Immunity 2004;20:477-94. (Pubitemid 38482125)
35. Matsuda JL, Zhang Q, Ndonye R, Richardson SK, Howell AR, Gapin L. T-bet concomitantly controls migration, survival, and effector functions during the development of Valpha14i NKT cells. Blood 2006;107:2797-805.