메뉴 건너뛰기




Volumn 104, Issue 3, 2011, Pages 305-311

Heme oxygenase-1 germ line GTn promoter polymorphism is an independent prognosticator of tumor recurrence and survival in pancreatic cancer

Author keywords

germ line polymorphism; heme oxygenase 1; pancreatic cancer; prognostic marker

Indexed keywords

HEME OXYGENASE 1;

EID: 80051551016     PISSN: 00224790     EISSN: 10969098     Source Type: Journal    
DOI: 10.1002/jso.21926     Document Type: Article
Times cited : (23)

References (64)
  • 1
    • 0028985078 scopus 로고
    • Treatment and survival in 13,560 patients with pancreatic cancer, and incidence of the disease, in the West Midlands: An epidemiological study
    • et al.:.
    • Bramhall SR, Allum WH, Jones AG, et al.: Treatment and survival in 13,560 patients with pancreatic cancer, and incidence of the disease, in the West Midlands: An epidemiological study. Br J Surg 1995; 82: 111-115.
    • (1995) Br J Surg , vol.82 , pp. 111-115
    • Bramhall, S.R.1    Allum, W.H.2    Jones, A.G.3
  • 2
    • 33747507299 scopus 로고    scopus 로고
    • One thousand consecutive pancreaticoduodenectomies
    • DOI 10.1097/01.sla.0000217673.04165.ea, PII 0000065820060700000003
    • Cameron JL, Riall TS, Coleman J, et al.: One thousand consecutive pancreaticoduodenectomies. Ann Surg 2006; 244: 10-15. (Pubitemid 44297442)
    • (2006) Annals of Surgery , vol.244 , Issue.1 , pp. 10-15
    • Cameron, J.L.1    Riall, T.S.2    Coleman, J.3    Belcher, K.A.4
  • 3
    • 0032985541 scopus 로고    scopus 로고
    • Pancreatic cancer: A report of treatment and survival trends for 100,313 patients diagnosed from 1985-1995, using the National Cancer Database
    • DOI 10.1016/S1072-7515(99)00075-7, PII S1072751599000757
    • Sener SF, Fremgen A, Menck HR, et al.: Pancreatic cancer: A report of treatment and survival trends for 100,313 patients diagnosed from 1985-1995, using the National Cancer Database. J Am Coll Surg 1999; 189: 1-7. (Pubitemid 29307735)
    • (1999) Journal of the American College of Surgeons , vol.189 , Issue.1 , pp. 1-7
    • Sener, S.F.1    Fremgen, A.2    Menck, H.R.3    Winchester, D.P.4
  • 4
    • 58149308587 scopus 로고    scopus 로고
    • Pancreatic cancer: A review and update
    • Dunphy EP,: Pancreatic cancer: A review and update. Clin J Oncol Nurs 2008; 12: 735-741.
    • (2008) Clin J Oncol Nurs , vol.12 , pp. 735-741
    • Dunphy, E.P.1
  • 6
    • 34547438258 scopus 로고    scopus 로고
    • Guidelines for the Surgical Management of Pancreatic Adenocarcinoma
    • DOI 10.1053/j.seminoncol.2007.05.004, PII S0093775407000991, Pancreatic Cancer
    • Ujiki MB, Talamonti MS,: Guidelines for the surgical management of pancreatic adenocarcinoma. Semin Oncol 2007; 34: 311-320. (Pubitemid 47176619)
    • (2007) Seminars in Oncology , vol.34 , Issue.4 , pp. 311-320
    • Ujiki, M.B.1    Talamonti, M.S.2
  • 7
    • 51649126682 scopus 로고    scopus 로고
    • Adjuvant therapy for adenocarcinoma of the pancreas: Analysis of reported trials and recommendations for future progress
    • Wolff RA, Varadhachary GR, Evans DB,: Adjuvant therapy for adenocarcinoma of the pancreas: Analysis of reported trials and recommendations for future progress. Ann Surg Oncol 2008; 15: 2773-2786.
    • (2008) Ann Surg Oncol , vol.15 , pp. 2773-2786
    • Wolff, R.A.1    Varadhachary, G.R.2    Evans, D.B.3
  • 9
    • 38049040752 scopus 로고    scopus 로고
    • Adjuvant therapy for pancreatic cancer: A review
    • Zuckerman DS, Ryan DP,: Adjuvant therapy for pancreatic cancer: A review. Cancer 2008; 112: 243-249.
    • (2008) Cancer , vol.112 , pp. 243-249
    • Zuckerman, D.S.1    Ryan, D.P.2
  • 10
    • 58249102096 scopus 로고    scopus 로고
    • Adjuvant radiotherapy for resected pancreatic cancer: A lack of benefit or a lack of adequate trials?
    • Gutt R, Liauw SL, Weichselbaum RR,: Adjuvant radiotherapy for resected pancreatic cancer: A lack of benefit or a lack of adequate trials? Nat Clin Pract Gastroenterol Hepatol 2009; 6: 38-46.
    • (2009) Nat Clin Pract Gastroenterol Hepatol , vol.6 , pp. 38-46
    • Gutt, R.1    Liauw, S.L.2    Weichselbaum, R.R.3
  • 11
    • 55249090895 scopus 로고    scopus 로고
    • Evidence-based guidelines for adjuvant therapy for resected adenocarcinoma of the pancreas
    • Iott MJ, Corsini MM, Miller RC,: Evidence-based guidelines for adjuvant therapy for resected adenocarcinoma of the pancreas. Clin J Oncol Nurs 2008; 12: 599-605.
    • (2008) Clin J Oncol Nurs , vol.12 , pp. 599-605
    • Iott, M.J.1    Corsini, M.M.2    Miller, R.C.3
  • 12
    • 43449094334 scopus 로고    scopus 로고
    • Treatment of Pancreatic Adenocarcinoma: A European Perspective
    • DOI 10.1016/j.soc.2008.02.005, PII S1055320708000100
    • Gouma DJ, Busch OR, van Gulik TM,: Treatment of pancreatic adenocarcinoma: A European perspective. Surg Oncol Clin N Am 2008; 17: 569-586, ix. (Pubitemid 351672068)
    • (2008) Surgical Oncology Clinics of North America , vol.17 , Issue.3 , pp. 569-586
    • Gouma, D.J.1    Busch, O.R.C.2    Van Gulik, T.M.3
  • 13
    • 34548401651 scopus 로고    scopus 로고
    • Progress on molecular markers of pancreatic cancer
    • DOI 10.1097/MOG.0b013e3282ba5724, PII 0000157420070900000005
    • Grote T, Logsdon CD,: Progress on molecular markers of pancreatic cancer. Curr Opin Gastroenterol 2007; 23: 508-514. (Pubitemid 47356736)
    • (2007) Current Opinion in Gastroenterology , vol.23 , Issue.5 , pp. 508-514
    • Grote, T.1    Logsdon, C.D.2
  • 14
    • 33344473620 scopus 로고    scopus 로고
    • Low efficacy of serum levels of CA 19-9 in prediction of malignant diseases in asymptomatic population in Taiwan
    • et al.:.
    • Chang CY, Huang SP, Chiu HM, et al.: Low efficacy of serum levels of CA 19-9 in prediction of malignant diseases in asymptomatic population in Taiwan. Hepatogastroenterology 2006; 53: 1-4.
    • (2006) Hepatogastroenterology , vol.53 , pp. 1-4
    • Chang, C.Y.1    Huang, S.P.2    Chiu, H.M.3
  • 15
    • 33748941924 scopus 로고    scopus 로고
    • Value of preoperative serum CA 19-9 levels in predicting resectability for pancreatic cancer
    • Kilic M, Gocmen E, Tez M, et al.: Value of preoperative serum CA 19-9 levels in predicting resectability for pancreatic cancer. Can J Surg 2006; 49: 241-244. (Pubitemid 44432800)
    • (2006) Canadian Journal of Surgery , vol.49 , Issue.4 , pp. 241-244
    • Kilic, M.1    Gocmen, E.2    Tez, M.3    Ertan, T.4    Keskek, M.5    Koc, M.6
  • 17
    • 44249107321 scopus 로고    scopus 로고
    • Resection margins and R1 rates in pancreatic cancer - Are we there yet?
    • DOI 10.1111/j.1365-2559.2007.02935.x
    • Verbeke CS,: Resection margins and R1 rates in pancreatic cancer-Are we there yet? Histopathology 2008; 52: 787-796. (Pubitemid 351724902)
    • (2008) Histopathology , vol.52 , Issue.7 , pp. 787-796
    • Verbeke, C.S.1
  • 19
    • 41149138021 scopus 로고    scopus 로고
    • Variability in reporting resection margin status in pancreatic cancer
    • DOI 10.1097/SLA.0b013e31816a7077, PII 0000065820080400000027
    • Verbeke CS, Menon KV,: Variability in reporting resection margin status in pancreatic cancer. Ann Surg 2008; 247: 716-717. (Pubitemid 351440631)
    • (2008) Annals of Surgery , vol.247 , Issue.4 , pp. 716-717
    • Verbeke, C.S.1    Menon, K.V.2
  • 21
    • 0034668216 scopus 로고    scopus 로고
    • Gene regulation of heme oxygenase-1 as a therapeutic target
    • Immenschuh S, Ramadori G,: Gene regulation of heme oxygenase-1 as a therapeutic target. Biochem Pharmacol 2000; 60: 1121-1128.
    • (2000) Biochem Pharmacol , vol.60 , pp. 1121-1128
    • Immenschuh, S.1    Ramadori, G.2
  • 22
    • 59149088542 scopus 로고    scopus 로고
    • Heme oxygenase and renal disease
    • Jarmi T, Agarwal A,: Heme oxygenase and renal disease. Curr Hypertens Rep 2009; 11: 56-62.
    • (2009) Curr Hypertens Rep , vol.11 , pp. 56-62
    • Jarmi, T.1    Agarwal, A.2
  • 23
    • 35848942608 scopus 로고    scopus 로고
    • Heme oxygenase-1 in tumors: Is it a false friend?
    • DOI 10.1089/ars.2007.1659
    • Jozkowicz A, Was H, Dulak J,: Heme oxygenase-1 in tumors: Is it a false friend? Antioxid Redox Signal 2007; 9: 2099-2117. (Pubitemid 350059009)
    • (2007) Antioxidants and Redox Signaling , vol.9 , Issue.12 , pp. 2099-2117
    • Jozkowicz, A.1    Was, H.2    Dulak, J.3
  • 24
    • 28844446987 scopus 로고    scopus 로고
    • Molecular basis of heme oxygenase-1 induction: Implications for chemoprevention and chemoprotection
    • DOI 10.1089/ars.2005.7.1688
    • Prawan A, Kundu JK, Surh YJ,: Molecular basis of heme oxygenase-1 induction: Implications for chemoprevention and chemoprotection. Antioxid Redox Signal 2005; 7: 1688-1703. (Pubitemid 41768002)
    • (2005) Antioxidants and Redox Signaling , vol.7 , Issue.11-12 , pp. 1688-1703
    • Prawan, A.1    Kundu, J.K.2    Surh, Y.-J.3
  • 26
    • 1442326158 scopus 로고    scopus 로고
    • Antiapoptotic role of heme oxygenase (HO) and the potential of HO as a target in anticancer treatment
    • DOI 10.1023/B:APPT.0000012119.83734.4e
    • Fang J, Akaike T, Maeda H,: Antiapoptotic role of heme oxygenase (HO) and the potential of HO as a target in anticancer treatment. Apoptosis 2004; 9: 27-35. (Pubitemid 38270426)
    • (2004) Apoptosis , vol.9 , Issue.1 , pp. 27-35
    • Fang, J.1    Akaike, T.2    Maeda, H.3
  • 28
    • 0842308302 scopus 로고    scopus 로고
    • Upregulation of heme oxygenase-1 and p21 confers resistance to apoptosis in human gastric cancer cells
    • DOI 10.1038/sj.onc.1207173
    • Liu ZM, Chen GG, Ng EK, et al.: Upregulation of heme oxygenase-1 and p21 confers resistance to apoptosis in human gastric cancer cells. Oncogene 2004; 23: 503-513. (Pubitemid 38175005)
    • (2004) Oncogene , vol.23 , Issue.2 , pp. 503-513
    • Liu, Z.-M.1    Chen, G.G.2    Ng, E.K.W.3    Leung, W.-K.4    Sung, J.J.Y.5    Chung, S.C.S.6
  • 29
    • 43549095276 scopus 로고    scopus 로고
    • HO-1 underlies resistance of AML cells to TNF-induced apoptosis
    • Rushworth SA, MacEwan DJ,: HO-1 underlies resistance of AML cells to TNF-induced apoptosis. Blood 2008; 111: 3793-3801.
    • (2008) Blood , vol.111 , pp. 3793-3801
    • Rushworth, S.A.1    MacEwan, D.J.2
  • 31
    • 67650093930 scopus 로고    scopus 로고
    • Heme oxygenase-1 and its metabolites affect pancreatic tumor growth in vivo
    • et al.:.
    • Nuhn P, Kunzli BM, Hennig R, et al.: Heme oxygenase-1 and its metabolites affect pancreatic tumor growth in vivo. Mol Cancer 2009; 8: 37.
    • (2009) Mol Cancer , vol.8 , pp. 37
    • Nuhn, P.1    Kunzli, B.M.2    Hennig, R.3
  • 32
    • 57349131700 scopus 로고    scopus 로고
    • Heme oxygenase-1 inhibits the proliferation of pancreatic stellate cells by repression of the extracellular signal-regulated kinase1/2 pathway
    • et al.:.
    • Schwer CI, Guerrero AM, Humar M, et al.: Heme oxygenase-1 inhibits the proliferation of pancreatic stellate cells by repression of the extracellular signal-regulated kinase1/2 pathway. J Pharmacol Exp Ther 2008; 327: 863-871.
    • (2008) J Pharmacol Exp Ther , vol.327 , pp. 863-871
    • Schwer, C.I.1    Guerrero, A.M.2    Humar, M.3
  • 34
    • 4644226200 scopus 로고    scopus 로고
    • The role of heme oxygenase-1 promoter polymorphisms in human disease
    • DOI 10.1016/j.freeradbiomed.2004.07.008, PII S0891584904005477
    • Exner M, Minar E, Wagner O, et al.: The role of heme oxygenase-1 promoter polymorphisms in human disease. Free Radic Biol Med 2004; 37: 1097-1104. (Pubitemid 39296737)
    • (2004) Free Radical Biology and Medicine , vol.37 , Issue.8 , pp. 1097-1104
    • Exner, M.1    Minar, E.2    Wagner, O.3    Schillinger, M.4
  • 36
    • 7944222236 scopus 로고    scopus 로고
    • Polymorphism in heme oxygenase-1 (HO-1) promoter is related to the risk of oral squamous cell carcinoma occurring on male areca chewers
    • et al.:.
    • Chang KW, Lee TC, Yeh WI, et al.: Polymorphism in heme oxygenase-1 (HO-1) promoter is related to the risk of oral squamous cell carcinoma occurring on male areca chewers. Br J Cancer 2004; 91: 1551-1555.
    • (2004) Br J Cancer , vol.91 , pp. 1551-1555
    • Chang, K.W.1    Lee, T.C.2    Yeh, W.I.3
  • 39
    • 49349098481 scopus 로고    scopus 로고
    • Increased risk of gastric cancer in Japanese subjects is associated with microsatellite polymorphisms in the heme oxygenase-1 and the inducible nitric oxide synthase gene promoters
    • et al.:.
    • Sawa T, Mounawar M, Tatemichi M, et al.: Increased risk of gastric cancer in Japanese subjects is associated with microsatellite polymorphisms in the heme oxygenase-1 and the inducible nitric oxide synthase gene promoters. Cancer Lett 2008; 269: 78-84.
    • (2008) Cancer Lett , vol.269 , pp. 78-84
    • Sawa, T.1    Mounawar, M.2    Tatemichi, M.3
  • 40
    • 49249123275 scopus 로고    scopus 로고
    • Microsatellite GTn-repeat polymorphism in the promoter of heme oxygenase-1 gene is an independent predictor of tumor recurrence in male oral squamous cell carcinoma patients
    • et al.:.
    • Vashist YK, Blessmann M, Trump F, et al.: Microsatellite GTn-repeat polymorphism in the promoter of heme oxygenase-1 gene is an independent predictor of tumor recurrence in male oral squamous cell carcinoma patients. J Oral Pathol Med 2008; 37: 480-484.
    • (2008) J Oral Pathol Med , vol.37 , pp. 480-484
    • Vashist, Y.K.1    Blessmann, M.2    Trump, F.3
  • 41
    • 60349123984 scopus 로고    scopus 로고
    • Haeme oxygenase-1 promoter polymorphism is an independent prognostic marker of gastrointestinal stromal tumour
    • et al.:.
    • Vashist YK, Uzunoglu G, Cataldegirmen G, et al.: Haeme oxygenase-1 promoter polymorphism is an independent prognostic marker of gastrointestinal stromal tumour. Histopathology 2009; 54: 303-308.
    • (2009) Histopathology , vol.54 , pp. 303-308
    • Vashist, Y.K.1    Uzunoglu, G.2    Cataldegirmen, G.3
  • 43
    • 43449107352 scopus 로고    scopus 로고
    • Most pancreatic cancer resections are R1 resections
    • et al.:.
    • Esposito I, Kleeff J, Bergmann F, et al.: Most pancreatic cancer resections are R1 resections. Ann Surg Oncol 2008; 15: 1651-1660.
    • (2008) Ann Surg Oncol , vol.15 , pp. 1651-1660
    • Esposito, I.1    Kleeff, J.2    Bergmann, F.3
  • 44
    • 42649085349 scopus 로고    scopus 로고
    • Prognostic versus predictive value of biomarkers in oncology
    • et al.:.
    • Oldenhuis CN, Oosting SF, Gietema JA, et al.: Prognostic versus predictive value of biomarkers in oncology. Eur J Cancer 2008; 44: 946-953.
    • (2008) Eur J Cancer , vol.44 , pp. 946-953
    • Oldenhuis, C.N.1    Oosting, S.F.2    Gietema, J.A.3
  • 45
    • 77649188501 scopus 로고    scopus 로고
    • A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33
    • et al.:.
    • Petersen GM, Amundadottir L, Fuchs CS, et al.: A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet 2010; 42: 224-228.
    • (2010) Nat Genet , vol.42 , pp. 224-228
    • Petersen, G.M.1    Amundadottir, L.2    Fuchs, C.S.3
  • 46
    • 69349097813 scopus 로고    scopus 로고
    • Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer
    • et al.:.
    • Amundadottir L, Kraft P, Stolzenberg-Solomon RZ, et al.: Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat Genet 2009; 41: 986-990.
    • (2009) Nat Genet , vol.41 , pp. 986-990
    • Amundadottir, L.1    Kraft, P.2    Stolzenberg-Solomon, R.Z.3
  • 47
    • 41649097333 scopus 로고    scopus 로고
    • Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers
    • et al.:.
    • Antoniou AC, Spurdle AB, Sinilnikova OM, et al.: Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers. Am J Hum Genet 2008; 82: 937-948.
    • (2008) Am J Hum Genet , vol.82 , pp. 937-948
    • Antoniou, A.C.1    Spurdle, A.B.2    Sinilnikova, O.M.3
  • 48
    • 55449108364 scopus 로고    scopus 로고
    • Genetic variation in the HSD17B1 gene and risk of prostate cancer
    • et al.:.
    • Kraft P, Pharoah P, Chanock SJ, et al.: Genetic variation in the HSD17B1 gene and risk of prostate cancer. PLoS Genet 2005; 1: e68.
    • (2005) PLoS Genet , vol.1
    • Kraft, P.1    Pharoah, P.2    Chanock, S.J.3
  • 49
    • 58749099290 scopus 로고    scopus 로고
    • Germ-line DNA polymorphisms and susceptibility to differentiated thyroid cancer
    • Adjadj E, Schlumberger M, de Vathaire F,: Germ-line DNA polymorphisms and susceptibility to differentiated thyroid cancer. Lancet Oncol 2009; 10: 181-190.
    • (2009) Lancet Oncol , vol.10 , pp. 181-190
    • Adjadj, E.1    Schlumberger, M.2    De Vathaire, F.3
  • 50
    • 74949112149 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms of gemcitabine metabolic genes and pancreatic cancer survival and drug toxicity
    • et al.:.
    • Okazaki T, Javle M, Tanaka M, et al.: Single nucleotide polymorphisms of gemcitabine metabolic genes and pancreatic cancer survival and drug toxicity. Clin Cancer Res 2010; 16: 320-329.
    • (2010) Clin Cancer Res , vol.16 , pp. 320-329
    • Okazaki, T.1    Javle, M.2    Tanaka, M.3
  • 51
    • 78449305536 scopus 로고    scopus 로고
    • Gemcitabine metabolic and transporter gene polymorphisms are associated with drug toxicity and efficacy in patients with locally advanced pancreatic cancer
    • et al.:.:. DOI: 10.1002/cncr.25282.
    • Tanaka M, Javle M, Dong X, et al.: Gemcitabine metabolic and transporter gene polymorphisms are associated with drug toxicity and efficacy in patients with locally advanced pancreatic cancer. Cancer 2010; 116: 5325-5335. DOI: 10.1002/cncr.25282.
    • (2010) Cancer , vol.116 , pp. 5325-5335
    • Tanaka, M.1    Javle, M.2    Dong, X.3
  • 53
    • 24944544420 scopus 로고    scopus 로고
    • Drug-metabolizing enzyme polymorphisms predict clinical outcome in a node-positive breast cancer cohort
    • et al.:.
    • DeMichele A, Aplenc R, Botbyl J, et al.: Drug-metabolizing enzyme polymorphisms predict clinical outcome in a node-positive breast cancer cohort. J Clin Oncol 2005; 23: 5552-5559.
    • (2005) J Clin Oncol , vol.23 , pp. 5552-5559
    • Demichele, A.1    Aplenc, R.2    Botbyl, J.3
  • 54
    • 0033626025 scopus 로고    scopus 로고
    • Pharmacogenetics: A tool for individualizing antineoplastic therapy
    • Innocenti F, Iyer L, Ratain MJ,: Pharmacogenetics: A tool for individualizing antineoplastic therapy. Clin Pharmacokinet 2000; 39: 315-325.
    • (2000) Clin Pharmacokinet , vol.39 , pp. 315-325
    • Innocenti, F.1    Iyer, L.2    Ratain, M.J.3
  • 55
    • 40349100347 scopus 로고    scopus 로고
    • Clinical correlates of low-risk variants in FGFR2, TNRC9, MAP3K1, LSP1 and 8q24 in a Dutch cohort of incident breast cancer cases
    • et al.:.
    • Huijts PE, Vreeswijk MP, Kroeze-Jansema KH, et al.: Clinical correlates of low-risk variants in FGFR2, TNRC9, MAP3K1, LSP1 and 8q24 in a Dutch cohort of incident breast cancer cases. Breast Cancer Res 2007; 9: R78.
    • (2007) Breast Cancer Res , vol.9
    • Huijts, P.E.1    Vreeswijk, M.P.2    Kroeze-Jansema, K.H.3
  • 56
    • 1642391048 scopus 로고    scopus 로고
    • Host genetics and tumour metastasis
    • DOI 10.1038/sj.bjc.6601590
    • Hunter KW,: Host genetics and tumour metastasis. Br J Cancer 2004; 90: 752-755. (Pubitemid 38406581)
    • (2004) British Journal of Cancer , vol.90 , Issue.4 , pp. 752-755
    • Hunter, K.W.1
  • 57
    • 52449099461 scopus 로고    scopus 로고
    • Genomic variation in myeloma: Design, content, and initial application of the Bank on A Cure SNP Panel to detect associations with progression-free survival
    • et al.:.
    • Van Ness B, Ramos C, Haznadar M, et al.: Genomic variation in myeloma: Design, content, and initial application of the Bank On A Cure SNP Panel to detect associations with progression-free survival. BMC Med 2008; 6: 26.
    • (2008) BMC Med , vol.6 , pp. 26
    • Van Ness, B.1    Ramos, C.2    Haznadar, M.3
  • 58
    • 69249222757 scopus 로고    scopus 로고
    • Targeting of Hsp32 in solid tumors and leukemias: A novel approach to optimize anticancer therapy
    • et al.:.
    • Gleixner KV, Mayerhofer M, Vales A, et al.: Targeting of Hsp32 in solid tumors and leukemias: A novel approach to optimize anticancer therapy. Curr Cancer Drug Targets 2009; 9: 675-689.
    • (2009) Curr Cancer Drug Targets , vol.9 , pp. 675-689
    • Gleixner, K.V.1    Mayerhofer, M.2    Vales, A.3
  • 59
    • 0025276590 scopus 로고
    • D(TG)n.d(CA)n sequences upstream of the rat prolactin gene form Z-DNA and inhibit gene transcription
    • Naylor LH, Clark EM,: d(TG)n.d(CA)n sequences upstream of the rat prolactin gene form Z-DNA and inhibit gene transcription. Nucleic Acids Res 1990; 18: 1595-1601.
    • (1990) Nucleic Acids Res , vol.18 , pp. 1595-1601
    • Naylor, L.H.1    Clark, E.M.2
  • 60
    • 33846252746 scopus 로고    scopus 로고
    • Mechanisms of egfr gene transcription modulation: Relationship to cancer risk and therapy response
    • DOI 10.1158/1078-0432.CCR-06-0626
    • Brandt B, Meyer-Staeckling S, Schmidt H, et al.: Mechanisms of egfr gene transcription modulation: Relationship to cancer risk and therapy response. Clin Cancer Res 2006; 12: 7252-7260. (Pubitemid 46095396)
    • (2006) Clinical Cancer Research , vol.12 , Issue.24 , pp. 7252-7260
    • Brandt, B.1    Meyer-Staeckling, S.2    Schmidt, H.3    Agelopoulos, K.4    Buerger, H.5
  • 62
    • 0033914059 scopus 로고    scopus 로고
    • Modulation of EGFR gene transcription by secondary structures, a polymorphic repetitive sequence and mutations - A link between genetics and epigenetics
    • Gebhardt F, Burger H, Brandt B,: Modulation of EGFR gene transcription by secondary structures, a polymorphic repetitive sequence and mutations-A link between genetics and epigenetics. Histol Histopathol 2000; 15: 929-936. (Pubitemid 30488572)
    • (2000) Histology and Histopathology , vol.15 , Issue.3 , pp. 929-936
    • Gebhardt, F.1    Burger, H.2    Brandt, B.3
  • 63
    • 0343569824 scopus 로고    scopus 로고
    • Modulation of EGFR gene transcription by a polymorphic repetitive sequence - A link between genetics and epigenetics
    • Gebhardt F, Burger H, Brandt B,: Modulation of EGFR gene transcription by a polymorphic repetitive sequence-A link between genetics and epigenetics. Int J Biol Markers 2000; 15: 105-110. (Pubitemid 30195494)
    • (2000) International Journal of Biological Markers , vol.15 , Issue.1 , pp. 105-110
    • Gebhardt, F.1    Burger, H.2    Brandt, B.3
  • 64
    • 0037326447 scopus 로고    scopus 로고
    • Relationship between microsatellite polymorphism in the haem oxygenase-1 gene promoter and longevity of the normal Japanese population [2]
    • Yamaya M, Nakayama K, Ebihara S, et al.: Relationship between microsatellite polymorphism in the haem oxygenase-1 gene promoter and longevity of the normal Japanese population. J Med Genet 2003; 40: 146-148. (Pubitemid 36232822)
    • (2003) Journal of Medical Genetics , vol.40 , Issue.2 , pp. 146-148
    • Yamaya, M.1    Nakayama, K.2    Ebihara, S.3    Hirai, H.4    Higuchi, S.5    Sasaki, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.