Modification of the ceramide moiety of isoglobotrihexosylceramide on its agonist activity in stimulation of invariant natural killer T cells

Journal of Medicinal Chemistry

Volumn 50, Issue 15, 2007, Pages 3489-3496

  Xia, Chengfeng ^a   Schümann, Jens ^b   Emmanuel, Rossy ^b   Zhang, Yalong ^a   Chen, Wenlan ^a   Zhang, Wenpeng ^a   De Libero, Gennaro ^b   Wang, Peng George ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA GALACTOSYLCERAMIDE; CD1D ANTIGEN; CERAMIDE; CYTOKINE; ISOGLOBOTRIHEXOSYLCERAMIDE; UNCLASSIFIED DRUG;

AGONIST; ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; AUTOIMMUNITY; CHEMICAL MODIFICATION; COMPLEX FORMATION; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; LYMPHOCYTE ACTIVATION; NATURAL KILLER T CELL; TH1 CELL; TH2 CELL;

ANTIGENS, CD1; CARBOHYDRATE SEQUENCE; CELL LINE; GLOBOSIDES; HUMANS; INTERFERON TYPE II; INTERLEUKIN-4; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; RECEPTORS, ANTIGEN, T-CELL; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TRIHEXOSYLCERAMIDES;

EID: 34547580534     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0701066     Document Type: Article

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