Haeme oxygenase-1 promoter polymorphism is an independent prognostic marker of gastrointestinal stromal tumour

Histopathology

Volumn 54, Issue 3, 2009, Pages 303-308

  Vashist, Yogesh K ^a   Uzunoglu, Guentac ^a   Cataldegirmen, Guelle ^a   Kalinin, Viacheslar ^a   Schurr, Paulus ^a   Koenig, Alexandra M ^a   Thieltges, Sabrina ^a   Zehler, Oliver ^a   Schneider, Claus ^a   Izbicki, Jacob R ^a   Yekebas, Emre F ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

Author keywords

Gastrointestinal stromal tumour; Haeme oxygenase 1; Polymorphism; Survival

Indexed keywords

HEME OXYGENASE 1; MICROSATELLITE DNA;

ADULT; AGED; ALLELE; ARTICLE; CANCER GROWTH; CANCER RECURRENCE; CANCER RISK; CANCER SURGERY; CANCER SURVIVAL; CARCINOGENESIS; CLINICAL ARTICLE; CONTROLLED STUDY; DNA DETERMINATION; DNA POLYMORPHISM; DNA SEQUENCE; FEMALE; GASTROINTESTINAL STROMAL TUMOR; GENOTYPE; HETEROZYGOTE; HUMAN; HUMAN TISSUE; MALE; METASTASIS; MICROSATELLITE INSTABILITY; PRIORITY JOURNAL; PROGNOSIS; PROMOTER REGION; PROPORTIONAL HAZARDS MODEL;

FEMALE; GASTROINTESTINAL STROMAL TUMORS; HEME OXYGENASE-1; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC; TUMOR MARKERS, BIOLOGICAL;

EID: 60349123984     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/j.1365-2559.2009.03221.x     Document Type: Article

References (23)

1. Fletcher CD, Berman JJ, Corless C et al. Diagnosis of gastrointestinal stromal tumors: a consensus approach. Hum. Pathol. 2002 33 459 465.
2. Fletcher CD, Berman JJ, Corless C et al. Diagnosis of gastrointestinal stromal tumors: a consensus approach. Int J Surg Pathol. 2002 10 81 89.
3. Miettinen M, Sobin LH, Lasota J. Gastrointestinal stromal tumors of the stomach: a clinicopathologic, immunohistochemical, and molecular genetic study of 1765 cases with long-term follow-up. Am. J. Surg. Pathol. 2005 29 52 68.
4. Lasota J, Wozniak A, Kopczynski J et al. Loss of heterozygosity on chromosome 22q in gastrointestinal stromal tumors (GISTs): a study on 50 cases. Lab. Invest. 2005 85 237 247.
5. DeMatteo RP, Lewis JJ, Leung D, Mudan SS, Woodruff JM, Brennan MF. Two hundred gastrointestinal stromal tumors: recurrence patterns and prognostic factors for survival. Ann. Surg. 2000 231 51 58.
6. Schurr P, Wolter S, Kaifi J et al. Microsatellite DNA alterations of gastrointestinal stromal tumors are predictive for outcome. Clin Cancer Res. 2006 12 5151 5157.
7. Fukasawa T, Chong JM, Sakurai S et al. Allelic loss of 14q and 22q, NF2 mutation, and genetic instability occur independently of c-kit mutation in gastrointestinal stromal tumor. Jpn. J. Cancer Res. 2000 91 1241 1249.
8. Schneider-Stock R, Boltze C, Lasota J et al. Loss of p16 protein defines high-risk patients with gastrointestinal stromal tumors: a tissue microarray study. Clin Cancer Res. 2005 11 (2 Pt 1 638 645.
9. Gunawan B, Bergmann F, Höer J et al. Biological and clinical significance of cytogenetic abnormalities in low-risk and high-risk gastrointestinal stromal tumors. Hum. Pathol. 2002 33 316 321.
10. Pylkkänen L, Sarlomo-Rikala M, Wessman M et al. Chromosome 22q alterations and expression of the NF2 gene product, merlin, in gastrointestinal stromal tumors. Hum. Pathol. 2003 34 872 879.
11. Shibahara S. The heme oxygenase dilemma in cellular homeostasis: new insights for the feedback regulation of heme catabolism. Tohoku J. Exp. Med. 2003 200 167 186.
12. Fang J, Akaike T, Maeda H. Antiapoptotic role of heme oxygenase (HO) and the potential of HO as a target in anticancer treatment. Apoptosis 2004 9 27 35.
13. Sunamura M, Duda DG, Ghattas MH et al. Heme oxygenase-1 accelerates tumor angiogenesis of human pancreatic cancer. Angiogenesis 2003 6 15 24.
14. Yamada N, Yamaya M, Okinaga S et al. Microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with susceptibility to emphysema. Am. J. Hum. Genet. 2000 66 187 195.
15. Chang KW, Lee TC, Yeh WI et al. Polymorphism in heme oxygenase-1 (HO-1) promoter is related to the risk of oral squamous cell carcinoma occurring on male areca chewers. Br. J. Cancer 2004 91 1551 1555.
16. Kikuchi A, Yamaya M, Suzuki S et al. Association of susceptibility to the development of lung adenocarcinoma with the heme oxygenase-1 gene promoter polymorphism. Hum. Genet. 2005 116 354 360.
17. Okamoto I, Krogler J, Endler G et al. A microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with risk for melanoma. Int. J. Cancer 2006 119 1312 1315.
18. Lo SS, Lin SC, Wu CW et al. Heme oxygenase-1 gene promoter polymorphism is associated with risk of gastric adenocarcinoma and lymphovascular tumor invasion. Ann. Surg. Oncol. 2007 14 2250 2256.
19. Becker JC, Fukui H, Imai Y et al. Colonic expression of heme oxygenase-1 is associated with a better long-term survival in patients with colorectal cancer. Scand. J. Gastroenterol. 2007 42 852 858.
20. Berberat PO, Dambrauskas Z, Gulbinas A et al. Inhibition of heme oxygenase-1 increases responsiveness of pancreatic cancer cells to anticancer treatment. Clin Cancer Res. 2005 11 3790 3798.
21. Tsuji MH, Yanagawa T, Iwasa S et al. Heme oxygenase-1 expression in oral squamous cell carcinoma as involved in lymph node metastasis. Cancer Lett. 1999 138 53 59.
22. Goodman AI, Choudhury M, da Silva JL, Schwartzman ML, Abraham NG. Overexpression of the heme oxygenase gene in renal cell carcinoma. Proc. Soc. Exp. Biol. Med. 1997 214 54 61.
23. Yamaya M, Nakayama K, Ebihara S, Hirai H, Higuchi S, Sasaki H. Relationship between microsatellite polymorphism in the haem oxygenase-1 gene promoter and longevity of the normal Japanese population. J. Med. Genet. 2003 40 146 148.